Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
作者机构：Zhejiang Provincial Key Laboratory of Pancreatic DiseaseThe First Affiliated HospitalSchool of MedicineZhejiang University310003 HangzhouZhejiangChina Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalSchool of MedicineZhejiang University310003 HangzhouZhejiangChina Innovation Center for the Study of Pancreatic DiseasesZhejiang Province310003 HangzhouZhejiangChina Zhejiang University Cancer Center310003 HangzhouZhejiangChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第3期
页 面：743-755页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(81830089 to T.L,81871925 and 81672337 to X.B.,31970696 and 81502975 to X.H.) National Key Research and Development Program(2019YFC1316000 to T.L) Key Research and Development Program of Zhejiang Province(2020C03117 to X.B.) China Postdoctoral Science Foundation(2016T90413 and 2015M581693 to X.H.)
摘 要：Despite great success in cancer immunotherapy,immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer *** evidence suggests that the tumor immune microenvironment plays a critical role in anticancer immunity,which may result in immune checkpoint blockade therapy being ineffective,in addition to other novel immunotherapies in cancer *** the present review,we discuss the deficiencies of current cancer *** importantly,we highlight the critical role of tumor immune microenvironment regulators in tumor immune surveillance,immunological evasion,and the potential for their further translation into clinical *** on their general targetability in clinical therapy,we believe that tumor immune microenvironment regulators are promising cancer immunotherapeutic *** the tumor immune microenvironment,alone or in combination with immune checkpoint-targeting drugs,might benefit cancer patients in the future.
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