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World Journal of Diabetes 2024年第7期15卷 1615-1626页

作者： Xiao-Lan Ma Dan Ge xue-Jian hu Department of Endocrinology and Metabolism The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Islets of Langerhans beta cells diminish in autoimmune type 1 diabetes mellitus(T1DM).Teplizumab,a humanized anti-CD3 monoclonal antibody,may help *** long-term implications on clinical T1DM development,safety,and efficacy are *** To assess the effectiveness and safety of teplizumab as a therapeutic intervention for individuals with *** A systematic search was conducted using four electronic databases(PubMed,Embase,Scopus,and Cochrane Library)to select publications published in peerreviewed journals written in *** odds ratio(OR)and risk ratio(RR)were calculated,along with their 95%*** assessed heterogeneity using Cochrane Q and I2 statistics and the appropriate P *** There were 8 randomized controlled trials(RCTs)in the current meta-analysis with a total of 1908 T1DM patients from diverse age cohorts,with 1361 patients receiving Teplizumab and 547 patients receiving a *** was found to have a substantial link with a decrease in insulin consumption,with an OR of 4.13(95%CI:1.72 to 9.90).Teplizumab is associated with an improved Cpeptide response(OR 2.49;95%CI:1.62 to 3.81)and a significant change in Glycated haemoglobin A1c(HbA1c)levels in people with type 1 diabetes[OR 1.75(95%CI:1.03 to 2.98)],and it has a RR of 0.71(95%CI:0.53 to 0.95).CONCLUSION In type 1 diabetics,teplizumab decreased insulin consumption,improved C-peptide response,and significantly changed HbA1c levels with negligible side *** appears to improve glycaemic control and diabetes management with good safety and efficacy.

关键词： Type-1 diabetes mellitus Teplizumab Anti-CD3 monoclonal antibody Insulin Glycated haemoglobin A1c Cpeptide

Simulation and structural parameter optimization of rotary blade cutting soil based on SPH method

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 82-90页

作者： Xiongye Zhang xue hu Lixin Zhang Abdalla Noureldin Osman Kheiry College of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832000XinjiangChina Bingtuan Energy Development Institute Shihezi UniversityShihezi 832000XinjiangChina Xinjiang Production and Construction Corps Key Laboratory of Modern Agricultural Machinery Shihezi 832000XinjiangChina Key Laboratory of Northwest Agricultural Equipment Ministry of Agriculture and Rural AffairsShihezi 832000XinjiangChina College of Agricultural Engineering Sudan University of Science and TechnologyKhartoum 999129Sudan

Pre-sowing mechanical tillage in crop fields is a primary task and important aspect of crop *** interaction between the tillage components and the soil plays a crucial role in determining the energy consumption of tillage ***,it is essential to investigate soil-tool interaction mechanisms and optimize tool design for energy savings in soil *** study employed the Smoothed Particle Hydrodynamics(SPH)method to investigate the soil cutting process of a typical rotary *** article describes the principles and modeling process of the SPH method in *** includes the selection of constitutive models,boundary treatments,and particle conversion.A high-precision soil-tool interaction model was established to analyze the deformation zone of the soil,cutting energy,cutting resistance,and soil particle *** simulation experiments and response surface methodology were used to optimize key design parameters of the rotary blade considering both the reduction in cutting power consumption and the impact on the structural performance of the *** optimal parameters were determined as follows:a bending point included angle of 30°,a side cutting edge bending line direction angle of 51°,and a bending angle of 120°.These parameters resulted in a minimum power consumption of 0.181 kW while meeting the required structural ***,experiments were conducted on field rotary tillage,and the measured power consumption showed a deviation of 7.1%from the simulated power *** optimized power consumption was reduced by 9.52%compared to the initial power consumption,validating the accuracy of the simulation process and the effectiveness of energy savings.

关键词： rotary blade Smoothed Particle Hydrodynamics response surface methodology energy consumption optimization

An Improved Golden Jackal Optimization Algorithm Based on Multi-strategy Mixing for Solving Engineering Optimization Problems

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Journal of Bionic Engineering 2024年第2期21卷 1092-1115页

作者： Jun Wang Wen-chuan Wang Kwok-wing Chau Lin Qiu Xiao-xue hu Hong-fei Zang Dong-mei Xu College of Water Resources North China University of Water Resources and Electric PowerZhengzhou450046People’s Republic of China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China

