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交替惩罚三线性分解结合室温磷光法快速解析土壤中芴的含量

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山地农业生物学报 2024年第5期43卷 1-7页

作者：王韬翔吴欣冉张臻王优安蓉卿湘东湖南城市学院黑茶金花湖南省重点实验室/材料与化学工程学院湖南益阳413000

多环芳烃是土壤中常见的有机污染物,具有致癌、致畸、致基因突变等“三致作用”。本文建立了一种基于交替惩罚三线性分解结合三维室温磷光法(APTLD-TRTP)测定不同类型土壤(如农田区、生活区和工业区)中多环芳烃芴(FLU)的方法,并与基于... 详细信息

多环芳烃是土壤中常见的有机污染物,具有致癌、致畸、致基因突变等“三致作用”。本文建立了一种基于交替惩罚三线性分解结合三维室温磷光法(APTLD-TRTP)测定不同类型土壤(如农田区、生活区和工业区)中多环芳烃芴(FLU)的方法,并与基于平行因子分析的方法(PARAFAC-TRTP)进行比较。首先构建一个验证集来探索开发方法的预测能力,然后利用其对加标土壤样和实际未知土壤样品中FLU进行定量分析。在N=3时,APTLD-TRTP和PARAFAC-TRTP获得土壤加标样中FLU的平均回收率分别为(90.4±5.6)%和(90.3±4.8)%,预测均方根误差(RMSEP)分别为0.32μg/mL和0.31μg/mL。方法预测的工业区土壤样中FLU的浓度范围为0.34~0.96μg/g,显著高于相关标准限值0.05μg/g,表明该研究区域土壤已受到FLU污染,其污染源可能来源于钢铁工业区煤炭燃烧、石油泄漏和汽车尾气排放等。

关键词：平行因子分析交替惩罚三线性分解室温磷光法芴土壤

Identification of de novo Mutations in the Chinese Autism Spectrum Disorder Cohort via Whole-Exome Sequencing Unveils Brain Regions Implicated in Autism

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Neuroscience Bulletin 2023年第10期39卷 1469-1480页

作者： Bo Yuan Mengdi Wang xinran wu Peipei Cheng Ran Zhang Ran Zhang Shunying Yu Jie Zhang Yasong Du Xiaoqun Wang Zilong Qiu Songjiang Research Institute Songjiang HospitalShanghai Jiao Tong University School of MedicineShanghai 201600China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200032China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Center for Brain Science and Brain-Inspired Intelligence TechnologyChinese Academy of SciencesShanghai 200032China Beijing Normal University Beijing 100875China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai 200433China

Autism spectrum disorder(ASD)is a highly heritable neurodevelopmental disorder characterized by deficits in social interactions and repetitive *** hundreds of ASD risk genes,implicated in synaptic formation and transcriptional regulation,have been identified through human genetic studies,the East Asian ASD cohorts are still under-represented in genome-wide genetic ***,we applied whole-exome sequencing to 369 ASD trios including probands and unaffected parents of Chinese *** a joint-calling analytical pipeline based on GATK toolkits,we identified numerous de novo mutations including 55 high-impact variants and 165 moderate-impact variants,as well as de novo copy number variations containing known ASD-related ***,combined with single-cell sequencing data from the developing human brain,we found that the expression of genes with de novo mutations was specifically enriched in the pre-,post-central gyrus(PRC,PC)and banks of the superior temporal(BST)regions in the human *** further analyzing the brain imaging data with ASD and healthy controls,we found that the gray volume of the right BST in ASD patients was significantly decreased compared to healthy controls,suggesting the potential structural deficits associated with ***,we found a decrease in the seed-based functional connectivity between BST/PC/PRC and sensory areas,the insula,as well as the frontal lobes in ASD *** work indicated that combinatorial analysis with genome-wide screening,single-cell sequencing,and brain imaging data reveal the brain regions contributing to the etiology of ASD.

