Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model

作     者：SHI Qin GAO Wei HAN XingLong ZHU XueSong SUN Jie XIE Fang HOU XiangLin YANG HuiLin DAI JianWu CHEN Liang 

作者机构：Orthopedic Department the First Affiliated Hospital of Soochow University Orthopedic Department the Sixth People's Hospital of Hangzhou Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences Pathological Department Medical School of Soochow University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第2期

页      面：232-240页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(81101369,81071450) the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China(to Shi Qin),Ph.D.Programs Foundation of State Education Ministry(20113201110013) Jiangsu Provincial Special Program of Medical Science(BL2012004,BK2011264) Jiangsu Province’s Key Provincial Talents Program(RC2011102) 

主　　题：collagen scaffold basic fibroblast growth factor spinal cord injury nerve regeneration 

摘      要：Nerve conduit is one of strategies for spine cord injury(SCI)***,studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury ***,the scaffold by itself was difficult to meet the need of SCI functional *** basic fibroblast growth factor(bFGF)administration significantly promotes functional recovery after organ ***,using a rat model of T9 hemisected SCI,we aimed at assessing the repair capacity of implantation of collagen scaffold(CS)modified by collagen binding bFGF(CBD-bFGF).The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection *** CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group,when evaluated by the 21-point Basso-Beattie-Bresnahan(BBB)score and footprint *** hematoxylin and eosin(H&E)and immunohistochemical staining of neurofilament(NF)and glial fibrillary acidic protein(GFAP)demonstrated that fibers were guided to grow through the *** findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery.