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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Artificial liver support molecular adsorbents recirculating system therapy as a bridge to re-transplantation in two cases of long anhepatic duration

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 316-317页

作者： Yi-He Liu, Yu Wang, Li-xin Yu, Li-ying sun, Bao-Lan Feng, Zhong-Yang Shen and Min-Min Wang Tianjin, ChinaTianjin Organ Transplantation Institute, Tianjin First Central Hospital, Tianjin 300192 , China Therapeutic Blood Purification Research Cen- ter , University of Rostock, Germany Tianjin Organ Transplantation Institute Tianjin First Central Hospital Tianjin 300192 China.

BACKGROUND: Molecular adsorbents recirculating sys- tem (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful ap- plication of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration. METHODS: MARS therapy was given after failure plasma- exchange ( PE) treatment, which resulted in circulatory de- rangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year- old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase. RESULTS: The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy. CONCLUSION: Our experience proves that MARS artifi- cial liver can be an effective support for long time bridging PNF until re-transplantation is available.

关键词： artificial liver support liver transplantation anhepatic molecular adsorbents recirculating system

RasGRF1在结直肠癌细胞中的表达及其对癌细胞生物学行为的影响

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中国现代医学杂志 2022年第6期32卷 44-48页

作者：王硕杨其贤殷旭薇孙颖昕江苏大学医学院江苏镇江212013 南京医科大学附属常州市第二人民医院检验科江苏常州213004

目的探究RasGRF1在结直肠癌细胞中的表达及对癌细胞生物学功能的影响。方法采用实时荧光定量聚合酶链反应(qRT-PCR)检测不同结直肠癌细胞系DiFi、SNU175、HT-29、HCT-15细胞中RasGRF1mRNA;体外培养人结肠癌细胞,随机分为si-RasGRF1-NC组... 详细信息

目的探究RasGRF1在结直肠癌细胞中的表达及对癌细胞生物学功能的影响。方法采用实时荧光定量聚合酶链反应(qRT-PCR)检测不同结直肠癌细胞系DiFi、SNU175、HT-29、HCT-15细胞中RasGRF1mRNA;体外培养人结肠癌细胞,随机分为si-RasGRF1-NC组(阴性对照)、si-RasGRF1组(沉默RasGRF1表达)、NG组(空白对照)。采用qRT-PCR检测各组RasGRF1 mRNA,CCK-8法检测细胞存活情况,AnnexinV/PITC双染法检测细胞凋亡,Western blotting检测细胞PI3K/Akt通路蛋白。结果DiFi细胞中RasGRF1 mRNA相对表达量最高(P<0.05),选择DiFi细胞进行后续实验。si-RasGRF1组光密度值低于NG组、si-RasGRF1-NC组(P<0.05)。si-RasGRF1组细胞凋亡率高于NG组和si-RasGRF1-NC组(P<0.05)。si-RasGRF1组p-PI3K/PI3K、p-Akt/Akt蛋白相对表达量低于NG组和si-RasGRF1-NC组(P<0.05),Caspase-3蛋白相对表达量高于NG组和si-RasGRF1-NC组(P<0.05)。结论RasGRF1在结直肠癌细胞中异常高表达,抑制RasGRF1表达可抑制DiFi细胞增殖并诱导细胞凋亡,且该作用是通过抑制DiFi细胞PI3K/Akt通路活化来实现的。

关键词：结直肠癌 RasGRF1 细胞增殖凋亡

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气候变化对北京地下水资源的影响分析

节水灌溉 2017年第5期 80-83,89页

作者：李鹏王新娟孙颖刘殷陈芃中国地质大学(北京) 北京100083 北京市水文地质工程地质大队北京100195

总结了北京地下水资源概况,对近60 a来北京气温、降水、蒸发的变化特征进行了分析。结果表明:北京气温在波动中增暖,增幅约为0.08℃/a,而年降水量表现为下降趋势,平均变幅为-3.45 mm/a;年总水面蒸发量表现为明显的下降趋势,平均变幅为-8... 详细信息

总结了北京地下水资源概况,对近60 a来北京气温、降水、蒸发的变化特征进行了分析。结果表明:北京气温在波动中增暖,增幅约为0.08℃/a,而年降水量表现为下降趋势,平均变幅为-3.45 mm/a;年总水面蒸发量表现为明显的下降趋势,平均变幅为-8.04 mm/a。降水减少加之超量开采给地下水资源带来不利影响,导致地下水位持续下降,局部浅层含水层疏干,1999-2013年,第四系地下水累计亏损量达65.82亿m3,年均亏损量4.39亿m3,地下水水质也随之变差。平原区地下水蒸发量由1960-1980年的年均4.95亿m3/a,降至2001年以来的年均0.44亿m3/a。气温对地下水的影响是间接和微弱的。

关键词：气候变化地下水资源储存变化量

N5,N10-亚甲基四氢叶酸还原酶基因多态性及血浆同型半胱氨酸与冠心病的关系

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中国动脉硬化杂志 2016年第10期24卷 1023-1026页

