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本振光功率锁定方法应用于激光外差辐射计的研究

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物理学报 2023年第9期72卷 187-194页

作者：李月李竣薛正跃王晶晶王贵师高晓明谈图中国科学技术大学环境科学与光电技术学院合肥230026 中国科学院合肥物质科学研究院安徽光学精密机械研究所合肥230031

激光外差辐射计具备成本低、体积小、光谱分辨率高等优势,可扩展现有的地面碳测量网络,验证卫星观测结果,并能在卫星观测区域外提供数据覆盖.本文在现有的激光外差辐射计的基础上,报道了基于掺铒光纤放大器的可实现本振光功率锁定的近... 详细信息

激光外差辐射计具备成本低、体积小、光谱分辨率高等优势,可扩展现有的地面碳测量网络,验证卫星观测结果,并能在卫星观测区域外提供数据覆盖.本文在现有的激光外差辐射计的基础上,报道了基于掺铒光纤放大器的可实现本振光功率锁定的近红外激光外差辐射计原型机.该激光外差辐射计利用一个中心波长为1.603μm的分布反馈式半导体激光器作为本振光源,采用掺铒光纤放大器放大本振光功率,并利用自动功率控制电路实现掺铒光纤放大器输出端光功率的锁定,消除了由本振光功率变化引起的基线斜率,从而实现免基线拟合的整层大气透过率谱的测量.详细评估了基于掺铒光纤放大器的高度集成化的激光外差辐射计的仪器性能,并在合肥市科学岛(31.9°N, 117.2°E)地区进行了整层大气CO_(2)透过率谱的测量.在一天的测量时间内得到6组大气CO_(2)透过率谱,与大气辐射模型模拟结果进行比对,测量结果一致.实验结果表明,掺铒光纤放大器的应用可以提高激光外差辐射计的性能,优化其结构,进而为实现无人值守的长期大气CO_(2)浓度观测和构建全面的碳观测网络提供仪器设备的补充.

关键词：激光外差光学设计掺铒光纤放大器高光谱分辨率

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Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao Zhao Yu-Chen Wang Ying-Juan Sun Jun-yue Wang Xiao-Dan Jiang xue-Min Li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(P<0.001)were important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

糖尿病性心肌病血浆类胰蛋白酶与血糖相关性的分析

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第二军医大学学报 2016年第10期37卷 1293-1297页

作者：厉娜郑鳕洋岳温恒黄志刚第二军医大学长征医院心内科上海200003 第二军医大学长征医院器官移植科上海200003

目的观察肥大细胞特异性分泌的类胰蛋白酶在糖尿病性心肌病(DCM)患者中的表达及其与空腹血糖的关系。方法选取2012年8月至2013年3月在第二军医大学长征医院心内科就诊的DCM患者26例(DCM组)、缺血性心肌病(ICM)患者32例(ICM组)、健康志愿... 详细信息

目的观察肥大细胞特异性分泌的类胰蛋白酶在糖尿病性心肌病(DCM)患者中的表达及其与空腹血糖的关系。方法选取2012年8月至2013年3月在第二军医大学长征医院心内科就诊的DCM患者26例(DCM组)、缺血性心肌病(ICM)患者32例(ICM组)、健康志愿者20例(健康对照组)。收集各组受试者的一般临床资料并检测其空腹血糖等生化指标。采用酶联免疫吸附法检测各组受试者的血浆类胰蛋白酶水平,分析类胰蛋白酶水平与空腹血糖的相关性。结果 3组受试者的一般临床资料和空腹血糖差异均无统计学意义。DCM组和ICM组患者的血浆类胰蛋白酶水平高于对照组[(7.19±0.62)μg/L、(6.81±0.94)μg/L vs(2.37±0.56)μg/L,P<0.01];DCM组患者的血浆类胰蛋白酶水平高于ICM组,但差异无统计学意义。Pearson相关性分析结果显示,血浆类胰蛋白酶水平与空腹血糖呈正相关(r=0.637,P<0.01)。结论 DCM患者体内的血浆类胰蛋白酶水平升高,且与空腹血糖呈正相关。

关键词：糖尿病并发症心肌病类胰蛋白酶类肥大细胞心脏重构

基于激光外差探测的大气N_(2)O吸收光谱测量与廓线反演

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物理学报 2021年第21期70卷 290-298页

作者：薛正跃李竣刘笑海王晶晶高晓明谈图中国科学技术大学环境科学与光电技术学院合肥230031 中国科学院合肥物质科学研究院安徽光学精密机械研究所合肥230031

激光外差光谱探测由于其光谱分辨率高、体积小、重量轻等优点近年来得到了快速的发展,可用于大气温室气体垂直廓线测量和碳卫星地面定标等.本文报道了利用3.939μm带间级联激光器作为本振光源的测量大气N_(2)O的激光外差系统,自制高精... 详细信息

