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AN EFFECTIVE CONTINUOUS ALGORITHM FOR APPROXIMATE SOLUTIONS OF LARGE SCALE MAX-CUT PROBLEMS

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Journal of Computational Mathematics 2006年第6期24卷 749-760页

作者： Cheng-xian xu xiao-liang feng-min xu Department of Mathematics Xi 'an Jiaotong University Xi ' an 710049 China

An effective continuous algorithm is proposed to find approximate solutions of NP-hard max-cut problems. The algorithm relaxes the max-cut problem into a continuous nonlinear programming problem by replacing n discrete constraints in the original problem with one single continuous constraint. A feasible direction method is designed to solve the resulting nonlinear programming problem. The method employs only the gradient evaluations of the objective function, and no any matrix calculations and no line searches are required. This greatly reduces the calculation cost of the method, and is suitable for the solution of large size max-cut problems. The convergence properties of the proposed method to KKT points of the nonlinear programming are analyzed. If the solution obtained by the proposed method is a global solution of the nonlinear programming problem, the solution will provide an upper bound on the max-cut value. Then an approximate solution to the max-cut problem is generated from the solution of the nonlinear programming and provides a lower bound on the max-cut value. Numerical experiments and comparisons on some max-cut test problems （small and large size） show that the proposed algorithm is efficient to get the exact solutions for all small test problems andwell satisfied solutions for most of the large size test problems with less calculation costs.

关键词： Max-cut problems Algorithm Feasible direction method Laplacian matrix,Eigenvectors.

微型钢板与克氏针固定治疗闭合掌骨骨折的疗效比较

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临床骨科杂志 2024年第4期27卷 595-596页

作者：朱卫徐晓峰周理峰常熟市支塘人民医院骨科江苏常熟215500

2020年8月~2022年8月,我科采用微型钢板和克氏针固定治疗72例闭合掌骨骨折患者,报道如下。1材料与方法1.1病例资料本组72例,均为闭合掌骨骨折。按固定方式不同将患者分为微型钢板组(38例)和克氏针组(34例)。①微型钢板组:男25例,女13例... 详细信息

2020年8月~2022年8月,我科采用微型钢板和克氏针固定治疗72例闭合掌骨骨折患者,报道如下。1材料与方法1.1病例资料本组72例,均为闭合掌骨骨折。按固定方式不同将患者分为微型钢板组(38例)和克氏针组(34例)。①微型钢板组:男25例,女13例,年龄19~57(39.8±8.9)岁。

关键词：微型钢板克氏针闭合掌骨骨折

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畜禽日粮豆粕减量替代研究进展

中国奶牛 2024年第4期 5-9页

作者：喻方勇徐晓锋宁夏大学动物科技学院银川750021 宁夏大学农学院银川750021

豆粕作为传统的饲料蛋白质来源,具有优质、营养丰富的特点,但其价格波动大,成本较高,且对大豆进口依赖性较高。因此,寻找饲料蛋白质替代是当前的国家战略需求和营养研究热点。替代旨在降低饲料成本、减少对豆粕的依赖,并提高动物饲料蛋... 详细信息

豆粕作为传统的饲料蛋白质来源,具有优质、营养丰富的特点,但其价格波动大,成本较高,且对大豆进口依赖性较高。因此,寻找饲料蛋白质替代是当前的国家战略需求和营养研究热点。替代旨在降低饲料成本、减少对豆粕的依赖,并提高动物饲料蛋白应用的可持续性。本文从豆粕减量替代的意义、不同豆粕替代原料的研究和应用现状进行了综述,以期为日粮或饲料中豆粕减量替代提供参考。

关键词：日粮豆粕饲料蛋白质减量替代

Can pigment gallstones be induced by biliary stricture and prevented by medicine in Guinea pigs?

