The roles of zinc finger proteins in non-alcoholic fatty liver disease
作者机构：Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2020年第4卷第1期
页 面：35-39页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by funds from the National Natural Science Foundation of China(31770840 to X.Ma and 31800989 to L.Xu) the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(TP2017042 to X.Ma)
主 题：Non-alcoholic fatty liver disease(NAFLD) Hepatic steatosis Zinc finger proteins(ZFPs) Glioma-associated oncogene(GLI) Krüppel-like factor(KLF) Yin Yang 1(YY1) Mechanistic network
摘 要：Non-alcoholic fatty liver disease(NAFLD)is a common chronic disease characterized by excessive fat accumulation in hepatocytes in the absence of alcohol *** trends towards excessive calorie intake and sedentary life styles have increased the prevalence of NAFLD accompanied by obesity and type 2 ***,the molecular mechanisms underlying the initiation and progression of NAFLD are not *** finger proteins(ZFPs)are a superfamily of metalloproteins that contain zinc finger *** play diverse physiological roles in tissue homeostasis and also contribute to many pathological conditions,including metabolic,cardiovascular,and neurodegenerative diseases and various types of *** this review,we highlight our current knowledge of several ZFPs that play critical roles in the progression of NAFLD,describe their mechanistic functional networks,and discuss the potential for ZFPs as therapeutic targets for NAFLD.
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