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Progression and Regression of Abdominal Aortic Aneurysms in Mice

Current Medical Science 2021年第5期41卷 901-908页

作者： Yu-chao DING Xian-jing zhang Ji-xiu zhang Zi-yi ZHAI mei-xia zhang Bao-hong JIANG Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China The College of Basic Medical Science China Medical UniversityShenyang 110122China

Objective:Abdominal aortic aneurysm(AAA)is a significant medical problem with a high mortality ***,the underlying mechanism for the progression and regression of AAA is ***:Experimental model of AAA was first created by porcine pancreatic elastase incubation around the infrarenal aorta of C57BL/6 ***,AAA progression and regression were evaluated based on the diameter and volume of *** aortas were harvested for hematoxylin-eosin staining(HE),orcein staining,sirius red staining,immunofluorescence analysis and peris’prussian blue staining at the indicated time ***,P-aminopropionitrile monofumarate(BAPN)was used to explore the underlying mechanism of the regression of ***:When we extended the observation period to 100 days,we not only observed an increase in the AAA diameter and volume in the early stage,but also a decrease in the late *** with AAA diameter and volume,the aortic thickness showed the same tendency based on HE *** elastin and collagen content first degraded and then regenerated,which corresponds to the early deterioration and late regression of ***,endogenous up-regulation of lysyl oxidase(LOX)was detected,accompanying the regression of AAA,as detected by an immunofluorescent *** and LOX inhibitor considerably inhibited the regression of AAA,paralleling the degradation of elastin lamella and ***:Taken together,we tentatively conclude that endogenous re-generation of LOX played an influential role in the regression of ***,regulatory factors on the generation of LOX exhibit promising therapeutic potential against AAA.

关键词： abdominal aortic aneurysm disease progression disease regression elastogenesis lysyl oxidase

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Ferulic acid alleviates lipopolysaccharide-induced depression-like behavior by inhibiting inflammation and apoptosis

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Asian Pacific Journal of Tropical Biomedicine 2020年第12期10卷 523-531页

作者： xiu-mei Bo Ruo-Bing Yu Sai-Jun Du Rong-Li zhang Ling He Medical Biological Experiment Credit Center Basic Medical CollegeXuzhou Medical UniversityXuzhou 221004China The First Clinical Medical College Xuzhou Medical UniversityXuzhou 221004China College of Life Sciences Xuzhou Medical UniversityXuzhou 221004China Department of Chemistry Xuzhou Medical UniversityXuzhou 221004China

Objective:To identify the anti-depressive effect of ferulic acid(FA)in mice exposed to lipopolysaccharide(LPS)and explore its molecular ***:The mice were divided into 5 groups as follows:Control,LPS,LPS+SP,LPS+FA,and LPS+FA+*** LPS+FA and LPS+FA+anisomycin groups were administered with FA(100 mg/kg,i.p.)once daily continuously for 7 days,and the other groups received an equivalent volume of *** the 7 th day,LPS(0.1 mg/m L,i.p.)was injected in all mice except the control group 30 min after FA or saline *** LPS+SP and LPS+FA+anisomycin groups were intravenously administered with SP600125[c-Jun N-terminal kinase(JNK)inhibitor](100μL/site,i.v.)and anisomycin(JNK activator)(100μL/site,i.v.)15 min before LPS,*** depressive behaviors were assessed by open field test,sucrose preference test,and forced swimming test at 24 h post-LPS *** necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)levels in plasma were measured by *** levels of phospho-JNK,TNF-α,IL-1β,Bcl-2,Bax,cytochrome c and caspase-3 were evaluated by Western ***:FA alleviated depression symptoms caused by LPS in mice,including increasing sucrose water consumption in sucrose preference test and reducing the immobility time in forced swimming *** could inhibit upregulated levels of phospho-JNK,TNF-α,and IL-1β.FA also markedly decreased Bax,caspase-3,and cytochrome c,and increased Bcl-2 ***,SP600125 showed neuroprotective effect similar to FA which was attenuated by ***:FA attenuates inflammation and apoptosis by inhibiting LPS-induced activation of JNK to alleviate depressionlike behaviors.

关键词： Ferulic acid Lipopolysaccharide Depression JNK Inflammation Apoptosis

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Application of multidisciplinary collaborative nursing with family care for enhanced recovery after surgery in children with inguinal hernia

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 1932-1940页

作者： xiu-mei Wang Qiang Hou Department of Pediatric Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina Department of Burns The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina

BACKGROUND Perioperative nursing can reduce the stress reaction and improve the prognosis of *** To elucidate the influence of multidisciplinary collaborative nursing for enhanced recovery after surgery(ERAS)with family care in perioperative nursing children with an inguinal hernia and its impact on the *** The data of 100 children with inguinal hernia were retrospectively *** participants were divided into three groups according to different nursing methods:Groups A(n=38),B(n=32),and C(n=30).Group A received multidisciplinary collaborative ERAS nursing combined with family care nursing;Group B received multidisciplinary collaborative nursing for ERAS;and Group C received routine *** postoperative recovery results of the three groups were compared,including intraoperative blood loss and postoperative feeding time,time of getting out of bed,hospitalization time,and defecation ***,the incidence of common complications was also compared between the three *** There was less intraoperative blood loss in Groups A and B than in Group C(P0.05).Each index had no statistical significance between Groups A and B(P>0.05).The incidence of urinary retention,infection,hematoma,and hernia recurrence in Group A was less than that in Group C(P0.05).CONCLUSION The application of multidisciplinary collaborative nursing combined with family care in the perioperative care of children with an inguinal hernia for ERAS may promote postoperative rehabilitation for children and reduce the incidence of complications.

