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Chinese Chemical Letters 2012年第7期23卷 765-768页

作者： He nan xu Zhe Jin Si Jie Liu Hong Min Liu Shuo Li Huang Quan Lin David Chicheong Wan Chun Hu New Drug Research & Development Center Zhengzhou University Zhengzhou 450052 China Key Laboratory of Structure-Based Drug Design Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China Department of Biochemistry The Chinese University of Hong Kong Hong Kong SAR China

Bromination is used as a strategy to improve biological activity in medicinal *** order to study on the structure-activity relationships of the novel acetylcholinesterase inhibitors with 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one scaffold,based on our previous work and molecular modeling,a series of novel 3-aryl-6-（bromoarylrnethyl）-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were designed by molecular docking,synthesized and characterized by mass spectra,infrared spectra,proton NMR and elemental *** study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive *** of all target compounds exhibited more than 45%inhibition at 10μmol/*** preliminary structureactivity relationship was the bromine atoms and the hydroxyl group at the phenyl ring at the C6 position of the parent nucleus played significant roles in the AChE inhibitory activity of the target compounds.

关键词： Acetylcholinesterase inhibitor Bromination Heterocycle Synthesis 7H-Thiazolo[3,2-b]-l, 2, 4-triazin-7-one derivatives

澳大利亚“黛比”热带气旋登陆前后附近海岸线变化的卫星观测

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科学通报 2017年第26期62卷 3040-3043页

作者：徐南宫鹏清华大学地球系统科学系地球系统数值模拟教育部重点实验室北京100084 全球变化研究协同创新中心北京100875

2017年3月28日,热带气旋"黛比"从澳大利亚昆士兰州登陆,给当地民众的生命安全和公共财产带来了巨大威胁.热带气旋在短时间内改变了局部海岸地形,并使海岸线位置迅速发生变化.针对海波因特附近的海岸进行研究,收集了热带气旋登陆前后的... 详细信息

2017年3月28日,热带气旋"黛比"从澳大利亚昆士兰州登陆,给当地民众的生命安全和公共财产带来了巨大威胁.热带气旋在短时间内改变了局部海岸地形,并使海岸线位置迅速发生变化.针对海波因特附近的海岸进行研究,收集了热带气旋登陆前后的两景陆地卫星图像,结合水体指数和人工检查进行海陆分类制图,并得到海岸线变化空间分布图.计算表明,"黛比"登陆前后,海波因特附近海岸区域陆地面积净增加54.50 km^2,98.2%的海岸线表现为淤积,仅1.8%的海岸线表现为侵蚀.准确及时的海岸线变化信息可以帮助港口恢复运营,还可以用于发展风暴潮-波浪-泥沙数值模式.

关键词：热带气旋黛比卫星观测海岸线变化 Landsat-8 OLI

Echocardiography in the diagnosis of Shone’s complex and analysis of the causes for missed diagnosis and misdiagnosis

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World Journal of Clinical Cases 2022年第11期10卷 3369-3378页

作者： Ye-Dan Li Hong Meng Kun-Jing Pang Mu-Zi Li nan xu Hao Wang Shou-Jun Li Jun Yan Department of Echocardiography Fuwai HospitalBeijing 100037China Department of Cardiovascular Surgery Fuwai HospitalBeijing 100037China

BACKGROUND Shone’s complex is a rare syndrome characterized by congenital left heart defects that can differ among the *** To use echocardiography in the diagnosis of Shone’s complex and analyze the causes of missed diagnosis and *** This was a retrospective study of patients who underwent echocardiography and repair surgery from February 14,2008,to November 22,*** patients were followed once a year at the outpatient clinic after *** Sixty-six patients were *** patients were 2.7(0.8-5.6)years of age,and 54.5%were ***(15.2%)had a history of heart *** most common heart defect was the Annulo-Leaflet mitral ring(ALMR)(50/66,75.8%),followed by coarctation of the aorta(CoA)(43/66,65.2%).The patients had a variety of combinations of *** two(3.0%)patients had all four *** of the patients had a family history of congenital heart *** preoperative echocardiographic findings were examined against the intraoperative *** missed an ALMR in 31 patients(47.0%),a parachute mitral valve(PMV)in one patient(1.5%),subaortic stenosis in one patient(1.5%),and CoA in two patients(3.0%).CONCLUSION Echocardiography is an effective method to diagnose the Shone’s *** to this disease’s complexity and interindividual variability, Improving the understanding of thedisease can reduce misdiagnosis and missed diagnosis.

