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Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway

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Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao yang Jia-Qi Chen Tian-Jie Liu Yu-Le Chen Zhen-Kun Ma Yi-Zeng Fan Zi-Xi wang Shan Xu Ke wang xin-yang wang Lei Li Hong-Jun Xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

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人体解剖学教学建设的一点探讨

四川解剖学杂志 2024年第3期32卷 191-194页

作者：庞爱兰刘乃心杨新旺孟步亮昆明医科大学第一附属医院神经内科昆明650032 昆明医科大学基础医学院人体解剖学与组织胚胎学系昆明650500

目的:探索人体解剖学教学建设的架构.方法:通过总结教学实例,从教学内容、教学方法以及课程思政三方面探讨人体解剖学的教学建设.结果:人体解剖学的教学建设中教学内容建设实施了完善形态功能的描述,确立定义与概念的体系,探索总结基本... 详细信息

目的:探索人体解剖学教学建设的架构.方法:通过总结教学实例,从教学内容、教学方法以及课程思政三方面探讨人体解剖学的教学建设.结果:人体解剖学的教学建设中教学内容建设实施了完善形态功能的描述,确立定义与概念的体系,探索总结基本规律;教学方法建设主要为发扬现行方法的亮点、复兴优秀传统方法、提倡综合与逻辑;课程思政建设包括成为身心健康的人、进一步讲奉献、更要心系天下三方面.结论:上述研究结果初步构筑了人体解剖学教学与学科建设的三三架构.

关键词：学科建设人体解剖学教学内容教学方法课程思政

Control on Crystal Forms of Ultrafine Barium Carbonate Particles and Study on its Mechanism

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1290-1297页

作者： HUO Ji-Chuan LIU Shu-xin yang Ding-Ming wang Hai-Bin Institute of Materials Science and Engineering Southwest University of Science and Technology Mianyang 621010 China

Barium carbonate particles were prepared by using homogeneous precipitation method and co-precipitation method respectively. Through adding different crystalline controlling modifiers, Barium carbonate particles in five different shapes including linear, needle-like, pillarlike, sphere-like and dumbbell-like were synthesized. These particles were characterized by SEM and XRD, and their synthetic mechanism was discussed in this paper.

关键词： barium carbonate crystalline controlling synthesis mechanism

Solid-conversion synthesis of three-dimensionally ordered mesoporous ZSM-5 catalysts for the methanol-to-propylene reaction

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 111-122页

作者： Weilong Chun Chenbiao yang Xu wang xin yang Huiyong Chen School of Chemical Engineering Northwest UniversityXi’an 710069China International Science&Technology Cooperation Base for Clean Utilization of Hydrocarbon Resources Chemical Engineering Research Center of the Ministry of Education for Advanced Use Technology of Shanbei EnergyCollaborative Innovation Center for Development of Energy and Chemical Industry in Northern ShaanxiNorthwest UniversityXi’an 710069China

A facile synthesis of hierarchical ZSM-5 with the three-dimensionally ordered mesoporosity(3DOm ZSM-5)was achieved by solid conversion(SC)of SiO_(2)colloidal crystals to high-crystalline *** products of 3DZ5_S/C and 3DZ5_S,which were severally transformed from the carbon-padded SiO_(2)colloidal crystals and the initial SiO_(2)colloidal crystals,exhibited not only a similar ordered structure and acidity but also higher crystallinity and more balanced meso-/micropore combination in comparison with 3DZ5_C obtained by the conventional confined space crystallization *** three synthesized 3DZ5 catalysts showed improved methanol-to-propylene performance than the commercially microporous ZSM-5(CZ5),embodied in five times longer lifetime,higher propylene selectivity and S_(propylene)/S_(ethylene) ratio(P/E),and superior coke toleration with lower formation rate of coke(R_(coke)).Moreover,the 3DZ5_S catalyst in situ converted from SiO_(2)colloidal crystals presented the highest selectivities of propylene(42.51%)and light olefins(74.6%)among all three 3DZ5 *** high efficiency in synthesis and in situ utilization of SiO_(2)colloidal crystals demonstrate the proposed SC strategy to be more efficiently and eco-friendly for the high-yield production of not only 3DOm ZSM-5 but also other types of hierarchical zeolites.

关键词： hierarchical zeolite three-dimensionally ordered mesoporosity ZSM-5 solid conversion methanol-to-propylene

Entropy Evolution in the Interior Volume of a Charged f(R) Black Hole

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Communications in Theoretical Physics 2019年第6期71卷 718-722页

作者： Shad Ali xin-yang wang Wen-Biao Liu Department of Physics Beijing Normal University

Based on the 4-dimensional black hole solution of f(R) theory coupled to a nonlinear Maxwell field, we calculate the interior volume of a charged f(R) black hole using the method proposed by Christodoulou and *** massless scalar field in the interior volume and Hawking radiation carrying only energy, we calculate the entropy of the scalar field inside a charged f(R) black hole and investigate the evolution of the entropy under Hawking radiation. In the meantime, the evolution of the Bekenstein-Hawking entropy under Hawking radiation has also been calculated. Based on these results, the proportional relation is obtained between the evolution of the scalar field entropy and the evolution of Bekenstein-Hawking entropy under Hawking radiation. According to the result, we investigate and discuss how the modified coefficient b in f(R) gravity theory affects the evolution relation between the two types of entropy. It is shown that the radiation rate for Hawking radiation of a charged f(R) black hole can increase with the modified coefficient b.