关键词： Multidisciplinary collaborative Enhanced recovery after surgery Family care Perioperative nursing Prognosis Postoperative complications

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Comparative evaluation of a biomimic collagen/ hydroxyapatite/β-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen

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Frontiers of Materials Science 2016年第2期10卷 122-133页

作者： Tong WANG Qing LI Gui-feng zhang Gang ZHOU Xin YU Jing zhang xiu-mei WANG Zhi-hui TANG The 2nd Dental Center Peking University School and Hospital of Stomatology Beijing 100101 China Center of Digital Dentistry Peking University School and Hospital of Stomatology Beijing 100081 China National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100081 China Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China Institute of Regenerative Biomaterials Tsinghua University Beijing 100084 China

Bone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-I collagen and hydroxyapatite （HA）/β-tricaleium phosphate （TCP） scaffold （CHTS） by incorporating type-I collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.

关键词： hydroxyapatite β-tricaleium phosphate (TCP) collagen scaffold ridgepreservation

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Constructing Order Two Superconvergent WG Finite Elements on Rectangular Meshes

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Numerical Mathematics(Theory,Methods and Applications) 2023年第1期16卷 230-241页

作者： xiu Ye Shangyou zhang Department of Mathematics University of Arkansas at Little RockLittle RockAR 72204USA Department of Mathematical Sciences University of DelawareNewarkDE 19716USA

In this paper,we introduce a stabilizer free weak Galerkin(SFWG)finite element method for second order elliptic problems on rectangular *** a special weak Gradient space,an order two superconvergence for the SFWG finite element solution is obtained,in both L 2 and H1 norms.A local post-process lifts such a Pk weak Galerkin solution to an optimal order Pk+2 *** numerical results confirm the theory.

关键词： Finite element weak Galerkin method stabilizer free rectangular mesh

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Improving Impact Toughness of Polylactide/Ethylene-co-vinyl-acetate Blends via Adding Fumed Silica Nanoparticles:Effects of Specific Surface Area-dependent Interfacial Selective Distribution of Silica

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Chinese Journal of Polymer Science 2021年第8期39卷 1040-1049,I0008页

作者： Ting-Ting zhang mei-Xi Zhou Zhen-You Guo You-Bo Zhao Di Han Hao xiu Hong-Wei Bai Qin zhang Qiang Fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Adding fumed silica(Si0_(2))has been considered as an effective method for tailoring the phase morphology and performance of elastomer-toughened plastic binary *** has been demonstrated that the selective distribution of SiO_(2) plays a decisive role in the mechanical properties of plastic/elastomer/SiO_(2)nanocomposites,especially for the impact *** this work,we aim to illuminate the role of specific surface area in controlling their selective distribution of fumed SiO_(2) and consequent mechanical properties of plastic/elastomer binary *** types of SiO_(2) with different specific surface areas were incorporated into polylactide/ethylene-co-vinyl-acetate(PLA/EVA)model blends by melt blending *** was found that the selective distribution of SiO_(2) is largely determined by their specific surface areas,***_(2) nanoparticles with low specific surface area has a stronger tendency to be located at the interface between PLA matrix and EVA dispersed phase as compared to those with high specific surface *** specific surface area-dependent interfacial selective distribution of SiO_(2) is mainly attributed to the extent of increased viscosity of EVA dispersed phase in which SiO_(2)nanoparticles are initially dispersed and resultant migration rate of SiO_(2) *** interfacial localized SiO_(2) nanoparticles induce an obvious enhancement in the impact toughness with strength and modulus well *** importantly,in the case of the same interfacial distribution,toughening efficiency is increased with the specific surface area of SiO_(2).Therefore,this is an optimum specific surface area of SiO_(2) for the *** work not only provides a novel way to manipulate the selective distribution of SiO_(2) in elastomer-toughened plastic blends toward high-performance,but also gives a deep insight into the role of interfacial localized nanoparticles in the toughening mechanism.