关键词： Shone’s syndrome Congenital heart disease Mitral valve Echocardiography Left heart Misdiagnosis

Role of intelligent/interactive qualitative and quantitative analysisthree-dimensional estimated model in donor-recipient size mismatch following deceased donor liver transplantation

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World Journal of Gastroenterology 2023年第44期29卷 5894-5906页

作者： Han Ding Zhi-Guo Ding Wen-Jing Xiao xu-nan Mao Qi Wang Yi-Chi Zhang Hao Cai Wei Gong Department of Transplantation Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China Department of General Surgery The Third People’s Hospital of YangzhouYangzhou 225126Jiangsu ProvinceChina Department of Tuberculosis Control Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Department of Biliary-Pancreatic Surgery Shanghai Changzheng HospitalSecond Military Medical UniversityShanghai 200003China Department of Pathology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029JiangsuChina Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai200092China

BACKGROUND Donor-recipient size mismatch(DRSM)is considered a crucial factor for poor outcomes in liver transplantation(LT)because of complications,such as massive intraoperative blood loss(IBL)and early allograft dysfunction(EAD).Liver volumetry is performed routinely in living donor LT,but rarely in deceased donor LT(DDLT),which amplifies the adverse effects of DRSM in *** to the various shortcomings of traditional manual liver volumetry and formula methods,a feasible model based on intelligent/interactive qualitative and quantitative analysis-three-dimensional(IQQA-3D)for estimating the degree of DRSM is *** To identify benefits of IQQA-3D liver volumetry in DDLT and establish an estimation model to guide perioperative *** We retrospectively determined the accuracy of IQQA-3D liver volumetry for standard total liver volume(TLV)(sTLV)and established an estimation TLV(eTLV)index(eTLVi)*** operating characteristic(ROC)curves were drawn to detect the optimal cut-off values for predicting massive IBL and EAD in DDLT using donor sTLV to recipient sTLV(called sTLVi).The factors influencing the occurrence of massive IBL and EAD were explored through logistic regression ***,the eTLVi model was compared with the sTLVi model through the ROC curve for *** A total of 133 patients were included in the *** Changzheng formula was accurate for calculating donor sTLV(P=0.083)but not for recipient sTLV(P=0.036).Recipient eTLV calculated using IQQA-3D highly matched with recipient sTLV(P=0.221).Alcoholic liver disease,gastrointestinal bleeding,and sTLVi>1.24 were independent risk factors for massive IBL,and drug-induced liver failure was an independent protective factor for massive *** donor-female recipient combination,model for end-stage liver disease score,sTLVi≤0.85,and sTLVi≥1.32 were independent risk factors for EAD,and viral hepatitis was an independent protective factor for *** overall surv

关键词： Intelligent/interactive qualitative and quantitative analysis-three-dimensional Donor-recipient size mismatch Intraoperative blood loss Early allograft dysfunction

Neuroprotective effect of Cerebralcare Granule after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2016年第4期11卷 623-629页

作者： Xiao-xiao Zhang Fen-fen He Gui-lin Yan Ha-ni Li Dan Li Yan-ling Ma Fang Wang nan xu Fei Cao Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Neurology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and Technology

Cerebralcare Granule（CG） improves cerebral microcirculation and relieves vasospasm,but studies investigating its therapeutic effect on cerebral ischemia/reperfusion injury are *** the present study,we administered CG（0.3,0.1 and 0.03 g/m L intragastrically） to rats for 7 consecutive *** then performed transient occlusion of the middle cerebral artery,followed by reperfusion,and administered CG daily for a further 3 or 7 *** with no treatment,high-dose CG markedly improved neurological function assessed using the Bederson and Garcia *** 3 days,animals in the high-dose CG group had smaller infarct volumes,greater interleukin-10 expression,and fewer interleukin-1β-immunoreactive cells than those in the untreated model ***,at 7 days,high-dose CG-treated rats had more vascular endothelial growth factor-immunoreactive cells,elevated angiopoietin-1 and vascular endothelial growth factor expression,and improved blood coagulation and flow indices compared with untreated model *** results suggest that CG exerts specific neuroprotective effects against cerebral ischemia/reperfusion injury.

关键词： nerve regeneration Cerebralcare Granule cerebral ischemia/reperfusion angiogenesis inflammatory response blood coagulation hemorheology neural regeneration

Identification of risk factors for poor language outcome in surgical resection of glioma involving the arcuate fasciculus:an observational study

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Neural Regeneration Research 2021年第2期16卷 333-337页

作者： Fang-Ye Li Hong-Yu Liu Jun Zhang Zheng-Hui Sun Jia-Shu Zhang Guo-Chen Sun Xin-Guang Yu Xiao-Lei Chen Bai-nan xu Department of Neurosurgery First Medical Center of Chinese PLA General HospitalBeijingChina Department of Neurosurgery Hainan Hospital of Chinese

