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Timing of the formation of the Baiyinnuo'er skarn Zn–Pb deposit,NE China:evidence from sulfide Rb–Sr dating

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Acta Geochimica 2022年第2期41卷 185-196页

作者： Yixin Li Qihai Shu xudong niu Fan Yu Qingwen Zeng Liangmin Wei Yang Xiao Xianglin Dai State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing 100083China Chifeng Hongling Nonferrous Mining Co.Ltd.(Shandong Gold Group) Chifeng 025420Inner MongoliaChina

The Baiyinnuo’er deposit in northern China is located in the south section of the Great Xing’an Range,and it is the largest skarn Zn–Pb deposit in the *** and Zn–Pb orebodies mainly occur between the different units of the Permian Huanggangliang Formation,or within the contact zone between the intrusive rocks and the *** Baiyinnuo’er has been well investigated previously,the timing of the Zn–Pb mineralization is still controversial,largely due to the lack of appropriate ore or alteration minerals that could be directly used for isotopic *** this study,we report the results of Rb–Sr isotopic analysis for sphalerite and pyrite samples from the Baiyinnuo’er orebodies,which yielded two isochron ages of 137.4±3.4 and 140.0±7.8 Ma,respectively,constraining the Zn–Pb mineralization time of the deposit as the Early *** data are also consistent with the age of the granitoids in the mining area,indicating a potential genetic relationship between the Early Cretaceous magmatism and *** other intrusion-related hydrothermal deposits(including the two typical skarns,Huanggang and Haobugao)in the southern Great Xing’an Range also share similar mineralization ages(i.e.,140–130 Ma).Together,these data suggest an Early Cretaceous mineralization event in this region,and this largescale mineralization could be related to the regional tectonic regime transition from compression to extension as a result of the rollback of the subducted Paleo-Pacific *** initial87 Sr/86 Sr ratios of the sphalerite and pyrite samples are 0.70569 and 0.70616,respectively,implying that the ore-forming material could have a significant contribution from the mantle *** current study shows that sulfide Rb–Sr dating could be used in deciphering the timing of skarn deposit formation.

关键词： Rb-Sr dating Sphalerite and pyrite Skarn Zn-Pb deposit Baiyinnuo’er Southern Great Xing’an Range

整合数据库筛选胰腺导管腺癌铁死亡核心基因及预后分析

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数理医药学杂志 2024年第5期37卷 349-359页

作者：牛旭东许书齐叶磊鞠成林王小艺包亚男牛占军齐齐哈尔医学院基础医学院黑龙江齐齐哈尔161006 齐齐哈尔医学院药学院黑龙江齐齐哈尔161006 内蒙古医科大学第三附属医院耳鼻咽喉科内蒙古包头014030