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World Journal of Gastroenterology 2007年第19期13卷 2703-2706页

作者： Zhi xu xiao-feng Ling Wan-Hua Zhang xiao-Si Zhou Department of Surgery Third Hospital of Peking UniversityBeijing 100083 China

AIM: To determine the relationship between biliary stricture and pigment gallstone formation, and the prevention of pigment gallstones with medicine. METHODS: One hundred and eighteen male guinea pigs were randomly divided into four groups: stricture group (S, n = 30) underwent partial ligation of common bile duct, and fed on regular chow; S plus medicine group (S+M, n = 27) underwent the same operation but fed on medicinal chow (0.3 g chenodeoxycholic acid, 0.5 g glucurolactone, and 0.5 g aspirin were mixed up in 1.2 kg regular chow); medicinal control group (C+M, n = 30) was free of operation, and fed on medicinal chow; and control group (C, n = 31) was free of operation and fed on regular chow. One week later, laparotomy was performed, and the bile of gallbladder was collected, measured, and cultured. RESULTS: Gallstones were identif ied. Pigment gallstones were induced by biliary stricture in 95% (22/23) of S group. In the S+M group, the incidence of gallstone was reduced to 55% (11/20, vs S group, P < 0.01). The changes of indirect bilirubin and ionized calcium in the bile were consistent with gallstone incidences. CONCLUSION: Biliary stricture can cause pigment gallstone formation in guinea pigs, and the medicines used can lower the incidence of gallstones. The bilirubin and ionized calcium play important roles in pigment gallstone formation.

关键词： Biliary stricture Pigment gallstone formation Prophylaxis Animal model

基于转录组测序对不同月龄舍饲滩羊羔羊肌肉脂肪代谢相关基因差异表达分析

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饲料研究 2024年第5期47卷 60-65页

作者：康燕王小伟杜佳文张宁李海波徐晓锋张力莉宁夏大学动物科技学院宁夏银川750021

试验旨在探究在舍饲模式下不同月龄滩羊羔羊的肌肉组织脂肪代谢的相关差异表达基因。将体况相近的12只舍饲滩羊为研究对象,分别于2月龄和6月龄挑选3只体重相近的滩羊进行屠宰,取背最长肌和股二头肌。采用Illumina对背最长肌和股二头肌... 详细信息

试验旨在探究在舍饲模式下不同月龄滩羊羔羊的肌肉组织脂肪代谢的相关差异表达基因。将体况相近的12只舍饲滩羊为研究对象,分别于2月龄和6月龄挑选3只体重相近的滩羊进行屠宰,取背最长肌和股二头肌。采用Illumina对背最长肌和股二头肌进行转录组测序,筛选脂肪代谢相关基因。结果显示,6月龄与2月龄滩羊羔羊股二头肌共筛选出差异表达基因146个,其中69个上调基因,77个下调基因。差异表达基因富集在40个GO条目中,主要在内皮细胞凋亡过程的调节、羧酸代谢过程及上皮细胞凋亡过程的负向调节等生物过程中。KEGG显著富集在4个通路中,与脂肪代谢密切相关的通路为过氧化物酶体增生物激活受体(PPAR)信号通路与脂肪细胞因子信号通路等。根据转录组数据分析血管生成样素蛋白4 (ANGPTL4)、脂肪酸合成酶(FASN)及肉毒碱棕榈酰基转移酶Ⅰ肝脏亚型(CPT1A)基因与脂肪代谢相关。6月龄与2月龄滩羊羔羊背最长肌共筛选出差异表达基因1 418个,其中774个上调基因,644个下调基因。GO富集主要体现在细胞-细胞黏附、单个生物体的细胞-细胞黏附及单个生物体的细胞黏附,KEGG显著富集在18个通路中,与脂肪代谢密切相关的为PPAR信号通路与脂肪酸代谢等通路。根据转录组数据分析瘦素(LEP)、胰岛素样生长因子2 (IGF2)、心脏型脂肪酸结合蛋白3 (FABP3)基因与脂肪代谢相关。研究表明,舍饲条件下,ANGPTL4、FASN、CPT1A基因在不同月龄滩羊羔羊股二头肌脂肪代谢过程中发生调节作用,而LEP、IGF2、FABP3基因对背最长肌脂肪代谢发挥调节作用。

