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歪闪古建木构架整体纠偏方法与数值模拟

建筑技术 2024年第14期55卷 1762-1766页

作者：李胜才赵孟君吴碧桥曹鹏 Gabriele Milani 刘国明扬州大学建筑科学与工程学院江苏扬州225127 江苏省华建建设股份有限公司江苏扬州225002 意大利米兰理工大学米兰20133

由于环境与人为等因素的长期影响,木结构古建筑普遍存在倾斜歪闪等损伤问题,严重影响了古木建筑的安全,亟需纠偏修复。研究尝试提出一种整体纠偏方法,构建木构架结构纠偏理论计算模型,通过数值模拟方法分析了纠偏过程的可行性,并以某多... 详细信息

由于环境与人为等因素的长期影响,木结构古建筑普遍存在倾斜歪闪等损伤问题,严重影响了古木建筑的安全,亟需纠偏修复。研究尝试提出一种整体纠偏方法,构建木构架结构纠偏理论计算模型,通过数值模拟方法分析了纠偏过程的可行性,并以某多层木结构建筑的纠偏复位过程为例加以验证。结果表明:纠偏后结构楼层偏移明显减小,纠偏过程中主要结构构件仍然处于弹性范围内,纠偏效果良好,可为同类古建木构架纠偏理论研究提供借鉴。

关键词：木结构古建筑纠偏程序悬臂梁模型歪闪成因

妊娠期糖尿病对早期新生儿呼吸系统疾病的影响

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医学信息 2024年第18期37卷 70-74页

作者：陆岸锋黄海燕黄萍黄培禄毕雷黄国盛钦州市妇幼保健院新生儿科钦州市妇幼保健院产科

目的探讨母亲妊娠期糖尿病（GDM）对早期新生儿呼吸系统疾病的影响。方法以2018年1月-12月钦州市妇幼保健院产科分娩的单胎、活产新生儿5702例为研究对象，根据母亲是否患GDM将新生儿分为GDM组（n=830）和非GDM组（n=4872）；再根据... 详细信息

目的探讨母亲妊娠期糖尿病（GDM）对早期新生儿呼吸系统疾病的影响。方法以2018年1月-12月钦州市妇幼保健院产科分娩的单胎、活产新生儿5702例为研究对象，根据母亲是否患GDM将新生儿分为GDM组（n=830）和非GDM组（n=4872）；再根据其母孕期血糖是否在控制目标值内，将GDM组分为血糖控制达标组（n=755）和血糖控制不达标组（n=75）。比较各组新生儿呼吸窘迫综合征（RDS）、新生儿湿肺、感染性肺炎、气胸、胎粪吸入综合征的发生率和机械通气需求情况。结果 GDM组早产（10.60%vs.7.02%）、巨大儿（5.42%vs.2.36%）、剖宫产（42.41%vs.34.56%）发生率高于非GDM组，差异有统计学意义（P<0.05）;GDM组湿肺发生率高于非GDM组（1.20%vs.0.39%,P<0.05）。母亲孕期血糖控制不达标组呼吸系统疾病（17.33%vs.2.91%）、新RDS(5.33%vs.1.32%)、湿肺（8.00%vs.0.53%）发生率高于血糖控制达标组，需要呼吸支持的比例高于血糖控制达标组（8.0%vs.1.2%），差异有统计学意义（P<0.05）;GDM母亲血糖控制不达标是呼吸系统疾病（OR=6.986,95%CI:3.357～14.540, P=0.000）、新生儿湿肺（OR=3.593,95%CI:1.990～6.488,P=0.000）的危险因素。结论孕期血糖控制不良的GDM母亲分娩的新生儿呼吸系统疾病、RDS、湿肺的发生率和需呼吸支持比例增高，GDM母亲血糖控制不达标是呼吸系统系统疾病、新生儿湿肺的危险因素，应重视GDM母亲围产保健，使其孕期的血糖得到良好控制以改善新生儿的临床预后。

关键词：妊娠期糖尿病呼吸系统疾病新生儿血糖湿肺

Temozolomide resistance in high grade gliomas

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上海交通大学学报（医学版） 2018年第1期38卷 117-124页

作者：卫翔宇 XIE Chao-ran YOU Chao-guo CHEN Zheng 郑学胜 Department of Neurosurgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine

High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic regimen of surgical resection followed by radiation therapy and chemotherapy. Alkylating agent temozolomide has been established as the standard chemotherapy while its resistance inevitable during treatment. This phenomenon seriously influences the prognosis of patients suffering from high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O^6-methylguanine-DNA methyltransferase(MGMT) methylation, mismatch repair mutation and epigenetic regulation consisting of p21, chromatin and histone, Y-box binding protein-1 and micro RNAs.

