Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

作     者：You-An Xiao Zhi-Qiang Wang Xue-Min Wang Yi Hui Yong Ling Xin-Yang Wang Li-Qin He 

作者机构：Anhui University of Traditional Chinese MedicineAnhui Key Laboratory of Modernized Chinese Material Medical Medical CollegeNantong University Department of Natural Medicinal ChemistryChina Pharmaceutical University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第8期

页      面：727-730页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：support by the Nature and Science Foundation of Department of Education,Anhui province(No.KJ2013A168) Applied Research Projects of Nantong City(No.BK2012085) a project funded by the Priority Academic Programs Development of Jiangsu Higher Education Institutions(PAPD) 

主　　题：Synthesis 2 Aminoimidazolone Anti tumor agents Cytotoxic activities Cell apoptosis 

摘      要：Novel 2-aminoimidazolone derivatives were *** compounds displayed strong anticancer activities against human carcinoma cells in *** 8a,8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells ***,the lC_（50）s of 8b（12.6-21.5μmol/L） against five tumor cells were 1 -4 fold less than those of 5-FU（18.4-56.1μmol/L） in ***,comp以ound 8b could induce SMMC-7721 cell apoptosis in a dose-dependent ***,our novel findings may provide a new framework for the design of new 2-aminoimidazolone derivatives for the treatment of cancer.