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TRPC6:an underlying target for human glaucoma

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 523-526页

作者： Qian Fan Wen-Bin Huang and xiu-Lan zhang Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou 510060 Guangdong Province China

Glaucoma is one of the leading causes of visual impairment and blindness worldwide. Of known risk factors for glaucoma, an increased in intraocular pressure is most highly correlated with glaucomatous damage. Irrespective of the cause, apoptosis of the retinal ganglion cells is the eventual outcome. It is widely accepted that glaucoma is a neurodegenerative disease that is strongly correlated with central nervous system disorders, such as Alzheimer's disease. These two disorders also share some similarities in pathogenic mechanisms. Recent studies suggest that the transient receptor potential canonical 6 channel could work together with brain-derived neurotrophic factor to promote neuron survival in brain and retina. In this study, we propose that transient receptor potential canonical 6 may contribute to the pathogenesis of human glaucoma and become a potential therapeutic target.

关键词： glaucoma transient receptor potential canonical 6 channel neuroprotection

Cod liver oil: a potential protective supplement for human glaucoma

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 648-651页

作者： Wen-Bin Huang Qian Fan and xiu-Lan zhang Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou 510060 Guangdong Province China

Glaucoma is one of the leading causes of visual impairment and blindness. Improved knowledge of the pathogenesis of this disease has allowed the exploration of new therapeutic methods. In general, elevated intraocular pressure (IOP), oxidative stress, and vascular insufficiency are accepted as the major risk factors for the progression of glaucoma. Many natural compounds have been found beneficial for glaucoma. Nutritional therapies are now emerging as potentially effective in glaucomatous therapy. One nutritional supplement with potential therapeutic value is cod liver oil, a dietary supplement that contains vitamin A and omega-3 polyunsaturated fatty acids (PUFAs). Vitamin A is important for preserving normal vision and it is a well-known antioxidant that prevents the oxidative damage that contributes to the etiology and progression of glaucoma. Vitamin A is also a crucial factor for maintaining the integrity of conjunctival and corneal ocular surfaces, and preventing the impairment of ocular epithelium caused by topical antiglaucomatous drugs. Omega-3 fatty acids are beneficial for glaucoma patients as they decrease IOP, increase ocular blood flow, and improve optic neuroprotective function. In this article, we propose that cod liver oil, as a combination of vitamin A and omega-3 fatty acids, should be beneficial for the treatment of glaucoma. However, further studies are needed to explore the relationship between cod liver oil and glaucoma.

关键词： cod liver oil glaucoma omega-3 fatty acids vitamin A

A New Method of Identifying 3D Null Points in Solar Vector Magnetic Fields

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Chinese Journal of Astronomy and Astrophysics 2005年第5期5卷 443-447页

作者： Hui Zhao Jing-xiu Wang Jun zhang Chi-Jie Xiao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

Employing the Poincar6 index of isolated null-points in a vector field, we worked out a mathematical method of searching for 3D null-points in coronal magnetic fields. After introducing the relevant differential topology, we test the method by using the analytical model of Brown ＆ Priest. The location of nullpoint identified by our method coincides precisely with the analytical solution. Finally we apply the method to the 3D coronal magnetic fields reconstructed from an observed MDI magnetogram of a super-active region （NOAA 10488）. We find that the 3D null-point seems to be a key element in the magnetic topology associated with flare occurrence.

关键词： Sun: flares - Sun: corona- Sun: magnetic fields

Impact of letters to the editor and publications in 2023

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Zoological Research 2024年第1期45卷 136-137页

作者： xiu-Ping zhang Xue-Long Jiang Yong-Gang Yao Editorial Office of ZR&ZRDC Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovation,and conciseness,thereby serving as an effective means to disseminate cuttingedge scientific *** the past five years,there has been a considerable increase in the number of letters published,representing the highest growth rate(approximately 20%)observed in the last three decades(Figure 1A).In the field of academic publishing,letters to the editor are typically more concise than typical research papers.

关键词： journal editor Figure

Morphological characterization of metal porphyrin tailed with aspirin interacting with bovine serum albumin congeries

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Chinese Chemical Letters 2007年第12期18卷 1455-1459页

作者： Kai Wang Lei Wu xiu Lan zhang Zao Ying Li College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China Hubei Key Laboratory of Novel Reactor ＆ Green Chemical Technology Wuhan 430074 China

The porphyrins tailed with acetylsalicylic acid （ASA） and Zn （or Cu） complexes were prepared. Meanwhile, morphological images, such as shape and size of porphyrins-BSA congeries were observed by using atomic force microscopy （AFM）. The result showed the interaction of BSA and prepared porphyrins led to obvious change of shape and size of BSA congeries.

