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Analysis of the key networks,metabolic pathways,and regulation substances of hypoxia based on the omics and zebrafish model

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中国药理学与毒理学杂志 2017年第10期31卷 1023-1024页

作者： Yi MA Bin-bin XIA Jing-yi li Zheng-chao XIA Ping-xiang XU li Xiao-rong Ming xue Department of Pharmacology School of Basic Medical SciencesCapital Medical University

OBJECTIVE Hypoxia is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via the key gene,protein and endogenous metabolite *** to date,the exact molecular mechanism of hypoxia still remains *** this work,we further explore the molecular mechanism of hypoxia and adaption to attenuate the damage in zebrafish model that have potential to resist hypoxic *** The hypoxic zebrafish model was established in different concentration of oxygen with 3%,5%,10%,21%in *** brain tissue was separated and the RNA-seq was used to identify the differentially expressed *** related endogenous metabolites profiles were obtained by LC-HDMS,and the multivariate statistics was applied to discover the important metabolites candidates in hypoxic *** candidates were searched in HMDB,KEGG and lipid Maps *** The zebrafish hypoxic model was successfully constructed via the different concentration of oxygen,temperature and hypoxic *** activities of the related hypoxic metabolic enzymes and factors including HIF-1a,actate dehydrogenase(LDH)and citrate synthase(CS)were *** differences(P2)in the expression of 422 genes were observed between the normal and 3% hypoxic *** them,201 genes increased depended on the lower concentration of oxygen.53 metabolites were identified that had significant difference between the hypoxia and control groups(P1.5 and VIP>1.5).The ten key metabolites were increased gradually while six compounds were *** endogenous hypoxic metabolites of phenylalanine,D-glucosamine-6P and several important lipids with the relevant hub genes had similar change in hypoxic *** addition,the metabolic pathways of phenylalanine,glutamine and glycolipid were influenced in both the levels of genes and *** The up-regulation of phenylalanine,D-glucosamine-6P and lipid may hav

关键词： hypoxia adaptation metabolic pathway omics zebrafish model

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Body Composition as A Determinant of Pharmacokinetics and Toxicity of Anticancer Drugs

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Journal of Nutritional Oncology 2017年第3期2卷 137-144页

作者： xue lian liu Wei li Cancer Center the First Hospital of Jilin UniversityChangchun 130012China

Chemotherapy-induced toxicity,resulting from inter-individual variability in pharmacokinetics is emerging as a highly active area of *** composition analysis,primarily concerning the amount of fat mass(FM)and lean body mass(LBM),has provided a proof-concept that the inter-individual variability in pharmacokinetics and toxicity profiles may be partially explained by the discrepancies of FM and LBM in *** research suggests a close relationship among body composition,pharmacokinetics and toxicity of anticancer *** LBM and FM,significantly influence the exposure to drugs,they are considered as the promising predictors of chemotherapy-induced toxicity and a potential basis for optimizing the dosing of oncology drugs and the *** review summarizes the recent studies rendering the aforementioned correlations to highlight that a critical evaluation of body composition has initiated a new era for dose standardization.

关键词： Body Composition Anticancer Drugs Pharmacokinetics Toxicity

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Conductive photo-thermal responsive bifunctional hydrogel system with self-actuating and self-monitoring abilities

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Nano Research 2022年第8期15卷 7703-7712页

作者： Neng Chen Yang Zhou Yinping liu Yuanyuan Mi Sisi Zhao Wang Yang Sai Che Hongchen liu FengJiang Chen Chong Xu Guang Ma xue Peng Yongfeng li State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China

Despite enormous efforts in actuators,most researches are only limited to various actuation behaviors and demonstrations of soft *** has not yet been reported to capture and monitor its movement status in an invisible ***,it is of great significance to develop a self-sensing and self-actuating dual-function hydrogel actuator system to realize real-time ***,we report a bifunctional hydrogel system with self-actuating and self-monitoring abilities,which combines the functions of photothermal actuation and electrical resistance sensing into a single *** bilayer tough conductive hydrogel synthesized by unconventional complementary concentration recombination and cryogenic freezing technique presents a dense conductive network and high-porosity structure,achieving high toughness at 190.3 kPa of tensile strength,high stretchability(164.3%strain),and the toughness dramatically(1,471.4 kJ·m^(−3)).The working mechanism of the monitoring and self-sensing system is accomplished through the integrated monitoring device of surface temperature–bending angle–electron current,to solve the problem of not apperceiving actuator motion state when encountering obstacles in an invisible *** demonstrated for the first time a photothermal actuator’s motion of a football player and goalkeeper to finish the penalty and a soft actuator hand,which can achieve the action of sticking to grab and release under photo-thermal *** connected to the control closed circuit,the actuator realized closed-loop monitoring and sensing *** development of bifunctional hydrogel systems may bring new opportunities and ideas in the fields of material science,circuit technology,sensors,and mechanical engineering.

