检索结果-南通市图书馆

Regulations of m^(6)A and other RNA modifications and their roles in cancer

Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-hui Chen Kun-Xiong Guo Jing Li Shu-hui xu huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Catalytic effect in lithium metal batteries: From heterogeneous catalyst to homogenous catalyst

引用

Journal of Energy Chemistry 2024年第3期90卷 305-326,I0008页

作者： Haining Fan xuan-Wen Gao Hailong xu Yichun Ding Shi-xue Dou Wen-bin Luo School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong 100872China Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghai 200000China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710000ShaanxiChina

Lithium metal batteries are regarded as prominent contenders to address the pressing needs owing to the high theoretical *** the broader implementation,the primary obstacle lies in the intricate multi-electron,multi-step redox reaction associated with sluggish conversion kinetics,subsequently giving rise to a cascade of parasitic *** order to smooth reaction kinetics,catalysts are widely introduced to accelerate reaction rate via modulating the energy *** past decades,a large amount of research has been devoted to the catalyst design and catalytic mechanism exploration,and thus the great progress in electrochemical performance has been ***,it is necessary to make a comprehensive review toward key progress in catalyst design and future development *** this review,the basic mechanism of lithium metal batteries is provided along with corresponding advantages and existing challenges detailly *** main catalysts employed to accelerate cathode reaction with emphasis on their catalytic mechanism are summarized as ***,the rational design and innovative direction toward efficient catalysts are suggested for future application in metal-sulfur/gas battery and *** review is expected to drive and benefit future research on rational catalyst design with multi-parameter synergistic impacts on the activity and stability of next-generation metal battery,thus opening new avenue for sustainable solution to climate change,energy and environmental issues,and the potential industrial economy.

关键词： Energy storage and conversion Metal battery Sulfur battery Air battery Catalytic effect Heterogeneous catalyst Homogeneous catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Viscosity and structure of CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags for continuous casting of high titanium steel with different Tio2 absorption

引用

Journal of Iron and Steel Research International 2024年第8期31卷 1936-1946页

作者： Ya-tao Cui xue-you Wang xu-bin Zhang Qiang-qiang Wang Sheng-ping He College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effect of TiO_(2) absorption into two different CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags from the steel plant on the viscosity,melting performance and microstructure of slags was investigated through the measurement of the viscosity-temperature relationship,melting temperature and Raman *** parameter of the number of non-bridging oxygen per tetrahedrally-coordinated atom(NBO/T)was also calculated to explain the microstructure variation of molten slags with different TiO_(2) *** variation of the actual slag consumption and the depth of the liquid slag in mold was explained through the comparison of the viscosity and the melting temperature of two different *** viscosity of mold slags(basicity=0.6)decreased from 1.1 to 0.68 Pa s with the increase in the Ti0_(2) absorption from 0 to 10%,while that of slags(basicity=0.7)decreased from 0.76 to 0.56 Pa s with the Ti0_(2) absorption from 0 to 6%.The activation energy of both two groups of slags had the tendency to decrease with the increasing TiO_(2) *** network structure of both two groups of slags measured by the Raman spectra showed that the fraction of complex structure units(Q^(1),Q^(2),Q^(3) and A1-O-Al)decreased and simple structure units(Al-O-and Q^(0))increased with the increase in TiO_(2) ***/T also increased with the increase in the TiO2 absorption,indicating that the absorption of TiO_(2) into slags resulted in the destruction of silicate/aluminate ***,the absorption of TiO_(2) into the current CaO-BaO-SiO_(2)-Al_(2)O_(3) mold slags decreased the degree of polymerization of these slags and then led to the decrease of viscosity.

关键词： Mold slag Viscosity Melting temperature Slag consumption Liquid slag depth Structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glymphatic function and its influencing factors in different glucose metabolism states

引用

World Journal of Diabetes 2024年第7期15卷 1537-1550页

作者： bin Tian Chen Zhao Jia-Li Liang hui-Ting Zhang Yi-Fan xu hui-Lei Zheng Jia Zhou Jiang-Nian Gong Shu-Ting Lu Zi-San Zeng Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Magnetic Resonance Research Collaboration Siemens HealthineersGuangzhou 510620Guangdong ProvinceChina Magnetic Resonance Research Collaboration Siemens Healthineers Ltd.Wuhan 430071Hubei ProvinceChina Department of Health Management The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well *** To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states,the present study employed diffusion tensor imaging along the perivascular space(DTI-ALPS)*** Sample size was calculated using the pwr package in R *** crosssectional study enrolled 22 patients with normal glucose metabolism(NGM),20 patients with prediabetes,and 22 patients with type 2 diabetes mellitus(T2DM).A 3.0T magnetic resonance imaging was used to evaluate the function of the glymphatic *** mini-mental state examination(MMSE)was used to assess general cognitive *** DTI-ALPS index of bilateral basal ganglia and the mean DTI-ALPS index was ***,the correlation between DTI-ALPS and clinical features was *** The left-side,right-side,and mean DTI-ALPS index in the T2DM group were significantly lower than that in the NGM *** right-side DTI-ALPS and mean DTI-ALPS index in the T2DM group were significantly lower than those in the prediabetes ***-ALPS index lateralization was not *** MMSE score in the T2DM group was significantly lower than that in the NGM and prediabetes *** controlling for sex,the left-side DTI-ALPS and mean DTI-ALPS index in the prediabetes group were positively correlated with 2-hour postprandial blood glucose level;the left-side DTI-ALPS index was negatively correlated with total cholesterol and low-density lipoprotein *** right-side DTI-ALPS and mean DTI-ALPS index were negatively correlated with the glycosylated hemoglobin level and waist-to-hip ratio in the prediabetes *** left-side,right-side,and mean DTI-ALPS index in the T2DM group were positively correlated with *** left-side and mean DTIALPS index in the T2DM group were negatively