The arcuate fasciculus is a critical component of the neural substrate of human language *** resection of glioma adjacent to the arcuate fasciculus likely damages this *** this study,we evaluated the outcome of surgical resection of glioma adjacent to the arcuate fasciculus under the guidance of magnetic resonance imaging and diffusion tensor imaging,and we aimed to identify the risk factors for postoperative linguistic *** total,54 patients with primary glioma adjacent to the arcuate fasciculus were included in this observational *** patients comprised 38 men and 16 women(aged 43±11 years).All patients underwent surgical resenction of glioma under the guidance of magnetic resonance imaging and diffusion tensor *** images were updated when necessary for further *** gross total resection rate of the 54 patients increased from 38.9%to 70.4%by intraoperative magnetic resonance *** language function and glioma-to-arcuate fasciculus distance were associated with poor language *** logistic regression analyses showed that glioma-to-arcuate fasciculus distance was the major independent risk factor for poor *** cutoff point of glioma-to-arcuate fasciculus distance for poor outcome was 3.2 *** findings suggest that intraoperative magnetic resonance imaging combined with diffusion tensor imaging of the arcuate fasciculus can help optimize tumor resection and result in the least damage to the arcuate ***,glioma-to-arcuate fasciculus distance is a key independent risk factor for poor postoperative language *** study was approved by the Ethics Committee of the Chinese PLA General Hospital,China(approval No.S2014-096-01)on October 11,2014.

关键词： arcuate fasciculus central nervous system brain diffusion tensor imaging intraoperative magnetic resonance imaging language function risk factor trial

Physiological and biochemical characteristics of boscalid resistant isolates of Sclerotinia sclerotiorum from asparagus lettuce

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Journal of Integrative Agriculture 2023年第12期22卷 3694-3708页

作者： SHI Dong-ya LI Feng-jie ZHANG Zhi-hui xu Qiao-nan CAO Ying-ying Jane Ifunanya MBADIANYA LI Xin WANG Jin CHEN Chang-jun Department of Pesticide Science College of Plant ProtectionNanjing Agricultural UniversityNanjing 210095P.R.China Jiangsu Pesticide Research Institute Co. Ltd.Nanjing 210046P.R.China

Laboratory mutants of Sclerotinia sclerotiorum(Lib)de Bary,resistant to boscalid,have been extensively ***,the resistance situation in the lettuce field remains largely *** this study,among the 172 *** isolates collected from asparagus lettuce field in Jiangsu Province,China,132 isolates(76.74%)exhibited low-level resistance to boscalid(Bos^(LR)),with a discriminatory dose of 5μg *** comparison to the boscalid-sensitive(BosS)isolates,most Bos^(LR)isolates demonstrated a slightly superior biological fitness,as evidenced by data on mycelial growth,sclerotium production and ***,most Bos^(LR)isolates showed comparable levels of oxalic acid(OA)accumulation,increased exopolysaccharide(EPS)content and reduced membrane permeability when compared to the BosS ***,their responses to distinct stress factors diverged ***,the effectiveness of boscalid in controlling Bos^(LR)isolates on radish was diminished compared to its efficacy on BosS *** mutations were identified in the SDH genes of Bos^(LR)isolates,revealing the existence of three resistant genotypes:I(^(A11V)at SDHB,SDHB^(A11V)),II(^(Q38R)at SDHC,SDHC^(Q38R))and III(SDHB^(A11V)+SDHC^(Q38R)).Importantly,no cross-resistance was observed between boscalid and other fungicides such as thifluzamide,pydiflumetofen,fluazinam,or *** molecular docking analysis indicated that the docking total score(DTS)of the type I resistant isolates(1.3993)was lower than that of the sensitive isolates(1.7499),implying a reduced affinity between SDHB and boscalid as a potential mechanism underlying the boscalid resistance in *** findings contribute to an enhanced comprehension of boscalid’s mode of action and furnish valuable insights into the management of boscalid resistance.

关键词： Sclerotinia sclerotiorum boscalid asparagus lettuce SDHB^(A11V) SDHC^(Q38R)

Clostridium difficile infection following colon subtotal resection in a patient with gallstones: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3048-3056页

作者： Feng Ke Zhen-Hua Dong Fan Bu Cheng-nan Li Qi-Tong He Zhi-Cheng Liu Ji Lu Kai Yu Da-Guang Wang He-nan xu Chang-Tao Ye Department of General Surgery Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Encephalopathy Rehabilitation Chaoyi HospitalYanbian Korean Autonomous PrefectureYanji 133000Jilin ProvinceChina Department of Urology The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