关键词： photo-thermal hydrogel actuator graphene nanosheets self-monitoring self-actuating surface temperature-bending angle-electron current

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Study on the Strategies of Logistics Enterprises' Development From the Legal Perspective1——Taking linyi as an Example

Study on the Strategies of Logistics Enterprises' Developmen...

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2013年教育技术与管理科学国际会议

作者： xue li linyi University

Modern logistics industry’s development degree has become an important sign to measure the level of the national industrialization and the national comprehensive competitiveness. And yet, Chinese logistic enterprises now display such characteristics as "large in number and little in scale, loose in organization, weak in management, and underdeveloped in efficiency", which severely affects the speed and depth of the development of modern logistic industry, and makes people worry about the survival situation of these enterprises. Through the literature review combined with field research, deduction combined with induction, comparative analysis and qualitative methods combined with quantitative methods, the paper finally reaches the conclusion that in order to make the logistic enterprises become bigger and stronger, four strategies must be carried out, which are reforming the operation mode, exploring new business, strengthening contract control and boosting the construction of informatization. At the same time, the paper considers that the construction of personnel is the impetus to the development of logistic enterprises.

关键词： legal perspective logistic enterprises large in number and little in scale, loose in organization and weak in management, and underdeveloped in efficiency development strategies

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A Study on the Rhetorical Strategies of Translation

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海外英语 2015年第19期 143-145页

作者：王侃 li xue-qing China University of Petroleum Shandong University of Finance and Economics

As a method of word fineness,rhetoric plays an important role in the process of *** to differences of language and cultural background,rhetoric is different between English and *** a result,how to deal with rhetoric in translation has become a hot ***,this paper presents the definition of rhetoric in ***,four strategies are put forward to solve problems in the process of translation:literal translation,literal translation plus notes,substitution and free translation.

关键词： rhetoric strategies translation

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On Social-technical Control of Safety Development in Economic Transition Background

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Frontiers of Engineering Management 2015年第3期2卷 234-240页

作者： xue-qiu He Song li School of Civil and Environment Engineering University of Science&Technology Beijing Anhui University of Science and Technology

Industrial safety and economic growth, two vital and inextricable forces affecting national culture and development, are worthy of much more interest and attention than this article can hope to generate. Following economic growth, industrial safety remains as a high priority in this nation's quest for sustainable *** present, while China is on its way to transforming its economic structure and growth models, talk of industrial safety appears with special regularity, for it also is undergoing profound changes as an important facet of modern China.

关键词： safety development economic growth economic transition social-technical control

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Tetrahydroxystilbene glucoside protects against sodium azide-induced mitochondrial dysfunction in human neuroblastoma cells

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Chinese Herbal Medicines 2021年第2期13卷 255-260页

作者： Ru-yi Zhang Xu Zhang Lan Zhang Yan-chuan Wu xue-jing Sun lin li Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing Engineering Research Centre for Nerve System DrugsBeijing Institute for Brain DisordersKey Laboratory for Neurodegenerative Diseases of Ministry of EducationBeijing 100053China Department of Central Laboratory Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Haematology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China

Objective:Mitochondrial dysfunction is evident in the early stage of Alzheimer's disease(AD).Therefore development of drugs that protect mitochondrial function is a promising strategy for *** present work was to investigate the effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucosides(TSG) on a mitochondrial dysfunction cell model induced by sodium azide and elucidate the underlying ***:Mitochondrial membrane potential(MMP) was detected by a fluorescence *** adenosine triphosphate(ATP) level was measured using a firefly luciferase-based *** oxygen species(ROS) was detected using dichlorofluorescin diacetate(DCFH-DA).The expression levels of Bcl-2 and Bax were measured by Western blotting *** cytometry was utilized to measure ***:Pretreatment of TSG(25-200 μmol/L) for 24 h significantly elevated MMP and ATP content,reduced ROS level and Bax/Bcl-2 ratio,and inhibited apoptosis in SH-SY5 Y cells exposed to sodium ***:These results suggest that TSG protects SH-SY5 Y cells against sodium azide-induced mitochondrial dysfunction and *** findings are helpful to understand the protective effect of TSG on mitochondria,which are involved in the early stage of AD.