激光外差光谱探测由于其光谱分辨率高、体积小、重量轻等优点近年来得到了快速的发展,可用于大气温室气体垂直廓线测量和碳卫星地面定标等.本文报道了利用3.939μm带间级联激光器作为本振光源的测量大气N_(2)O的激光外差系统,自制高精度太阳跟踪仪收集太阳光作为激光外差的信号光源,其跟踪精度达到7 arcsec,激光外差系统的光谱分辨率达到0.004 cm^(–1),测量了合肥地区(31.902°N,117.167°E)大气N_(2)O吸收光谱,得到2838.336和2539.344 cm^(–1)两个强吸收峰,并对吸收信号进行波长标定,得到了N_(2)O分子的整层大气透过率谱,信噪比为93.将高分辨率光谱数据进行归一化处理和频率校正,利用参考正向模型和最优估计算法得到N_(2)O大气整层浓度廓线,标准偏差体积分数为0.000031×10^(–6)—0.0026×10^(–6),对应相对误差范围为0.009%—0.83%.研究结果表明,所搭建的激光外差系统能够实现对大气中N_(2)O的吸收光谱测量以及对N2O的廓线反演,为长期观测大气N_(2)O浓度提供保证.

关键词：激光外差透过率光谱氧化亚氮(N_(2)O) 反演计算

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氨基酸对食物过敏的调控机制研究进展

中国兽医学报 2020年第10期40卷 2079-2084页

作者：郑雪玥王浩印遇龙邓近平华南农业大学动物科学学院广东省动物营养调控重点实验室广东广州510642

近年来,食物过敏的发生率逐年攀升,牛奶、大豆等多种食物过敏原诱发的过敏反应严重威胁着人类及畜禽的健康及安全。过敏反应依赖于过敏效应细胞的活化及肠道菌群调控。国内外研究表明,氨基酸作为维持动物生长及细胞功能的必需营养物质,... 详细信息

近年来,食物过敏的发生率逐年攀升,牛奶、大豆等多种食物过敏原诱发的过敏反应严重威胁着人类及畜禽的健康及安全。过敏反应依赖于过敏效应细胞的活化及肠道菌群调控。国内外研究表明,氨基酸作为维持动物生长及细胞功能的必需营养物质,参与过敏效应细胞功能维持及过敏机体肠道菌群稳态的调控。现对氨基酸调控食物过敏的潜在机制及应用前景进行综述,旨在为今后通过氨基酸缓解人类及畜禽食物过敏的应用研究提供参考。

关键词：氨基酸免疫细胞肠道菌群食物过敏

TavWA1 is critical for wheat growth by modulating cell morphology and arrangement

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Journal of Integrative Plant Biology 2025年第1期67卷 71-86页

作者： Guowei Chang yue Li Lei Peng Chuncai Shen Yipeng Lu Wan Teng Yangyang Liu Yingchun Wang Weiqi Zhu Cuimin Liu xue He Yiping Tong xueqiang Zhao Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Zhaoxian Experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 515300China

Plant growth is determined by the production of cells and initiation of new *** genes that control cell number and cell size is of great significance for understanding plant growth *** this study,we characterized two wheat mutants,ah and dl,with abnormal *** ah mutant is a naturally occurring variant characterized by severe dwarfism,increased tiller number,and reduced grain length,while the dl mutant is derived from an ethyl methane sulfonate(EMS)-mutagenized population and exhibits smaller grain size and slightly reduced plant *** analyses revealed abnormal cell number,cell morphology and arrangement in the stems and leaves of the ah mutant,along with reduced cell length in the grains of the dl ***-based cloning identified that both mutants carry mutations in the same gene TavWA1-7D,which encodes a protein with a von Willebrand factor A(vWA)*** ah mutant harbors a 174-bp insertion in the 1,402-bp coding sequence(CDS)of TavWA1-7D,causing premature termination of protein translation,while the dl mutant contains a Glu420Lys *** the TavWA1-7D ahthrough clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease 9-mediated genome editing leads to a severe dwarfism *** C-terminus of the protein is crucial for its correct subcellular localization and interaction,supporting its critical role for TavWA1-7D *** analysis showed that the dwarf phenotype of the ah mutant is associated with impaired photosynthesis,ribosome function,and nucleosome ***,TavWA1-7D interacts with an E3 ligase,Ta VIP1-3B,the expression levels of which are elevated in both *** and knockout studies of TaVIP1-3B demonstrated its negative regulatory role in cell length and grain ***,our findings suggest that TavWA1-7D plays a vital role in regulating wheat growth and yield-related traits,with the dl mutant's short grain phen

关键词： grain size severe dwarf TaVIP1 TavWA1 wheat

The GECAM ground search system for gamma-ray transients

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 161-174页

作者： Ce Cai Yan-Qiu Zhang Shao-Lin Xiong Ping Wang Jian-Hui Li Xiao-Bo Li Cheng-Kui Li yue Huang Shi-Jie zheng Li-Ming Song Shuo Xiao Qi-Bin Yi Yi Zhao Sheng-Lun Xie Rui Qiao Yan-Qi Du Zhi-Wei Guo Wang-Chen xue Chao zheng Jia-Cong Liu Chen-Wei Wang Wen-Jun Tan yue Wang Jin-Peng Zhang Chao-Yang Li Guo-Ying Zhao Xiao-Yun Zhao Xiao-Lu Zhang Zhen Zhang Wen-Xi Peng Xiang Ma Jing-Yan Shi Dong-Ya Guo Jin Wang Xin-Qiao Li Xiang-Yang Wen zheng-Hua An Fan Zhang College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang050024China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang550001China School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China School of Computer and Information Dezhou UniversityDezhou253023China Institute of Astrophysics Central China Normal UniversityWuhan430079China