目的筛选胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)铁死亡核心基因及预后分析。方法基于基因表达综合(Gene Expression Omnibus,GEO)数据库,选取GSE71989数据集,借助limma包和铁死亡数据集对差异表达基因(differentially expressed genes,DEGs)进行筛选。利用Metascape数据库进行富集分析、String数据库建立蛋白质互作网络(protein-protein interaction network,PPI),采用最大集团中心性(matthews correlation coefficient,MCC)算法筛选预后相关核心基因。利用Kaplan Meier plotter、R、GEPIA2和TIMER数据库对所筛选的核心基因进行预后分析并验证,基于CMap数据库筛选PDAC潜在治疗药物。结果筛选共得到2038个DEGs,其中上调基因1552个、下调基因486个,与铁死亡数据集相交,得到66个共同DEGs;京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路分析显示,铁死亡相关基因富集通路包括铁死亡途径、白介素-17(interleukin-17,IL-17)信号通路、化学致癌作用-活性氧通路、过氧化物酶体增殖物活化受体(peroxisome proliferator-activated receptor,PPAR)信号通路和低氧诱导因子-1(hypoxia inducible factor-1,HIF-1)信号通路等;MCC算法得到预后核心靶点:还原氢氧化酶4(NADPH oxidase 4,NOX4)、小窝蛋白-1(caveolin-1,CAV1)、缺氧诱导因子1α(hypoxia inducible factor 1 subunit alpha,HIF1A)、过氧化物酶体增殖因子激活受体γ(peroxisome proliferator activated receptor gamma,PPARG)、白介素-6(interleukin-6,IL-6)、前列腺素内过氧化物合成酶2(prostaglandin-endoperoxide synthase 2,PTGS2);验证分析提示核心基因均为高表达基因、与患者总生存率密切且均具有诊断价值(P<0.05);免疫浸润表明NOX4、HIF1A和IL-6基因与巨噬细胞、中性粒细胞浸润水平呈正相关关系(P<0.05)。NOX4、CAV1和H1F1A基因与CD8+、DC细胞浸润水平呈正相关关系(P<0.05)。筛选所得小分子药物包括HU-211、伊斯平斯和熊果酸,且所得小分子均与PDAC有较强相关性。结论基于整合数据库筛选所得铁死亡相关基因(NOX4、CAV1、HIF1A、PPARG、IL-6、PTGS2)对PDAC有较高诊断价值,可能为预后相关诊断指标。

关键词：胰腺导管腺癌铁死亡预后分析生物信息学

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孕前女性维生素D和同型半胱氨酸的水平及影响因素分析

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宁夏医学杂志 2024年第4期46卷 307-310页

作者：杨生秀王金霞张亚娟牛旭东宁夏银川市妇幼保健院宁夏银川750001 宁夏医科大学公共卫生学院宁夏银川750004

目的探讨孕前女性维生素D和同型半胱氨酸水平现状及其影响因素,为改善孕前女性营养状况和预防不良妊娠结局提供科学依据。方法选取进行孕前优生健康检查的405名育龄妇女作为研究对象,采用二元logistic回归模型分析维生素D缺乏和高同型... 详细信息

目的探讨孕前女性维生素D和同型半胱氨酸水平现状及其影响因素,为改善孕前女性营养状况和预防不良妊娠结局提供科学依据。方法选取进行孕前优生健康检查的405名育龄妇女作为研究对象,采用二元logistic回归模型分析维生素D缺乏和高同型半胱氨酸血症的影响因素。结果孕前女性维生素D水平为13.04(10.30,16.48)ng/mL,同型半胱氨酸水平为9.6(8.0,11.5)μmol/L。二元logistic回归结果显示,年龄<35岁(OR=2.491,95%CI:1.181~5.255)和夏季(OR=0.235,95%CI:0.066~0.834)是维生素D缺乏的影响因素。自费(OR=6.501,95%CI:2.501~16.900)和亚甲基四氢叶酸还原酶(MTHFR)检测中风险(OR=17.933,95%CI:3.916~82.124)是高同型半胱氨酸血症的影响因素。结论银川市孕前女性维生素D缺乏率较高,同型半胱氨酸平均水平较高,应当重视孕前女性维生素D的补充和控制同型半胱氨酸水平,保障围产期健康。

关键词：孕前维生素D 同型半胱氨酸

实时腔镜手术视频联合CBL教学模式在住院医师规范化培训教学中的应用

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中国病案 2024年第4期25卷 91-94页

作者：王小东牛旭东张磊李曜行王靖宇山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院) 山西省太原市030032

目的探讨实时腔镜手术视频联合CBL教学模式在住院医师规培教学中的应用效果,为提高教学质量提供参考依据。方法以2021年10月1日-2023年5月31日50名在某院泌尿外科参加住院医师规培的医师为研究对象,随机分为对照组和观察组各25名。对照... 详细信息