关键词： Fumed silica Specific surface area Selective distribution Polylactide Impact toughness

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Two Weighted Estimates for the Commutators of Multilinear Maximal Singular Integral Operators with Dini-type Kernels

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Acta Mathematica Sinica,English Series 2023年第3期39卷 459-480页

作者： Chun mei zhang School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

The main purpose of this paper is to investigate the properties of the higher order commutators of maximal Calderón-Zygmund operators with Dini-type *** weighted estimates have been established for these *** results ... 详细信息

关键词： Commutators sparse domination multlinear maximal singular integral operators Dinitype kenels two weighted boundedness

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Geographic variation in the yield formation of single-season high-yielding hybrid rice in southern China

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Journal of Integrative Agriculture 2021年第2期20卷 438-449页

作者： WANG Dan-ying LI Xu-yi YE Chang XU Chun-mei CHEN Song CHU Guang zhang Yun-bo zhang xiu-fu State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006P.R.China Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066P.R.China Hubei Collaborative Innovation Center for Grain Industry Yangtze UniversityJingzhou 434025P.R.China

Environmental conditions greatly affect the growth of rice. To investigate the geographic differences in yield formation of single-season high-yielding hybrid rice in southern China, experiments were conducted in 2017 and 2018 in the upper and middle–lower reaches of the Yangtze River with 10–30 main locally planted high-yielding hybrid cultivars used as materials. Compared with rice planted in the middle–lower reaches of the Yangtze River, rice planted in the upper reaches has a longer tillering duration, higher accumulated temperature(≥10℃) during tillering period, but lower accumulated temperature and solar radiation from initial booting to maturity. Yield traits comparison between the upper and the middle–lower reaches of Yangtze River showed that the former had 48.1% more panicles per unit area while the latter had 46.4% more grains per panicle;the rice yield in the former was positively correlated with the seed setting rate and the dry matter accumulation before heading, while the latter was positively correlated with grains per panicle and dry matter accumulation from booting to maturity. Comparison of the same variety Tianyouhuazhan planted in different regions showed there was a significant positive correlation between panicle number and the duration of and accumulated temperature during the tillering period(r=0.982^(**), r=0.993^(**), respectively), and between grains per panicle and accumulated solar radiation during booting period(r=0.952~*). In the upper reaches of the Yangtze River, more than 90% of cultivars with an yield of greater than 11 t ha^(–1) had an effective panicle number of 250–340 m^(–2), and there was a significant negative correlation between seed setting rate and grains per panicle;therefore, the high-yielding rice production in these regions with a long effective tillering period(>40 d) should choose varieties with moderate grains per panicle, adopt crop managements such as good fertilizer and water measures during vegetative growth pe

关键词： single-season hybrid rice geographic variation yield climatic factor southern China

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Two new tetrahydronaphthalenes from the stem of Impatiens balsamina L.

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Chinese Chemical Letters 2010年第4期21卷 440-442页

作者： Chen, xiu mei Qian, Shi Hui Feng, Feng Jiangsu Prov Acad Tradit Chinese Med Nanjing 210028 Peoples R China China Pharmaceut Univ Dept Phytochem Nanjing 210009 Peoples R China

Two new tetrahydronaphthalenes,lα,2α-diol-4α-ethoxy-1,2,3,4-tetrahydronaphthalene(1) and 1a,2a,4β-triol-1,2,3,4- tetrahydronaphthalene(2),were isolated from the stem of Impatiens balsamina *** structures were eluc... 详细信息

关键词： Impatiens balsamina L. Balsaminaceae Tetrahydronaphthalene

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Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid

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World Journal of Gastroenterology 2004年第12期10卷 1769-1774页

作者： GangCheng FengAn mei-JuanZou JinSun xiu-HuaHao Yun-XiaHe DepartmentofBiopharmaceutics SchoolofPharmacyShenyangPharmaceuticalUniversityShenyang110016LiaoningProvinceChina SchoolofPharmacy JilinUniversityChangchun130021JilinProvinceChina

AIM: To investigate Time- and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively. METHODS: DS tablets and 5-ASA pellets were coated by ethylcellulose (EC) and methacrylic acid copolymers (Eudragit L100 and $100), respectively. The in vitro release behavior of the DS coated tablets and 5-ASA coated pellets were examined, and then in vivo absorption kinetics of DS coated tablets in dogs were further studied. RESULTS: Release profile of time-dependent DS coated tablets was not influenced by pH of the dissolution medium, but the lag time of DS release was primarily controlled by the thickness of the coating layer. The thicker the coating layer, the longer the lag time of DS release is. On the contrary, in view of the pH-dependent 5-ASA coated pellets, 5-ASA release was significantly governed by pH. Moreover, the 5-ASA release features from the coated pellets depended upon both the combination ratio of the Eudragit~ L100 and S100 pH-sensitive copolymers in the coating formulation and the thickness of the coating layer. The absorption kinetic studies of the DS coated tablets in dogs demonstrated that in vivo lag time of absorption was in a good agreement with in vitro lag time of release. CONCLUSION: Two types of CDDS, prepared herein by means of the regular coating technique, are able to achieve site-specific drug delivery targeting at colon following oral administration, and provide a promising strategy to control drug release targeting the desired lower gastrointestinal region.

关键词：特效药麻醉药环氟拉嗪二氯苯二磺酰胺钠 5-对氨基水杨酸动力学

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