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不同中医证型非酒精性脂肪性肝病患者外周血Th17/Treg水平及相关性研究

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中国中西医结合消化杂志 2024年第4期32卷 328-334页

作者：袁星星高婷婷高佳炜杨柳欣雷智勇张雅丽黑龙江省中医药科学院哈尔滨150040 黑龙江中医药大学张雅丽全国名老中医药专家传承工作室

目的分析不同中医证型非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)与外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)的相关性。方法收集100例2022年1月—2023年4月就诊的NAFLD患者,根据中医辨证分为5个不同的中医证型... 详细信息

目的分析不同中医证型非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)与外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)的相关性。方法收集100例2022年1月—2023年4月就诊的NAFLD患者,根据中医辨证分为5个不同的中医证型组,另选取15例健康受试者作为对照组。分别检测各组受试者的肝功能、血脂、血糖、BMI、受控衰减参数(controlled attenuation parameter,CAP)值、外周血Th17/Treg和细胞因子水平,并通过Pearson检验分析病情指数与外周血T淋巴细胞水平的相关性。结果相关性分析结果显示,NAFLD患者的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰基转移酶(GGT)、碱性磷酸酶(ALP)、总胆固醇(TC)、甘油三酯(TG)、BMI、空腹血糖(FBG)、CAP、IL-17、IL-22水平与Th17水平呈正相关(P<0.05),而与Treg水平呈负相关(P<0.05)。与对照组比较,NAFLD患者的AST、ALT、GGT、ALP、TC、TG、BMI、FBG、CAP、IL-17、IL-22、Th17水平和Th17/Treg比值显著升高,IL-10和Treg水平显著降低(P<0.05)。不同中医证型NAFLD患者的各项指标比较,AST、ALT、GGT、ALP、TC、TG、BMI、FBG、CAP、IL-17、IL-22、Th17水平和Th17/Treg比值按证型排序,从高到低依次为湿热蕴结证组、痰瘀互结证组、湿浊内停证组、脾肾两虚证组和肝郁脾虚证组;而不同中医证型中,Treg水平的排序则相反。结论NAFLD患者的中医证型与Th17/Treg平衡呈现一定的相关性,其中以湿热蕴结证患者Th17水平最高。

关键词：非酒精性脂肪性肝病中医证型辅助性T细胞17 调节性T细胞

Hydrogen sulfide-linked persulfidation of ABI4 controls ABA responses through the transactivation of MAPKKK18 in Arabidopsis

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Molecular Plant 2021年第6期14卷 921-936页

作者： Mingjian Zhou Jing Zhang Jie Shen Heng Zhou Didi Zhao Cecilia Gotor Luis CRomero Ling Fu Zongmin Li Jing Yang Wenbiao Shen xingxing yuan Yanjie Xie Laboratory Center of Life Sciences College of Life SciencesNanjing Agricultural UniversityNanjing 210095PR China Instituto de Bioquímica Vegetal y Fotosíntesis Consejo Superior de Investigaciones Científicas y Universidad de SevillaAvenida Américo Vespucio 4941092 SevillaSpain State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences BeijingBeijing Institute of LifeomicsBeijing 102206China Institute of Industrial Crops Jiangsu Academy of Agricultural SciencesNanjing 210014China

Hydrogen sulfide(H2S)is a signaling molecule that regulates plant hormone and stress *** phytohormone abscisic acid(ABA)plays an important role in plant adaptation to unfavorable environmental conditions and induces the persulfidation of L-CYSTEINE DESULFHYDRASE1(DES1)and the production of H2S in guard ***,it remains largely unclear how H2S and protein persulfidation participate in the relay of ABA *** this study,we discovered that ABSCISIC ACID INSENSITIVE 4(ABI4)acts downstream of DES1 in the control of ABA responses in ***4 undergoes persulfidation at Cys250 that is triggered in a time-dependent manner by ABA,and loss of DES1 function impairs this ***250 and its persulfidation are essential for ABI4 function in the regulation of plant responses to ABA and the H2S donor NaHS during germination,seedling establishment,and stomatal closure,which are abolished in the ABI4Cys250Ala mutated *** of the ABI4Cys250Ala variant into the abi4 des1 mutant did not rescue its hyposensitivity to ***250 is critical for the binding of ABI4 to its cognate motif in the promoter of Mitogen-Activated Protein Kinase Kinase Kinase 18(MAPKKK18),which propagates the MAPK signaling cascade induced by ***,the DES1-mediated persulfidation of ABI4 enhances the transactivation activity of ABI4 toward MAPKKK18,and ABI4 can bind the DES1 promoter,forming a regulatory *** together,these findings advance our understanding of a post-translational regulatory mechanism and suggest that ABI4 functions as an integrator of ABA and MAPK signals through a process in which DES1-produced H2S persulfidates ABI4 at Cys250.