关键词：滩羊舍饲肌肉组织脂肪代谢

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国产图迈机器人在腹腔镜根治性前列腺切除术的应用研究

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中华男科学杂志 2024年第8期30卷 696-700页

作者：位志峰陈宇豪朱泽鹏蒋齐熊宇陆烽烽宋震乾江斌朱晓峰冯天昊徐晓峰杨刚魏武姚爱兵葛京平南京医科大学第四附属医院泌尿外科东部战区总医院泌尿外科南京中医药大学附属南京市中医院泌尿外科

目的:使用国产图迈机器人行腹腔镜根治性前列腺切除手术，观察其安全性及使用效果。方法:收集2023年1月至2023年5月前列腺癌患者40例，患者均行机器人辅助腹腔镜根治性前列腺切除术，采取保留膀胱颈和最大长度功能性尿道的手术方法。按... 详细信息

目的:使用国产图迈机器人行腹腔镜根治性前列腺切除手术，观察其安全性及使用效果。方法:收集2023年1月至2023年5月前列腺癌患者40例，患者均行机器人辅助腹腔镜根治性前列腺切除术，采取保留膀胱颈和最大长度功能性尿道的手术方法。按使用机器人系统不同，分为观察组(图迈机器人组)和对照组(达芬奇机器人组),观察机械臂安装时间、腔内手术时间、尿道吻合时间、术中出血量、术后尿控等指标。结果:所有患者均顺利完成手术，观察组和对照组机械臂中位安装时间分别为6 min vs 5 min (P>0.05),腔内手术中位时间分别为146 min vs 130 min (P0.05)。术后即刻、1个月、3个月、6个月尿控恢复率分别为9/15(60.0%)vs16/25(64.0%)、12/15(80.0%)vs 19/25(76.0%)、14/15(93.3%)vs 23/25(92.0%),15/15(100%)vs 24/25(96%),两组比较无显著差异(P>0.05)。结论:国产图迈机器人系统行腹腔镜根治性前列腺切除手术安全可靠，术后尿控效果满意。

关键词：机器人手术前列腺癌根治性前列腺切除术尿控

A preliminary evaluation of the psychometric profiles in Chinese men with chronic prostatitis/chronic pelvic pain syndrome

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Chinese Medical Journal 2011年第4期124卷 514-518页

作者： ZHANG Guo-xi BAI Wen-jun xu Tao WANG xiao-feng Department of Urology Peking University People's HospitalBeijng 100044 China

Background As one of the most commonly diagnosed diseases, chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is characterized by a variety of complex symptoms. Anxiety and depression are two of the most prevalent clinical manifestations of patients with CP/CPPS, and have adverse effects on the health of the subjects and prognosis of comorbidities. Such psychological disorders, however, have not been deeply and thoroughly studied in China. The aim of this study was to investigate the prevalence and severity of psychological disorders in Chinese adults with CP/*** From April 2008 to June 2009, 80 patients and 40 age-matched healthy men participating in a voluntary health examination were recruited. The majority of the subjects completed the questionnaires on the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI） as well as the hospital anxiety and depression scale （HADS）.Results Of all the participants, 77 （96.3%） patients and 37 （92.5%） healthy controls completed the questionnaires. The average NIH-CPSI total score was 21.0±9.5 for the patients and 2.2±1.5 for the controls （P=0.03）. Of the 77 patients with CP/CPPS, 48 （62.3%）, 5 （6.5%）, and 1 （1.2%） had anxiety symptoms, depression symptoms, or both anxiety and depression symptoms, respectively. For the controls, the average HADS anxiety and depression scores in patients were 14.5±6.8 and 5.2±4.5, which were both significantly higher than in controls. Moreover, the prevalence and the symptom scores of both the HADS anxiety and depression were higher for the younger age group （〈35 years） than for the older age group （〈35 years）.Conclusions This preliminary study revealed that male patients with CP/CPPS had a higher prevalence of psychological disorders than in the control subjects. Moreover, the differences of the prevalence and severity of the psychological symptoms between the two different age groups may imply that psychological disorders related to CP/CPPS may be relieved

