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Study on the Promotion of Wound Healing in Mice with Burn Injuries by Bioactive Glass 1393

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 9-16,26页

作者： xia Wei-dong XU ke ZHENG Chao-yu CHEN xue-nan National Clinical key Specialty(Wound Repair Department) Wenzhou Medical University Affiliated First HospitalWenzhou Zhejiang 325000China Institute of Life Sciences Wenzhou UniversityWenzhou Zhejiang 325000China Wuhan University of Science and Technology School of Medicine Wuhan Hubei 430000China

Objective:To investigate the effect and mechanism of bioactive glass1393 on wound healing in mice with burn ***:A benchtop temperature-controlled scald instrument was used to establish a mouse burn wound model,which was divided into an injury group(simple scald group)and a bioactive glass 1393treatment *** wound healing of burn injuries in mice was observed at different times after the operation,and the formation of granulation tissue,collagen deposition and tissue proliferation in the wounds were observed by HE staining,Masson staining and Ki67 staining,and the levels of apoptosis-related proteins and the expression of wnt3a/β-catenin signaling pathway were detected in the wounds by Western ***:Compared with the injury group,the bioactive glass 1393 group accelerated burn wound healing and promoted granulation tissue formation,collagen deposition,and cell *** addition,compared with the injury group,the bioactive glass 1393 group promoted the expression of Bcl-2 protein,inhibited the expression of Bax protein and up-regulated the expression of Wnt3a andβ-catenin ***:Bioactive glass 1393 promotes burn wound healing in mice by inhibiting apoptosis through modulation of wnt3a/β-catenin signaling pathway.

关键词： bioactive glass 1393 wound healing apoptosis

PEGylated bacteria restore intestinal mucosal barrier

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4186-4188页

作者： Menghang Zu xue xia Bo xiao State key Laboratory of Resource Insects College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China

The mucosal barrier of the gastrointestinal tract(GIT)is crucial for the overall health of the *** disruption permits the infiltration of intestinal microorganisms into the underlying mucosa,resulting in infections and inflammatory conditions,such as inflammatory bowel disease(IBD),metabolic disorders,and autoimmune diseases1,***,strategies to protect the mucosal barrier from exogenous stimuli or to facilitate its recovery have become increasingly ***,immunomodulators,corticosteroids,and biological agents have been widely employed to treat IBD by alleviating inflammation and enhancing mucosal ***,they can also produce serious systemic toxicity3,4;therefore,there is an urgent need for exploiting innovative strategies to fortify the intestinal mucosal barrier against the invasion of exogenous damaging factors.

关键词： PEGylation Probiotic Mucus penetration Colonic mucosal barrier Colitis Diabetes

Low friction under ultrahigh contact pressure enabled by self-assembled fluorinated azobenzene layers

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Friction 2024年第7期12卷 1434-1448页

作者： Dandan xue Zhi XU Linyuan GUO Wendi LUO Liran MA Yu TIAN Ming MA Qingdao ZENG ke DENG Wenjing ZHANG Yichun xia Shizhu WEN Jianbin LUO State key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China National Center for Nanoscience and Technology Beijing 100190China

Extensive efforts have been made to pursue a low-friction state with promising applications in many fields,such as mechanical and biomedical *** which,the load capacity of the low-friction state has been considered to be crucial for industrial ***,we report a low friction under ultrahigh contact pressure by building a novel self-assembled fluorinated azobenzene layer on an atomically smooth highly-oriented pyrolytic graphite(HOPG)*** friction coefficients could be as low as 0.0005 or even lower under a contact pressure of up to 4 *** demonstrates that the low friction under ultrahigh contact pressure is attributed to molecular *** fluorination leads to effective and robust lubrication between the tip and the self-assembled layer and enhances tighter rigidity which can reduce the stress concentration in the substrate,which was verified by density functional theory(DFT)and molecular dynamics(MD)*** work provides a new approach to avoid the failure of ultralow friction coefficient under relatively high contact pressure,which has promising potential application value in the future.

关键词： ultrahigh contact pressure self-assembled layer fluorination robust lubrication

Characteristic Study of Self-Powered Sensors Based on Native Protein Composite Film

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Energy & Environmental Materials 2024年第1期7卷 222-228页

作者： Jiehui xue Huijing xiang Yanrong Zhang Jun Yang xia Cao Zhonglin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Resources Environment and MaterialsSchool of PhysicsScience and TechnologyCenter on Nanoenergy ResearchGuangxi UniversityNanning 530004China Center for Green Innovation School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China Research Centre of Information Technology Shenzhen Institute of Information TechnologyShenzhen 518172China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta GA 30332-0245USA

Flexible electronic sensors composed of flexible film and conductive materials play an increasingly important role in wearable and internet information *** has received more and more attention and made some progress over the ***,it is still a great challenge to prepare biocompatible and highly transparent conductive *** white is a pure natural protein-rich *** cellulose has a good compatibility and high transparency,which is an ideal material for flexible ***,we overcome the problem of poor mechanical flexibility and electrical conductivity of protein,and develop a high transparency and good flexibility hydroxypropylmethyl cellulose/egg white protein composite membrane-based triboelectric nanogenerator('X'-TENG).The experimental results show that the flexible pressure sensor based on'X'-TENG has a high sensitivity,fast response speed,and low detection *** can even be used as a touch/pressure sensing artificial electronic *** can also be made into an intelligent waffle keyboard for recording and tracking users of the *** strategy may provide a new way to easily build flexible electronic sensors and move toward practical applications.