Nowadays,optimization techniques are required in various engineering domains to find optimal solutions for complex *** a result,there is a growing tendency among scientists to enhance existing nature-inspired algorithms using various evolutionary strategies and to develop new nature-inspired optimization methods that can properly explore the feature *** recently designed nature-inspired meta-heuristic,named the Golden Jackal Optimization(GJO),was inspired by the collaborative hunting actions of the golden jackal in nature to solve various challenging ***,like other approaches,the GJO has the limitations of poor exploitation ability,the ease of getting stuck in a local optimal region,and an improper balancing of exploration and *** overcome these limitations,this paper proposes an improved GJO algorithm based on multi-strategy mixing(LGJO).First,using a chaotic mapping strategy to initialize the population instead of using random parameters,this algorithm can generate initial solutions with good diversity in the search ***,a dynamic inertia weight based on cosine variation is proposed to make the search process more realistic and effectively balance the algorithm's global and local search ***,a position update strategy based on Gaussian mutation was introduced,fully utilizing the guidance role of the optimal individual to improve population diversity,effectively exploring unknown regions,and avoiding the algorithm falling into local *** evaluate the proposed algorithm,23 mathematical benchmark functions,CEC-2019 and CEC2021 tests are *** results are compared to high-quality,well-known optimization *** results of the proposed method are compared from different points of view,including the quality of the results,convergence behavior,and *** superiority and high-quality performance of the proposed method are demonstrated by comparing the ***,to demonstrate

关键词： Golden jackal optimization Chaotic mapping Dynamic inertia weight Dimensional Gaussian variation Muskingum

Hypertension and NAFLD risk:Insights from the NHANES 2017-2018 and Mendelian randomization analyses

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Chinese Medical Journal 2024年第4期137卷 457-464页

作者： Mengqin Yuan Jian He xue hu Lichao Yao Ping Chen Zheng Wang Pingji Liu Zhiyu Xiong Yingan Jiang Lanjuan Li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430000China Department of Gastroenterology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510010China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Centre for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310000China

Background:Hypertension and non-alcoholic fatty liver disease(NAFLD)share several pathophysiologic risk factors,and the exact relationship between the two remains *** study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey(NHANES)2017-2018 and Mendelian randomization(MR)***:Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES ***,a two-sample MR study was performed using the genome-wide association study(GWAS)summary statistics to identify the causal association between hypertension,systolic blood pressure(SBP),diastolic blood pressure(DBP),and *** primary inverse variance weighted(IVW)and other supplementary MR approaches were conducted to verify the causal association between hypertension and *** analyses were adopted to confirm the robustness of the ***:A total of 3144 participants were enrolled for our observational study in *** multivariable-adjusted logistic regression analysis suggested that hypertension was positively related to NAFLD risk(odds ratio[OR]=1.677;95%confidence interval[CI],1.159-2.423).SBP≥130 mmHg and DBP≥80 mmHg were also significantly positively correlated with ***,hypertension was independently connected with liver steatosis(β=7.836[95%CI,2.334-13.338]).The results of MR analysis also supported a causal association between hypertension(OR=7.203[95%CI,2.297-22.587])and *** results were observed for the causal exploration between SBP(OR=1.024[95%CI,1.003-1.046]),DBP(OR=1.047[95%CI,1.005-1.090]),and *** sensitive analysis further confirmed the robustness and reliability of these findings(all P>0.05).Conclusion:Hypertension was associated with an increased risk of NAFLD.

关键词： Hypertension Non-alcoholic fatty liver disease National Health and Nutrition Examination Survey Mendelian randomization analysis Causality

Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai GUO Chang-ya LIU Gao-hui LI Jian-ping XIANG Xiao-chang LENG Yi-ke CAI xue-bin hu Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang Wan xue-Chun hu Yi-Xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-hua Jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

Fucoxanthin promotes the chain lengthening reaction of polyunsaturated fatty acids in vivo by enhancing FADS2 enzyme activity

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Food Science and human Wellness 2024年

作者： Xiao-Yue Li Tian-Xin Yang Ying-Cai Zhao Cheng-Cheng Wang Chang-hu xue Teruyoshi Yanagita Yu-Ming Wang Tian-Tian Zhang SKL of Marine Food Processing & Safety Control College of Food Science and Engineering Ocean University of China Laboratory of Nutrition Biochemistry Department of Applied Biochemistry and Food Science Saga University

Alpha-linolenic acid (ALA) is capable of synthesizing EPA and DHA in vivo， but the conversion rate is hard to meet the body's need for rapid DHA supplementation. Studies have shown that fucoxanthin can increase DHA content in the liver of mice， but the mechanism is not clear. Moreover， the effect of fucoxanthin and its metabolite fucoxanthinol on the chain lengthening reaction of n-6 polyunsaturated fatty acids (PUFAs) is little studied. In this study， the effects of fucoxanthin and fucoxanthinol on the chain elongation of n-3 and n-6 series PUFAs were investigated in mice. Results showed that fucoxanthin and fucoxanthinol significantly increased the conversion of n-3 series ALA to DHA and n-6 series LA to AA in the serum， liver， small intestine， and heart of mice. In addition， fucoxanthin accelerated the rate of DHA supplementation by ALA in the brain. Further mechanistic studies revealed that the role of fucoxanthin in promoting PUFAs conversion was not regulated at transcriptional level， but by increasing the activity of fatty acid desaturase 2 (FADS2)， a key enzyme of chain elongation reaction of n-3 and n-6 PUFAs. This study fundamentally provided theoretical bases for a new strategy of dietary supplementation of n-3 and n-6 PUFAs.