关键词： f(R) black hole interior volume Hawking radiation Bekenstein-Hawking entropy

Phenolic compounds from the aqueous extract of Acacia catechu

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Chinese Chemical Letters 2011年第11期22卷 1331-1334页

作者： xing Cui Li Li xin yang Hong Qing wang Ruo Yun Chen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

From the aqueous extract of Acacia catechu,two new phenolic compounds（3R,4R）-3-（3,4-dihydroxyphenyl）-4-hydroxycy-clohexanone （1） and（4R）-5-（1-（3,4-dihydrophenyl）-3-oxobutyl）-dihydrofuran-2（3H）-one（2） w... 详细信息

关键词： Acacia catechu Phenolic compounds Free-radical scavenging activity

The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

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Food Science and Human Wellness 2024年第2期13卷 778-790页

作者： Tao wang Shuang wang Shuchen Dong Ruiling wang Shuxuan wang Jie yang xin wang xin Lü College of Food Science and Engineering Northwest Agriculture and Forestry UniversityYangling 712100China Faculty of Food Science and Engineering Kunming University of Science and TechnologyKunming 650500China School of Life Science and Technology Xinjiang UniversityUrumqi 830046China

Intestinal microbiota imbalance may worsen the progression of ulcerative colitis(UC).Lacticaseibacillus rhamnosus LS8(LR)has the potential ability to regulate microbiota through producing a novel antibacterial substance,cyclic opine:*** study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation(FMT)*** results showed that both LR and FMT attenuated UC as evidenced by 1)alleviating disease activity index and colonic pathology;2)up-regulating MUCs and tight junction proteins;3)increasing oxidative mediators and decreasing antioxidant mediators;4)down-regulating proinflammatory cytokines and *** results were mainly attributable to the microbiota-regulating effect of LR,including increasing beneficial bacteria(like Akkermansia)and its related SCFAs,while decreasing harmful bacteria(like Proteobacteria)and its related LPS,thereby suppressing the hyperactivation of TLR4/NF-κB ***,LR can alleviate UC and is a potential dietary supplement to attenuate UC.

关键词： Gut barrier Gut microbiota Fecal microbiota transplantation Lacticaseibacillus rhamnosus Oxidative stress Ulcerative colitis

Synthesis and biological evaluation of novel farnesylthiosalicylic acid/salicylic acid hybrids as potential anti-tumor agents

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Chinese Chemical Letters 2014年第12期25卷 1545-1549页

作者： Zhi-Qiang wang Ren-An Chang Hai-Ying Huang Xue-Min wang xin-yang wang Li Chen Yong Ling Department of Natural Medicinal Chemistry China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University School of Pharmacy Nantong University Department of Hepatobiliary Surgery Affiliated HospitalNantong University

A series of FTS/salicylic acid hybrids was designed and synthesized and their in vitro antitumor activities were *** was found that the anti-proliferation activities of hybrids were better than that of *** 10 a displayed the strongest antitumor activities with IC50 values of 5.72-9.76 μmol/L and selectively inhibited tumor cell *** addition,10 a induced tumor cell apoptosis in a dosedependent manner by up-regulating the expression of Bax and caspase-3 and down-regulating *** findings suggest that these novel hybrids may hold a great promise as therapeutic agents for the intervention of human cancers.

关键词： Farnesylthiosalicylic acid Salicylic acid Antitumor activities Cell apoptosis

Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

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Chinese Chemical Letters 2013年第8期24卷 727-730页

作者： You-An Xiao Zhi-Qiang wang Xue-Min wang Yi Hui Yong Ling xin-yang wang Li-Qin He Anhui University of Traditional Chinese Medicine Anhui Key Laboratory of Modernized Chinese Material Medical Medical College Nantong University Department of Natural Medicinal Chemistry China Pharmaceutical University

Novel 2-aminoimidazolone derivatives were *** compounds displayed strong anticancer activities against human carcinoma cells in *** 8a,8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells ***,the lC_（50）s of 8b（12.6-21.5μmol/L） against five tumor cells were 1 -4 fold less than those of 5-FU（18.4-56.1μmol/L） in ***,comp以ound 8b could induce SMMC-7721 cell apoptosis in a dose-dependent ***,our novel findings may provide a new framework for the design of new 2-aminoimidazolone derivatives for the treatment of cancer.

关键词： Synthesis 2-Aminoimidazolone Anti-tumor agents Cytotoxic activities Cell apoptosis