关键词： Glymphatic system Prediabetes Type 2 diabetes mellitus Magnetic resonance imaging Diffusion tensor imaging along the perivascular space

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Constructing a 3D multichannel structure to enhance performance of Ni–Co–Mn hydroxide electrodes for flexible supercapacitors

引用

Rare Metals 2024年第1期43卷 148-163页

作者： Zhi-hui xu Shi-Shuai Sun xue-Lei Li Zhi-hui Zhang Hai-Ying Li Shuang-Ting Ruan Shou-Gen Yin Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)and Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China College of Science Tianjin University of TechnologyTianjin 300384China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

The balancing of the electrochemical performance,mechanical stability,and processing technology for applying supercapacitors to flexible and wearable electronics continues to encounter severe ***,we prepare Ni-Co-Mn hydroxide electrodes with a threedimensional multichannel structure via a simple hydrothermal *** are constructed using vertically contiguous nano sheets with a uniform thickness and rough *** electrodes can provide numerous electroactive sites and accelerate the transmission of electrolyte *** relationship between the structure and electrochemical performances is verified by experiments and theoretical ***-dimensional(2D)planar and one-dimensional(1D)fiber electrodes are prepared using a flexible carbon cloth(CC)and carbon fiber(CF),respectively,as *** assembled quasi-solid-state flexible asymmetric supercapacitor(FASC)with a twodimensional sandwich structure using NiCoMn-OH/CC as the electrode achieves a remarkable energy density of73.8 Wh·kg^(-1)at a power density of 1.03 kW·kg^(-1).The quasi-solid-state FASC with a 1D linear structure using NiCoMn-OH/CF as the electrode also attains a high energy density(12.9 Wh·kg^(-1)at a power density of0.75 W·kg^(-1)).Moreover,the electrochemical performances of the NiCoMn/CC//AC/CC and NiCoMn/CF//AC/CF FASCs are not disturbed at different bending angles(0°,45°,90°,135°and 180°),This indicates the superior flexibility of the *** also assemble a self-powered energy-harvesting storage system by integrating FASCs and commercial solar cells to verify its *** displays sustainable development potential for energy storage.

关键词： Supercapacitors Flexible Ni–Co–Mn hydroxide 3D multichannel structure High performances

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Janus Quasi‑Solid Electrolyte Membranes with Asymmetric Porous Structure for High‑Performance Lithium‑Metal Batteries

引用

Nano-Micro Letters 2024年第6期16卷 221-232页

作者： Zerui Chen Wei Zhao Qian Liu Yifei xu Qinghe Wang Jinmin Lin Hao bin Wu Institute for Composites Science Innovation(InCSI)and State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Quasi-solid electrolytes(QSEs)based on nanoporous materials are promising candidates to construct high-performance Limetal batteries(LMBs).However,simultaneously boosting the ionic conductivity(σ)and lithium-ion transference number(t^(+)) of liquid electrolyte confined in porous matrix remains ***,we report a novel Janus MOFLi/MSLi QSEs with asymmetric porous structure to inherit the benefits of both mesoporous and microporous *** Janus QSE composed of mesoporous silica and microporous MOF exhibits a neat Li^(+) conductivity of 1.5.10^(–4)S cm^(−1) with t^(+) of 0.71.A partially de-solvated structure and preference distribution of Li^(+)near the Lewis base O atoms were depicted by MD ***,the nanoporous structure enabled efficient ion flux regulation,promoting the homogenous deposition of Li^(+).When incorporated in Li||Cu cells,the MOFLi/MSLi QSEs demonstrated a high Coulombic efficiency of 98.1%,surpassing that of liquid electrolytes(96.3%).Additionally,NCM 622||Li batteries equipped with MOFLi/MSLi QSEs exhibited promising rate performance and could operate stably for over 200 cycles at 1 *** results highlight the potential of Janus MOFLi/MSLi QSEs as promising candidates for next-generation LMBs.