BACKGROUND Clostridium difficile(***)infection(CDI)is a rare clinical disease caused by changes in the intestinal microenvironment,which has a variety of causes and a poor prognosis,and for which there is no standardized clinical *** SUMMARY A patient experienced recurrent difficulty in bowel movements over the past ***,symptoms worsened within the last ten days,leading to a clinic visit due to *** patient was subsequently referred to our ***,the patient was diagnosed with obstructed colon accom-panied by *** antibiotics were administered both before and after surgery to prevent *** the fourth day post-surgery,symptoms of CDI *** cultures confirmed the presence of *** *** involved a combination of vancomycin and linezolid,resulting in the patient's successful recovery upon ***,the patient failed to adhere to the prescribed medication after discharge and was discovered deceased during a follow-up two months *** CDI is the leading cause of nosocomial post-operative care,with limited clinical cases and poor patient prognosis,and comprehensive clinical treatment guidelines are still *** infection can be triggered by a variety of factors,including intestinal hypoxia,inappropriate antibiotic use,and bile acid circulation *** patients with chronic bowel disease and related etiologies,prompt preoperative attention to possible CDI and preoperative bowel preparation is *** and prolonged medication should be maintained in the treatment of CDI to prevent recurrence of the disease.

关键词： Cholecystolithiasis Clostridium difficile Bile acid circulation Intestinal microenvironment Case report

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基于曝气生物滤池工艺处理老龄垃圾渗滤液

应用基础与工程科学学报 2012年第1期20卷 1-10页

作者：崔锋许楠北京大学深圳研究生院环境与能源学院城市人居环境科学与技术重点实验室广东深圳518055 北京大学环境工程系教育部水沙科学重点实验室北京100871

分别在小试和工业化规模上系统研究了基于曝气生物滤池(BAF)的工艺对老龄垃圾渗滤液的处理效果.在实验室中,对比传统生化处理工艺,BAF单元对COD的去除率提高了20%.将基于BAF的组合工艺(厌氧+BAF+膜生物反应器MBR+反渗透RO)应用于深圳某... 详细信息

分别在小试和工业化规模上系统研究了基于曝气生物滤池(BAF)的工艺对老龄垃圾渗滤液的处理效果.在实验室中,对比传统生化处理工艺,BAF单元对COD的去除率提高了20%.将基于BAF的组合工艺(厌氧+BAF+膜生物反应器MBR+反渗透RO)应用于深圳某填埋场渗滤液处理,取得了较好的处理效果.BAF单元对COD、氨氮的去除率分别达到31%和94.2%.生物处理单元(包括BAF和MBR)对铜、锌的去除率达到70%以上,而对镍、铬、铅的去除率小于50%.RO膜对重金属的去除率均高于生物处理单元.该组合工艺既保证了生物降解的持续进行,又保证了RO膜的稳定运行.利用GC-MS对生物处理单元有机污染物成分进行了分析,并对其降解机理进行了初步探讨.

关键词：老龄渗滤液 BAF 有机污染物 GC-MS 重金属

南阿尔金地区早古生代中酸性侵入岩的岩石成因及其对构造演化的指示意义

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地质学报 2023年第12期97卷 4067-4084页

作者：徐楠吴才来刘畅安徽理工大学深部煤矿采动响应与灾害防控国家重点实验室安徽淮南232001 中国地质科学院地质研究所北京100037 核工业北京地质研究院中核集团铀资源勘查与评价技术重点实验室北京100029

南阿尔金造山带位于塔里木盆地和柴达木盆地之间,是中国西北地区重要的俯冲-碰撞杂岩带,其早古生代构造演化过程是近年来的研究热点之一,然而,洋壳俯冲的时限一直存在争议。本文对茫崖石英二长岩开展岩石学、地球化学、锆石U-Pb年代学... 详细信息

南阿尔金造山带位于塔里木盆地和柴达木盆地之间,是中国西北地区重要的俯冲-碰撞杂岩带,其早古生代构造演化过程是近年来的研究热点之一,然而,洋壳俯冲的时限一直存在争议。本文对茫崖石英二长岩开展岩石学、地球化学、锆石U-Pb年代学和锆石Lu-Hf同位素地球化学研究,探讨其岩石成因及成岩时的构造环境。样品显示高碱、富钾、低钛、贫铁及Nd-Ta-Ti异常等与钾玄岩相似的地球化学特征,成岩年龄为511~495 Ma,ε_(Hf)(t)主要为-3.51~-0.08,少量介于0.04~1.69之间。我们认为俯冲洋壳到达角闪岩相边界时释放大量水并上升进入地幔楔,导致地幔楔橄榄岩发生角闪石化交代作用,由于地幔楔沿俯冲带向下拖曳而温度升高,角闪石化橄榄岩熔融形成的熔体在上升过程诱发上地壳物质部分熔融,壳源岩浆混合少量幔源岩浆形成了石英二长岩,该期花岗岩是对造山带从大洋岛弧环境向活动大陆边缘过渡的岩石学响应。因此,南阿尔金洋壳可能在约517 Ma前已经开始俯冲。

关键词：南阿尔金造山带钾玄岩构造环境俯冲