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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Ectopic neurogenesis in forebrain cholinergic system-related areas of rat dementia model

Ectopic neurogenesis in forebrain cholinergic system-related...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： xin-hua zhang,Guo-hua JIN~*,Wei LI,Lin-Qing ZOU,Jin-Hong SHI,Jian-Bing QIN,Mei-Ling TIAN,Hao-Ming LI Department of Anatomy and Neurobiology,Jiangsu Key Laboratory of Neuroregeneration,Nantong University, Nantong 226000,China

＜正＞Lesions to the fimbria fornix（FiFx）plus cingulate bundle（CB）,the principal routes of communication of forebrain cholinergic regions,produce lasting impairment of spatial learning and memory in *** report that extensive neurogenesis takes place in the FiFx,CB and basalis magnocellularis（MBN）following FiFx plus CB *** revealed that nestin-expressing cells were present in all three areas following lesion;the majority of nestin-positive cells were also positive for 5-bromo-2-deoxy-uridine（BrdU）incorporation,a marker of DNA ***-positive proliferative cells were almost entirely absent from unlesioned *** cultured in vitro from lesioned FiFx displayed the characteristics of neural stem cells（NSCs）-proliferation, expression of embryonic markers,and multipotential differentiation into neurons,astrocytes and *** early stages after transection a small number of immature and migrating doublecortin（DCX）-immunopositive neurons were detected in lesioned FiFx where neuronal cell bodies are normally *** later stages post-lesion immature neurons developed intoβ-tubulinⅢ-positive mature *** labeling assay implied that the injury-induced neurogenesis in FiFx may be from local neurogenic astrocytes but not from dentate *** results demonstrate that insult to cholinergic tracts can stimulate NSC proliferation and neuronal regeneration not only in innervated regions but also in the projection pathways *** neurogenesis in cholinergic system-related areas provides an additional mechanism for repair of cholinergic innervation following damage.

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Effect of wet shot peening on Ti-6Al-4V alloy treated by ceramic beads

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Transactions of Nonferrous Metals Society of China 2014年第3期24卷 690-696页

作者：陈国清焦岩田唐永张新华李志强周文龙大连理工大学材料科学与工程学院大连116085 北京航空制造工程研究所北京100024

Ti-6Al-4V alloy was processed by wet shot peening with ceramic beads. The effects of the shot peened intensity on the microstructure, surface morphology, and residual stress were investigated. A tensile-tensile fatigue test was performed and the fracture mechanism was proposed. The results demonstrate that the surface roughness after wet shot peening is obviously lower than that after dry shot peening. With the increase of the shot peened intensity, the depth of the residual stress layer increases to 250 ktrn, and the maximum stress in this layer increases to -895 MPa. The fatigue strength also increases by 12.4% because of the wet shot peening treatment. The dislocation density of the surface layer is significantly enhanced after the wet shot peening with ceramic beads. The microstructure of the surface layer is obviously refined into ultra-fine grains.

关键词： Ti-6Al-4V alloy wet shot peening microstructure residual stress fatigue property

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InNi alloy-induced interface effect promoting the parallel electron transfer: improved photothermal catalytic CO2 hydrogenation

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Science China Chemistry 2025年

作者： Haoyu zhang Yuhang Li Yu Nie xinyu Dou Haodong Ji xin Tan Jinhua Ye Tao Yu School of Chemical Engineering and Technology Tianjin University Eco-environment and Resource Efficiency Research Laboratory School of Environment and Energy Peking University Shenzhen Graduate School School of Environmental Science and Engineering Tianjin University Advanced Catalytic Materials Research Center School of Materials Science and Engineering Tianjin University Research Center for Solar Driven Carbon Neutrality Hebei University

Photothermal catalytic CO2hydrogenation is an effective means of utilizing carbon ***,it is severely limited in terms of kinetics and ***,it is necessary to meticulously design catalysts to solve this ***,a sandwich structured NiO@InNi/In2O3is designed to intrinsically regulate the direction of photogenerated carriers transfer,resulting in a CO yield of 42.97 mmol g-1h-1(1290.3μmol h-1) with a selectivity near to 100%.InNi alloy favors the collection of photogenerated carriers by the parallel way and enhancement of the adsorption and activation of *** grown on the surface of InNi alloy not only improves the adsorption of H2and provides sufficient H+for the reaction,but also makes InNi alloy more stable during the reaction *** photothermal effect caused by In2O3accelerates the transfer of photogenerated carriers and increases the surface temperature of the catalyst,thereby synergistically promoting the reaction from a kinetic *** work ameliorates the kinetic and thermodynamic limitations of the photothermal catalytic CO2hydrogenation process through rationally designing the electron transfer direction of the sandwich structured catalysts to parallel way.