关键词： Metal-organic frameworks Mesoporous silicas Quasi-solid electrolytes Janus structure Lithium-metal battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review on the Fabrication of Surface Functional Structures for Enhancing Bioactivity of Titanium and Titanium Alloy Implants

引用

Chinese Journal of Mechanical Engineering 2024年第4期37卷 23-49页

作者： Heng Tang Jiaxiang xu bin Guo Yansong Xie Yalong Sun Yanjun Lu Yong Tang Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518000China School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450001China

Titanium and its alloys have been widely applied in many biomedical fields because of its excellent mechanical properties,corrosion resistance and good ***,problems such as rejection,shedding and infection will occur after titanium alloy implantation due to the low biological activity of titanium alloy *** structures with specific functions,which can enhance osseointegration and antibacterial properties,are fabricated on the surface of titanium implants to improve the biological activity between the titanium implants and human *** paper presents a comprehensive review of recent developments and applications of surface functional structure in titanium and titanium alloy *** applications of surface functional structure on different titanium and titanium alloy implants are introduced,and their manufacturing technologies are summarized and ***,the fabrication of various surface functional structures used for titanium and titanium alloy implants is reviewed and analyzed in ***,the challenges affecting the development of surface functional structures applied in titanium and titanium alloy implants are outlined,and recommendations for future research are presented.

关键词： Surface functional structure Titanium implant Manufacturing technology Bioactivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multicolor circularly polarized phosphorescence of axially chiral binuclear platinum(Ⅱ) complexes

引用

Science China Chemistry 2024年第11期67卷 3757-3766页

作者： Jintong Song Rui Zeng hui Xiao Hailiang Ni Zong-Xiang xu Haifeng Xiang College of Chemistry and Materials Science Sichuan Normal University Department of Chemistry Southern University of Science and Technology College of Chemistry Sichuan University

D-A charge transfer, including through-bond charge transfer and through-space charge transfer between two different electron donors（D） and electron acceptors（A）, is a fundamental and powerful tool to tune the optical properties of organic dyes. Herein,we demonstrate a unique strategy to tune phosphorescence and circularly polarized luminescence properties of axially chiral binuclear Pt（Ⅱ） complexes through long-range charge transfer, even though these molecules have two totally identical segments on either side of the chiral core. The presence of axial chirality would break not only the symmetry of molecular structure and π-conjugation system but also the symmetry of charge distribution for long-range charge transfer. These binaphthyl-based Pt（Ⅱ）complexes bearing coordinated atoms far away from chiral axis exhibit no Pt-Pt interactions but colorful concentrationdependent phosphorescence with quantum yield up to 86.4% and could be applied as emitters in highly efficient solutionprocessed organic light-emitting diodes to achieve luminance, luminance efficiency, power efficiency, external quantum efficiency, and asymmetry factor up to 8.94 × 10～3cd m-2, 41.9 cd A-1, 18.8 lm W-1, 12.6% and 2.98 × 10-3, respectively. Therefore,the present work affords a new and simple way to utilize the inherently asymmetric advantage of chirality for the design of D-Abased organic dyes.

关键词： Pt(II) complexes organic light-emitting diodes circularly polarized phosphorescence axial chirality

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms

引用

Neuroscience Bulletin 2024年第3期40卷 383-400页

作者： Zhixing xu hui Wang Siya Jiang Jiao Teng Dongxu Zhou Zhong Chen Chengping Wen Zhenghao xu First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Afliated Lin’an People’s Hospital of Hangzhou Medical College First People’s Hospital of Hangzhou Lin’an DistrictLin’anHangzhou 311300China School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Laboratory of Rheumatology and Institute of TCM Clinical Basic Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China

Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in *** though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is *** than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging *** this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza *** also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 *** addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment *** review may offer new insights into preventing or treating brain damage in COVID-19.

关键词： COVID-19 SARS-CoV-2 Brain Neurological pathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于总体最小二乘的泰勒级数展开的TOA的UWB定位方法

引用

科学技术与工程 2013年第21期21卷 6129-6133页

作者：任斌徐会彬东莞理工学院电子工程学院东莞523808 同济大学电子与信息工程系上海201815

泰勒级数展开算法在求解非线性定位方程组中有着高精度、强顽健性的特点。针对其在TOA定位的初始值确定问题,提出一种基于总体最小二乘的泰勒级数展开的TOA的UWB定位算法。考虑TOA的测量误差,利用总体最小二乘评估目标点的初始位置,将... 详细信息

泰勒级数展开算法在求解非线性定位方程组中有着高精度、强顽健性的特点。针对其在TOA定位的初始值确定问题,提出一种基于总体最小二乘的泰勒级数展开的TOA的UWB定位算法。考虑TOA的测量误差,利用总体最小二乘评估目标点的初始位置,将此值作为泰勒级数展开点。最后,使用加权最小二乘迭代计算搜索最优值,从而实现目标点的精准定位。仿真结果表明,所提出算法在定位精度近似于真实值的泰勒级数展开算法的性能。

关键词： UWB TOA 泰勒级数展开最小二乘总体最小二乘

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：