关键词： chronic prostatitis/chronic pelvic pain syndrome hospital anxiety and depression scale psychological disorders

Total Saponins of Rubus Parvifolius *** Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways

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Chinese Journal of Integrative Medicine 2018年第12期24卷 920-924页

作者： xu xiao-feng CHENG Ru-bin ZHANG xue-jin GAO Rui-lan Department of Hematology Hangzhou Red Cross HospitalHangzhou 310003China College of Pharmaceutical Science Zhejiang Chinese Medical UniversityHangzhou 310053China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China

Objective： To investigate the anti-leukemia effect of total saponins of Rubus parvifo/ius L. （TSRP） on K562 cell xenografts in nude mice and the mechanisms of action. Methods： The K562 cell xenografts in nude mice were established, and then randomly divided into 5 groups, the control group, the cytosine arabinoside group（Am-c） and 3 TSRP groups （20, 40 and 100 mg/kg）. The tumor volume and mass of each group of nude mice were measured and the anti-tumor rates of TSRP were calculated subsequently. The apoptosis status of tumor cells was detected by hematoxylin-eosin （HE） and terminal dexynucleotidyl transferase （TdT）-mediated dUTP nick end labeling （TUNEL） staining analysis. Finally, the activities of apoptosis related signaling of signal transducer and activator of transcription 3 （STAT3）, eukaryotic initiation factor 4E （eIF4E） and B-cell lymphoma-2 （bcl-2） were determined with immunohistochemistry tests. Results： Subcutaneous injection of K562 cells induced tumor formation in nude mice, and the TSRP treated group showed a significant inhibitory effect on tumor formation. The nude mice treated with TSRP showed a significant decrease in tumor growth rate and tumor weight in comparison to the control group （all P〈0.05）. The HE staining and TUNEL assay showed that TSRP induced cell death by apoptosis. The immunohistochemical assay showed down-regulation of the bcl-2 gene in the TSRP treated cells. The phosphorylation levels of elF4E and STAT3 were decreased obviously after the treatment of TSRP. Conclusion： TSRP had an excellent tumor-suppressing effect on K562 cells in the nude mice xenograft model, suggesting that TSPR can be developed as a promising anti-chronic myeloide leukemia drug.

关键词： total saponins of Rubus parvifolius L. xenograft model apoptosis signal transducer and activator of transcription 3 eukaryotic initiation factor 4E

Quantitative relationship between visibility and mass concentration of PM2.5 in Beijing

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Journal of Environmental Sciences 2006年第3期18卷 475-481页

作者： WANG Jing-li ZHANG Yuan-hang SHAO Min LIU xu-lin ZENG Li-min CHENG Cong-lan xu xiao-feng Institute of Urban Meteorology China Meteorological Administration Beijing 100089 China State Joint Key Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences Peking University Beijing 100871 China Beijing Meteorological Information and Network Center Beijing 100089 China

The pollution of particulate matter less than 2.5μm （PM2.5） is a serious environmental problem in Beijing. The annual average concentration of PM2.5 in 2001 from seasonal monitor results was more than 6 times that of the U,S, national ambient air quality standards proposed by U.S. EPA. The major contributors to mass of PM2.5 were organics, crustal elements and sulfate. The chemical composition of PM2.5 varied largely with season, but was similar at different monitor stations in the same season. The fine particles （PM2.5） cause atmospheric visibility deterioration through light extinction, The mass concentrations of PM2.5 were anti-correlated to the visibility, the best fits between atmospheric visibility and the mass concentrations of PM2.5 were somehow different： power in spring, exponential in summer, logarithmic in autumn, power or exponential in winter. As in each season the meteorological parameters such as air temperature and relative humidity change from day to day, probably the reason of above correlations between PM2.5 and visibility obtained at different seasons come from the differences in chemical compositions of PM2.5.

关键词： PM2.5 atmospheric urban aerosol air pollution meteorological factor visibility