关键词： high grade glioma temozolomide resistance O6-methylguanine-DNA methyltransferase mismatch repair

凡纳对虾核心育种群生长和抗WSSV性状的遗传参数估计

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渔业科学进展 2024年第5期45卷 155-164页

作者：和怡婧李旭鹏栾生孔杰曹宝祥罗坤谭建曹家旺陈宝龙代平邢群刘绵宇强光峰刘杨隋娟孟宪红海水养殖生物育种与可持续产出全国重点实验室、中国水产科学研究院黄海水产研究所山东青岛266071 青岛海洋科技中心海洋渔业科学与食物产出过程功能实验室山东青岛266237 上海海洋大学水产科学国家级实验教学示范中心上海201306 邦普种业科技有限公司山东潍坊261312

为开展凡纳对虾(Penaeus vannamei)生长和白斑综合征病毒(white spot syndrome virus,WSSV)抗性复合选育,本研究以凡纳对虾59个核心育种群家系1770尾77~94日龄的个体为实验材料,利用两性状动物模型、公母畜阈值模型,评估在WSSV感染情况... 详细信息

为开展凡纳对虾(Penaeus vannamei)生长和白斑综合征病毒(white spot syndrome virus,WSSV)抗性复合选育,本研究以凡纳对虾59个核心育种群家系1770尾77~94日龄的个体为实验材料,利用两性状动物模型、公母畜阈值模型,评估在WSSV感染情况下凡纳对虾体长、抗WSSV存活时间和家系WSSV半致死存活率的遗传力和遗传相关。结果显示,凡纳对虾体长、抗WSSV存活时间和家系WSSV半致死存活率遗传力估计值分别为0.17±0.05、0.18±0.05和0.14±0.05,均属于中等遗传力水平,且均与0差异极显著(P0.05);抗WSSV存活时间性状与家系WSSV半致死存活率性状的遗传相关系数为0.96±0.03,遗传相关与1差异不显著(P>0.05),为高度正相关。结果表明,在该育种群体中,凡纳对虾生长与WSSV抗性可根据育种需要,通过赋值制定综合选择指数,进行多性状复合选育。此外,为优化每代育种的操作过程,可选用家系WSSV半致死存活率作为WSSV抗性的指标性状。本研究为开展凡纳对虾生长和WSSV抗性优良品种的选育提供了基础数据和理论支撑。

关键词：凡纳对虾遗传参数生长存活 WSSV

Combustion characteristics of aluminium-iron oxide in SHS-gravitational process

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Journal of University of Science and Technology Beijing 2002年第3期9卷 221-223页

作者： Tao Lin, Shiju guo, sheng Yin, and Zhimeng guoMaterials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China (Received 2001-10-15) Beijing Univ Sci & Technol Sch Mat Sci & Engn Beijing 100083 Peoples R China

In order to get high quality of products, the combustion of aluminium-ironoxide thermite in SHS-gravitational process must be under control. The effects of thermite fillingdensity, hole in thermite and inclined angle of pipe on combustion rate were studied. It shows thatthe combustion rate decreases with the decrease of filling density. The thermite combusts downwardsthe pipe much more quickly if there are holes in the thermite. And the combustion rate increaseswith the increase of the inclined angle of pipe. The experiment results show that the combustion ofthermite is predominantly controlled by gas phase reaction, which is attributed to the hightemperature of the thermite combustion.

关键词： thermite reaction SHS chemical synthesis composites

Wet Cupping Therapy Improves Local Blood Perfusion and Analgesic Effects in Patients with Nerve-Root Type Cervical Spondylosis

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Chinese Journal of Integrative Medicine 2018年第11期24卷 830-834页

作者： MENG Xiang-wen WANG Ying PIAO sheng-ai LV Wen-tao ZHU Cheng-hui MU Ming-yuan LI Dan-dan LIU Hua-peng guo Yi College of Acupuncture and Massage Tianjin University of Traditional Chinese Medicine

Objective： To observe wet cupping therapy（WCT） on local blood perfusion and analgesic effects in patients with nerve-root type cervical spondylosis（NT-CS）. Methods： Fifty-seven NT-CS patients were randomly divided into WCT group and Jiaji acupoint-acupuncture（JA） group according a random number table. WCT group（30 cases） was treated with WCT for 10 min, and JA group（27 cases） was treated with acupuncture for 10 min. The treatment efficacies were evaluated with a Visual Analogue Scale（VAS）. Blood perfusion at Dazhui（GV 14） and Jianjing（GB 21） acupoints（affected side） was observed with a laser speckle flowmetry, and its variations before and after treatment in both groups were compared as well. Results： In both groups, the VAS scores significantly decreased after the intervention（P〈0.01）, while the blood perfusion at the two acupoints significantly increased after intervention（P〈0.05）; however, the increasement magnitude caused by WCT was obvious compared with JA（P〈0.05）. Conclusion： WCT could improve analgesic effects in patients with NT-CS, which might be related to increasing local blood perfusion of acupunct points.

