Comparative evaluation of a biomimic collagen/ hydroxyapatite/β-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen

作     者：Tong WANG Qing LI Gui-feng ZHANG Gang ZHOU Xin YU Jing ZHANG Xiu-mei WANG Zhi-hui TANG 

作者机构：The 2nd Dental Center Peking University School and Hospital of Stomatology Beijing 100101 China Center of Digital Dentistry Peking University School and Hospital of Stomatology Beijing 100081 China National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100081 China Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China Institute of Regenerative Biomaterials Tsinghua University Beijing 100084 China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2016年第10卷第2期

页      面：122-133页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 082204[工学-皮革化学与工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0822[工学-轻工技术与工程] 0702[理学-物理学] 

基　　金：supported by funds from the National Natural Science Foundation of China (NSFC) the Science Foundation of Beijing Research 

主　　题：hydroxyapatite β-tricaleium phosphate (TCP) collagen scaffold ridgepreservation 

摘      要：Bone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-I collagen and hydroxyapatite （HA）/β-tricaleium phosphate （TCP） scaffold （CHTS） by incorporating type-I collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.