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Isolation and chemotaxonomic significance of stenine- and stemoninine-type alkaloids from the roots of Stemona tuberosa

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Chinese Chemical Letters 2014年第9期25卷 1252-1255页

作者： Rong-Rong Zhang hai-Yan Tian Yi Wu Xiao-Hui sun Jian-Long Zhang Zhi-Guo Ma Ren-Wang Jiang Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan University Zhongshan Torch Polytechnic Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application Shenzhen Institute for Drug Control

One new stenine-type alkaloid, tuberostemonine D （1）, together with five known stenine-type alkaloids （2-6） and two known stemoninine-type alkaloids （7 and 8）, were isolated from the roots of Stemona tuberosa. Their structures were elucidated by extensive spectroscopic methods （IR, UV, MS, 1D and 2D NMR）, and the structure of I was further confirmed by X-ray diffraction analysis. First simultaneous isolation ofstenine- and stemoninine-type alkaloids not only added a new chemical type and increased the chemical diversity of Stemona tuberosa, but also provided chemotaxonomic clues for the close relationship between genera Stemona and Stichoneuron, and favored retaining them in the same family.

关键词： Sternona tuberosa Alkaloid Tuberostemonine-type

Interfacial defect engineering and photocatalysis properties of hBN/MX_(2)(M=Mo,W,and X=S,Se)heterostructures

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Chinese Physics B 2022年第6期31卷 625-634页

作者： Zhi-hai sun Jia-Xi Liu Ying Zhang Zi-Yuan Li Le-Yu Peng Peng-Ru Huang Yong-Jin Zou Fen Xu Li-Xian sun School of Material Science and Engineering Guilin University of Electronic TechnologyGuangxi Key Laboratory of Information MaterialsGuangxi Collaborative Innovation Center of Structure and Property for New Energy and MaterialsGuilin 541004China

Van der Waals(VDW)heterostructures have attracted significant research interest due to their tunable interfacial properties and potential applications in many areas such as electronics,optoelectronic,and *** this work,the influences of interfacial defects on the electronic structures and photocatalytic properties of hBN/MX_(2)(M=Mo,W,and X=S,Se)are studied using density functional theory *** results reveal that the band alignment of hBN/MX_(2) can be adjusted by introducing vacancies and atomic *** type-Ⅰband alignment of the host structure is maintained in the heterostructure with n-type doping in the hBN ***,the band alignment changed into the type-Ⅱheterostructrue due to V_(B) defect and p-type doping is introduced into the hBN *** can conduce to the separation of photo-generated electron-hole pairs at the interfaces,which is highly desired for heterostructure *** addition,two Z-type heterostructures including h BN(BeB)/MoS_(2),hBN(Be_(B))/MoSe_(2),and hBN(V_(N))/MoSe_(2)are achieved,showing the decreasing of band gap and ideal redox potential for water *** results reveal the possibility of engineering the interfacial and photocatalysis properties of hBN/MX_(2) heterostructures via interfacial defects.

关键词： hBN/MX_(2)heterostructures interfacial defect electronic state photocatalytic properties

Humulus lupulus L. Extract Prevents Ovariectomy-Induced Osteoporosis in Mice and Regulates Activities of Osteoblasts and Osteoclasts

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Chinese Journal of Integrative Medicine 2021年第1期27卷 31-38页

作者： XIA Tian-shuang LIN Liu-yue ZHANG Qiao-yan JIANG Yi-ping LI Chang-hui LIU Xiao-yan QIN Lu-ping xin hai-liang Department of Pharmacognosy School of PharmacySecond Military Medical UniversityShanghai(200433)China Schoolof Pharmacy Fujian University of Traditional Chinese MedicineFuzhou(350108)China School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou(310053)China

Objective:To systematically evaluate the protective effects of Humulus lupulus ***(HLE)on osteoporosis ***:In vivo experiment,a total of 3512-week-old female ICR mice were equally divided into 5 groups:the sham control group(sham);the ovariectomy with vehicle group(OVX);the OVX with estradiol valerate[EV,0.2 mg/(kg·d)];the OVX with low-or high-dose HLE groups[HLE,1 g/(kg·d)and 3 g/(kg·d)],7 in each *** began 1 week after the ovariectomized surgery and lasted for 12 *** mass and trabecular bone mircoarchitecture were evaluated by micro computed tomography,and bone turnover markers in serum were evaluated using enzyme-linked immunosorbent assay(ELISA)*** vitro experiment,osteoblasts and osteoclasts were treated with HLE at doses of 0,4,20 and 100μg/*** for bone formation in osteoblasts and bone resorption in osteoclasts were ***:Compared with the OVX group,HLE exerted bone protective effects by the increase of estradiol(P<0.05),the improvement of cancellous bone structure,bone mineral density(P<0.01)and the reduction of serum alkaline phosphatase(ALP),tartrate resistant acid phosphatase(TRAP),bone gla-protein,c-terminal telopeptides of typeⅠcollagen(CTX-Ⅰ)and deoxypyridinoline levels(P<0.01 for all).In vitro experiment,compared with the control group,HLE at 20μg/mL promoted the cell proliferation(P<0.01),and increased the expression of bone morphogenetic protein-2 and osteopontin levels in osteoblasts(both P<0.05).HLE at 100μg/mL increased the osteoblastic ALP activities,and HLE at all dose enhanced the extracellular matrix mineralization(both P<0.01).Furthermore,compared with the control group,HLE at 20μg/m L and 100μg/m L inhibited osteoclastic TRAP activity(P<0.01),and reduced the expression of matrix metalloproteinase-9 and cathepsin K(both P<0.05).Conclusion:HLE may protect against bone loss,and have potentials in the treatment of osteoporosis.