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红壤侵蚀裸地植被恢复及土壤有机碳对团聚体稳定性的影响

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生态学报 2003年第10期23卷 2176-2183页

作者：彭新华张斌赵其国中国科学院南京土壤研究所土壤圈物质循环开放实验室南京210008

植被恢复后土壤有机质提高 ,可能提高土壤团聚体稳定性 ,从而增强土壤抗蚀性 ,防止土壤退化。研究目的 :(1 )模拟自然条件下土壤团聚体破碎机制 ,研究不同恢复植被下团聚体稳定性的变化 ;(2 )确定不同恢复植被下土壤有机碳的积累与团聚... 详细信息

植被恢复后土壤有机质提高 ,可能提高土壤团聚体稳定性 ,从而增强土壤抗蚀性 ,防止土壤退化。研究目的 :(1 )模拟自然条件下土壤团聚体破碎机制 ,研究不同恢复植被下团聚体稳定性的变化 ;(2 )确定不同恢复植被下土壤有机碳的积累与团聚体稳定性的关系 ,以期理解侵蚀裸地植被恢复过程及土壤有机碳对土壤结构性质的贡献。供试土壤采为侵蚀裸地、恢复 1 4 a的胡枝子和樟树林地、30～ 40 a树龄的稀疏马尾松林地以及菜园地等 5种土地利用方式。研究结果表明快速湿润是团聚体破碎的主要机制 ,其团聚体稳定性 (NMWD)次序为 :快速湿润菜园地 >胡枝子 >樟树、裸地。湿润震荡处理后 ,其稳定性顺序是 :菜园地、马尾松 >裸地 >樟树 >胡枝子。而在慢速湿润中不同植被影响不明显。小团聚体的稳定性显著高于大团聚体的稳定性。快速湿润和湿润震荡下土壤团聚体稳定性与有机碳含量呈显著正相关 (r=0 .82 **,r=0 .66*) ,但慢速湿润下其相关性很低 (r=0 .2 2 )。结果还表明与活性 Al2 O3 相比 ,活性 Fe2 O3 对团聚体稳定性作用更显著。土壤团聚体湿润破碎后 ,有机碳含量和 C/N比随着破碎团聚体粒级的增大而提高。研究结果说明植被?

关键词：土壤退化植被恢复土壤有机碳团聚体稳定性

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Acceptor concentration dependent Fo?rster resonance energy transfer in nanocrystal-molecule complexes revealed by spectral analysis

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Optoelectronics Letters 2025年

作者： Rongxin zhang Zixiang ZHOU Lei WANG xin zhang Ying LIANG Guijie LIANG Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices， Hubei University of Arts and Science

A nanocrystal-molecule complex composed of CdSe donor and Rhodamine B (RhB) acceptor is prepared to investigate the effect of accepter-donor ratio on the Fo?rster resonance energy transfer (FRET) process. To highlight the FRET process， the energy level alignment between CdSe and RhB is purposefully designed and CdSe nanocrystal is coated with a wide band-gap ZnS shell. The carrier dynamics is observed via combined spectral analysis. The results reveal clear FRET process between the CdSe donor and RhB acceptor. The FRET is enhanced by increasing RhB/CdSe ratio and a gradual saturation will be present at high RhB concentration.

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Identification of radial glia cells from rat embryonic cerebral cortex

Identification of radial glia cells from rat embryonic cereb...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hao-Ming LI,Guo-hua JIN~*,Jian-Bing QIN,Wei-Wei YANG,Mei-Ling TIAN,Xue-Feng TAN,xin-hua zhang, Jin-Hong SHI,Lin-Qing ZOU Department of Anatomy and Neurobiology,the Jiangsu Key Laboratory of Neuroregeneration,Nantong University, Nantong 226001,China

＜正＞Objective Radial glia cells（RGCs） play an essential role during corticogenesis,whereas the precise distribution and contribution to cerebral cortex remains less *** In this research,we used Vimentin as an astroglia marker and Sox2 as a stem/progenitor maker to identify *** The Sox2+ cells in E16.5 cerebral cortex germinal zone co-localized with Vimentin or Nestin positive radial processes which extended to the pial *** vitro,the E16.5 cerebral cortex-derived Sox2+ radial glia（RG）-like cells shared some properties with RGCs in vivo,and these E16.5 RG-like cells displayed multiple differentiation *** Taken together,we identified some characterizations and properties of Sox2+ RGCs derived from rat embryonic cerebral cortex.

