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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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CO hydrogenation conversion driven by micro-environments of active sites over iron carbide catalysts

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Green Energy & Environment 2025年第2期10卷 367-373页

作者： Nan Song Xingxing Li Ebtihal Abograin Wenyao Chen Junbo cao Jing Zhang De Chen xuezhi Duan Xinggui Zhou State Key Laboratory of Chemical Engineering East China University of Science and Technology130 Meilong RoadShanghai200237China Department of Chemical Engineering Norwegian University of Science and TechnologyTrondheim7491Norway

Essentially clearing the structure-activity relationship between iron carbide catalysts involving multiple active centers to understand the reaction mechanism of CO hydrogenation conversion process is still a great ***,two main micro-environment factors,namely electronic properties and geometrical effects were found to have an integrated effect on the mechanism of CO hydrogenation conversion,involving active sites on multiple crystal *** Bader charge of the surface Fe atoms on the active sites had a guiding effect on the CO activation pathway,while the spatial configuration of the active sites greatly affected the energy barriers of CO *** the defective surfaces were more conducive to CO activation,the defective sites were not the only sites to dissociate CO,as CO always tended to dissociate in a wider *** synergistic effect of the micro-environment also occurred during the CO conversion *** C atoms on relatively flat configurations were more likely to form methane,while the electronic properties of the active sites could effectively describe the C-C coupling process,as well as distinguish the coupling mechanisms.

关键词： Micro-environment CO hydrogenation conversion Electronic property Local environment Synergistic effect

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Integrating well logs, 3D seismic, and earthquake data for comprehensive prediction of 3D in-situ stress orientations: A case study from the Weiyuan area in the Sichuan Basin, China

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Petroleum Science 2025年第1期22卷 210-221页

作者： Huan cao Yang Zhao Hai-Chao Chen Le-Le Zhang Cheng-Gang Xian Ji-Dong Yang Lu Liu State Key Laboratory of Petroleum Resources and Engineering and Unconventional Petroleum Research Institute China University of Petroleum (Beijing) Department of Geophysics China University of Petroleum (East China) Aramco Beijing Research Center Aramco Asia

Determining the orientation of in-situ stresses is crucial for various geoscience and engineering applications. Conventional methods for estimating these stress orientations often depend on focal mechanism solutions(FMSs) derived from earthquake data and formation micro-imager(FMI) data from well ***, these techniques can be costly, depth-inaccurate, and may lack spatial coverage. To address this issue, we introduce the use of three-dimensional(3D) seismic data(active sources) as a lateral constraint to approximate the 3D stress orientation field. Recognizing that both stress and fracture patterns are closely related to seismic velocity anisotropy, we derive the orientation of azimuthal anisotropy from multi-azimuth 3D seismic data to compensate for the lack of spatial stress orientation information. We apply our proposed workflow to a case study in the Weiyuan area of the Sichuan Basin, China, a region targeted for shale gas production. By integrating diverse datasets, including 3D seismic, earthquakes, and well logs, we develop a comprehensive 3D model of in-situ stress(orientations and magnitudes). Our results demonstrate that the estimated anisotropy orientations from 3D seismic data are consistent with the direction of maximum horizontal principal stress(SHmax) obtained from FMIs. We analyzed 12earthquakes(magnitude > 3) recorded between 2016 and 2020 for their FMSs and compressional axis(Paxis) orientations. The derived SHmax direction from our 3D stress model is 110°ES(East-South), which shows excellent agreement with the FMSs(within 3.96°). This close alignment validates the reliability and precision of our integrated method for predicting 3D SHmax orientations.