关键词： Porphyrin Acetylsalicylic acid Bovine serum albumin Atomic force microscopy

Surface nanostructures in commercial pure Ti induced by high energy shot peening

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中国有色金属学会会刊：英文版 2004年第z1期14卷 215-218页

作者： CHEN Chun-huan REN Rui-ming ZHAO xiu-juan zhang Yu-jun School of Materials Science and Engineering Dalian Jiaotong University Dalian 116028 China School of Materials Science and Engineering Dalian Jiaotong University Dalian 116028 China School of Materials Science and Engineering Dalian Jiaotong University Dalian 116028 China School of Materials Science and Engineering Dalian Jiaotong University Dalian 116028 China

The high-energy shot peening (HESP) technique was used to obtain the surface nanocrystalline microstructure for a hcp metal titanium. XRD, SEM and TEM were applied to characterize the microstructure of the surface layer. Large amount of the deformation twins in the surface layer were observed by SEM in the specimens after HESP treatment in a shot-time, and the number of deformation twins both in a single plane and in intersecting planes increases with HESP time, until the twin character disappears completely in the top surface layer, which means that the severe plastic deformation(SPD) occurs on the surface. The XRD analysis results show that after HESP treatmen for 30 - 60 min the surface grain size decreases to nanoscale. According to the TEM images and corresponding diffraction patterns from SPD areas of the 120 min-treatment specimen, the measured grain size near the surface is about 20 - 30 nm. The grain size in deformation layer increases with the depth from the surface, and the nanostructured layer is about 20 μm in depth. Therefore, the surface nanocrystalline and a gradient microstructure from the surface to the matrix are obtained, which results in the micro-hardness decreasing from surface to the matrix gradually.

关键词： surface nanocrystallization shot peening commercial pure Ti

Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan zhang xiu Qin JU Guang xiu SU Ya zhang Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

The generation and properties of human cortical organoids as a disease model for malformations of cortical development

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Neural Regeneration Research 2023年第10期18卷 2119-2126页

作者： xiu-Ping zhang Xi-Yuan Wang Shu-Na Wang Chao-Yu Miao Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghaiChina

As three-dimensional“organ-like”aggregates,human cortical organoids have emerged as powerful models for studying human brain evolution and brain disorders with unique advantages of humanspecificity,fidelity and *** cortical organoids derived from human pluripotent stem cells can elaborately replicate many of the key properties of human cortical development at the molecular,cellular,structural,and functional levels,including the anatomy,functional neural network,and interaction among different brain regions,thus facilitating the discovery of brain development and *** addition to studying the neuro-electrophysiological features of brain cortex development,human cortical organoids have been widely used to mimic the pathophysiological features of cortical-related disease,especially in mimicking malformations of cortical development,thus revealing pathological mechanism and identifying effective *** this review,we provide an overview of the generation of human cortical organoids and the properties of recapitulated cortical development and further outline their applications in modeling malformations of cortical development including pathological phenotype,underlying mechanisms and rescue strategies.

关键词： cortical development disease models human cortical organoids human cortical spheroids human pluripotent stem cells malformations of cortical development telencephalon organoids whole brain organoids

Late sowing enhances lodging resistance of wheat plants by improving the biosynthesis and accumulation of lignin and cellulose

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Journal of Integrative Agriculture 2023年第5期22卷 1351-1365页

作者： DONG xiu-chun QIAN Tai-feng CHU Jin-peng zhang xiu LIU Yun-jing DAI Xing-long HE Ming-rong State Key Laboratory of Crop Biology Ministry of Science and Technology/Key Laboratory of Crop Ecophysiology and Farming SystemMinistry of Agriculture and Rural Affairs/Agronomy CollegeShandong Agricultural UniversityTai’an 271018P.R.China Jining Agricultural Technology Extension Center Jining 272113P.R.China

Delayed sowing mitigates lodging in wheat. However, the mechanism underlying the enhanced lodging resistance in wheat has yet to be fully elucidated. Field experiments were conducted to investigate the effects of sowing date on lignin and cellulose metabolism, stem morphological characteristics, lodging resistance, and grain yield. Seeds of Tainong 18,a winter wheat variety, were sown on October 8(normal sowing) and October 22(late sowing) during both of the 2015–2016 and 2016–2017 growing seasons. The results showed that late sowing enhanced the lodging resistance of wheat by improving the biosynthesis and accumulation of lignin and cellulose. Under late sowing, the expression levels of key genes(Ta PAL, Ta CCR, Ta COMT, TaCAD, and TaCesA1, 3, 4, 7, and 8) and enzyme activities(TaPAL and TaCAD) related to lignin and cellulose biosynthesis peaked 4–12 days earlier, and except for the TaPAL, TaCCR, and TaCesA1 genes and TaPAL, in most cases they were significantly higher than under normal sowing. As a result, lignin and cellulose accumulated quickly during the stem elongation stage. The mean and maximum accumulation rates of lignin and cellulose increased, the maximum accumulation contents of lignin and cellulose were higher, and the cellulose accumulation duration was prolonged. Consequently, the lignin/cellulose ratio and lignin content were increased from 0 day and the cellulose content was increased from 11 days after jointing onward. Our main finding is that the improved biosynthesis and accumulation of lignin and cellulose were responsible for increasing the stem-filling degree, breaking strength, and lodging resistance. The major functional genes enhancing lodging resistance in wheat that are induced by delayed sowing need to be determined.

关键词： cellulose late sowing lignin lodging resistance wheat