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Journal of materials Science & Technology 2022年第35期130卷 86-92页

作者： xinran ma Yuping Duan Lingxi Huang Ben ma Hao Lei Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116085China

In the electronic information and intelligent era, microwave absorption materials have been focused on the issue of electromagnetic(EM) pollution, but high-performance absorbers with thin thickness are highly desirable. The positive action between structural design and component selection can be regarded as a function to optimize the microwave loss capacity, which contributes to understanding the response mechanisms from the micro and macro. Therefore, we designed the absorber with quasiperiodic structures of Penrose tiling that has finely engineered the location of maximum absorption peak, the spherical carbonyl iron in thin rhombus, and flakey carbonyl iron in fat rhombus, the effective absorption bandwidth(Reflection Loss ≤ –10 d B) was realized from 6.46 GHz to 15.78 GHz in the 2 mm thickness. The unique arrangement of Penrose tiling can respond alternatingly to EM waves at large scales, and multicomponent coupling is distinctly in the neighboring unit cells. In addition, spraying aluminum pigment as the upper layer, the infrared emissivity is less than 0.35 to meet the complex application *** work opens up novel ideas on quasiperiodic structure combined multicomponent and injects infinite vitality to provide prospects for broadband responsive and high-efciency EM absorbers.

关键词： Microwave absorber Penrose tiling Carbonyl iron Localized coupling

Deep Learning Quantum States for Hamiltonian Estimation

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Chinese Physics Letters 2021年第11期38卷 1-6页

作者： xinran ma Z.C.Tu Shi-Ju Ran Department of Physics Beijing Normal UniversityBeijing 100875China Department of Physics Capital Normal UniversityBeijing 100048China

Human experts cannot efficiently access physical information of a quantum many-body states by simply "reading"its coefficients, but have to reply on the previous knowledge such as order parameters and quantum *** demonstrate that convolutional neural network(CNN) can learn from coefficients of many-body states or reduced density matrices to estimate the physical parameters of the interacting Hamiltonians, such as coupling strengths and magnetic fields, provided the states as the ground states. We propose QubismNet that consists of two main parts: the Qubism map that visualizes the ground states(or the purified reduced density matrices) as images, and a CNN that maps the images to the target physical parameters. By assuming certain constraints on the training set for the sake of balance, QubismNet exhibits impressive powers of learning and generalization on several quantum spin models. While the training samples are restricted to the states from certain ranges of the parameters, QubismNet can accurately estimate the parameters of the states beyond such training regions. For instance, our results show that QubismNet can estimate the magnetic fields near the critical point by learning from the states away from the critical vicinity. Our work provides a data-driven way to infer the Hamiltonians that give the designed ground states, and therefore would benefit the existing and future generations of quantum technologies such as Hamiltonian-based quantum simulations and state tomography.

关键词： CNN MSE RDM image Hamiltonian Deep Learning Quantum States for Hamiltonian Estimation Quantum

The roles of zinc finger proteins in non-alcoholic fatty liver disease

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Liver Research 2020年第1期4卷 35-39页

作者： Guoqiang Li xinran ma Lingyan Xu Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina

Non-alcoholic fatty liver disease(NAFLD)is a common chronic disease characterized by excessive fat accumulation in hepatocytes in the absence of alcohol *** trends towards excessive calorie intake and sedentary life styles have increased the prevalence of NAFLD accompanied by obesity and type 2 ***,the molecular mechanisms underlying the initiation and progression of NAFLD are not *** finger proteins(ZFPs)are a superfamily of metalloproteins that contain zinc finger *** play diverse physiological roles in tissue homeostasis and also contribute to many pathological conditions,including metabolic,cardiovascular,and neurodegenerative diseases and various types of *** this review,we highlight our current knowledge of several ZFPs that play critical roles in the progression of NAFLD,describe their mechanistic functional networks,and discuss the potential for ZFPs as therapeutic targets for NAFLD.

