检索结果-南通市图书馆

Joint Biomedical Entity and Relation Extraction Based on Multi-Granularity Convolutional Tokens Pairs of Labeling

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第9期80卷 4325-4340页

作者： Zhaojie Sun Linlin xing Longbo zhang Hongzhen cai Maozu Guo Department of Computer Science and Technology Shandong University of TechnologyZibo255000China Department of Agricultural Engineering and Food Science Shandong University of TechnologyZibo255000China Department of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Extracting valuable information frombiomedical texts is one of the current research hotspots of concern to a wide range of *** biomedical corpus contains numerous complex long sentences and overlapping relational triples,making most generalized domain joint modeling methods difficult to apply effectively in this *** a complex semantic environment in biomedical texts,in this paper,we propose a novel perspective to perform joint entity and relation extraction;existing studies divide the relation triples into several steps or ***,the three elements in the relation triples are interdependent and inseparable,so we regard joint extraction as a tripartite classification *** the same time,fromthe perspective of triple classification,we design amulti-granularity 2D convolution to refine the word pair table and better utilize the dependencies between biomedical word ***,we use a biaffine predictor to assist in predicting the labels of word pairs for relation *** model(MCTPL)Multi-granularity Convolutional Tokens Pairs of Labeling better utilizes the elements of triples and improves the ability to extract overlapping triples compared to previous ***,we evaluated our model on two publicly accessible *** experimental results show that our model’s ability to extract relation triples on the CPI dataset improves the F1 score by 2.34%compared to the current optimal *** the DDI dataset,the F1 value improves the F1 value by 1.68%compared to the current optimal *** model achieved state-of-the-art performance compared to other baseline models in biomedical text entity relation extraction.

关键词： Deep learning biomedical joint extraction triple classification multi-granularity 2D convolution

Experimental and theoretical analysis of loading characteristics of electret filter media for charged particles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第10期93卷 87-98页

作者： Yiqi cai Rongrong cai Lizhi zhang Key Laboratory of Enhanced Heat Transfer and Energy Conservation of Education Ministry School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou510640China State Key Laboratory of Subtropical Building Science South China University of TechnologyGuangzhou510640China

The degradation of filtration performance in electret filter media during usage poses a significant challenge. Pre-charging of aerosols has been identified as an effective method to mitigate this issue. However, the effects of particle charging characteristics on the loading characteristics of electret filters still need a comprehensive understanding. In this study, a needle-cylinder corona charger was employed to pre-charge aerosols, and the particle charge state was determined by multiphysics simulation. The effects of particle charge polarity and charge quantity on the loading performance of the electret filter were quantitatively investigated. The results showed that the particle charge polarity had a negligible impact on the loading performance under the condition of the equivalent particle charge quantity. In addition, the charged particles effectively improved the efficiency degradation during the loading process of electret media, with higher charge quantities resulting in more pronounced improvements. The electrostatic attenuation factor showed a negative exponential correlation with the particle charge quantity. This was attributed to the uneven particle deposition on fiber surface due to the attraction of charged particles by the opposite charges on the electret fibers, which alleviated the effect of electrostatic shielding.

关键词： Electret filter Charged particles Loadingcharacteristic Corona charging Electrostatic screening

Value Iteration-Based Cooperative Adaptive Optimal Control for Multi-Player Differential Games With Incomplete Information

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： Yun zhang Lulu zhang Yunze cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration

SimHOEPI:A resampling simulator for generating single nucleotide polymorphism data with a high-order epistasis model

在线全文

学校读者我要写书评

暂无评论

Quantitative Biology 2024年第2期12卷 197-204页

作者： Yahan Li Xinrui cai Junliang Shang Yuanyuan zhang Jin-xing Liu School of Computer Science Qufu Normal UniversityRizhaoChina School of Information and Control Engineering Qingdao University of TechnologyQingdaoChina School of Health and Life Sciences University of Health and Rehabilitation SciencesQingdaoChina

Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex *** data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data *** this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data *** of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different *** results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.

关键词： high-order epistasis model penetrance table resampling strategy simulation single nucleotide polymorphisms

Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease(GSD)mouse model

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 38-50页

作者： Dongfang zhang Hao XU Chi QIN Kangming cai Jing zhang Xinqiu XIA Jingwen BI Li zhang Lianping xing Qianqian LIANG Wensheng WANG Laboratory of Molecular Medicine College of Life Science and State Key Laboratory of Cell Differentiation and RegulationHenan Normal UniversityXinxiang453007China Longhua Hospital&Spine Institute Shanghai University of Traditional Chinese MedicineShanghai200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai201203China Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochester14642USA

Gorham-Stout disease(GSD)is a sporadic chronic disease characterized by progressive bone dissolution,absorption,and disappearance along with lymphatic vessel infiltration in bone-marrow *** the osteolytic mechanism of GSD has been widely studied,the cause of lymphatic hyperplasia in GSD is rarely *** this study,by comparing the RNA expression profile of osteoclasts(OCs)with that of OC precursors(OCPs)by RNA sequencing,we identified a new factor,semaphorin 3A(Sema3A),which is an osteoprotective factor involved in the lymphatic expansion of *** to OCPs,OCs enhanced the growth,migration,and tube formation of lymphatic endothelial cells(LECs),in which the expression of Sema3A is low compared to that in *** the presence of recombinant Sema3A,the growth,migration,and tube formation of LECs were inhibited,further confirming the inhibitory effect of Sema3A on LECs in *** an LEC-induced GSD mouse model,the effect of Sema3A was examined by injecting lentivirus-expressing Sema3A into the tibiae in *** found that the overexpression of Sema3A in tibiae suppressed the expansion of LECs and alleviated bone loss,whereas the injection of lentivirus expressing Sema3A short hairpin RNA(shRNA)into the tibiae caused GSD-like *** staining further demonstrated that OCs decreased and osteocalcin increased after Sema3A lentiviral treatment,compared with the *** on the above results,we propose that reduced Sema3A in OCs is one of the mechanisms contributing to the pathogeneses of GSD and that expressing Sema3A represents a new approach for the treatment of GSD.