关键词： Humulus lupulus L. osteoporosis ovariectomy-induced mice osteoblasts osteoclasts

Gene expression profiles of peripheral blood mononuclear cells from patients with atopic dermatitis stimulated with Malassezia globosa

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Chinese Medical Journal 2021年第22期134卷 2759-2761页

作者： Mao Lu Ya-Ling Dai xin Ran Sushmita Pradhan hai-Rong Liu Mei Ou Hong-Mei Wu Yu-Ping Ran Department of Dermatovenereology Sichuan University West China HospitalChengduSichuan 610041China Department of Dermatovenereology The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China Department of Laboratory Medicine The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China.

To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still *** our study,the Affymetrix Human Prime View array was used to detect the effect of *** on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.

关键词： patients dermatitis pathogenesis

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速泡鲜腐竹加工工艺研究

中国调味品 2024年第9期49卷 157-161页

作者：孙军涛王德国肖付刚张志新肖锋杜冯柯史静洁许昌学院食品与药学院、河南省食品安全生物标识快检技术重点实验室河南许昌461000

在传统腐竹加工工艺的基础上,采用冷冻工艺制备速泡鲜腐竹。研究鼓风干燥预处理方式下冷冻时间、冷冻温度对速泡鲜腐竹复水率、泡发时间、感官品质的影响。分析不同加工工艺下腐竹的质构、色泽、泡发时间和复水率,以及炒制、油炸和煮制... 详细信息

在传统腐竹加工工艺的基础上,采用冷冻工艺制备速泡鲜腐竹。研究鼓风干燥预处理方式下冷冻时间、冷冻温度对速泡鲜腐竹复水率、泡发时间、感官品质的影响。分析不同加工工艺下腐竹的质构、色泽、泡发时间和复水率,以及炒制、油炸和煮制食用方式下产品的品质特点。结果表明,速泡鲜腐竹的最佳工艺为鼓风干燥温度40℃、干燥时间20 min、冷冻时间8 h、冷冻温度-20℃,该条件下制备的速泡鲜腐竹的水分含量为42.55%,泡发时间为3 min,复水率为58.87%。与市售干腐竹相比,速泡鲜腐竹的泡发时间缩短了90倍,油炸时的吸油率降低48.51%,速泡鲜腐竹无需浸泡,可以直接炒制、油炸和煮制,极大提高了食用的便捷性。

关键词：鲜腐竹速泡泡发时间复水率食用方式

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2012-2020年某院Ⅰ类切口手术围手术期预防用抗菌药物持续性综合规范管理实践及其效果

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中华医院感染学杂志 2024年第14期34卷 2149-2153页

作者：袁可欣孙薇翟秀伟刘净耿志伟石永丽张玉玺李杨大庆油田总医院感染管理科黑龙江大庆163001 大庆油田总医院院长办公室黑龙江大庆163001 大庆油田总医院医务部黑龙江大庆163001 大庆油田总医院药学部黑龙江大庆163001

目的评价2012-2020年某院Ⅰ类切口手术围手术期预防使用抗菌药物持续性综合规范管理实践及其效果.方法采取持续性综合规范管理措施,对Ⅰ类切口手术围手术期预防使用抗菌药物进行干预管理.对2011年1月1日-2020年12月31日大庆油田总医... 详细信息

目的评价2012-2020年某院Ⅰ类切口手术围手术期预防使用抗菌药物持续性综合规范管理实践及其效果.方法采取持续性综合规范管理措施,对Ⅰ类切口手术围手术期预防使用抗菌药物进行干预管理.对2011年1月1日-2020年12月31日大庆油田总医院Ⅰ类切口手术病例抗菌药物预防使用情况进行描述性分析.将对照组(2011年1月1日-12月31日)、1阶段干预组(2015年1月1日-12月31日)和2阶段干预组(2020年1月1日-12月31日)预防使用抗菌药物合理性及患者住院总费用及抗菌药物使用费用进行回顾性对比研究.结果医院2011-2020年Ⅰ类切口手术预防用药使用率呈逐年下降趋势,下降了 34.13%(P<0.05).经过两阶段干预,术前给药时间在0.5~1 h的比例、药品选择合理性及溶媒选择合理性均不同程度提高(P<0.05),术后用药时间也趋于规范化.患者人均预防性使用抗菌药物费用呈下降趋势,人均预防性使用抗菌药物费用占患者人均住院总费用的比例也在逐渐减小(P<0.05).结论通过医院顶层设计及指标制定到职能科室专项管理及反馈,再到临床科室执行及整改的闭环管理模式,运行临床抗菌药物预防应用的长效管理工作机制,使Ⅰ类切口手术抗菌药物预防使用向规范化、合理化逐渐转变,临床抗菌药物合理使用水平逐渐提升,同时减少了患者的住院费用.