关键词： Non-alcoholic fatty liver disease(NAFLD) Hepatic steatosis Zinc finger proteins(ZFPs) Glioma-associated oncogene(GLI) Krüppel-like factor(KLF) Yin Yang 1(YY1) Mechanistic network

Heat shock factor 1 in fat biology: comments on ‘Local hyperthermia therapy induces browning of white fat and treats obesity’

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Journal of Molecular Cell Biology 2022年第4期14卷 74-76页

作者： Lingyan Xu Yu Li Yankang Zhang Ting Zhang Dongmei Wang xinran ma Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China

Beige fat,a newly discovered adipose tissue featuring high functional flexibility,exhibits the characteristics of white fat at rest,but can be activated to function like brown fat under cold or β-adrenergic stimulation via a process termed‘browning of white fat’.This activation enables beige fat to greatly promote heat production and energy consumption,as well as to improve systemic glucose and lipid *** fat also exists in supraclavicular and paraspinal regions in human adults,which endows its great potential forintervention ofobesityandmetabolic diseases.

关键词： obesity stimulation white

Profiles of muscular amino acids,fatty acids,and metabolites in Shaziling pigs of different ages and relation to meat quality

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Science China(Life Sciences) 2023年第6期66卷 1323-1339页

作者： Yehui Duan Changbing Zheng Jie Zheng Lu ma xinran ma Yinzhao Zhong Xichen Zhao Fengna Li Qiuping Guo Yulong Yin CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing100049China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai200241China

Pork meat is closely related to physicochemical alterations during growth and development,resulting in differences in nutritional value and meat *** study aimed to evaluate the composition of amino acids,fatty acids,and metabolic profiles in the longissimus thoracis muscle(LM)of Shaziling pigs aged 30,90,150,210,and 300 *** results showed that the predominant fatty acids identified in the LM of Shaziling pigs were C16:0,C16:1,C18:0,C18:1n9c,and C18:*** opposite correlation was observed for C18:2n6c and n6/n3 polyunsaturated fatty acids(Pmate,Dglutamine,and D-glutamate metabolism were the main metabolic pathways for the Shaziling pig meat flavor(P<0.05).Moreover,the correlation coefficients revealed that the contents of anserine,C16:0,C16:1,and C18:1n9c were positively correlated with intramuscular fat and/or p H24hand were negatively correlated with the values of L^(*)(lightness)and b^(*)(yellowness)(P<0.05).In conclusion,age greatly affected the meat quality of Shaziling pigs,and the contents of muscular anserine,C16:0,C16:1,and C18:1n9c might be promising indicators for better meat quality.

关键词： Shaziling pigs meat quality amino acids fatty acids metabolites

Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression

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Cellular & Molecular Immunology 2022年第12期19卷 1333-1346页

作者： Tong Lei Jiayu Zhang Qian Zhang xinran ma Yanan Xu Yang Zhao Lianfeng Zhang Zhongbing Lu Yong Zhao State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina College of Life Science University of Chinese Academy of SciencesBeijingChina Cunji Medical School University of Chinese Academy of SciencesBeijingChina Key Laboratory of Human Diseases Comparative Medicine Ministry of HealthInstitute of Laboratory Animal ScienceChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

Tissue-resident macrophages are derived from different precursor cells and display different *** of the tissue-resident macrophages of inflamed or damaged tissues in adults can be achieved by bone marrow-derived monocytes/*** lysozyme(Lysm)-GFP-reporter mice,we found that alveolar macrophages(AMs),Kupffer cells,red pulp macrophages(Rpmacs),and kidney-resident macrophages were Lysm-GFP^(−),whereas all monocytes in the fetal liver,adult bone marrow,and blood were Lysm-GFP^(+).Donor-derived Lysm-GFP^(+)resident macrophages gradually became Lysm-GFP−in recipients and developed gene expression profiles characteristic of tissue-resident ***,Lysm may be used to distinguish newly formed and long-term surviving tissue-resident macrophages that were derived from bone marrow precursor cells in adult mice under pathological ***,we found that Irf4 might be essential for resident macrophage differentiation in all tissues,while cytokine and receptor pathways,mTOR signaling pathways,and fatty acid metabolic processes predominantly regulated the differentiation of Rpmacs,Kupffer cells,and kidney macrophages,*** in ST2,mechanistic target of rapamycin(mTOR)and fatty acid-binding protein 5(FABP5)differentially impaired the differentiation of tissue-resident macrophages from bone marrow-derived monocytes/macrophages in the lungs,liver,and *** results indicate that a combination of shared and unique signaling pathways coordinately shape tissue-resident macrophage differentiation in various tissues.