关键词： Alzheimer’s disease mitochondria tetrahydroxystilbene glucoside sodium azide

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机械手单片机控制系统设计

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制造业自动化 2013年第12期35卷 46-51页

作者：李荣学游少华广东佛山职业技术学院

近年来现代制造技术发展势头迅猛,三坐标测量仪已经成为了自动化生产中不可或缺的一种重要设备。如何将复杂加工件放置在测量台上是本文研究的主要问题,主要采用的措施为通过开发机械手及其控制系统来实现,本文主要对控制系统进行了深... 详细信息

近年来现代制造技术发展势头迅猛,三坐标测量仪已经成为了自动化生产中不可或缺的一种重要设备。如何将复杂加工件放置在测量台上是本文研究的主要问题,主要采用的措施为通过开发机械手及其控制系统来实现,本文主要对控制系统进行了深入研究。本文根据主要功能要求,首先进行了总体功能设计。在硬件电路设计上,通过单片机C8051F340和可编程逻辑器件CPLD联合作用,实现驱动通信管理功能。系统软件设计方面,通过DSG调速系统并且依托于RS-422串行通信接口来实现手自一体操作系统。最后,通过试验验证系统达到预期目标,可以广泛的应用到工业生产当中。

关键词：机械手单片机控制系统

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凉血化瘀中药与曲安奈德对脉络膜新生血管动物模型中MMP-9及TIMP-2表达的影响

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国际眼科杂志 2009年第4期9卷 656-659页

作者：李学晶唐由之中国中医科学院眼科医院中国北京市100040

目的:评价凉血化瘀中药及曲安奈德对氪激光诱导BN大鼠脉络膜新生血管(choroidal neovascularization CNV)中基质金属蛋白酶MMP-9和基质金属蛋白酶抑制剂TIMP-2表达的影响。方法:659nm激光诱导BN大鼠CNV模型,随机分成空白对照组(每日生... 详细信息

目的:评价凉血化瘀中药及曲安奈德对氪激光诱导BN大鼠脉络膜新生血管(choroidal neovascularization CNV)中基质金属蛋白酶MMP-9和基质金属蛋白酶抑制剂TIMP-2表达的影响。方法:659nm激光诱导BN大鼠CNV模型,随机分成空白对照组(每日生理盐水灌胃)、中药组(每日中药灌胃)和曲安奈德组(激光后1d玻璃体腔注射曲安奈德5μL,0.2mg)各16只。分别在光凝后7,14,21,28d随机选取4只大鼠处死,摘除眼球,行病理切片及免疫组织化学检测MMP-9及TIMP-2蛋白在CNV组织中的表达。结果:空白对照组在光凝后7dMMP-9达到高峰,此后逐渐下降;中药组在光凝后14d达到高峰,但峰值低于空白对照组,此后逐渐下降;曲安奈德组在光凝后7d达到高峰,峰值介于空白对照组和中药组之间,此后逐渐下降,在14～21d出现平台期。空白对照组在光凝后14dTIMP-2达到高峰,此后逐渐下降;中药组在光凝后14d达到高峰,峰值高于空白对照组,此后逐渐下降;曲安奈德组在光凝后14d达到高峰,峰值介于空白对照组和中药组之间,此后下降。结论:在下调MMP-9、上调TIMP-2的表达进而抑制CNV形成方面,凉血化瘀中药的作用强于曲安奈德。

关键词：凉血化瘀中药脉络膜新生血管曲安奈德 MMP-9 TIMP-2

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Improved optical coding method for orthogonal ASK/DPSK modulation format

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Frontiers of Optoelectronics 2008年第Z1期1卷 14-19页

作者： xue WANG Zhixue HE Hongxing liU Hong liU Wei li Dexiu HUANG Nan CHI Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Orthogonal ASK/DPSK labeling, which encodes label information on optical carriers in a modulation format, is regarded as a competing scheme to subcarrier multiplexed optical labeling. However, the inherent cross-talk limits the extinction ratio(ER) of the payload and label sensitivity. In this paper, two optical coding methods–Manchester coding and 8B10B coding–which can remarkably improve the system quality to obtain acceptable ER are discussed. A novel optical packet encoding method–mark-insertion coding–is demonstrated to significantly reduce cross-talk between the amplitude shift keying(ASK) payload and the differential phase shift keying(DPSK) label through spectrum shaping. The performance of mark-insertion coding depends on the number of inserted ‘marks'. Finally, the transmission over a 40 km single mode fiber(SMF) is compared with optical label swapping for a 40 Gbit/s ASK payload and 2.5 Gbit/s DPSK label under these coding schemes. The experimental result is consistent with the theoretical analysis.

关键词： orthogonal modulation amplitude shift keying (ASK) differential phase shift keying (DPSK) mark-insertion coding

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