关键词： hydrogen sulfide persulfidation DES1 ABI4 MAPKXK18 transactivation ABA response

柴郁清肝汤治疗非酒精性脂肪性肝病肝郁脾虚证患者的疗效观察及对Th17/Treg和相关炎症因子的影响

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中国中医药科技 2024年第2期31卷 196-199页

作者：张雅丽雷智勇高婷婷高佳炜杨柳欣袁星星黑龙江省中医药科学院黑龙江哈尔滨150036 张雅丽名老中医药专家工作室黑龙江哈尔滨150006 黑龙江中医药大学黑龙江哈尔滨150040

目的:观察柴郁清肝汤治疗非酒精性脂肪性肝病(NAFLD)肝郁脾虚证患者的临床疗效及对外周血Th17/Treg和相关炎症因子的影响。方法:将60例NAFLD患者随机分为观察组(30例)和对照组(30例),其中观察组给予柴郁清肝汤治疗,对照组给予维生素E软... 详细信息

目的:观察柴郁清肝汤治疗非酒精性脂肪性肝病(NAFLD)肝郁脾虚证患者的临床疗效及对外周血Th17/Treg和相关炎症因子的影响。方法:将60例NAFLD患者随机分为观察组(30例)和对照组(30例),其中观察组给予柴郁清肝汤治疗,对照组给予维生素E软胶囊治疗,治疗8周评价疗效;分别观察2组患者治疗前后肝功、血脂、外周血T淋巴细胞Th17、Treg的百分比及其相关炎症因子(IL-17、IL-22、IL-10)的变化。结果:治疗8周,观察组显效16例,有效12例,对照组显效8例,有效13例,2组比较差异具有统计学意义(P<0.05)。与治疗前比较,2组患者ALT、AST、GGT、ALP、TC、TG、LDL-C、Th17、IL-17和IL-22明显降低,Treg明显升高,差异具有统计学意义(P<0.05),2组间比较观察组均明显优于对照组(P<0.05)。结论:柴郁清肝汤能够有效治疗NAFLD患者,改善肝功能和血脂,调节Th17/Treg平衡及其相关炎性因子分泌是其作用机制之一。

关键词：非酒精性脂肪性肝病肝郁脾虚维生素E 柴郁清肝汤肝功能血脂 IL-17 IL-22 IL-10 辅助性T细胞17 调节性T细胞

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高产早熟夏大豆新品种苏夏18的选育

大豆科技 2024年第3期 51-54页

作者：黄璐张晓燕王书维袁星星陈新王润东薛晨晨江苏省农业科学院经济作物研究所南京210014

苏夏18是江苏省农业科学院经济作物研究所和南京沃蔬种业有限公司以苏7209为母本,皖豆2407为父本进行有性杂交,经系谱法选育而成的高产早熟夏大豆新品种。2019—2020年参加淮南夏大豆省农科院科企联合体区域试验,2年平均产量为2981.13 k... 详细信息

苏夏18是江苏省农业科学院经济作物研究所和南京沃蔬种业有限公司以苏7209为母本,皖豆2407为父本进行有性杂交,经系谱法选育而成的高产早熟夏大豆新品种。2019—2020年参加淮南夏大豆省农科院科企联合体区域试验,2年平均产量为2981.13 kg/hm^(2),较对照品种苏豆13平均增产5.09%。2020年参加淮南夏大豆省农科院科企联合体生产试验,平均产量为2854.32 kg/hm^(2),较对照品种苏豆13增产6.47%。该品种高产、早熟、籽粒大、商品性佳,平均生育期92.3 d,百粒重29.3 g,粗蛋白质含量为44.9%,粗脂肪含量为18.6%,适宜江苏淮南地区夏播种植。2021年通过江苏省农作物品种审定委员会审定,审定编号为苏审豆20210016。

关键词：苏夏18 大豆选育高产早熟

Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling

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Molecular Plant 2022年第4期15卷 651-670页

作者： Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen xingxing yuan Yanjie Xie Laboratory Center of Life Sciences College of Life SciencesNanjing Agricultural UniversityNanjing 210095PR China Institute for Biology and Biotechnology of Plants University of Muenster48149 MuensterGermany State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center 17 for Protein SciencesBeijingBeijing Institute of LifeomicsBeijing 102206China Institute of Industrial Crops Jiangsu Academy of Agricultural SciencesNanjing 210014China

Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses.