关键词： flexible sensors intelligent sensing natural protein-rich material triboelectric nanogenerators

Microbiome changes in esophageal cancer:implications for pathogenesis and prognosis

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Cancer Biology & Medicine 2024年第2期21卷 163-174页

作者： Yi Li Bing Wei xia xue Hongle Li Jun Li Department of Molecular Pathology Clinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan key Laboratory of Molecular Pathology Zhengzhou 450003China Henan key Laboratory of Helicobacter pylori&Microbiota and Gastrointestinal Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Esophageal cancer(EC)is an aggressive malignancy with a poor *** factors,including dietary habits,and antacid and antibiotic use,have been shown to influence the esophageal ***,enrichment and diversity of the esophageal microbiome can also impact its *** studies have revealed prevalent changes in the esophageal microbiome among patients with EC,thus suggesting the potential contribution of the esophageal microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the role of the esophageal microbiome in modulating treatment *** this review,we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases,with a focus on identifying microbial communities associated with EC pathogenesis and *** the role of the microbiome in EC may aid in early detection and optimized treatment strategies,ultimately leading to better outcomes for patients.

关键词： Esophageal cancer microbiome dysbiosis microenvironment carcinogenesis

Effect of Bimodal Quasicrystal Phase on the Dynamic Recrystallization of Mg–Zn–Gd Alloy during High-Pressure Torsion

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1128-1134页

作者： Ping Li Shuangwu xia Junfu Dong Liangwei Dai Zhicheng Luo kemin xue School of Material Science and Engineering Hefei University of TechnologyHefei230009China

The Mg–Zn–Gd alloy with quasicrystal icosahedral phase was processed by high-pressure torsion (HPT). The effect of bimodal I-phase on the dynamic recrystallization was analyzed by transmission electron microscopy. The results showed that the block I-phase can stimulate obvious particle-stimulated nucleation and dynamic recrystallization (DRX) grains were preferentially formed after HPT for 5 turns, while the granular I-phase only promoted the generation of sub-grains. The orientation relationship was determined as twofold//[1210] and fivefold//(0002)_(Mg). Moreover, after HPT for 9 turns, the DRX grains induced by block I-phase appeared to grow up and coarsened. Compared with block I-phase, the grains induced by granular I-phase presented much smaller size and distributed more homogeneous due to the strong pinning effect.

关键词： High-pressure torsion(HPT)-Quasicrystal phase Dynamic recrystallization Particle-stimulated nucleation Orientation relationship

Unlocking the potential of bispecific ADCs for targeted cancer therapy

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Frontiers of Medicine 2024年第4期18卷 597-621页

作者： Hongye Zeng Wenjing Ning xue Liu Wenxin Luo Ningshao xia State key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for Industry-Education Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen361102China

Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by *** innovative compounds enable precise drug delivery to tumor cells,minimizing harm to normal tissues and offering excellent prospects for cancer ***,monoclonal antibody-based ADCs still present challenges,especially in terms of balancing efficacy and *** antibodies are alternatives to monoclonal antibodies and exhibit superior internalization and selectivity,producing ADCs with increased safety and therapeutic *** this review,we present available evidence and future prospects regarding the use of bispecific ADCs for cancer treatment,including a comprehensive overview of bispecific ADCs that are currently in clinical *** offer insights into the future development of bispecific ADCs to provide novel strategies for cancer treatment.

关键词： antibody-drug conjugate bispecific antibody bispecific ADC cancer

Cold and humid climates enrich soil carbon stock in the Third Pole grasslands

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The Innovation 2024年第1期5卷 9-10页

作者： Yanfen Wang Anquan xia Kai xue College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China State key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China State key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou 256606China

As a unique geographic unit,the Third Pole is globally recognized as the largest and highest mountainous *** amounts of soil organic carbon(SOC)are stored in this region,whose top layer is active in biochemical processes and highly sensitive to environmental *** warming intensity in the Third Pole has been predicted to be at least 0.3℃ higher than the global average by the end of the 21^(st) century.1 Therefore,it is essential to understand the underlying mechanisms,especially the hydrothermal factors,controlling the top layer SOC in the Third *** may help to predict the dynamics of soil carbon stock in future climate scenarios.

关键词： soil mountainous globally

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li Yu-Shi Jiang xue-Ling Luo Xuming Ran Yuqiang Li Dong Wu Cheng-xue Pan Peng-Ju xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes