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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG xindan sheng XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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双编码端高分辨率遥感影像语义分割算法

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计算机科学与探索 2025年第1期19卷 187-195页

作者：吴梦可高心丹东北林业大学计算机与控制工程学院哈尔滨150000

遥感影像具有多尺度对象、复杂背景、不均衡类别等特点。基于卷积神经网络(CNN)的语义分割算法难以捕捉到影像的全局特征,导致分割效果不佳。针对以上问题,利用Swin Transformer的全局特征提取能力,提出了双编码端高分辨率遥感影像语义... 详细信息

遥感影像具有多尺度对象、复杂背景、不均衡类别等特点。基于卷积神经网络(CNN)的语义分割算法难以捕捉到影像的全局特征,导致分割效果不佳。针对以上问题,利用Swin Transformer的全局特征提取能力,提出了双编码端高分辨率遥感影像语义分割算法DEGFNet。设计特征融合模块(FFB)将Swin Transformer捕获的全局特征引入编码端,应对多尺度对象带来的挑战。在Swin Transformer中设计空间交互模块(SIB),降低复杂背景样本带来的负面影响;在解码端引入全局-局部注意力模块(GLTB)和特征细化模块(FRB),来更好地利用编码端提取的信息,提高语义分割的精确性;采用交叉熵损失和Dice Loss组成的混合损失函数训练模型,减轻样本类别不均衡带来的消极影响。在Vaihingen数据集上,宏观平均F1值(mF1)、平均交并比(mIoU)和整体准确率(OA)指标分别达到91.9%、84.8%和92.4%;在LoveDA数据集上,mIoU指标达到55.0%,均展现出了更好的语义分割效果和良好的泛化性。

关键词：高分辨率遥感影像语义分割卷积神经网络 Swin Transformer

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Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing- antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

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Signal Transduction and Targeted Therapy 2022年第3期7卷 622-624页

作者： sheng Lin Zimin Chen xindan Zhang Ao Wen Xin Yuan Chongzhang Yu Jing Yang Bin He Yu Cao Guangwen Lu West China Hospital Emergency Department(WCHED) State Key Laboratory of BiotherapyWest Chino HospitalSichuan University610041 ChengduSichuanChina Disaster Medicine Center West China HospitalSichuan University610041 ChengduSichuanChina

Dear Editor,The recent-emerging Omicron variant(B.1.1.529 lineage)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has raised serious public concern because of its rapid regional-and *** of 11th January 2022,the Omicron variant has spread to 140 countries,territories or areas through infected air travelers,and the number is continuously increasing.

关键词： ACE2 decoy RBD

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气吸式圆盘白萝卜播种机设计与试验

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农机化研究 2025年第1期47卷 148-156页

作者：尹家巧李骅齐新丹孙新平马云龙南京工业大学机械与动力工程学院南京211816 南京农业大学江苏省智能化农业装备重点实验室南京210031 南京农业大学工学院南京210031

针对目前白萝卜种子尺寸小、流动性差、形状不规则导致播种机吸种效果差、漏播率和重播率高等情况,设计了一款气吸式圆盘白萝卜播种机。通过对播种机结构组成和工作原理的分析,计算吸附单粒种子的受力情况,建立了力学模型,并得到单粒最... 详细信息

针对目前白萝卜种子尺寸小、流动性差、形状不规则导致播种机吸种效果差、漏播率和重播率高等情况,设计了一款气吸式圆盘白萝卜播种机。通过对播种机结构组成和工作原理的分析,计算吸附单粒种子的受力情况,建立了力学模型,并得到单粒最小吸附负压值;通过各级链数转动比,确定了播种机地轮与排种器链数关系。通过对吸种过程DEM-CFD耦合仿真单因素试验,计算确定播种机中排种器关键结构参数最优范围,即排种盘转速为1~2 rad/s、风机负压为4~5 kPa、吸孔直径为2.4~2.8 mm;并在此基础上进行田间试验,以排种盘转速、风机负压、吸孔直径为试验因素,以播种间距合格率指标、漏播率指标、重播率指标为评价标准,进行三因素三水平正交试验。利用Design-Expert软件构造数学回归方程和响应曲面模型,分析了各个参数对播种合格率指标的影响变化,并利用软件最优化模块,确定了结构参数最优组合,即排种盘转速为1.3 rad/s、风机负压为4.6 kPa、吸孔直径为2.5 mm。田间试验结果表明:播种行距合格率指标为92.35%,漏播率指标为3.97%,重播率指标为3.68%,满足白萝卜精量播种的农艺要求。