关键词： GPX1 SOH oxidative stress acetylation ZIP68 transactivation

Wulong Xiaozheng Wan medicated serum inhibits epithelial-mesenchymal transition in human gastric carcinoma cell line BGC823 by modulation of transforming growth factor-β1/Smad signaling

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Journal of Traditional Chinese Medicine 2019年第3期39卷 380-392页

作者： Zhang Yali Wang Bingyu Guo Xueying Yang Lei Li Dandan yuan xingxing Department of Gastroenterology Nangang branch of Heilongjiang Academy of Traditional Chinese Medicine Harbin 150006 China Pharmacological Laboratory of Heilongjiang Academy of Traditional Chinese Medicine Harbin 150036China

OBJECTIVE:To evaluate the effect of Wulong Xiaozheng Wan medicated serum on the epithelial-mesenchymal transition (EMT) of BGC823 cell induced by transforming growth factor-β,(TGF-β,) and to explore its ***:EMT model of BGC823 was stimulated by TGF-β*** Xiaozheng Wan medicated serum and LY-364947 were used as *** proliferation and adhesion of BGC823 were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide and flow cytometry was used to detect the *** invasion and migration were detected by *** level of matrix metalloproteins was detected by enzyme-linked immunosorbent *** expressions of related proteins and mRNA of EMT marker and TGF-β1/Smad signal pathway were detected by Western blot and reverse transcription-polymerase chain ***:Compared with the TGF-β1 group,Wulong Xiaozheng Wan medicated serum could inhibit the ability of proliferation,heterogeneous adhesion,invasion,and *** also promotes apoptosis and homotypic adhesion in BGC823,with a dose-dependent ***,Wulong Xiaozheng Wan medicated serum could regulate the expression of related proteins and mRNA of TGF-β1/Smad signaling pathway,and inhibit the expressions of EMT transcription factors and EMT ***:Wulong Xiaozheng Wan medicated serum inhibited epithelial-mesenchymal transition by down-regulated the expression of TβRI and the activation of TGF-β1/Smad signaling pathway.

关键词： Transforming growth factor beta1 Smad proteins Signal transduction Epithelial-mesenchymal transition Matrix metalloproteinases,secreted BGC823 cell Wulong Xiaozheng Wan

Comparative transcriptome analysis of the mungbean flowers from a new anther and stigma exsertion mutant and wild type

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Comparative transcriptome analysis of the mungbean flowers f...

Disease-resistant transgenic adzuki bean plants obtained through an efficient transformation system

第十四届全国植物基因组学大会

作者： Xiaoyan Cui Peerasak Srinives xingxing yuan Xin Chen Institute of Vegetable Crops Jiangsu Academy of Agricultural Sciences

The mungbean is cleistogamy,in which hybrid seed production is low due to the stigma and anthers not *** development of mungbean flower mechanism helps to improve the yield of mung bean by researching mungbean anther ... 详细信息

关键词： mungbean anther and stigma exposed mutant transcriptome floral

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Disease-resistant transgenic adzuki bean plants obtained thr...

中国作物学会2013年学术年会

作者： Huatao Chen Xin Chen Heping Gu xingxing yuan Hongmei Zhang Xiaoyan Cui Institute of Vegetable Crops Jiangsu Academy of Agricultural Sciences

An efficient regeneration and transformation system was established and optimized for adzuki bean(Vigna angularis *** & Ohashi).6-Benzylaminopurine at 5 mg l

关键词： Epicotyl Regeneration Vigna angularis Co-cultivation

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平板运动试验与冠心病诊断的关系

中国现代医学杂志 2009年第15期19卷 2321-2322,2326页

作者：袁星星罗国庆广东医学院附属深圳南山医院心电图室广东深圳518021

目的探讨平板运动试验阳性者在冠心病疾病诊断中的临床意义。方法回顾分析160例平板运动试验阳性者的冠状动脉造影结果,从而评估运动试验阳性者通过冠状动脉造影诊断为冠心病所占的比例。结果冠脉造影阳性108例,占67.5%。平板运动阳性... 详细信息

目的探讨平板运动试验阳性者在冠心病疾病诊断中的临床意义。方法回顾分析160例平板运动试验阳性者的冠状动脉造影结果,从而评估运动试验阳性者通过冠状动脉造影诊断为冠心病所占的比例。结果冠脉造影阳性108例,占67.5%。平板运动阳性伴胸痛98例中,冠脉造影阳性85例(86.7%),平板运动阳性不伴典型胸痛症状62例,冠脉造影阳性23例(37.1%)。两组阳性率差异有显著性(P<0.001)。结论在排除继发性ST-T改变的前提下,运动试验对冠心病的诊断有一定参考价值,但仍须慎重,应结合临床、患者症状等多方面进行综合分析。

关键词：运动试验冠心病诊断