关键词： In-situ stress orientation SHmax Azimuthal velocity anisotropy Focal source mechanism Formation micro-imager

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Influence of Rhamnolipids Biosurfactant on the Anodic Electrochemical Performance in Marine Sediment Microbial Fuel Cell and the Acceleration Degradation of Crude Petroleum

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Journal of Ocean University of China 2025年第1期24卷 139-146页

作者： HOU Luyao ZAI xuerong MENG Yao LIANG Shengkang cao Yali CHEN Yan ZHANG Huaijing HUANG Xiang FU Yubin College of Materials Science and Engineering Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China College of Marine Geosciences Ocean University of ChinaQingdao 266100China

Crude petroleum pollution causes some serious ecological disasters in the *** sediment microbial fuel cells(MSMFCs)have been utilized as a novel method for in-situ degradation and a long-term power ***,the effect of different concentrations of rhamnolipids biosurfactant on the electrochemical performance of MSMFCs anode and the higher efficiency of oil degradation are creatively *** results indicate that the anode in sediment containing rhamnolipids effectively enriches the indigenous electrogenic Pseudophaeobacter and Pseudomonas,which significantly enhances the electrochemical performance of the *** rhamnolipids at the concentration of 200 mg kg^(-1)in sediment,the anode specific capacitance(401.45 Fm^(-2)),exchange current density(4.87×10^(-2)mAm^(-2)),and cell maximum power density(140.24 mWm^(-2))increase by 2.50,38.65,and 2.11 times,respectively,in comparison with its natural *** the oil degradation rate(40.06%)was higher than the blank(17.55%).It demonstrates that the synergistic effect between electrochemical catalytic degradation and emulsifying solubilization of rhamnolipids surfactant directly accelerates the degradation of petroleum in marine sediment,which will provide a novel method and theoretical guidance for in-situ degradation and efficient removal of crude petroleum on ocean floor.

关键词： marine sediment microbial fuel cells petroleum pollution rhamnolipids biosurfactant electrochemical performance

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Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana

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Journal of Integrative Plant Biology 2025年第1期67卷 150-168页

作者： Weiwei Rao Tingting Ma Jiayuan cao Yajun Zhang Sisi Chen Shu Lin Xiaoxiao Liu Guangcun He Li Wan Key Laboratory of Plant Design CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Insects secret chemosensory proteins(CSPs)into plant cells as potential effector proteins during *** molecular mechanisms underlying how CSPs activate plant immunity remain largely *** show that CSPs from six distinct insect orders induce dwarfism when overexpressed in Nicotiana ***-mediated transient expression of Nilaparvata lugens CSP11(NlCSP11)triggered cell death and plant dwarfism,both of which were dependent on ENHANCED DISEASE SUSCEPTIBILITY 1(EDS1),N requirement gene1(NRG1)and SENESCENCE-ASSOCIATED GENE 101(SAG101),indicating the activation of effector-triggered immunity(ETI)in *** of NlCSP11 led to stronger systemic resistance against Pseudomonas syringae DC3000 lacking effector HopQ1-1 and tobacco mosaic virus,and induced higher accumulation of salicylic acid(SA)in uninfiltrated leaves compared to another effector XopQ that is recognized by a Tollinterleukin-1 receptor(TIR)domain nucleotidebinding leucine-rich repeat receptor(TNL)called ROQ1 in ***,NlCSP11-induced dwarfism and systemic resistance,but not cell death,were abolished in *** transgenic line expressing the SA-degrading enzyme Nah *** large-scale virus-induced gene silencing screening,we identified a TNL protein that mediates the recognition of CSPs(RCSP),including aphid effector MP10 that triggers resistance against aphids in ***,bimolecular fluorescence complementation and Alpha Fold2 prediction unveiled an interaction between NlCSP11 and ***,RCSP does not contain the conserved catalytic glutamic acid in the TIR domain,which is required for TNL *** findings point to enhanced ETI and systemic resistance by a TNL protein via hyperactivation of the SA ***,RCSP is the first TNL identified to recognize an insect effector.

