检索结果-南通市图书馆

Comparison of outcomes with stapler versus hand-sewn closure of the pancreatic stump following minimally invasive distal pancreatectomy: a retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

胰腺病学杂志(英文) 2024年第2期07卷 106-110页

作者： Qian Tao Huang Kaiquan Chen Wen bai xueli Gao Shunliang Shen Yan Zhang Min Wu Jian Yu Jun Ma Tao Liang Tingbo Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province Hangzhou China Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases Hangzhou China Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou China Cancer Center Zhejiang University Hangzhou China

Background: Pancreatic fistula after distal pancreatectomy is a common and potentially lethal complication. The optimal closure method for the pancreatic remnant during minimally invasive distal pancreatectomy (MDP) remains ***: Data of consecutive patients who underwent MDP in our institution between July 2018 and June 2021 were collected. The outcomes of MDP with stapler and hand-sewn closure were compared. The primary outcome was clinically relevant postoperative pancreatic fistula (CR-POPF) per the International Study Group of Pancreatic Surgery ***: Of the 384 patients (stapler closure, 339; hand-sewn closure, 45) enrolled, 249 developed CR-POPF (grades B and C: 242 and 7 patients, respectively). The rates of grade B and grade C POPF in the stapler group were similar to the corresponding rates in the hand-sewn group (64.6% and 1.5% vs 51.1% and 4.4%,P = .078 andP = .223, respectively). No differences between the stapler and hand-sewn groups were observed regarding the median operation time (207 vs 222 minutes,P = .139), incidence of major complications (16.5% vs 20.0%,P = .559), and mortality (0.2% vs 0%,P = 1.000). The independent risk factors of CR-POPF were abdominal abscess, prolonged operation time, and transection site (P = .004, .006, and .001, respectively).Conclusion: The incidence and severity of CR-POPF by stapler closure of the pancreatic stump were comparable to those associated with hand-sewn closure in MDP in this retrospective cohort. Randomized controlled trials are needed to verify this finding.

关键词： Distal pancreatectomy Minimally invasive surgery Outcome Postoperative pancreatic fistula Stapler closure

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

机器人辅助保留功能胰腺手术治疗新进展

中华消化外科杂志 2024年第1期23卷 102-108页

作者：白雪莉洪一帆张晓雨杨加琦梁廷波浙江大学医学院附属第一医院肝胆胰外科杭州310003

保留功能胰腺手术作为一种限制性切除技术,应用于胰腺良性、交界性或低度恶性病变,能显著改善患者术后短期和长期生命质量。与传统腹腔镜手术比较,机器人手术系统在胰腺手术中更高效、精确,其安全性与可靠性在医学界也得到广泛认可。然... 详细信息

保留功能胰腺手术作为一种限制性切除技术,应用于胰腺良性、交界性或低度恶性病变,能显著改善患者术后短期和长期生命质量。与传统腹腔镜手术比较,机器人手术系统在胰腺手术中更高效、精确,其安全性与可靠性在医学界也得到广泛认可。然而,目前对于机器人系统在保留功能胰腺手术中的应用研究仍然较少。因此,笔者总结分析机器人辅助保留功能胰腺手术的最新进展,重点介绍手术范围、手术方式及相关预后情况。

关键词：胰腺肿瘤机器人手术保留功能胰腺手术手术方式进展

在线全文

学校读者我要写书评

暂无评论

铁改性煤矸石去除废水中镉的研究

化工新型材料 2024年第S1期52卷 272-277,284页

作者：白雪莉蒲彦君周建民税永红成都纺织高等专科学校固体废物生态低碳资源化重点实验室成都611756 四川轻化工大学材料科学与工程学院自贡643000 西南交通大学地球科学与环境工程学院成都611756

废水中的镉会严重威胁环境和人体健康。采用水热法制备铁改性煤矸石,并将其应用于含镉废水的处理。利用红外光谱(FT-IR)、X射线衍射(XRD)、扫描电镜(SEM)、比表面积(BET)和Zeta电位等方法对材料的结构和表面性质进行分析,研究铁改性煤... 详细信息

废水中的镉会严重威胁环境和人体健康。采用水热法制备铁改性煤矸石,并将其应用于含镉废水的处理。利用红外光谱(FT-IR)、X射线衍射(XRD)、扫描电镜(SEM)、比表面积(BET)和Zeta电位等方法对材料的结构和表面性质进行分析,研究铁改性煤矸石对Cd^(2+)的吸附行为,考察了pH和共存离子等因素对其吸附性能的影响,探讨了其吸附动力学、吸附等温线。结果表明:铁改性煤矸石经改性后其比表面积提高了2.85倍,最佳反应pH为8,共存离子CO_(3)^(2-)、SO_(4)^(-)、F-促进吸附反应;据伪二级动力学和Freundlich吸附等温式,表明对Cd^(2+)的吸附是单分子层化学吸附,吸附过程是自发吸热过程;30℃和50℃时铁改性煤矸石对Cd^(2+)最大拟合吸附量分别为32mg/g和34.18mg/g。铁改性煤矸石对废水中的Cd^(2+)具有良好的吸附性,有望用于重金属离子废水的处理。

关键词：煤矸石改性 Cd^(2+) 吸附性能吸附机理

A female surgeon’s thoughts on gender attributes in surgery

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第3期10卷 370-372页

作者： xueli bai Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

There is a Chinese old saying that started in the 19th century:“A woman is vulnerable,but being a mother makes one strong”.This seems to make sense,considering the status of women in society around a hundred years *** of us lived in that period,but we can imagine that women who lived back then might not have been obligated to work or assume a ***.