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基于强化学习的多技能项目调度算法

控制理论与应用 2024年第3期41卷 502-511页

作者：胡振涛崔南方胡雪君雷晓琪华中科技大学管理学院湖北武汉430074 湖南大学工商管理学院湖南长沙410082

多技能项目调度存在组合爆炸的现象,其问题复杂度远超传统的单技能项目调度,启发式算法和元启发式算法在求解多技能项目调度问题时也各有缺陷.为此,根据项目调度的特点和强化学习的算法逻辑,本文设计了基于强化学习的多技能项目调度算法... 详细信息

多技能项目调度存在组合爆炸的现象,其问题复杂度远超传统的单技能项目调度,启发式算法和元启发式算法在求解多技能项目调度问题时也各有缺陷.为此,根据项目调度的特点和强化学习的算法逻辑,本文设计了基于强化学习的多技能项目调度算法.首先,将多技能项目调度过程建模为符合马尔科夫性质的序贯决策过程,并依据决策过程设计了双智能体机制.而后,通过状态整合和行动分解,降低了价值函数的学习难度.最后,为进一步提高算法性能,针对资源的多技能特性,设计了技能归并法,显著降低了资源分配算法的时间复杂度.与启发式算法的对比实验显示,本文所设计的强化学习算法求解性能更高,与元启发式算法的对比实验表明,该算法稳定性更强,且求解速度更快.

关键词：多技能资源项目调度智能算法强化学习并行调度

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知识产权保护能否改善地区创新资本错配

中国科技论坛 2024年第1期 82-92页

作者：薛虎谢昌凡耿献辉南京农业大学经济管理学院江苏南京210018

本文从创新技术研发系统和创新技术转化系统双重视角探讨知识产权保护对地区创新资本错配的影响及其作用机制,并基于2004—2021年30个省级面板数据进行实证检验。研究发现:(1)知识产权保护存在地区创新资本错配的改善效应,随着时间的推... 详细信息

本文从创新技术研发系统和创新技术转化系统双重视角探讨知识产权保护对地区创新资本错配的影响及其作用机制,并基于2004—2021年30个省级面板数据进行实证检验。研究发现:(1)知识产权保护存在地区创新资本错配的改善效应,随着时间的推移这种改善效应逐渐增强;(2)地区创新资本错配方向的不同会对研究结果产生影响,在创新资本配置过度地区中知识产权保护会加剧地区创新资本错配;(3)随着技术位置的前移,知识产权保护的地区创新资本错配改善效应更大;(4)机制检验表明,知识产权保护通过技术市场治理效应、技术市场扩张效应、创新能力提升效应来改善地区创新资本错配。本文的研究结论可为健全知识产权制度和优化创新资源配置提供经验证据和决策参考。

关键词：知识产权保护创新资本错配市场扭曲

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颅缝发育与颅缝早闭的分子机制

中国生物化学与分子生物学报 2024年第2期40卷 151-159页

作者：叶剑青胡雪峰福建师范大学生命科学学院福建省发育与神经生物学重点实验室福州350117

颅骨的发育依赖于颅缝(cranial suture)正常的骨供给,期间颅缝的间充质干细胞经历系统地增殖和成骨分化以保证骨的正常生长。遗传因素或外界干扰则可能引起干细胞的过度成骨分化,导致颅骨的过早闭合,称为颅缝早闭。颅缝细胞与细胞外基... 详细信息

颅骨的发育依赖于颅缝(cranial suture)正常的骨供给,期间颅缝的间充质干细胞经历系统地增殖和成骨分化以保证骨的正常生长。遗传因素或外界干扰则可能引起干细胞的过度成骨分化,导致颅骨的过早闭合,称为颅缝早闭。颅缝细胞与细胞外基质、骨膜以及脑膜共同构成颅缝微环境(niche)。它们相互调节以保证颅缝的正常发育。临床研究发现,绝大多数颅缝早闭(craniosynostosis)患者都伴有硬脑膜和细胞外基质(extracellular matrixc,ECM)的异常。许多研究也发现,作用于颅缝的异常外界机械刺激也可能导致颅缝发育的异常。考虑到颅缝发育受多方面因素影响,本篇综述将介绍近年来有关颅缝微环境异常,以及机械力在调控颅缝发育中的研究进展,总结颅缝早闭发生的分子机制和目前研究方向,旨在为该病的诊断治疗提供新的思路。

关键词：颅缝早闭硬脑膜细胞外基质机械力