检索结果-南通市图书馆

Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease(GSD)mouse model

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 38-50页

作者： Dongfang ZHANG Hao XU Chi QIN Kangming CAI Jing ZHANG Xinqiu XIA Jingwen BI Li ZHANG Lianping xing Qianqian LIANG Wensheng WANG Laboratory of Molecular Medicine College of Life Science and State Key Laboratory of Cell Differentiation and RegulationHenan Normal UniversityXinxiang453007China Longhua Hospital&Spine institute Shanghai University of Traditional Chinese MedicineShanghai200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai201203China department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochester14642USA

Gorham-Stout disease(GSD)is a sporadic chronic disease characterized by progressive bone dissolution,absorption,and disappearance along with lymphatic vessel infiltration in bone-marrow *** the osteolytic mechanism of GSD has been widely studied,the cause of lymphatic hyperplasia in GSD is rarely *** this study,by comparing the RNA expression profile of osteoclasts(OCs)with that of OC precursors(OCPs)by RNA sequencing,we identified a new factor,semaphorin 3A(Sema3A),which is an osteoprotective factor involved in the lymphatic expansion of *** to OCPs,OCs enhanced the growth,migration,and tube formation of lymphatic endothelial cells(LECs),in which the expression of Sema3A is low compared to that in *** the presence of recombinant Sema3A,the growth,migration,and tube formation of LECs were inhibited,further confirming the inhibitory effect of Sema3A on LECs in *** an LEC-induced GSD mouse model,the effect of Sema3A was examined by injecting lentivirus-expressing Sema3A into the tibiae in *** found that the overexpression of Sema3A in tibiae suppressed the expansion of LECs and alleviated bone loss,whereas the injection of lentivirus expressing Sema3A short hairpin RNA(shRNA)into the tibiae caused GSD-like *** staining further demonstrated that OCs decreased and osteocalcin increased after Sema3A lentiviral treatment,compared with the *** on the above results,we propose that reduced Sema3A in OCs is one of the mechanisms contributing to the pathogeneses of GSD and that expressing Sema3A represents a new approach for the treatment of GSD.

关键词： Semaphorin 3A Gorham-Stout disease Osteoclast Osteolysis Lymphatic endothelial cell

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-xing Hu Xiao-Jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou Province Guiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2.and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

Intelligent decision-making method for vehicles in emergency conditions based on artificial potential fields and finite state machines

在线全文

学校读者我要写书评

暂无评论

Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2024年第1期7卷 19-29页

作者： Xunjia Zheng Huilan Li Qiang Zhang Yonggang Liu xing Chen Hui Liu Tianhong Luo Jianjie Gao Lihong Xia china Automotive Engineering Research institute Co. Ltd.Chongqing 401122China School of Intelligent Manufacturing Engineering Chongqing University of Arts and SciencesChongqing 402160China department of Information and Intelligence Engineering Chongqing City Vocational CollegeChongqing 402160China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Intelligent Policing Key Laboratory of Sichuan Province Luzhou 646000China

This study aims to propose a decision-making method based on artificial potential fields(APFs)and finite state machines(FSMs)in emergency *** study presents a decision-making method based on APFs and FSMs for emergency *** modeling the longitudinal and lateral potential energy fields of the vehicle,the driving state is identified,and the trigger conditions are provided for path planning during lane *** addition,this study also designed the state transition rules based on the longitudinal and lateral virtual *** established the vehicle decision-making model based on the finite state machine to ensure driving safety in emergency *** illustrate the performance of the decision-making model by considering APFs and finite state *** version of the model in the co-simulation platform of MATLAB and CarSim shows that the developed decision model in this study accurately generates driving behaviors of the vehicle at different time *** contributions of this study are two-fold.A hierarchical vehicle state machine decision model is proposed to enhance driving safety in emergency *** models for determining the transition thresholds of lateral and longitudinal vehicle states are established based on the vehicle potential field model,leading to the formulation of transition rules between different states of autonomous vehicles(AVs).