关键词： Autism Cohorts Whole-exome sequencing Single-cell sequencing

Observation of robust anisotropy in WS_(2)/BP heterostructures

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Nano Research 2024年第7期17卷 6749-6756页

作者： xinran Li Xing Xie Biao wu Junying Chen Shaofei Li Jun He Zongwen Liu Jian-Tao Wang Yanping Liu Institute of Quantum Physics School of PhysicsCentral South University932 South Lushan RoadChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South University932 South Lushan RoadChangsha 410083China School of Chemical and Biomolecular Engineering The University of SydneyNSW 2006Australia The University of Sydney Nano Institute The University of SydneyNSW 2006Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Shenzhen Research Institute of Central South University Shenzhen 518000China

Two-dimensional(2D)anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical,optical,thermal,and mechanical *** extensive research has delved into the optical and electrical characteristics of these materials,there remains a need for further exploration to identify novel materials and structures capable of fulfilling device requirements under various ***,we employ heterojunction interface engineering with black phosphorus(BP)to disrupt the C_(3) rotational symmetry of monolayer WS_(2).The resulting WS_(2)/BP heterostructure exhibits pronounced anisotropy in exciton emissions,with a measured anisotropic ratio of 1.84 for neutral *** a comprehensive analysis of magnetic-field-dependent and temperature-evolution photoluminescence spectra,we discern varying trends in the polarization ratio,notably observing a substantial anisotropy ratio of 1.94 at a temperature of 1.6 K and a magnetic field of 9 *** dynamic behavior is attributed to the susceptibility of the WS_(2)/BP heterostructure interface strain to fluctuations in magnetic fields and *** findings provide valuable insights into the design of anisotropic optoelectronic devices capable of adaptation to a range of magnetic fields and temperatures,thereby advancing the frontier of material-driven device engineering.

关键词： two-dimensional materials in-plane anisotropy black phosphorus heterojunctions optoelectronic devices photoluminescence spectra

Stability Analysis of Switching System in Space Power Supply

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Stability Analysis of Switching System in Space Power Supply

PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts

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作者： Ningxin wu Qing wu Jiahao Shi xinran wu Yongqing Su College of Electronics and Information Engineering Tongji University Air Force Research Institute Shanghai Institute of Space Power Supply

In order to maintain the stability of the bus voltage,the space power supply switches between the discharge circuit module,the charging circuit module and the shunt circuit module according to the change of the solar cell and the load,and the switching transition process can be approximately equivalent to the dead zone *** this paper,the system is modeled by the small-signal modeling method,and according to the average dwell time method,we can find the average dwell time index which can make the system *** we calculate the real-time dwell time index of the system by Markov analysis method,and compare with the average dwell time index to judge the stability of the ***,the effectiveness of the proposed method is proved by simulation.

关键词： Switching System Dead Zone Lyapunov Function and Average Dwell Time

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Journal of Genetics and Genomics 2024年第2期51卷 243-251页

作者： xinran Dong Yulan Lu Lanting Guo Chuan Li Qi Ni Bingbing wu Huijun Wang Lin Yang Songyang wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang Center for Molecular Medicine Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Department of Bioinformatics Hangzhou Nuowei Information Technology Co.LtdHangzhouZhejiang 310000China The Third Research Institute of the Ministry of Public Security Shanghai 200031China Xiamen Campus of Children's Hospital of Fudan University XiamenFujian 361006China Institutes for Systems Genetics West China HospitalChengduSichuan 610041China Shanghai Putuo People's Hospital Tongji UniversityShanghai 200060China

The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://***:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.

关键词： Privacy protecti on Rare diseases in children Genetic testing Web system Trusted executi on envir onment

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透过散射介质的散斑统计特性研究

物理实验 2024年第5期44卷 47-53页

作者：林艾扬罗永锜王文皓谢欣欣杨家瑶吴欣然罗劲明张海宁嘉应学院物理与电子工程学院广东梅州514015

复杂散射介质的衍射通常会形成散斑图像,该特性使得其在激光技术、电子和光电子等领域具有重要的应用价值.搭建了透过散射介质衍射形成的散斑测量系统,研究了CCD曝光时间、衍射距离和散射面直径对散斑统计特性的影响.实验结果表明:改变... 详细信息