目的探讨实时腔镜手术视频联合CBL教学模式在住院医师规培教学中的应用效果,为提高教学质量提供参考依据。方法以2021年10月1日-2023年5月31日50名在某院泌尿外科参加住院医师规培的医师为研究对象,随机分为对照组和观察组各25名。对照组以CBL教学方式学习,观察组在对照组的基础上引入术中实时视频教学,均由同一教师进行教授。通过基础理论、实践考核及教学满意度调查评估教学效果。结果两组一般资料及培训前基础理论考核成绩差异无统计学意义(P>0.05)。培训后观察组和对照组的基础理论考核中基础知识成绩分别为(21.00±3.11)、(20.84±2.56)分,差异无统计学意义(P>0.05)。而在术前准备、手术步骤、并发症及处理方面,观察组明显优于对照组,在这三个部分以及总体得分上,观察组的分数分别为(21.56±2.43)、(22.16±1.70)、(20.64±2.66)、(85.36±5.74)分;对照组分别为(18.60±2.41)、(19.00±2.31)、(17.60±2.96)和(76.04±5.54)分,差异有统计学意义(P<0.05)。此外,观察组规培医师实践成绩及对教学方式的满意度明显优于对照组(P<0.05)。结论实时腔镜手术视频联合CBL教学模式有助于提高教学效率,加深学生对腔镜手术的理解,提高操作技能和临床实践水平,值得广泛推广。

关键词：实时视频案例导向教学法住院医师规范化培训泌尿外科

基于网络药理学与代谢组学和分子对接的整合药理学策略研究温胆汤治疗慢性阻塞性肺疾病的作用机制

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中国药学杂志 2024年第11期59卷 998-1010页

作者：牛旭东何溢琨何梓龙陈爱灵高文浩任腾飞朱珍珍汪芳任睿楠林松王天阳齐齐哈尔医学院基础医学院黑龙江齐齐哈尔161006 齐齐哈尔医学院药学院黑龙江齐齐哈尔161006 齐齐哈尔医学院基础医学院基础医学科研中心黑龙江齐齐哈尔161006 黑龙江省药食同源资源与代谢性疾病防治重点实验室黑龙江齐齐哈尔161006

目的探讨温胆汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的作用机制。方法首先,基于网络药理学方法,利用中药系统药理学数据库与分析平台(TCMSP)、Swiss Target Prediction和Metascape等数据库,揭示温胆汤治... 详细信息

目的探讨温胆汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的作用机制。方法首先,基于网络药理学方法,利用中药系统药理学数据库与分析平台(TCMSP)、Swiss Target Prediction和Metascape等数据库,揭示温胆汤治疗COPD的潜在机制;其次,采用代谢组学方法,研究温胆汤对COPD诱发内源性代谢物紊乱的干预作用;最后,借助MetScape算法,整合网络药理学与代谢组学研究结果,并采用分子模拟对接和分子生物学方法,深入研究温胆汤治疗COPD的作用机制。结果网络药理学结果揭示温胆汤的102个潜在活性成分及其治疗COPD的98个潜在靶点。进一步分析显示温胆汤的11个潜在药效物质,包括3-叔丁基己二酸、6-甲基姜辣二醇双乙酸酯和甘草异黄烷酮等可能通过调节脂质与动脉粥样硬化、环磷腺苷(cyclic adenosine monophosphate,cAMP)信号通路、磷脂酰肌醇3激酶-蛋白激酶B(phosphoinositide 3-kinase-protein kinase B,PI3K-Akt)信号通路和白介素17(interleukin-17,IL-17)信号通路等发挥疗效。另一方面代谢组学研究显示,丙二醇、N-乙酰神经氨酸、苏氨酸、原胆酸、2-氧异戊酸酯、乙酰磷酸、柠檬酸盐和异丁酸等9种内源性物质,可能是温胆汤治疗COPD的关键代谢物。最后整合分析显示,脂质代谢与氨基酸代谢可能是温胆汤治疗COPD的关键过程,黄嘌呤脱氢酶(xanthine dehydrogenase,XDH)、激酶插入区受体(kinase insert domain receptor,KDR)、磷酸二酯酶5A(phosphodiesterase 5A,PDE5A)、细胞色素P450家族2亚家族C成员9(cytochrome P450 family 2 subfamily C member 9,CYP2C9)和成员19(cytochrome P450 family 2 subfamily C member 19,CYP2C19)等同氧化和炎症相关的基因可能是温胆汤发挥治疗作用的关键靶点;并且结果显示温胆汤可有效改善COPD大鼠肺部充血、水肿和炎性细胞浸润等多种病理状态,显著降低COPD大鼠肺组织中白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)含量和丙二醛(malonaldehyde,MDA)活性,提高超氧化物歧化酶(superoxide dismutase,SOD)活性;而且分子对接结果也揭示了潜在药效物质与核心靶点基因之间的关联性。结论基于代谢组学、网络药理学和分子对接的整合药理学研究表明温胆汤可能通过调控炎症反应、氧化应激、脂质代谢和氨基酸代谢等途径实现治疗COPD的作用。