关键词： decision-making artificial potential field finite state machines emergency conditions autonomous driving

多晶体金属疲劳寿命随晶粒尺寸变化的理论研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理学报 2003年第8期52卷 2092-2095页

作者：李眉娟胡海云邢修三北京理工大学应用物理系北京100081

在疲劳断裂非平衡统计理论框架的基础上 ,根据界面能模型 ,推导出了多晶体金属的疲劳寿命随晶粒尺寸、应变振幅的变化公式 .还与有关实验结果进行了比较 ,发现理论与实验较为相符 .

关键词：多晶体金属疲劳寿命晶粒尺寸疲劳断裂非平衡统计理论界面能模型应变振幅

“Saturate packing and uniform packing”,structural characters in lanthanide and actinide coordination compounds

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1985年第3期3卷 285-289页

作者： LI xing-Fu FENG Xi-Zhang XU Ying-Ting Application department,The {2. of High Energy physics,Academia Sinica,beijing,P.O.Box 2.32.SUN Peng-Nian The University of Science and technology of china,Hefei SHI Jie Petroleum School,Tian Jing University,Tianjing Application department The Institute of High Energy Physics Academia Sinica Beijing P. O. Box 2732 The University of Science and technology of china Hefei Petroleum School Tian Jing University Tianjing

In structural chemistry,it has been well accepted that,besides orbital interactions,geo-metrical factors *** and shape of the bonded atoms and groups,may also play ***,a quantitative study of these factors has long been *** the point that steric effects should become more remarkable in weak bond compounds,it is expected that coordination and organometallic chemistry of f-group elements,owing totheir low CFSE and high coordination numbers,and also to their poor directionality of ioniccharacter,is assumed to be an appropriate field for study on steric effects while a rapid de-

关键词： Li Saturate packing and uniform packing structural characters in lanthanide and actinide coordination compounds

Saturation Estimation with Complex Electrical Conductivity for Hydrate-Bearing Clayey Sediments:An Experimental Study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of china 2024年第1期23卷 173-189页

作者： xing Lanchang ZHANG Shuli ZHANG Huanhuan WU Chenyutong WANG Bin LAO Liyun WEI Wei HAN Weifeng WEI Zhoutuo GE Xinmin DENG Shaogui College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China School of Water Energy and EnvironmentCranfield UniversityCranfield MK430ALUnited Kingdom department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Clays have considerable influence on the electrical properties of hydrate-bearing *** is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(S_(h))models for reservoir evaluation and *** electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 *** effects of clay and Sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(EDL),*** quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in *** the in-phase conductivity and quadrature conductivity decrease consistently with increasing Sh from 0.50 to *** sets of models for Sh evaluation were *** model based on the Simandoux equation outperforms Archie’s formula,with a root-mean-square error(E_(RMS))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase *** fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(E_(RMS)=11.6%and 13.2.,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two *** second-order Cole-Cole formula can be used to fit the complex-conductivity *** pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict S_(h) with an E_(RMS) of 5.05%and 9.05%,respectively.

关键词： gas hydrate complex electrical conductivity hydrate-bearing clayey sediment hydrate saturation Simandoux equation frequency dispersion Cole-Cole formula

Is appendoscope a new option for the treatment of acute appendicitis?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第28期30卷 3386-3392页

作者： Shu-Jiong Feng Yi-Feng Zhou Jian-Feng Yang Hong-Zhang Shen Guang-xing Cui Xiao-Feng Zhang department of Gastroenterology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310000Zhejiang ProvinceChina department of Gastroenterology Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang ProvinceHangzhou 310000Zhejiang ProvinceChina department of Gastroenterology Hangzhou Institute of Digestive DiseasesHangzhou 310000Zhejiang ProvinceChina

Acute appendicitis is a common surgical *** is commonly caused by obstruction of the appendiceal lumen due to fecaliths,tumors,or lymphoid *** over a century,appendectomy has been the primary treatment for acute *** Groves performed the first open appendectomy in *** 1983,Kurt Semm completed the first laparoscopic appendectomy,heralding a new era in ***,appendectomy is associated with certain complications and a rate of negative *** have suggested controversy over the impact of appendectomy on the development of inflammatory bowel disease and Parkinson’s disease,but an increasing number of studies indicate a possible positive correlation between appendectomy and colorectal cancer,gallstones,and cardiovascular *** the recognition that the appendix is not a vestigial organ and the advancement of endoscopic technology,Liu proposed the endoscopic retrograde appendicitis *** is an effective minimally invasive alternative for treating uncomplicated acute *** team has developed an appendoscope with a disposable digital imaging system operated through the biopsy channel of a colonoscope and successfully applied it in the treatment of *** article provides an overview of the progress in endoscopic treatment for acute appendicitis and offers a new perspective on the future direction of appendiceal disease treatment.