复杂散射介质的衍射通常会形成散斑图像,该特性使得其在激光技术、电子和光电子等领域具有重要的应用价值.搭建了透过散射介质衍射形成的散斑测量系统,研究了CCD曝光时间、衍射距离和散射面直径对散斑统计特性的影响.实验结果表明:改变光学系统参量,透过散射片的散斑特性也会随之改变;选择合适的曝光时间能够获取对比度和光强分布适中的散斑图像,其空间衍射特性可用散斑平均尺寸表征,但对于散斑特性的微小变化,则可利用相关系数和数字图像相关结果进行辅助分析.

关键词：散射介质衍射散斑统计特性

CD146,a therapeutic target involved in cell plasticity

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Science China(Life Sciences) 2024年第8期67卷 1563-1578页

作者： Zhenzhen wu Yuzhe Zang Chuyi Li Zhiheng He Jingyu Liu Zhaoqi Du xinran Ma Lin Jing Hongxia Duan Jing Feng Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical ScienceZhengzhou 451163China Joint Laboratory of Nanozymes in Zhengzhou University School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China

Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair and regeneration,tumor progression,fibrosis disease,and *** research has revealed that CD146 is involved in various signaling pathways as a receptor or coreceptor in these *** correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis,prognosis,and targeted *** better comprehend the versatile roles of CD146,we have summarized its research history and synthesized findings from numerous reports,proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development,regeneration,and various *** CD146 would consequently halt cell state shifting during the onset and progression of these related ***,the development of therapy targeting CD146 holds significant practical value.

关键词： CD146 cell plasticity therapeutic target

A rapid assessment of MWRI-RM/FY3G brightness temperature

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 42-46页

作者： Wenying He xinran Xia Shengli wu Peng Zhang Hongbin Chen Xiang'ao Xia Yuquan Zhou Miao Cai LAGEO Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina School of Hydrology and Water Resources Nanjing University of Information Science&TechnologyNanjingChina National Satellite Meteorological Centure Chinese Meteorological AdministrationBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina Key Laboratory of Cloud-Precipitation Physics and Weather Modification CMABeijingChina

2023年4月发射的FY-3G上搭载17个频率的测雨微波成像仪(MWRI-RM),其业务定标的微波亮温(Tb)数据于2023年10月23日公开发布.本文比对了发布10天的MWRI-RM与全球降水测量(GPM)卫星上的微波成像仪(GMI)相匹配的Tb数据,并借助辐射传输模式... 详细信息

2023年4月发射的FY-3G上搭载17个频率的测雨微波成像仪(MWRI-RM),其业务定标的微波亮温(Tb)数据于2023年10月23日公开发布.本文比对了发布10天的MWRI-RM与全球降水测量(GPM)卫星上的微波成像仪(GMI)相匹配的Tb数据,并借助辐射传输模式进行双差分(DD)交叉定标分析,旨在快速评估新一代MWRI-RM观测数据质量.观测比较表明,MWR1-RM与GMI测量的Tb一致性很好,大多通道的平均偏差(MBE)和均方根误差(RMSE)均小于1K.两种传感器由于观测角度略有不同在水面产生约0.5 K差异.DD分析也展示出MWRI-RM的大多数通道性能与GMI相当接近,尤其是首次启用的高频166 GHz和183 GHz.

关键词： FY3G MWRI-RM GMI 亮度温度双差分方法

A study on some elements and their phases in sediments of Changjiang Estuary by X-ray spectrometer and X-ray diffractometer

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Acta Oceanologica Sinica 1997年第1期16卷 121-125页

作者： Han Jiancheng, Li Li, Chen Qiming, wu xinran, Chen Banglin and Han QingpingDepartment of Chemistry, East China Normal University, Shanghai 200062, China

INTRODUCTIONThe studies on the quantitative distribution of the conventional elements and their phases in the sediments of the Changjiang Estuary are of great importance to the understanding of the chemical processes ... 详细信息

关键词： A study on some elements and their phases in sediments of Changjiang Estuary by X-ray spectrometer and X-ray diffractometer