In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than *** gravitational wave high-energy electromagnetic counterpart all-sky monitor(GECAM)is a dedicated mission to monitor gamma-ray transients,launched in December,2020.A real-time on-board trigger and location software,using the traditional signal-to-noise ratio(SNR)method for blind search,is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time *** this work,we developed a ground-based pipeline for GECAM to search for various transients,especially for weak bursts missed by on-board *** pipeline includes both automatic and manual mode,offering options for blind search and targeted *** targeted search is specifically designed to search for interesting weak bursts,such as gravitational wave-associated gamma-ray bursts(GRBs).From the ground search of the data in the first year,GECAM has been triggered by 54 GRBs and other transients,including soft gamma-ray repeaters,X-ray binaries,solar flares,terrestrial gamma-ray *** report the properties of each type of triggers,such as trigger time and light *** this search pipeline and assuming a soft Band spectrum,the GRB detection sensitivity of GECAM is increased to about 1.1×10^(-8)erg cm^(-2)s^(-1)(10-1000 ke V,burst duration of 20 s).These results demonstrate that the GECAM ground search system(both blind search and targeted search)is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.

关键词： gamma-ray sources gravitational waves data analysis gamma-ray telescopes

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Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice

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Food Science and Human Wellness 2025年

作者： Meng Wang Man Yao Hao yue Yingying Tian Zifang Zhao Changhu xue Tiantian Zhang Yuming Wang SKL of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China Institute of Food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences Hainan Huayan Collagen Technology Co. Sanya Institute of Oceanography， Ocean University of China

It has been reported that sea cucumber intestine hydrolysates (SCIH) could promote glutamine metabolism in mice， while there is a close connection between glutamine metabolism and insulin sensitivity. However， the effect of SCIH on insulin resistance is still unclear. The results showed that SCIH hydrolyzed by flavor protease had significant activity using the insulin-induced HepG2 cell model. Animal experiments exhibited that SCIH supplementation significantly improved the high-fat and high-sucrose diet-induced impaired glucose tolerance， reduced fasting serum glucose and glycosylated serum protein. Besides， SCIH ameliorated islet vacuolization and decreased the pancreas TNF-α and IL-6 by 32.1% and 36.2%， respectively. Immunofluorescence staining results showed that SCIH promoted insulin secretion. Interestingly， SCIH significantly increased the liver glutamine levels and upregulated the expression of glutaminase1 (GLS1) and glutamate dehydrogenase 1 (GLUD1). Furthermore， SCIH increased liver acetyl-CoA levels to enhance histone acetylation and activate the gene transcription and translation on glucose metabolism-related IRS/PI3K/AKT signaling pathway， thereby attenuating insulin resistance. The present findings proposed the potential value for developing functional foods in SCIH utilization.

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DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 188-201页

作者： Hui Xie Hui Wang Ru-Hong Li yue-Wen Zhang Xi-Rui Fan Xiao-xue He Ao-Ran Guan Department of General Surgery Yan’an Hospital of Kunming CityKunming 650051Yunnan ProvinceChina Department of Digestive Internal Medicine Yan’an Hospital of Kunming CityKunming 650051Yunnan ProvinceChina

BACKGROUND Gastric cancer(GC)is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and ***(miR)are important diagnostic markers and therapeutic targets in this *** To explore the mechanism of miR-125a-5p in the pathogenesis of *** The expression levels of miR-125a-5p,SERPINE1 and DNMT1 in GC cells and tissues were detected by real-time polymerase chain reaction(PCR)and Western ***-specific PCR was used to detect the level of miR-125a-5p methylation.A cell counting kit 8 assay,scratch test,and a Transwell assay were performed to detect the proliferation,migration,and invasiveness of HGC27 cells,*** expression of the epithelial mesenchymal transition(EMT)-related proteins E-cadherin,N-cadherin and vimentin in HGC27 cells was detected by Western blotting,while the expression of vimentin was detected by *** This study revealed that miR-125a-5p was expressed at low levels in GC clinical samples and cells and that miR-125a-5p overexpression inhibited the proliferation,migration,invasiveness and EMT of GC ***,miR-125a-5p can reduce GC cell proliferation,promote E-cadherin expression,inhibit N-cadherin and vimentin expression,and reduce the EMT of GC cells,thus constraining GC cells to a certain ***,DNMT1 inhibited miR-125a-5p expression by increasing the methylation of the miR-125a-5p promoter,thereby promoting the expression of SERPINE1,which acts together with miR-125a-5p to exert antagonistic effects on *** Our study revealed that DNMT1 promoted SERPINE1 protein expression by inducing miR-125a-5p methylation,which led to the proliferation,migration and occurrence of EMT in GC cells.

关键词： Gastric cancer microRNA-125a-5p DNA methyltransferase 1 SERPINE1 Methylation