关键词： Acute appendicitis Endoscopic technology Endoscopic retrograde appendicitis therapy Appendoscope Appendiceal disease treatment

High Efficiency ELID Grinding of Garnet Ferrite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

厦门大学学报（自然科学版） 2002年第S1期41卷 1-页

作者： ZHANG Fei-hu 1, QIU Zhong-jun 1, KANG Gui-wen 1, YUAN Zhe-jun 1, YANG Yong-shan 2. SHI xing-kuan 2.(1. department of Mechanical Manufacturing and Automation, Harbin {2. of technology, Harbin 150001, china 2. beijing Radio Measuring {2., beijing 100854, china)

Hard and brittle materials such as ferrite, optical glass and ceramics have been widely used in many fields because of their good characteristics and still gain more attentions. However, it is difficult to machine and get good surface quality. Some parts made of these materials have large machining allowances and need to be produced with large batch, but the machining efficiency is very low with usual grinding method. So it is of great importance to research the high efficiency grinding technology of hard and brittle materials. Electrolytic in-process dressing (ELID) grinding is a new grinding technology which has been adopted to the ultra-precision machining of hard and brittle materials. With the function of in-process dressing of metal bond diamond and CBN wheel, ELID grinding has the ability to keep the sharpness of the wheel surface and is widely used in fine abrasive grinding, but it also has the potentialities to high efficiency grinding. In this paper, the mechanism of ELID grinding and its grinding performance are analyzed, then the cast iron bond diamond wheels and ELID grinding device are used on a surface grinder to research the feasibility of ELID grinding to high efficiency grinding. To make comparison, the garnet ferrite (YAG) work piece has been machined in plunge grinding both by ELID grinding and by the resin bond diamond wheel. The grinding force and surface quality are tested and analyzed. It has been found that the grinding force of the cast iron bond diamond wheel with ELID grinding is apparently smaller than that of the resin bond diamond wheel. Under the same conditions, it is about 2.5～3/5 as the force using the resin bond diamond wheel. So with the same grinder and machining conditions, ELID grinding can machine work piece with greater depth of cut. Because of the smaller grinding force, it is also beneficial to avoid the edge collapse of the work piece and keep the integrity of the grinding surface. This experiment shows that the grinding

关键词： grinding ELID grinding hard and brittle material ferrite

MAL2.DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 36-39页

作者： Hao Luo xing Xiao Weiliang Hou Jing Cai Ming Chen Qisheng Tang Yusheng Tong Zengxin Qi Kaicheng Li Liang Chen department of Neurosurgery Huashan HospitalShanghai Medical CollegeState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain Science and Institutes of Brain ScienceFudan UniversityShanghai 200040China National Center for Neurological Disorders Shanghai 200040China Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration Shanghai 200040China Tianqiao and Chrissy Chen institute Clinical Translational Research Center Shanghai 200040China Shanghai QuietD Biotechnology Co. Ltd.Shanghai 201210China

Glioma is a common and malignant brain tumor,and molecular diagnostics for glioma have received increasing attention.1,2.Previous studies have suggested that the MAL2.gene may be involved in the transcytosis of various cancers.3 This study aimed to investigate the potential of MAL2.as a biomarker for *** candidate MAL2.CpG sites were validated by pyrosequencing and used to construct a diagnostic model for *** analysis was also conducted to determine the relationship between highly methylated MAL2.specific CpG sites and the prognosis of *** findings also showed that MAL2.was more highly methylated in glioma than in other *** constructed diagnostic model can distinguish glioma from other cancers with high sensitivity(93.3%)and specificity(86.5%).Additionally,a risk score model was built based on MAL2.methylation to assess the prognosis of glioma。

关键词： glioma diagnosis MAL