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Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1465-1478页

作者： Yu-Xin Zhao Yan Cui Xin-Hong Li Wen-Hong Yang Shi-Xiang An Jia-Xian Cui Min-Yu Zhang Jing-Kun Lu Xuan Zhang xiu-mei wang Li-Li Bao Peng-Wei Zhao Department of Anesthesiology Inner Mongolia Chest HospitalThe Fourth HospitalHohhot 010035Inner Mongolia Autonomous RegionChina College of Humanities and Education Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Radiotherapy The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina School of Basic Medical Science Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Medical Oncology The Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHohhot 010050Inner Mongolia Autonomous RegionChina

BACKGROUND Colorectal cancer has a low 5-year survival rate and high mortality.Humanβ-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer cells.Long non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and growth.AIM To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 cells.METHODS CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug concentration.Colony formation assay was employed to assess the effect of hBD-1 on SW620 cell proliferation.Bioinformatics was used to screen potentially biologically significant lncRNAs related to the mTOR pathway.Additionally,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot analysis.RESULTS hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to hBD-1.hBD-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I protein.Furthermore,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR pathway.The lncRNA TCONS_00014506 was ultimately selected.Following the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein expression.CONCLUSION hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

关键词： Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin Autophagy

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Application of multidisciplinary collaborative nursing with family care for enhanced recovery after surgery in children with inguinal hernia

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 1932-1940页

作者： xiu-mei wang Qiang Hou Department of Pediatric Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina Department of Burns The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina

BACKGROUND Perioperative nursing can reduce the stress reaction and improve the prognosis of children.AIM To elucidate the influence of multidisciplinary collaborative nursing for enhanced recovery after surgery(ERAS)with family care in perioperative nursing children with an inguinal hernia and its impact on the prognosis.METHODS The data of 100 children with inguinal hernia were retrospectively analyzed.The participants were divided into three groups according to different nursing methods:Groups A(n=38),B(n=32),and C(n=30).Group A received multidisciplinary collaborative ERAS nursing combined with family care nursing;Group B received multidisciplinary collaborative nursing for ERAS;and Group C received routine nursing.The postoperative recovery results of the three groups were compared,including intraoperative blood loss and postoperative feeding time,time of getting out of bed,hospitalization time,and defecation time.Furthermore,the incidence of common complications was also compared between the three groups.RESULTS There was less intraoperative blood loss in Groups A and B than in Group C(P0.05).Each index had no statistical significance between Groups A and B(P>0.05).The incidence of urinary retention,infection,hematoma,and hernia recurrence in Group A was less than that in Group C(P0.05).CONCLUSION The application of multidisciplinary collaborative nursing combined with family care in the perioperative care of children with an inguinal hernia for ERAS may promote postoperative rehabilitation for children and reduce the incidence of complications.

关键词： Multidisciplinary collaborative Enhanced recovery after surgery Family care Perioperative nursing Prognosis Postoperative complications

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PM-compact Graphs and Vertex-deleted Subgraphs

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Acta Mathematicae Applicatae Sinica 2022年第4期38卷 955-965页

作者： Yi-pei ZHANG xiu-mei wang Jin-jiang YUAN School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

The perfect matching polytope of a graph G is the convex hull of the incidence vectors of all perfect matchings of G.A graph G is PM-compact if the 1-skeleton graph of the prefect matching polytope of G is complete.Equivalently,a matchable graph G is PM-compact if and only if for each even cycle C of G,G-V(C)has at most one perfect matching.This paper considers the class of graphs from which deleting any two adjacent vertices or nonadjacent vertices,respectively,the resulting graph has a unique perfect matching.The PM-compact graphs in this class of graphs are presented.

关键词： perfect matching nice cycle bicritical graph PM-compact graph

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Comparison of bone regeneration in alveolar bone of dogs on mineralized collagen grafts with two composition ratios of nanohydroxyapatite and collagen

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Regenerative Biomaterials 2016年第1期3卷 33-40页

作者： Yan-Fuwang Cheng-Yue wang PengWan Shao-Gangwang xiu-mei wang Graduate School Liaoning Medical UniversityJinzhou 121000China Department of Prosthodontics Affiliated Stomatological Hospital of Liaoning Medical UniversityJinzhou 121000China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute for Regenerative Medicine and Biomimetic Materials School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

To study the effect of two composition ratios of nano-hydroxyapatite and collagen(NHAC)composites on repairing alveolar bone defect of dogs.Eighteen healthy adult dogs were randomly divided into three groups.Two kinds of the NHAC composites were prepared according to the constituent ratios of 3:7 and 5:5;immediately after extraction of the mandibular second premolars,each kind of the NHAC composite was implanted into extraction socket,respectively:Group I,nHA/Col紏3:7;Group II,nHA/Col紏5:5 and Group III,blank control group.The bone-repairing ability of the two grafts was separately analyzed by morphometric measurement,X-ray tomography examination and biomechanical analysis at 1st,3rd and 6th month post-surgical,respectively.The NHAC composites were absorbed gradually after implanting into alveolar bone defect and were replaced by new bone.The ratios of new bone formation of Group I was significantly higher than that of Group II after 3 months(P<0.05).The structure and bioactive performance can be improved when the ratio between the collagen and the hydroxyapatite was reasonable,and the repairing ability and effect in extraction sockets are obviously better.