关键词：气吸播种机耦合仿真田间试验正交试验白萝卜

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A Self‑Powered,Highly Embedded and Sensitive Tribo‑Label‑Sensor for the Fast and Stable Label Printer

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Nano-Micro Letters 2023年第2期15卷 228-237页

作者： xindan Hui Zhongjie Li Lirong Tang Jianfeng Sun Xingzhe Hou Jie Chen Yan Peng Zhiyi Wu Hengyu Guo School of Physics Chongqing UniversityChongqing 400044People’s Republic of China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100101People’s Republic of China College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331People’s Republic of China Electric Power Research Institute State Grid Chongqing Electric Power CompanyChongqing 401123People’s Republic of China

Label-sensor is an essential component of the label printer which is becoming a most significant tool for the development of Internet of Things(IoT).However,some drawbacks of the traditional infrared label-sensor make the printer fail to realize the high-speed recognition of labels as well as stable ***,we propose a selfpowered and highly sensitive tribo-label-sensor(TLS)for accurate label identification,positioning and counting by embedding triboelectric nanogenerator into the indispensable roller structure of a label *** sensing mechanism,device parameters and deep comparison with infrared sensor are systematically studied both in theory and *** the results,TLS delivers 6 times higher signal magnitude than traditional ***,TLS is immune to label jitter and temperature variation during fast printing and can also be used for transparent label directly and shows long-term *** work may provide an alternative toolkit with outstanding advantages to improve current label printer and further promote the development of IoT.

关键词： label-sensor Infrared sensor Triboelectric nanogenerator Self-powered Embedded sensor

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A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

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Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin Wang xindan Zhang An Chen Liming Zou Zhongling Wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of ***,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic *** polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO ***,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer ***,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from *** showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser *** results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

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A Perspective:Electrospun Fibers for Repairing Spinal Cord Injury

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Chemical Research in Chinese Universities 2021年第3期37卷 404-410页

作者： ZHANG xindan GONG Bowen ZHAI Jiliang ZHAO Yu LU Yonglai ZHANG Liqun XUE Jiajia Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing100029P.R.China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029P.R.China Department of Orthopaedics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing100730P.R.China

Patients with spinal cord injury(SCI)are suffering disability and accompanying *** to the complex biological processes and inhibitory microenvironment after SCI,advances in clinical treatment show obvious limitations for achieving a successful ***,we summarize recent advances in engineering strategies of using electrospun nanofibers to promote the neural regeneration and functional recovery after *** firstly introduce the pathological mechanism of SCI and thus point out the challenges on the regeneration of the *** then discuss the regenerative approaches by combining electrospun nanofibrous scaffolds with physical cues,biochemical cues(e.g.,cells,growth factors and other biomolecules),external stimuli,and supporting materials filling in the inner lumen of the *** these strategies have indicated their potentials to enhance the efficacy of repairing the *** last,we provide a perspective on the future direction for designing the electrospun nanofibrous scaffolds in combination with imaging systems to realize the in-situ monitoring of regeneration progress for further improving the treatment outcome.

关键词： Spinal cord injury Electrospun fiber Growth factor Cell therapy External stimuli

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Optimization of the cylindrical sieves for separating threshed rice mixture using EDEM

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International Journal of Agricultural and Biological Engineering 2022年第2期15卷 236-247页

作者： Jianbo Yuan Jufei Wang Hua Li xindan Qi Yongjian Wang Chao Li School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China Key Laboratory of Intelligent Agricultural Equipment in Jiangsu Province/Nanjing Agricultural University Nanjing 210031China