关键词： Ⅰ类切口手术抗菌药物围手术期持续性综合管理措施效果

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薛禹胜院士:科学家办科技期刊的楷模

编辑学报 2024年第4期36卷 355-359页

作者：姜海孔丽蓓王志鸿吴崇昊左萍汪骏原万志超代长振郑颖徐鑫顾晓荣国网电力科学研究院有限公司(南瑞集团有限公司) 南京211106

《电力系统自动化》和《现代电力系统与清洁能源学报》(英文)主编薛禹胜院士拥有赤诚的家国情怀,凭借自己的坚韧与执着,在电力系统安全稳定领域的科研与开发方面取得了巨大成就,不仅坚持把论文写在祖国的大地上,而且充满着炽烈的办刊热... 详细信息

《电力系统自动化》和《现代电力系统与清洁能源学报》(英文)主编薛禹胜院士拥有赤诚的家国情怀,凭借自己的坚韧与执着,在电力系统安全稳定领域的科研与开发方面取得了巨大成就,不仅坚持把论文写在祖国的大地上,而且充满着炽烈的办刊热情,所办期刊发展迅速,成绩斐然,成为科学家办科技期刊的楷模。

关键词：薛禹胜院士《电力系统自动化》《现代电力系统与清洁能源学报》(英文) 科技期刊家国情怀楷模

Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus

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Chinese Journal of Natural Medicines 2021年第11期19卷 874-880页

作者： LIU Hui-Bo LIU Zhao-Ming CHEN Yu-Chan Tan hai-Bo LI Sai-Ni LI Dong-Li LIU Hong-xin ZHANG Wei-Min State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Chemical and Environmental Engineering Wuyi UniversityJiangmen 529020China Program for Natural Products Chemical Biology Key Laboratory of Plant Resources Conservation and Sustainable UtilizationGuangdong Provincial Key Laboratory of Applied BotanySouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus *** the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction *** potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB *** 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).

关键词： Deep-see-derived fungus Phomopsis lithocarpus 2 3-Dihydro-1H-indene isomers Benzophenone derivatives

Planarized Polymer Acceptor Featuring High Electron Mobility for Efficient All-Polymer Solar Cells

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Chinese Journal of Polymer Science 2022年第8期40卷 968-978,I0011页

作者： Feng Liu Ri sun Cheng-Yu Wang Liang Zhou Wen-Li Su Qi-Hui Yue Shuai sun Wu-Yue Liu hai-Jun Fan Wen-Kai Zhang Yun-Long Guo Li-Heng Feng Xiao-Zhang Zhu School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing100190China Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum StudiesBeijing Normal UniversityBeijing100875China University of Chinese Academy of Sciences Beijing100049China

Significant progress has been achieved for all-polymer solar cells(APSCs)in the last few years by the use of polymerized small molecular acceptors(PSMAs).Developing high electron mobility polymer acceptors has been considered a feasible solution to further improve the photovoltaic performance of APSCs and fabricate thick film devices,which contributed to roll-to-roll printing *** this work,we designed and synthesized PSV,an A-DA’D-A small molecule acceptor-based PSMA with the vinyl group as a bridged linkage to reduce the steric hindrance between the 1,1-dicyanomethylene-3-indanone(IC)terminal *** comparison with the C-C bond linked polymer acceptor PS,PSV exhibits an almost planar conjugated framework and well-ordered molecular stacking in the thin ***,PSV exhibits superior n-type semiconducting properties with high electron mobility of up to 0.54 cm^(2)·V^(−1)·s^(−1),which is the highest value among reported *** utilizing PM6 as a polymer donor,PSV-based blend forms a favorable nanomorphology and exhibits high and well-balanced hole/electron mobilities,which is beneficial for exciton separation and charge ***,APSCs based on PM6:PSV achieved high power conversion efficiencies of up to 15.73%,with a simultaneously realized high Voc of 0.923 V,Jsc of 23.2 mA·cm^(-2),and FF of *** superior features enable PSV with excellent thickness-insensitive properties and over 13%PCE was obtained at 300 *** the best of our knowledge,the high PCE of 15.73%with excellent electron mobility of 0.54 cm^(2)·V^(−1)·s^(−1)is the highest values reported for *** results point to the great significance of developing polymer acceptors with a high electron mobility for boosting the performance of APSCs.

关键词： All-polymer solar cells Polymerized small molecular acceptors Planarization Electron mobility Thick film organic solar cells