关键词： radial glia cells cerebral cortex Sox2 vimentin rat

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自拟毓液消痔汤治疗炎性外痔临床疗效观察

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中国生化药物杂志 2017年第6期37卷 111-113页

作者：章新花张利萍俞斌绍兴第二医院肛肠外科

目的本次实验将采用自拟毓液消痔汤治疗炎性外痔,并对临床疗效进行评价分析.方法本次实验选取了2016年6月-2016年12月在绍兴第二医院就诊的120例炎性外痔患者为研究对象,随机分为对照组和观察组,每组60例患者.其中,对照组患者采用痔... 详细信息

目的本次实验将采用自拟毓液消痔汤治疗炎性外痔,并对临床疗效进行评价分析.方法本次实验选取了2016年6月-2016年12月在绍兴第二医院就诊的120例炎性外痔患者为研究对象,随机分为对照组和观察组,每组60例患者.其中,对照组患者采用痔宁片治疗,观察组则采用自拟毓液消痔汤熏蒸坐浴治疗.记录患者治疗前后3d、7d、14d时的症状变化情况,包括出血、肛门不适、直肠下段黏膜、脱出、排便不适等,并采用四等级三分法进行评分.对比2组患者的病情改善情况和复发率,进一步探究治疗有效性.2组.结果 2组患者治疗后病情均有所缓解,且观察组患者改善效果更佳,具体而言,涉及到出血、肛门不适、直肠下段黏膜、脱出、排便不适等问题,且观察组治疗3d、7d、14d总分分别为（10.2±4.0）、（8.6±3.5）、（5.3±3.1）,对照组对应则为（11.3±4.2）、（9.9±3.5）、（6.4±3.2）,2组对比差异有统计学意义（P〈0.05）.但在综合治疗有效率上,2组差异较小,无统计学意义.结论采用自拟毓液消痔汤治疗炎性外痔具有良好的改善作用,具有消除水肿,起效快、医药费用较低等显著特点,且避免了手术带来的心理压力和经济压力,值得在临床治疗过程中推广应用.

关键词：自拟毓液消痔汤炎性外痔痔宁片复发率肛门

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耐利福平结核分支杆菌rpoB基因突变位点的分析

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复旦学报（医学版） 2001年第5期28卷 413-415页

作者：庞茂银翁心华张文宏胡忠义复旦大学附属华山医院传染科上海200040 上海市疾病预防控制中心上海200336

目的　研究上海地区耐利福平结核分支杆菌rpoB基因的突变特点 ,探讨DNA序列分析在药敏测定中的意义。方法　对 5 8株结核分支杆菌rpoB基因片段 (约 2 13bp)进行PCR扩增 ,其中包括核心突变区的 6 9个碱基 ,并对PCR产物进行DNA测序。其中... 详细信息

目的　研究上海地区耐利福平结核分支杆菌rpoB基因的突变特点 ,探讨DNA序列分析在药敏测定中的意义。方法　对 5 8株结核分支杆菌rpoB基因片段 (约 2 13bp)进行PCR扩增 ,其中包括核心突变区的 6 9个碱基 ,并对PCR产物进行DNA测序。其中耐药株 36株 ,敏感株 2 2株。结果　所有 5 8株中 ,36株耐药株均存在rpoB基因突变 ,氨基酸突变率 5 31位为 47.2 % ,5 2 6位为 2 5 .0 % ,2 2株敏感株均无突变。结论　rpoB基因核心突变区发生突变是结核分支杆菌对利福平耐药的主要原因 ,其中 5 31位丝氨酸和 5 2

关键词：结核分支杆菌耐药性利福平基因突变 ropB基因

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十二指肠间质瘤的诊治和讨论

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中华普通外科学文献（电子版） 2008年第4期2卷 50-51页

作者：张信华何裕隆中山大学附属第一医院胃肠外科广州510080

胃肠问质瘤（gastrointestinal stromal tumor，GIST）是消化道最常见的问叶组织来源肿瘤。十二指肠GIST部位较特殊，较胃和空、回肠GIST少见，诊断和治疗都较困难。自2000年以后，我院诊治的十二指肠GIST病例逐年增加，到目前已超过30... 详细信息

胃肠问质瘤（gastrointestinal stromal tumor，GIST）是消化道最常见的问叶组织来源肿瘤。十二指肠GIST部位较特殊，较胃和空、回肠GIST少见，诊断和治疗都较困难。自2000年以后，我院诊治的十二指肠GIST病例逐年增加，到目前已超过30例。现选取1例作回顾性分析，并对十二指肠GIST的临床诊治作进一步探讨。

关键词：十二指肠间质瘤临床诊治 GIST 组织来源消化道胃肠

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