关键词： Tissue-resident macrophages Kupffer cells Lysozyme Inflammation Metabolism Cytokine

Regulatory Mechanisms of Lipid Metabolism

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Regulatory Mechanisms of Lipid Metabolism

CD146,a therapeutic target involved in cell plasticity

第四届中国生物物理学会代谢生物学分会学术研讨会

作者： ma xinran East China Normal University

＜正＞Adipose tissues and liver are major lipid metabolic organs. Imbalance of lipid synthesis and breakdown in adipose tissues and liver disrupts lipid homeostasis and leads to metabolic diseases, including obesity and non-alcoholic fatty liver. Our lab focuses on the identification of key lipid metabolic regulators in adipose tissues and livers that sense extracellular temperature and nutritional stress stimuli and internal factors such as aging and cellular senescence, with underlying mechanisms.

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来源： cnki会议评论

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Science China(Life Sciences) 2024年第8期67卷 1563-1578页

作者： Zhenzhen Wu Yuzhe Zang Chuyi Li Zhiheng He Jingyu Liu Zhaoqi Du xinran ma Lin Jing Hongxia Duan Jing Feng Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical ScienceZhengzhou 451163China Joint Laboratory of Nanozymes in Zhengzhou University School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China

Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair and regeneration,tumor progression,fibrosis disease,and *** research has revealed that CD146 is involved in various signaling pathways as a receptor or coreceptor in these *** correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis,prognosis,and targeted *** better comprehend the versatile roles of CD146,we have summarized its research history and synthesized findings from numerous reports,proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development,regeneration,and various *** CD146 would consequently halt cell state shifting during the onset and progression of these related ***,the development of therapy targeting CD146 holds significant practical value.

关键词： CD146 cell plasticity therapeutic target

A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome

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Cellular & Molecular Immunology 2023年第8期20卷 908-923页

作者： Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo xinran ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan Key Laboratory of Protein and Peptide Pharmaceutical Institute of BiophysicsChinese Academy of SciencesBejing 100101China Institute of Analysis and Testing Beijing Academy of Science and Technology(Bejing Center for Physical and Chemical Analysis)No.7 Fengxian Middle StreetHaidian DistrictBeijing 100094China Sino-Danish College University of Chinese Academy of SciencesBeijing100049China Laboratory of Proteomics Institute of BiophysicsChinese Academy of SciencesBeijingChina College of Life Sciences University of Chinese Academy of SciencesBeijing100049China Department of Interventional Oncology Beijing Ditan HospitalCapital Medical UniversityNo.8 Jingshun East StreetChaoyang DistrictBeijing100015China Joint Laboratory of Nanozymes in Zhengzhou University School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China

As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B.

关键词： Tumor-associated macrophages CD146 Inflammasome TMEM176B Tumor immunotherapy

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扁平句法与对言性——“自然书面语”视角

当代修辞学 2024年第4期 48-57页

作者：马欣然张伯江中国社会科学院大学文学院北京102488

本文从自然书面语角度观察汉语句法的扁平性,探究其后的对言性本质。首先观察了几种主要句法结构之间的可断可连现象,然后讨论了说明性句法背后的递系性关系和互文性语义呈现,最后描写和解释了几种充分语法化的典型对言格式的表达效力... 详细信息

本文从自然书面语角度观察汉语句法的扁平性,探究其后的对言性本质。首先观察了几种主要句法结构之间的可断可连现象,然后讨论了说明性句法背后的递系性关系和互文性语义呈现,最后描写和解释了几种充分语法化的典型对言格式的表达效力。这几项考察足以说明,对言语法的扁平观和互文观对我们观察语言的实际应用、理解句子的编码策略、感受语法与修辞的效力,都有极大的帮助。本文提倡对自然书面语要有足够的重视,因为它是汉语各种语体里最为自然、集中地反映汉语特点、表达准确而鲜明生动的常用语体。

关键词：扁平句法对言性自然书面语递系性互文性