The design of the cylindrical sieve equipment used for the screening and separation of agricultural granular materials is mainly through the experimental method,which has the disadvantages of a long development cycle and high *** solve this problem,the discrete element method(DEM)was utilized to accurately build the particle models of threshed rice components(grains,shriveled grains,and short stalks),and simulated the separation of grains from the mixture in a cylindrical *** influences of rotational speed(A),cylindrical sieve diameter(B),cylindrical sieve aperture(C),and inclinational angle(D)on screening cleaning rate,screening loss rate,and screening efficiency were ***,the optimal parameters of the cylindrical sieve were obtained using a central composite design(CCD)under response surface methodology(RSM).The results of CCD showed that the quadratic multinomial model is credible and revealed that the cylindrical sieve aperture has a significant impact on the screening *** is predicted that the optimal values for screening cleaning rate,loss rate,and efficiency were 97.84%,0.27%,and 85.38%,respectively,while A,B,C,and D were 23.6 r/min,297 mm,8.7 mm,and 2°,*** experimental results using a real threshed rice mixture were found to be in good agreement with the optimal simulation *** study proved a reliable research method and provides a design reference for the cylinder sieving systems for threshed rice or separation of other bulk material.

关键词： cylindrical sieve threshed rice mixture discrete element method separation rice optimization

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Optimized design of the pneumatic precision seed-metering device for carrots

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International Journal of Agricultural and Biological Engineering 2023年第6期16卷 134-147,F0003页

作者： Dinghao Feng Xinping Sun Hua Li xindan Qi Yongjian Wang Samuel Mbugua Nyambura College of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China Key Laboratory of Intelligent Agricultural Equipment in Jiangsu Province Nanjing Agricultural UniversityNanjing 210031China College of Engineering Nanjing Agricultural UniversityNanjing 210031China CSSC Jiangnan Shipyard(Group)Co. Shanghai 201913China

The small size, light weight, irregular shape, and impurities that characterize seed groups increase clogging tendencies in the traditional seed-metering device thereby making it difficult to achieve high-speed precision seeding. A pneumatic seed-metering device with good seed-filling performance for carrot was designed in this study. By analyzing the movement state of seeds in the device under the theoretical condition, it was concluded that the minimum critical negative pressure value of air chamber was 0.32 kPa, which provided a theoretical basis for simulation and testing. ANSYS 17.0 Software was used to simulate the shape of the seeding plate hole. By comparing the pressure, air flow stability between the suction surface and the plug removal surface of the convection field, it was concluded that the conical hole was optimal. A bench verification test was conducted on the device. The average qualified rate, missing rate, and replaying rate were 81.48%, 4.07%, and 14.45%, respectively, which provided a strong reference for the design of carrot precision seed-metering device.

关键词： seed-metering device carrot precision seeding bench verification test

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A recently evolved BAHD acetyltransferase,responsible for bitter soyasaponin A production,is indispensable for soybean seed germination

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Journal of Integrative Plant Biology 2023年第11期65卷 2490-2504页

作者： Jia Yuan Liya Ma Yan Wang xindan Xu Rui Zhang Chengyuan Wang Wenxiang Meng Zhixi Tian Yihua Zhou Guodong Wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed Designthe Chinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100039China State Key Laboratory of Molecular Developmental Biology the Chinese Academy of SciencesBeijing 100190China The Center for Microbes Development and HealthInstitute of Pasteur of Shanghaithe Chinese Academy of SciencesShanghai 200031China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed Designthe Chinese Academy of SciencesBeijing 100101China

Soyasaponins are major small molecules that accumulate in soybean(Glycine max)*** them,type-A soyasaponins,fully acetylated at the terminal sugar of their C22 sugar chain,are responsible for the bitter taste of soybean-derived ***,the molecular basis for the acetylation of type-A soyasaponins remains ***,we identify and characterize Gm SSAc T1,encoding a BADH-type soyasaponin acetyltransferase that catalyzes three or four consecutive acetylations on type-A soyasaponins in vitro and in *** analysis and biochemical assays suggest that Gm SSAc T1 likely evolved from acyltransferases present in leguminous plants involved in isoflavonoid ***-of-function mutants of Gm SSAc T1 exhibited impaired seed germination,which attribute to the excessive accumulation of null-acetylated type-A *** conclude that Gm SSAc T1 not only functions as a detoxification gene for high accumulation of type-A soyasaponins in soybean seeds but is also a promising target for breeding new soybean varieties with lower bitter soyasaponin content.

关键词： BAHD acyltransferase seed germination soyasaponin soybean

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