关键词： chemosensory protein effector effector-triggered immunity salicylic acid TIR-NBS-LRR

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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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Science China Life Sciences 2025年

作者： Xiaonan Wang Ning Zhou xuejiao J.Gao Zijing Zhu Minmin Sun Qian Wang Haolin cao xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu lei Chen Jing Jiang Pengcheng Bu Lizeng Gao CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Advancing the recovery of iron and rare earth elements from the solid waste at Bayan Obo

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International Journal of Mining Science and Technology 2025年第2期35卷 295-306页

作者： Na Zhao Qiang Zhang Hongwei Ma Yongsheng Sun Peng Gao Zhao cao Zhenyue Zhang School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China Mineral Processing Plant of Jinchuan Group Nickel Cobalt Co. Ltd.Jinchang 737100China School of Mining and Coal Engineering Inner Mongolia University of Science and TechnologyBaotou 014010China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430074China

The storage of solid waste in Bayan Obo has resulted in significant resource wastage and environmental *** this study,an efficient process was developed to recover iron and rare earth elements(REEs)from this waste by processes of hydrogen-based mineral phase transformation(HMPT),magnetic separation,and *** optimal HMPT conditions(525℃,12.5 min,and 30%H_(2)concentration),an iron concentrate with a TFe grade of 64.09%and a recovery of 95.33%was *** magnetic properties of the solid waste were greatly enhanced by HMPT,allowing the effective magnetic separation of iron *** optimization of the flotation process resulted in a REEs concentrate with a rare earth oxide(REO)grade of 65%-70%and a REEs recovery of 60%-65%.Hematite was reduced to magnetite during HMPT,and bastnaesite was decomposed to REEs oxides and fluorides,and the particle structure was significantly ***,changes in monazite,fluorite,and barite were minimal.

关键词： Hydrogen-based mineral phase transformation Flotation Reduction characteristics Microstructure evolution Surface chemistry

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液氮循环冷冲击作用下高温花岗岩I型断裂特性研究

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岩土力学 2025年第2期46卷 422-436页

作者：薛熠杨博鹍刘勇孙强张云曹正正西安理工大学岩土工程研究所陕西西安710048 河南理工大学瓦斯地质与瓦斯治理国家重点实验室培育基地河南焦作454000 西安科技大学能源学院陕西西安710054

液氮循环压裂技术是一种环境友好且高效的新型无水压裂方法,通过多次液氮冷却作用在干热岩中产生显著的热应力,从而有效地对干热岩储层进行致裂和增渗。为了揭示液氮循环冷冲击作用对干热岩断裂特性及损伤特征的影响机制,对花岗岩试样... 详细信息

液氮循环压裂技术是一种环境友好且高效的新型无水压裂方法,通过多次液氮冷却作用在干热岩中产生显著的热应力,从而有效地对干热岩储层进行致裂和增渗。为了揭示液氮循环冷冲击作用对干热岩断裂特性及损伤特征的影响机制,对花岗岩试样进行不同循环次数的高温加热-液氮冷却处理,通过三点弯曲试验对处理后的花岗岩试样物理力学特性(包括断裂韧度和破裂特征)进行了分析。基于三维激光扫描技术和分形理论对三点弯曲试验后花岗岩断口表面形貌特征及断面粗糙度进行了定量评价。采用数值方法,利用随机四参数生成法重构非均质花岗岩基质,建立了热-力耦合的混合相场模型,对不同液氮循环次数下高温花岗岩的微裂隙演化及宏观断裂过程进行模拟,分析了液氮循环冷冲击作用对高温花岗岩宏观断裂特性的影响。试验和数值结果表明:高温加热-液氮冷却循环作用会加剧花岗岩的损伤程度,导致断裂韧度等力学参数显著下降。断面分形维数以及形态特征参数与循环次数呈显著正相关,在高循环次数下断面展现出复杂曲折的宏观主裂纹扩展路径。热-力耦合混合相场模型能够有效再现高温加热-液氮冷却循环作用下花岗岩的热-力开裂行为。花岗岩的热损伤主要集中在最大拉伸应变能区域。液氮循环作用下,高温花岗岩的微破裂主要由温度梯度和相邻矿物颗粒之间的热膨胀变形差异引起。液氮循环冷却诱导的微裂隙使得花岗岩I型断裂的扩展路径更加曲折和复杂。

关键词：液氮花岗岩断裂韧度断面粗糙度相场法

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