作者：张良峰王新李海燕陈新宋瑛孙铃张秋南京医科大学附属常州第二人民医院心内科江苏省常州市213000

目的研究N5,N10-亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性、血浆同型半胱氨酸（Hcy）与冠心病的关系。方法选取2013年至2015年在我院住院的冠心病患者256例,按年龄分为〈60岁组（中青年组）107例及≥60岁组（老年组）149例,选取... 详细信息

目的研究N5,N10-亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性、血浆同型半胱氨酸（Hcy）与冠心病的关系。方法选取2013年至2015年在我院住院的冠心病患者256例,按年龄分为〈60岁组（中青年组）107例及≥60岁组（老年组）149例,选取同期行健康体检的人群145例作为对照组,应用聚合酶链反应（PCR）技术和基因芯片分析技术检测MTHFR基因C677T多态性,应用高效液相色谱法测定血浆Hcy水平,分析不同组群之间MTHFR基因C677T多态性的分布及Hcy水平。结果 MTHFR基因分布频率：中青年组CC型、CT型、TT型基因频率分别为26.2%,43.9%,29.9%,C等位基因频率为48.1%,T等位基因频率为51.9%。中青年组CC型、CT型、TT型基因频率分别为35.6%,42.3%,22.1%,C等位基因频率为56.8%,T等位基因频率为43.2%。对照组CC型、CT型、TT型基因频率分别为37.9%,40.1%,21.4%,C等位基因频率为58.3%,T等位基因频率为41.7%。中青年组T等位基因频率明显高于对照组（χ2=5.10,P=0.015）,中青年组Hcy浓度明显高于对照组。老年组T等位基因频率与对照组比较差异无显著性（χ2=0.147,P=0.382）,两组间Hcy浓度差异无显著性。各组的TT基因型者血浆Hcy浓度均明显高于CC和TC基因型者（P〈0.01）,而后两者间差异无显著性。结论 MTHFR基因TT型可导致Hcy水平明显升高,MTHFR基因C677T点突变仅与中青年组冠心病患者相关,与老年组冠心病患者无明显相关,Hcy水平升高及MTHFR基因T等位基因频率增高可能为中青年冠心病患者的危险因素,提示不同年龄阶段的冠心病患者发病的机制可能存在差异。

关键词：亚甲基四氢叶酸还原酶同型半胱氨酸基因多态性冠心病

血清LncRNA PVT1、LncRNA H19表达与前列腺癌患者术后复发转移的关系

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中国现代医学杂志 2021年第22期31卷 44-49页

作者：陈金玉张平孙颖昕潘敏杰周珊南京医科大学附属常州市第二人民医院检验科江苏常州213000 南京医科大学附属常州市第二人民医院泌尿外科江苏常州213000

目的探讨血清长链非编码RNA(LncRNA)浆细胞瘤可变易位基因1(PVT1)、LncRNA H19表达与前列腺癌患者术后复发转移的关系。方法选取2016年5月—2018年5月南京医科大学附属常州市第二人民医院收治的169例前列腺癌患者作为前列腺癌组,统计患... 详细信息

目的探讨血清长链非编码RNA(LncRNA)浆细胞瘤可变易位基因1(PVT1)、LncRNA H19表达与前列腺癌患者术后复发转移的关系。方法选取2016年5月—2018年5月南京医科大学附属常州市第二人民医院收治的169例前列腺癌患者作为前列腺癌组,统计患者术后3年复发转移率。另选取同期该院健康体检者74例作为对照组。qRT-PCR检测血清LncRNA PVT1、LncRNA H19表达。多因素Cox回归分析前列腺癌患者术后复发转移影响因素。ROC曲线分析血清LncRNA PVT1、LncRNA H19表达对前列腺癌患者术后复发转移的预测价值。结果前列腺癌组血清LncRNA PVT1、LncRNA H19相对表达量高于对照组(P0.05)。多因素Cox回归分析结果显示,TNM分期Ⅲ期[O^R=3.722(95 CI:1.416,7.784),P<0.05]、Gleason评分≥7分[O^R=4.626(95%CI:1.670,9.815),P<0.05]、LncRNA PVT1[O^R=1.982(95 CI%:1.521,2.584),P<0.05]、LncRNA H19[O^R=1.868(95%CI:1.327,2.630),P<0.05]是前列腺癌患者术后复发转移的独立危险因素。联合血清LncRNA PVT1、LncRNA H19表达预测AUC大于单独预测。结论前列腺癌患者血清LncRNA PVT1、LncRNA H19高表达,为术后复发转移的独立危险因素,可作为前列腺癌患者术后复发转移预测指标。

关键词：前列腺癌术后复发转移长链非编码RNA

Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhou, Chengwang Ding, Zhezheng ying, Shengzhe Jiang, Hao Wang, Yan Fang, Timing Zhang, You sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen sun Liang Xue Wenyao Zhang Pan Xiong xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond