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Glutamine transporters as effective targets in digestive system malignant tumor treatment

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Oncology Research 2024年第10期32卷 1661-1671页

作者： fei CHU KAI TONG XIANG GU mei BAO YANFEN CHEN BIN WANG YANHUA SHAO LING WEI School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou510006China Department of Pharmacy Tianjin Medical University General HospitalTianjin300070China

Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human *** cells take up a large amount of glutamine to meet their rapid proliferation requirements,which is supported by the upregulation of glutamine *** inhibition of glutamine transporters effectively inhibits cell growth and proliferation in *** all cancers,digestive system malignant tumors(DSMTs)have the highest incidence and mortality rates,and the current therapeutic strategies for DSMTs are mainly surgical resection and *** to the relatively low survival rate and severe side effects associated with DSMTs treatment,new treatment strategies are urgently *** article summarizes the glutamine transporters involved in DSMTs and describes their role in ***,glutamine transportertarget drugs are discussed,providing theoretical guidance for the further development of drugs DSMTs treatment.

关键词： Glutamine transporter Targeted therapy Inhibitors Cancer

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si mei Xue-fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

社区糖尿病健康教育存在的问题分析与整改措施

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中国卫生产业 2016年第6期13卷 99-101页

作者：费秀梅徐亚芬许大雪长春汽车经济技术开发区西湖医院门诊注射室吉林长春130000 吉林省肿瘤医院内镜科吉林长春130012 吉林省肿瘤医院新农合科吉林长春130012

目的为了提高社区糖尿病的健康教育质量与护理水平。方法对社区糖尿病的健康教育工作中的现状进行总结,对出现的问题进行分析,并且针对出现的问题提出整改措施。结果社区糖尿病健康教育质量得到进一步的提升,对护理人员的健康教育专业... 详细信息

目的为了提高社区糖尿病的健康教育质量与护理水平。方法对社区糖尿病的健康教育工作中的现状进行总结,对出现的问题进行分析,并且针对出现的问题提出整改措施。结果社区糖尿病健康教育质量得到进一步的提升,对护理人员的健康教育专业知识水平以及护理水平有所提高。结论针对健康教育出现的问题整改措施具有较高的应用价值,有效的健康教育对于糖尿病患者有效的控制血糖,提高自我管理能力,自我保健意识,使得社区糖尿病的健康教育工作更加规范合理,值得推广。

关键词：糖尿病健康教育整改措施

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心理护理对癫痫病的重要性

中国蒙医药（蒙） 2024年第4期19卷 159-162页

作者：秀美不详

张家口地区枯水期地下水水化学特征及其成因机制分析

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环境科学 2024年第2期45卷 826-836页

作者：金爱芳殷秀兰李长青李文娟庞菊梅金晓媚中国地质环境监测院北京100081 中国地质调查局自然资源综合调查指挥中心北京100055 中国地质大学(北京)水资源与环境学院北京100083

为更好支撑首都水源涵养功能区和生态环境支撑区建设,开展张家口地区枯水期地下水水化学特征及其形成机制研究,对地下水资源合理开发利用具有重要参考意义.采集41组地下水样品,运用描述性统计分析、Piper三线图、相关性分析、Gibbs图及... 详细信息

为更好支撑首都水源涵养功能区和生态环境支撑区建设,开展张家口地区枯水期地下水水化学特征及其形成机制研究,对地下水资源合理开发利用具有重要参考意义.采集41组地下水样品,运用描述性统计分析、Piper三线图、相关性分析、Gibbs图及离子比值等方法,分析了研究区地下水水化学类型、组成特征和控制因素.结果表明,研究区地下水整体呈弱碱性,总硬度变化范围为105.00~1433.00 mg·L^(-1),ρ(TDS)变化范围在137.00~2286.00 mg·L^(-1),坝上地区地下水中总硬度和TDS质量浓度均高于坝下地区.研究区地下水中HCO_(3)^(-)和Na^(+)为主要优势阴、阳离子.地下水中主要组分超标率最高的为总硬度,超标率为36.59%,坝上地区地下水中各组分的超标率和最大超标倍数均大于坝下地区.研究区地下水水化学类型以HCO_(3)-Ca·Mg·Na型为主,坝上地区和坝下地区水化学类型差异较小,SO_(4)^(2-)、Cl^(-)、HCO_(3)^(-)、Na^(+)和Mg^(2+)对TDS的贡献最大.地下水水化学特征受盐岩、钠长石和白云岩等岩石矿物风化溶滤作用、阳离子交换作用和人类活动的共同影响,蒸发结晶和大气降水对研究区地下水主要离子来源贡献较小.坝上地区地下水受人类活动影响要大于坝下地区,其中NO_(3)^(-)主要来源于农业活动.

关键词：地下水水化学特征控制因素超标率阳离子交换人类活动

Clinical and genetic characteristics of a child with Sotos syndrome and attention-deficit/hyperactivity disorder:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5131-5139页

作者： Ya-Jing Yang Bei-Yi Li Ke-Xin Gan Jing Liu xiu-Qin Lv Dong-mei Zhang Hui-Juan Ma Department of Internal Medicine North China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Internal Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Endocrinology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of Hebei Medical UniversityShijiazhuang 050023Hebei ProvinceChina

BACKGROUND Sotos syndrome is an autosomal dominant disorder,whereas attention-deficit/hyperactivity disorder(ADHD)is a neurodevelopmental *** report aimed to summarize the clinical and genetic features of a pediatric case of Soros syndrome and ADHD in a child exhibiting precocious *** SUMMARY The patient presented with accelerated growth and advanced skeletal maturation;however,she lacked any distinct facial characteristics related to specific genetic *** analyses revealed a paternally inherited heterozygous synonymous mutation[c.4605C>T(***1535Arg)].Functional analyses suggested that this mutation may disrupt splicing,and bioinformatics analyses predicted that this mutation was likely *** an initial diagnosis of Sotos syndrome,the patient was diagnosed with ADHD during the follow-up period at the age of 8 years and 7 *** The potential for comorbid ADHD in Sotos syndrome patients should be considered to avoid the risk of a missed diagnosis.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Nuclear receptor binding SET domain protein 1 Case report Developmental disabilities Diagnosis Como rbidity Management

Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3445-3456页

作者： Fan Zeng Da-Ya Zhang Shi-Ju Chen Run-Xiang Chen Chen Chen Shi-mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology Qionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of Gastroenterology Sanya Central HospitalSanya 572022Hainan ProvinceChina Department of Gastroenterology Hainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of Gastroenterology Dongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan Province Haikou 570216Hainan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean

关键词： Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province

Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang mei-Rou Liang Shi-Jin Cheng xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics