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Reactive protein, plasminogen activator inhibitor type-1 （PAI-1） levels, PAI-1 promoter 4G/5G polymorphism and acute myocardial infarction

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Journal of Geriatric Cardiology 2010年第3期7卷 147-151页

作者： xue-lei cao Chang-Yong Zhou lei Yin Shao-Chun Wang Xiu-Ling Jia Huan Huang Xiao-Hong Sun Qingdao University Medical College Qingdao266003China Emergency Department Affiliated Hospital of Qingdao University Medical College Qingdao 266003 China.

Objective To investigate the relationship between CRP, plasminogen activator inhibitor type 1 （PAI-1） levels, PAI-1 gene promoter 4G/5G polymorphism and the type of acute myocardial infarction （ST elevation myocardial infarction, STEMI vs the non-ST elevation Myocardial infarction, NSTEMI）. Methods One hundred seventy-six consecutive patients with AMI were included for the study, of whom 60 had STEMI and 56 had NSTEMI, and 60 adults without cardiovascular and cerebrovascular disease were selected as controls. Blood samples were obtained from patients within 6 h of AMI and the plasma PAI-1, CRP, and the gene polymorphism were measured. Results Plasma levels of PAI- 1 and CRP were higher in AMI groups, compared those in the control group, and plasma levels of PAI-1 were significantly higher in patients with STEMI compared to those with NSTEMI （80.12ng/ml VS.73.01ng/ml, P 〈0.01）, while CRP levels were not significantly different between patient with STEMI and NSTEMI （3.87 ± 0.79 mg/ml VS.4.01 ±0.69mg/ml, P〉0.05）. PAI-1 levels presented a significant correlation with CRP levels in the NSTEMI subjects. However, PAI-1 and CRP levels could explain the lack of a significant relationship between them in control and STEMI *** frequencies of 4G/4G genotype in the AMI group were higher than those in the control group and higher in patient with STEMI than in patient with NSTEMI. Plasma levels of PAI-1 in subjects with 4G/4G genotype were significantly increased as compared to those in subjects with 4G/5G and 5G/5G genotype. Conclusions Plasma PAI-1 levels were associated with different myocardial infarction type, and PAI-1 promoter 4G/5G polymorphisms and CRP may be related to plasma PAI-1 levels

关键词： ST-segment elevation myocardial infarction non-ST segment elevation myocardial infarction Plasminogen activatorinhibitor- 1 C-reactive protein

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Five-year in-orbit background of Insight-HXMT

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Radiation Detection Technology and Methods 2023年第1期7卷 34-47页

作者： Jin-Yuan Liao Shu Zhang Juan Zhang Gang Li Zhi Chang Yu-Peng Chen Ming-Yu Ge Jing Jin xue-Feng Lu Yuan You xue-lei cao Yong Chen Yue Huang Wei-Chun Jiang Xiao-Bo Li Xu-Fang Li Zheng-Wei Li Cong-Zhan Liu Ying Tan Yan-Ji Yang Yi-Fei Zhang Hai-Sheng Zhao Fang-Jun Lu Yu-Peng Xu Jin-Lu Qu Li-Ming Song Shuang-Nan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China Key Laboratory of Stellar and Interstellar Physics and School of Physics and Optoelectronics Xiangtan UniversityYuhu DistrictXiangtan 411105China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of Sciences20A Datun RoadChaoyang DistrictBeijing 100012China

Purpose We present the five-year in-orbit background evolution of Insight-HXMT since the launch,as well as the effects of the background model in data *** The backgrounds of the three main payloads,i.e.,low-energy telescope,medium-energy telescope,and high-energy telescope,are *** evolution of the background over time is obtained by simply comparing the background in every year during the in-orbit operation of *** The major observational characteristics of the Insight-HXMT in-orbit background are presented,including the light curve,spectrum,geographical distribution,and long-term *** systematic error in background estimation is investigated for every *** The observational characteristics of the five-year in-orbit background are consistent with our knowledge of the satellite design and the space environment,and the background model is still valid for the latest observations of Insight-HXMT.

关键词： Instrumentation:detectors Space vehicles:instruments Methods:data analysis X-rays:general

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong cao Ping lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Discrete Numerical Study on Type II Fracture of Partially Detached Concrete Panels in Cold Region

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Structural Durability & Health Monitoring 2025年第1期19卷 167-191页

作者： Huayi Zhang Maobin Song lei Shen Nizar Faisal Alkayem Maosen cao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China Haihe River Huaihe River and Xiaoqinghe River Basin Water Conservancy Management and Service Center of Shandong ProvinceJinan250100China College of Mechanics and Engineering Science Hohai UniversityNanjing211100China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-ﬁlled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during con-struction,the inﬂuence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefﬁcient on the bending stiffness are analyzed parametrically by the numerical simula-tion technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placementﬁrst and then prestress-tensioning is proposed.