关键词：温胆汤慢性阻塞性肺疾病网络药理学代谢组学分子对接炎症因子

Insight into the experiment and extraction mechanism for separating carbazole from anthracene oil with quaternary ammonium-based deep eutectic solvents

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Chinese Journal of Chemical Engineering 2024年第1期65卷 188-199页

作者： xudong Zhang Yanhua Liu Jun Shen Yugao Wang Gang Liu Yanxia niu Qingtao Sheng College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China

Carbazole is an irreplaceable basic organic chemical raw material and intermediate in *** separation of carbazole from anthracene oil by environmental benign solvents is important but still a challenge in chemical *** eutectic solvents (DESs) as a sustainable green separation solvent have been proposed for the separation of carbazole from model anthracene *** this research,three quaternary ammonium-based DESs were prepared using ethylene glycol (EG) as hydrogen bond donor and tetrabutylammonium chloride (TBAC),tetrabutylammonium bromide or choline chloride as hydrogen bond *** explore their extraction performance of carbazole,the conductor-like screening model for real solvents (COSMO-RS) model was used to predict the activity coefficient at infinite dilution (γ^(∞)) of carbazole in DESs,and the result indicated TBAC:EG (1:2) had the stronger extraction ability for carbazole due to the higher capacity at infinite dilution (C^(∞)) ***,the separation performance of these three DESs was evaluated by experiments,and the experimental results were in good agreement with the COSMO-RS prediction *** TBAC:EG (1:2) was determined as the most promising ***,the extraction conditions of TBAC:EG (1:2) were optimized,and the extraction efficiency,distribution coefficient and selectivity of carbazole could reach up to 85.74%,30.18 and 66.10%,***,the TBAC:EG (1:2) could be recycled by using environmentally friendly water as *** addition,the separation performance of TBAC:EG (1:2) was also evaluated by real crude anthracene,the carbazole was obtained with purity and yield of 85.32%,60.27%,***,the extraction mechanism was elucidated byσ-profiles and interaction energy *** calculation results showed that the main driving force for the extraction process was the hydrogen bonding ((N–H...Cl) and van der Waals interactions (C–H...O and C–H...π),which correspondin

关键词： Carbazole Model anthracene oil Deep eutectic solvents COSMO-RS Extraction mechanism

Self-Powered Absorptive Reconfigurable Intelligent Surfaces for Securing Satellite-Terrestrial Integrated Networks

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China Communications 2024年第9期21卷 276-291页

作者： Lin Zhi niu Hehao He Yuanzhi An Kang Zhong xudong Chu Zheng Xiao Pei College of Electronic Engineering National University of Defense TechnologyHefei 230037China Sixty-Third Research Institute National University of Defense TechnologyNanjing 210007China Institute of Systems Engineering Academy of Military ScienceBeijing 100141China Department of Electrical and Electronic Engineering University of Nottingham Ningbo ChinaNingbo 315100China Institute for Communication Systems University of SurreyGuildford GU27XHU.K.