关键词： gender mother assume

Eating self for not be eaten:Pancreatic cancer suppresses selfimmunogenicity by autophagy-mediated MHC-I degradation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 1626-1627页

作者： Xing Huang Xiaozhen Zhang xueli bai Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina

In a recent study in Nature,1 Yamamoto et *** that MHC-I is a selective substrate of autophagy in tumor immune ***,it was reported that autophagy-mediated lysosomal degradation of MHC-I suppresses pancreatic cancer immunogenicity and the effectiveness of *** findings indicate the potential of autophagy inhibition as a strategy to activate anti-pancreatic cancer immunity.

关键词： cancer al mediated

Multiplex imaging reveals the architecture of the tumor immune microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2021年第4期18卷 949-954页

作者： Junlei Zhang Jinyuan Song Jianpeng Sheng xueli bai Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial Key Laboratory of Pancreatic Diseasethe First Affiliated HospitalZhejiang University School of MedicineZhejiang University Cancer CentreZhejiang UniversityHangzhou 310002China

The tumor immune microenvironment(TME)is composed of a variety of components,such as tumor cells,immune cells,and the extracellular *** TME has been studied through transcriptomic,proteomic,metabolomic,and phosphoprot... 详细信息

关键词： immune tumor microenvironment

Computed tomography-based delta radiomics of tumor core_edge combination for systemic treatment response evaluation in pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

Journal of Pancreatology 2024年第3期7卷 181-190页

作者： Xiang Li Na Lu Peijun Hu Yiwen Chen Liying Liu Xinyuan Liu Chengxiang Guo Wenbo Xiao Ke Sun Jingsong Li xueli bai Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Key Laboratory of Pancreatic Disease HangzhouChina Research Center for Healthcare Data Science Zhejiang LabHangzhou China Department of Radiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhouChina Zhejiang University Cancer Center HangzhouChina

Background:As a systemic disease,pancreatic cancer(PC)can be treated systemically to raise the R0 resection rate and enhance patient *** best ways to assess the treatment response to systemic treatment of patients with PC are still ***:A total of 122 PC patients were enrolled;25 of these patients were used as an independent testing *** to the pathologic response,PC patients were classified into the responder and nonresponder *** whole tumor,core,edge,and peritumoral were segmented from the enhanced computed tomography(CT)***-learning models were created by extracting the variations in radionics features before and after therapy(delta radiomics features).Finally,we compared the performance of models based on radiomics features,changes in tumor markers,and radiologic ***:The model based on the core(area under curve[AUC]=0.864)and edge features(AUC=0.853)showed better performance than that based on the whole tumor(AUC=0.847)or peritumoral area(AUC=0.846).Moreover,the tumor core_edge combination model(AUC=0.899)could better increase confidence in treatment response than using either of them *** accuracies of models based on changes in tumor markers and radiologic evaluation were relatively poorer than of the radiomics ***,Patients predicted to respond to therapy using the radiomics model showed a relatively longer overall survival(43 vs 27 months),although there were no significant differences(P=.063).Conclusions:The tumor core_edge combination delta radiomics model is an effective approach to evaluate pathologic response in PC patients with systemic treatment.

关键词： Computed tomography Delta radiomics Pancreatic cancer Pathologic response Systemic treatment

Blocking PD-L1 for anti-liver cancer immunity:USP22 represents a critical cotarget

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2020年第7期17卷 677-679页

作者： Xing Huang Xiaozhen Zhang xueli bai Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalSchool of MedicineZhejiang University79 Qingchun RoadHangzhou 310003 ZhejiangChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina Innovation Center for the Study of Pancreatic Diseases Zhejiang ProvinceHangzhou 310003 ZhejiangChina

MULTIPLE LEVELS OF PD-L1 REGULATION IN CANCER IMMUNOTHERAPY To date,the PD-1/PD-L1 blockade strategy has been tested in a variety of cancer ***,only bladder cancer,melanoma,mismatch repair-deficient colorectal cancer,and certain hematopoietic malignancies have been highly responsive in terms of clinical outcomes.1,2 It is presumed that the expression level of the PD-L1 protein largely determines the therapeutic efficacy of PD-1/PD-L1-targeted cancer immunotherapy.3,4 Previous studies have shown that several transcriptional factors are involved in the upregulation of PD-L1 by directly binding to its promoter region.5 For instance,individual activation of STAT1,NF-κB,HIF-1α,c-Myc,or MAPK increased PD-L1 transcription and immune evasion of tumor *** the other hand,oncogenic RAS signaling reportedly stabilizes PD-L1 mRNA to promote tumor immunoresistance.

关键词： USP22 immunity bladder

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第3期6卷 743-755页

作者： Tianyu Tang Xing Huang Gang Zhang Zhengtao Hong xueli bai Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalSchool of MedicineZhejiang University310003 HangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang University310003 HangzhouZhejiangChina Innovation Center for the Study of Pancreatic Diseases Zhejiang Province310003 HangzhouZhejiangChina Zhejiang University Cancer Center 310003 HangzhouZhejiangChina

Despite great success in cancer immunotherapy,immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer *** evidence suggests that the tumor immune microenvironment plays a critical role in anticancer immunity,which may result in immune checkpoint blockade therapy being ineffective,in addition to other novel immunotherapies in cancer *** the present review,we discuss the deficiencies of current cancer *** importantly,we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance,immunological evasion,and the potential for their further translation into clinical *** on their general targetability in clinical therapy,we believe that tumor immune microenvironment regulators are promising cancer immunotherapeutic *** the tumor immune microenvironment,alone or in combination with immune checkpoint-targeting drugs,might benefit cancer patients in the future.

关键词： drugs cancer immunity