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Experimental investigation of the thermally induced vibration of a space boom section

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Science China(Physics,Mechanics & Astronomy) 2015年第4期58卷 58-66页

作者： su xinming ZHANG JunHui WANG Jing BI YanQiang QIE DianFu XIANG ZhiHai XUE MingDe Beijing Institute of Spacecraft Environment Engineering College of Architecture and Civil Engineering North China University of Technology Science and Technology on Reliability and Environmental Engineering Laboratory Beijing Institute of Spacecraft Environment Engineering Key Laboratory of Applied Mechanics School of Aerospace Engineering Tsinghua University

Thermally induced vibration(TIV)is a typical failure of large-scale space *** paper reports a laboratory experiment that aims to investigate this unusual structural behavior of complex engineering *** the help of a Fourier finite element program,the fixing of a space boom section is well designed so that the TIV can be successfully *** the observed torsional vibration mode is different from the bending vibration mode predicted by the classic theory based on a simple beam model,it can be successfully explained by the general thermal structural interaction *** demonstrates the validity of the theoretical model and the necessity of using finite element program to analyze complex engineering structures.

关键词： thermal-structural interaction vibration experiment

组蛋白去乙酰化修饰在气道炎症性疾病中的研究进展

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国际呼吸杂志 2024年第8期44卷 971-977页

作者：陈贤玲孙佳敏白诗瑶苏新明中国医科大学附属第一医院呼吸与危重症医学科沈阳110001

组蛋白乙酰化酶和组蛋白去乙酰化酶(HDAC)共同调控组蛋白乙酰化修饰。HDAC及其抑制剂在慢性阻塞性肺疾病、支气管哮喘、肺部感染性疾病和急性肺损伤等气道炎症性疾病的病理生理过程中发挥重要作用。全面深入地探究HDAC与气道炎症性疾病... 详细信息

组蛋白乙酰化酶和组蛋白去乙酰化酶(HDAC)共同调控组蛋白乙酰化修饰。HDAC及其抑制剂在慢性阻塞性肺疾病、支气管哮喘、肺部感染性疾病和急性肺损伤等气道炎症性疾病的病理生理过程中发挥重要作用。全面深入地探究HDAC与气道炎症性疾病之间的联系,将为治疗气道炎症性疾病带来新突破。本综述重点总结HDAC在气道炎症性疾病中的综合分子机制和作用,并探讨其对气道炎症性疾病的治疗潜力。

关键词：肺疾病慢性阻塞性哮喘肺部感染性疾病急性肺损伤组蛋白去乙酰化酶

Th17/Treg免疫平衡治疗气道炎症的研究进展

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国际呼吸杂志 2024年第2期44卷 148-153页

作者：麻雪晴白诗瑶赵杰禹孙佳敏苏新明中国医科大学附属第一医院呼吸疾病研究所沈阳110001

辅助性T细胞17(Th17)和调节性T细胞(Treg)共同来自幼稚的CD4+T淋巴细胞。研究显示,在气道炎症中Th17细胞对炎症有促进作用,而Treg细胞抑制自身免疫。Th17和Treg细胞比例失衡会促使气道炎症的出现。因此,维持Th17/Treg细胞免疫平衡在气... 详细信息

辅助性T细胞17(Th17)和调节性T细胞(Treg)共同来自幼稚的CD4+T淋巴细胞。研究显示,在气道炎症中Th17细胞对炎症有促进作用,而Treg细胞抑制自身免疫。Th17和Treg细胞比例失衡会促使气道炎症的出现。因此,维持Th17/Treg细胞免疫平衡在气道炎症的治疗上至关重要。同时,一些影响这些细胞产生和维持的调节因子也很重要,包括T细胞受体信号、共刺激信号、细胞因子信号等。本文就Th17/Treg细胞与这些调节因子之间的平衡的功能、作用及其在慢性阻塞性肺疾病和支气管哮喘中的临床意义进行阐述。

关键词：哮喘肺疾病,慢性阻塞性辅助性T细胞17 T淋巴细胞,调节性平衡

Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation

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Chinese Medical Journal 2022年第17期135卷 2110-2112页

作者： Yuan Ren Menglu Li Shiyao Bai xinming su Department of Pulmonary and Critical Care Medicine Institute of Respiratory DiseasesThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Department of the First Comprehensive Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning 110001China

To the Editor:Bronchial asthma is a respiratory disease with pathological features that mainly comprise changes in airway inflammation,airway remodeling,and airway hyperresponsiveness.

关键词： inflammation asthma airway

Current insights into the oncogenic roles of lncRNA LINC00355

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Cancer Innovation 2023年第6期2卷 448-462页

作者： Jinze Shen xinming su Ming Pan Zehua Wang Yufei Ke Qurui Wang Jingyin Dong Shiwei Duan Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiangChina

Long noncoding RNAs(lncRNAs)are a class of nonprotein-coding transcripts that are longer than 200 ***00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various *** regulates the expression of downstream genes at both transcriptional and posttranscriptional levels,including eight microRNAs(miR-15a-5p,miR-34b-5p,miR-424-5p,miR-1225,miR-217-5p,miR-6777-3p,miR-195,and miR-466)and three protein-coding genes(ITGA2,RAD18,and UBE3C).LINC00355 plays a role in regulating various biological processes such as cell cycle progression,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and metastasis of cancer *** is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling *** of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival,recurrence-free survival,and disease-free ***00355 upregulation has been linked to several unfavorable clinical characteristics,including advanced tumor node metastasis and World Health Organization stages,reduced Karnofsky Performance Scale scores,increased tumor size,greater depth of invasion,and more extensive lymph node ***00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes,namely HMGA2,ABCB1,ITGA2,WNT10B,and CCNE1 *** summary,LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.