Satellite communications have attracted significant interests due to its advantages of large footprint and massive ***,the commonly used onboard beamforming is hard to achieve reliable security because of the highly correlated legitimate and wiretap downlink *** exploit the benefits of satellite-terrestrial integrated network(STIN)and a novel absorptive reconfigurable intelligent surface(RIS)for improving the security of satellite downlink communications(SDC)in the presence of eavesdroppers(Eves).This paper aims to maximize the achievable secrecy rate of the earth station(ES)while satisfying the signal reception constraints,harvested power threshold at the RIS,and total transmit power *** solve this nonconvex problem,we propose a penalty-function based dual decomposition scheme,which firstly transforms the original problem into a two-layer optimization ***,the outer layer and inner problems are solved by utilizing the successive convex approximation,Lagrange-dual and Rayleigh quotient methods to obtain the beamforming weight vectors and the reflective coefficient ***,simulation results verify the effectiveness of the proposed scheme for enhancing the SDC security.

关键词： absorptive RIS beamforming design secure communications STIN

PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity

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Science China(Life Sciences) 2024年第9期67卷 2033-2035页

作者： Meihan Gong Ye Yuan Zhongye Dai Xuejiao Lv Jiacheng Su Dawei Huo Lin niu Xu Chen xudong Wu State Key Laboratory of Experimental Hematology The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsKey Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Bone Marrow Transplantation Center the First Affiliated HospitalZhejiang University School of MedicineLiangzhu LaboratoryInstitute of HematologyZhejiang UniversityHangzhou 311113China

Dear Editor,Polycomb group proteins,conserved epigenetic transcriptional repressors,are crucial for orchestrating diverse developmental gene expression programs(Schuettengruber et al.,2017).The polycomb repressive complex 2(PRC2)catalyzes H3 lysine-27 trimethylation(H3K27me3)to establish a delicate balance with H3K4me3,forming a bivalent chromatin state at target gene promoters and thereby poising them for subsequent transcription activation(Bernstein et al.,2006).

关键词： valent thereby subsequent

Practical fixed-time adaptive fuzzy control of uncertain nonlinear systems with time-varying asymmetric constraints: a unified barrier function based approach

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Frontiers of Information Technology & Electronic Engineering 2024年第9期25卷 1282-1294页

作者： Zixuan HUANG Huanqing WANG Ben niu xudong ZHAO Adil M.AHMAD College of Engineering Bohai UniversityJinzhou 121013China College of Mathematical Science Bohai UniversityJinzhou 121013China School of Information Science and Engineering Shandong Normal UniversityJinan 250014China Faculty of Electronic Information and Engineering Dalian University of TechnologyDalian 116024China Communication Systems and Networks Research Group Department of Information TechnologyFaculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahSaudi Arabia

A practical fixed-time adaptive fuzzy control strategy is investigated for uncertain nonlinear systems with time-varying asymmetric constraints and input quantization. To overcome the difficulties of designing controllers under the state constraints, a unified barrier function approach is employed to construct a coordinate transformation that maps the original constrained system to an equivalent unconstrained one, thus relaxing the time-varying asymmetric constraints upon system states and avoiding the feasibility check condition typically required in the traditional barrier Lyapunov function based control approach. Meanwhile, the “explosion of complexity” problem in the traditional backstepping approach arising from repeatedly derivatives of virtual controllers is solved by using the command filter method. It is verified via the fixed-time Lyapunov stability criterion that the system output can track a desired signal within a small error range in a predetermined time, and that all system states remain in the constraint range. Finally, two simulation examples are offered to demonstrate the effectiveness of the proposed strategy.

关键词： Unified barrier function Time-varying asymmetric state constraints Fuzzy logic systems Fixed-time control Command filter