关键词： Beam-string structure(BSS) concrete-ﬁlled steel tube(CFST) bending stiffness timing of concrete placement prestress-tensioning

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1kW推挽升压开关电源设计

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河北工业大学学报 2016年第5期45卷 7-15页

作者：张维强李永建薛刚曹磊河北工业大学电磁场与电器可靠性省部共建重点实验室天津300130

介绍一款以SG3525为主控芯片,采用推挽拓扑结构,利用高频变压器对12 V直流进行隔离升压的开关电源;通过SG3525控制器产生高频脉宽调制(PWM)波,控制开关管通断,对输入信号进行升压整流.推挽电路中加入了有源钳位电路,可以减少开关管的漏... 详细信息

介绍一款以SG3525为主控芯片,采用推挽拓扑结构,利用高频变压器对12 V直流进行隔离升压的开关电源;通过SG3525控制器产生高频脉宽调制(PWM)波,控制开关管通断,对输入信号进行升压整流.推挽电路中加入了有源钳位电路,可以减少开关管的漏极尖峰.变压器的设计利用初级并联次级串联方式来提高整机的效率.并设计了电池过压、欠压、过流、过热等保护电路.经仿真和实验验证该开关电源具有效率高、可靠性高、电路简单、电磁干扰小等优点.

关键词：推挽升压 SG3525 脉宽调制保护电路

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MTCR-CR Routing Strategy for Connection-Oriented Routing over Satellite Networks

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China Communications 2024年第5期21卷 280-296页

作者： Li Changhao Sun xue Yan lei cao Suzhi The University of Chinese Academy of Sciences Beijing 100094China Key Laboratory of Space Utilization Chinese Academy of SciencesBeijing 100094China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100094China

The high-speed movement of satellites makes it not feasible to directly apply the mature routing scheme on the ground to the satellite ***-DVTR in the snapshot-based connectionoriented routing strategy is one of the representative solutions,but it still has room for improvement in terms of routing *** this paper,we propose an improved scheme for connection-oriented routing strategy named the Minimal Topology Change Routing based on Collaborative Rules(MTCR-CR).The MTCR-CR uses continuous time static topology snapshots based on satellite status to search for intersatellite link(ISL)construction solutions that meet the minimum number of topology changes to avoid route *** simulation results in Beidou-3 show that compared with DT-DVTR,MTCR-CR reduces the number of routing changes by about 92%,the number of path changes caused by routing changes is about38%,and the rerouting time is reduced by approximately 47%.At the same time,in order to show our algorithm more comprehensively,the same experimental index test was also carried out on the Globalstar satellite constellation.

关键词： ISL routing stability satellite networks satellite routing dynamic strategy

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基于CGI接口实现嵌入式系统远程控制

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微机发展 2004年第9期14卷 7-9,13页

作者：姚洪智郑雪峰曹磊北京科技大学计算机系北京100083

伴随着"把互联网带到生活中"的口号,依托互联网络对硬件终端设备进行远程控制已成为网络发展的重要方向。嵌入式技术的发展使在硬件设备中广泛使用的嵌入式操作系统也能提供WebServer功能。基于其提供的CGI接口,使用C语言和JavaScript... 详细信息

伴随着"把互联网带到生活中"的口号,依托互联网络对硬件终端设备进行远程控制已成为网络发展的重要方向。嵌入式技术的发展使在硬件设备中广泛使用的嵌入式操作系统也能提供WebServer功能。基于其提供的CGI接口,使用C语言和JavaScript脚本相结合编写CGI脚本,并完成相应的控制功能,使用JavaScript生成客户端界面,通过CGI接口实现浏览器到服务器端的通信,这样就可以很方便地在嵌入式系统中实现一个基于B/S模型的远程控制方法。

关键词： CGI接口远程控制 B/S模型嵌入式操作系统 Web Server

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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深板层角膜移植与穿透性角膜移植治疗基质角膜营养不良预后的比较

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中国组织工程研究 2025年第8期29卷 1626-1633页

作者：静如意陈颖欣曹蕾北部战区总医院辽宁省沈阳市110000

背景:基质角膜营养不良的传统手术治疗方式为穿透性角膜移植,近年来越来越多的医生开始考虑使用深板层角膜移植治疗基质角膜营养不良。目前国内对比穿透性角膜移植和深板层角膜移植治疗基质角膜营养不良的研究少有报道。目的:比较深板... 详细信息

背景:基质角膜营养不良的传统手术治疗方式为穿透性角膜移植,近年来越来越多的医生开始考虑使用深板层角膜移植治疗基质角膜营养不良。目前国内对比穿透性角膜移植和深板层角膜移植治疗基质角膜营养不良的研究少有报道。目的:比较深板层角膜移植和穿透性角膜移植治疗基质角膜营养不良的疗效。方法:选择2000年1月至2018年1月北部战区总医院收治的基质角膜营养不良患者57例(57眼),男18例,女39例,平均年龄(52.9±20.0)岁,按照手术治疗方式分为深板层角膜移植组(n=21)、穿性角膜移植组(n=36),术后随访观察最佳矫正视力、角膜内皮细胞密度、角膜植片透明度、术中及术后并发症、原病复发情况。结果与结论:①两组患者术后1,3,6,12个月的视力均高于术前(P0.05);随着术后时间的延长,两组患者角膜内皮细胞密度逐渐降低,穿透性角膜移植组患者术后6,12个月的角膜内皮细胞密度年丢失率均高于深板层角膜移植组(P0.05);②深板层角膜移植组有6例出现并发症,穿透性角膜移植组有14例出现并发症,57例患者术后12个月内均无复发,两组患者术后5年的复发率比较差异无显著性意义(P>0.05),穿透性角膜移植组和深板层角膜移植组术后5年的移植物存活率分别为83%和86%,组间比较差异无显著性意义(P>0.05);③结果表明,基质角膜营养不良的治疗可考虑使用深板层角膜移植替代一部分穿透性角膜移植。

关键词：穿透性角膜移植深板层角膜移植基质角膜营养不良最佳矫正视力角膜植片透明度角膜内皮细胞密度并发症复发

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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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