关键词： nano-hydroxyapatite collagen dental extraction socket alveolar ridge preservation ratios

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Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

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Frontiers of Materials Science 2015年第1期9卷 1-13页

作者： Xi LID Bin PI Hui wang xiu-mei wang National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University Suzhou 215123 China Institute for Regenerative Medicine and Biomimetic Materials Key Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University Beijing 100084 China Department of Orthopedics The First Affiliated Hospital of Soochow University Suzhou 215006 China

Central nervous system （CNS） presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanoflber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of selfassembling peptide nanoflber hydrogels for CNS regeneration.

关键词： self-assembling peptide hydrogel central nervous system （CNS） nerveregeneration

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Novel combined shield design for eye and face protection from COVID-19

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Advances in Manufacturing 2021年第1期9卷 130-135页

作者： xiu-Ling Huang Jin-Rong Yang Yu-Xiang Sun Yi-Wen Chen xiu-mei wang Shui-Miao Du Zi-Kai Hua School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People's Republic of China Sino European School of Technology of Shanghai University Shanghai 200444People's Republic of China

The World Health Organization emphasized the importance of goggles and face shields for protection of medical personnel at the outbreak of the COVID-19 pandemic.Unsurprisingly,almost all countries suffered from a critical supply shortage of goggles and face shields,as well as many other types of personal protective equipment(PPE),for a long period,owing to the lack of key medical material supplies and the inefficiency of existing fabrication methods arising from the need to avoid crowds during the outbreak of COVID-19.In this paper,we propose a novel combined shield design for eye and face protection that can be rapidly fabricated using three-dimensional printing technology.The designed prototype eye-face shield is accessible to the general public,offering more possibilities for yield improvement in PPE during emergent infectious disease events such as COVID-19.

关键词： Goggles Face shield Three-dimensional(3D)printing COVID-19

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A Characterization of PM-compact Hamiltonian Bipartite Graphs

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 313-324页

作者： xiu-mei wang Jin-jiang YUAN Yi-xun LIN School of Mathematics and Statistics Zhengzhou University

The perfect matching polytope of a graph G is the convex hull of the incidence vectors of all perfect matchings in G. A graph is called perfect matching compact（shortly, PM-compact）, if its perfect matching polytope has diameter one. This paper gives a complete characterization of simple PM-compact Hamiltonian bipartite graphs. We first define two families of graphs, called the H2C-bipartite graphs and the H23-bipartite graphs, respectively. Then we show that, for a simple Hamiltonian bipartite graph G with ｜V（G）｜ ≥ 6, G is PM-compact if and only if G is K3,3, or G is a spanning Hamiltonian subgraph of either an H2C-bipartite graph or an H23-bipartite graph.

关键词： perfect matching polytope perfect-matching graph bipartite graph hamiltonian graph

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Tanshinone ⅡA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

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Neural Regeneration Research 2017年第2期12卷 267-275页

作者： Yong-dong Yang Xing Yu xiu-mei wang Xiao-hong Mu Feng He Department of Orthopedics Dongzhimen Hospital Beijing University of Chinese Medicine School of Materials Science and Engineering Tsinghua University

Tanshinone ⅡA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone ⅡA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone ⅡA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion（L6–S1） cells was less after treatment with tanshinone ⅡA. The effects of tanshinone ⅡA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone ⅡA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.

关键词： nerve regeneration spinal cord injury tanshinone IIA spinal pathway lower urinary tract dysfunction neurogenic bladder dorsal root ganglion detrusor-sphincter dyssynergia urodynamics neural regeneration

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Scaffolds for central nervous system tissue engineering

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Frontiers of Materials Science 2012年第1期6卷 1-25页

作者： Jin HE xiu-mei wang Myron SPECTOR Fu-Zhai CUI Institute for Regenerative Medicine and Biomimetic Materials State Key Laboratory of New Ceramics and Fine ProcessingDepartment of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Orthopedic Research Laboratory Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115USA

Traumatic injuries to the brain and spinal cord of the central nervous system （CNS） lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.

关键词： central nervous system （CNS） tissue engineering scaffold hydrogel

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Calcium carbonate crystallization controlled by functional groups： A mini-review

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Frontiers of Materials Science 2013年第1期7卷 62-68页

作者： Hua DENG Xing-Can SHEN xiu-mei wang Chang DU State Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Chemical Engineering Guangxi Normal University Guilin 541004 China School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China

Various functional groups have been suggested to play essential roles on biomineralization of calcium carbonate (CaCO3) in natural system. 2D and 3D models of regularly arranged functional groups have been established to investigate their effect on CaCO3 crystallization. This mini-review summarizes the recent progress and the future development is prospected.

关键词： functional group biomineralization crystallization CaCO 3

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