关键词： wet cupping nerve-root type cervical spondylosis blood perfusion amount acupuncture Jiaji acupoint

Neuroprotective effect of interleukin-6 regulation of voltage-gated Na^+ channels of cortical neurons is time-and dose-dependent

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Neural Regeneration Research 2015年第4期10卷 610-617页

作者： Wei Xia guo-yi Peng Jiang-tao sheng Fang-fang Zhu Jing-fang guo Wei-qiang Chen Department of Interventional Radiology First Affiliated HospitalShantou University Medical College Department of Neurosurgery First Affiliated HospitalShantou University Medical College Department of Pathogenic Microbiology and Immunology Shantou University Medical College

Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour expo-sure of interleukin-6 on cortical neurons at various concentrations （0.1, 1, 5 and 10 ng/mL） and the effects of 10 ng/mL interleukin-6 exposure to cortical neurons for various durations （2, 4, 8, 24 and 48 hours） by studying voltage-gated Na＋ channels using a patch-clamp technique. Volt-age-clamp recording results demonstrated that interleukin-6 suppressed Na＋ currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na＋channels in rat corti-cal neurons by interleukin-6 is time- and dose-dependent.

关键词： nerve regeneration brain injury inflammatory reaction interleukin-6 voltage-gated Na+ channel cortical neurons cerebrospinal fluid neuroimmunomodulation neuroprotection action potential patch clamp neurophysiology NSFC grants neural regeneration

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 348-355页

作者： Jian LIU Jian-zhong SHENTU Li-hua WU Jing DOU Qi-yang XU Hui-li ZHOU guo-lan WU Ming-zhu HUANG xing-jiang HU Jun-chun CHEN State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Infectious Disease Centerthe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Research Center for Clinical Pharmacy the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total of 32 volunteers participated in the study. Plasma concentrations were analyzed by non- stereospecific liquid chromatography/tandem mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative bioavailability was assessed by calculating individual AUC0-t (the area under the concentration-time curve from time zero to the last measurable concentration), AUC0-∞ (the area under the concentration-time curve extrapolated to infinity), Cmax (the maximum observed concentration), and Tpeak (the time to Cmax) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals (CIs) of AUC0-t, AUC0-∞, and Cmax were 85.4%-99.0%/88.8%-98.6%/87.6%-99.4%, 85.5%-99.2%/89.0%-98.6%/88.5%-101.3%, and 72.3%-87.6%/79.6%-91.1%/88.4%-99.1% for OPZ/OH-OPZ/ OPZ-SFN, respectively, and Tpeak values did not differ significantly. In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, Cmax, and Tpeak.

关键词： Omeprazole 5-Hydroxyomeprazole Omeprazole sulfone Bioavailability Pharmacokinetics Liquid chromatography/tandem mass spectrometry (LC-MS/MS)

Treatment of chronic prostatitis in Chinese men

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Asian Journal of Andrology 2009年第2期11卷 153-156页

作者： Chao-Zhao Liang Hong-Jun Li Zhi-Ping Wang Jun-Ping xing Wei-Lie Hu Tao-Fu Zhang Wei-Wei Ge Zong-Yao Hao Xian-sheng Zhang Jun Zhou Yu Li Zheng-xing Zhou Zhi-guo Tang Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730030China Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Urology Guangzhou Army General HospitalGuangzhou 510010China

The aim of this study is to assess the status of treatment of chronic prostatitis(CP)in Chinese men.A population-based cross-sectional survey was performed,in which 15000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index(NIH-CPSI)status,therapeutic efficacy and 28 other items.A total of 12743 men(84.95%)completed the questionnaire,of whom 1071(8.4%)were identified as having prostatitis-like symptoms and 517(4.5%)were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like *** the CP patients,372(65%)underwent long-term routine treatment 12 times per ***,217(72.8%)patients received antibiotic therapy and 215(79.3%)men showed therapeutic *** treatment cost USD 1151(8059 yuan)per person per year on *** CP patients received routine treatment,in most cases with *** was costly and most CP patients were not satisfied with its *** treatment might have been effective primarily in patients with bacterial disease.

关键词： chronic prostatitis epidemiology prevalence