关键词： Semaphorin 3A Gorham-Stout disease Osteoclast Osteolysis Lymphatic endothelial cell

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： Ji zhang Tong zhang Qiao An Peng zhang cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-xing Hu Xiao-Jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou Province Guiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

Exceptional Early Jurassic fossils with leathery eggs shed light on dinosaur reproductive biology

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第6期11卷 146-158页

作者： Fenglu Han Yilun Yu Shukang zhang Rong Zeng Xinjin Wang Huiyang cai Tianzhuang Wu Yingfeng Wen Sifu cai Chun Li Rui Wu Qi Zhao xing Xu School of Earth Sciences China University of Geosciences (Wuhan) Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of Sciences University of Chinese Academy of Sciences Guizhou Provincial Museum Guizhou Provincial Institute of Cultural Relics and Archaeology Pingba Institute of Cultural Relics Administration Centre for Vertebrate Evolutionary Biology Yunnan University

Our understanding of pre-Cretaceous dinosaur reproduction is hindered by a scarcity of evidence within fossil records. Here we report three adult skeletons and five clutches of embryo-containing eggs of a new sauropodomorph from the Lower Jurassic of southwestern China, displaying several significant reproductive features that are either unknown or unlike other early-diverging sauropodomorphs, such as relatively large eggs with a relatively thick calcareous shell formed by prominent mammillary cones, synchronous hatching and a transitional prehatching posture between the crocodilians and living birds. Most significantly,these Early Jurassic fossils provide strong evidence for the earliest known leathery eggs. Our comprehensive quantitative analyses demonstrate that the first dinosaur eggs were probably leathery, elliptical and relatively small, but with relatively long eggshell units, and that along the line to living birds, the most significant change in reptilian egg morphology occurred early in theropod evolution rather than near the origin of Aves.

关键词： dinosaur sauropodomorph Jurassic embryo egg evolution reproductive behavior

An optimization-oriented modeling approach using input convex neural networks and its application on optimal chiller loading

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第4期17卷 639-655页

作者： Shanshuo xing Jili zhang Song Mu Dalian University of Technology Dalian116024China Guangdong Airport Baiyun Information Technology Co. Ltd.Guangzhou510000China

Optimization for the multi-chiller system is an indispensable approach for the operation of highly efficient chiller *** optima obtained by model-based optimization algorithms are dependent on precise and solvable objective *** classical neural networks cannot provide convex input-output mappings despite capturing impressive nonlinear fitting capabilities,resulting in a reduction in the robustness of model-based *** this paper,we leverage the input convex neural networks(ICNN)to identify the chiller model to construct a convex mapping between control variables and the objective function,which enables the NN-based OCL as a convex optimization problem and apply it to multi-chiller optimization for optimal chiller loading(OCL).Approximation performances are evaluated through a four-model comparison based on an experimental data set,and the statistical results show that,on the premise of retaining prior convexities,the proposed model depicts excellent approximation power for the data set,especially the unseen ***,the ICNN model is applied to a typical OCL problem for a multi-chiller system and combined with three types of optimization *** with conventional and meta-heuristic methods,the numerical results suggest that the gradient-based BFGS algorithm provides better energy-saving ratios facing consecutive cooling load inputs and an impressive convergence speed.

关键词： chiller plant input convex neural network optimal load distribution convex optimization

Numerical simulation study on the hygrothermal performance of building exterior walls under dynamic wind-driven rain condition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第2期17卷 207-221页

作者： xing Hu Huibo zhang Hui Yu School of Design Shanghai Jiao Tong UniversityShanghai200240China

Wind-driven rain(WDR)has a significant influence on the hygrothermal performance,durability,and energy consumption of building *** calculation of WDR loads using semi-empirical models has been incorporated into the boundary conditions of coupled heat and moisture transfer ***,prior research often relied on fixed WDR absorption ratio,which fail to accurately capture the water absorption characteristics of porous building materials under rainfall ***,this study aims to investigate the coupled heat and moisture transfer of exterior walls under dynamic WDR boundary conditions,utilizing an empirically obtained WDR absorption ratio model based on field *** developed coupled heat and moisture transfer model is validated against the HAMSTAD *** findings reveal that the total WDR flux calculated with the dynamic WDR boundary is lower than that obtained with the fixed WDR boundary,with greater disparities observed in orientations experiencing higher WDR *** variations in moisture flow significantly impact the surface temperature and relative humidity of the walls,influencing the calculation of cooling and heating loads by different *** to the transient heat transfer model,the coupled heat and moisture transfer model incorporating dynamic WDR boundary exhibits maximum increases of 17.6%and 16.2%in cooling and heating loads,*** dynamic WDR boundary conditions provide more precise numerical values for surface moisture flux,offering valuable insights for the thermal design of building enclosures and load calculations for HVAC systems.

关键词： wind-driven rain building component hygrothermal model transient simulation cooling and heating loads