关键词： ceRNA chemotherapy resistance lncRNA LINC00355 miRNA prognosis

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三维机翼结冰模拟

航空学报 2011年第2期32卷 212-222页

作者：常士楠苏新明邱义芬北京航空航天大学航空科学与工程学院北京100191

针对机翼结冰问题,利用欧拉法求解空气水滴两相流流场,通过Fluent软件用户自定义函数功能编程求解三维机翼表面水滴局部收集系数以及结冰情况。在计算中,将水溢流方向沿机翼弦向和展向分解,以此对Messinger结冰热力学模型进行改进,使之... 详细信息

针对机翼结冰问题,利用欧拉法求解空气水滴两相流流场,通过Fluent软件用户自定义函数功能编程求解三维机翼表面水滴局部收集系数以及结冰情况。在计算中,将水溢流方向沿机翼弦向和展向分解,以此对Messinger结冰热力学模型进行改进,使之更符合三维情况,并在此基础上进行三维传质传热分析;修正传统的二维表面对流换热系数求解方法,得到求解三维表面对流换热系数的改进方法。采用沿壁面法向结冰的方式进行冰生长计算,通过与国外冰风洞试验结果及结冰计算软件LEWICE结果的比较,证明本文三维结冰计算方法是正确的。

关键词：机翼结冰结冰模拟欧拉法对流换热系数三维水滴撞击特性

Design of Assembled PCB Imaging System Based on Laser Triangulation

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Aerospace China 2021年第4期22卷 28-34页

作者： LIU Qingfeng LI Bo WANG Qi ZHAO Sheng AN Wanqing su xinming LIU Xiaoning ZHU Xi School of Astronautics Harbin Institute of TechnologyHarbin 150001 Beijing Institute of Spacecraft Environment Engineering Beijing 100094

With the increasing miniaturisation and integration of electronic products and the increase of heat, it is necessary to design and introduce heat sinks and install fans. The volume of electronic components, especially the height, is very important for the structural and thermal design of electronic devices. This paper presents a design scheme of an online height measurement device based on laser triangulation and commercial charge coupled device(CCD). It analyzes the principles of electronic component height measurement, and expounds the composition and working principle of the laser measurement system. In addition, the commonly used methods to determine the center position are compared and analysed. These methods include circle fitting, gray centroid and extension method or Gaussian fitting. These methods usually lead to different results. The experimental results show that the fitting speed of the gray centroid is faster. The 3 D model of components is given through measurement, and the error factors affecting measurement are analysed.

关键词： laser triangulation electronic component height assembled PCB

Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang su Tao Wang Juying Lin Wei sun Xiaodong Hu Guohua Zhang xinming Wang Ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

呼出气一氧化氮检测与稳定期慢性阻塞性肺疾病患者小气道改变及预后的相关性

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中国医科大学学报 2023年第1期52卷 12-17页

作者：崔可慧苏新明中国医科大学附属第四医院第一呼吸与危重症医学科沈阳110034 中国医科大学附属第一医院呼吸与危重症医学科沈阳110001

目的分析呼出气一氧化氮(FeNO)检测与稳定期慢性阻塞性肺疾病(COPD)患者小气道改变及预后的相关性。方法收集156例稳定期COPD患者的临床资料,分析患者FeNO与第1秒用力肺活量占预计值的百分比(FEV1%pred)、FEV1与用力肺活量(FVC)的比值(F... 详细信息

目的分析呼出气一氧化氮(FeNO)检测与稳定期慢性阻塞性肺疾病(COPD)患者小气道改变及预后的相关性。方法收集156例稳定期COPD患者的临床资料,分析患者FeNO与第1秒用力肺活量占预计值的百分比(FEV1%pred)、FEV1与用力肺活量(FVC)的比值(FEV1/FVC)及小气道改变[25%肺活量时的最大呼气流速占预计值百分比(MEF25%pred)、50%肺活量时的最大呼气流速占预计值百分比(MEF50%pred)、75%肺活量时的最大呼气流速占预计值百分比(MEF75%pred)]的相关性。根据受试者操作特征曲线评估FeNO诊断稳定期重度COPD的截断值,将156例COPD患者分为高FeNO组与低FeNO组,比较随访12个月内急性加重次数和未急性加重生存时间的差异。结果Pearson相关分析显示,稳定期COPD患者中FeNO与FEV1%pred FEV1/FVC、MEF25%pred、MEF50%pred、MEF75%pred均呈明显负相关(P<0.001)。随访12个月内,高FeNO组急性加重次数明显高于低FeNO组(P<0.001),其未急性加重生存时间明显低于低FeNO组(P<0.001)。结论FeNO与稳定期COPD小气道改变密切相关,能辅助判断患者急性加重情况。

关键词：慢性阻塞性肺疾病呼出气一氧化氮小气道急性加重