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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu xin-Yian Guo jian-Gang shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Functional catalysts for polysulfide conversion in li-S batteries:from micro/nanoscale to single atom

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Rare Metals 2022年第4期41卷 1080-1100页

作者： Wei-Ming Zhao Jia-Dong shen Xi-jun Xu Wei-xin He li liu Zhong-hua chen jun liu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of TechnologyGuangzhou 510641China shenzhen FBTech Electronics Ltd Shenzhen 518116China

lithium-sulfur(li-S) batteries have the advantages of low-cost and ultra-high energy density(2600 Wh·kg;),which have attracted considerable ***,the practical application of li-S batteries still suffers various intractable problems,such as low electrical conductivity,significant volume expansion,and the shuttle effect of sulfur *** to now,many tremendous efforts and significant progress have been devoted to settle these *** of the most effective strategies is that introducing metal-based compounds(e.g.,metal oxides,-sulfides,-nitrides,carbides,-phosphate,single-metal compounds) to enhance the electrochemical performance of S cathode benefiting from superior adsorption/catalytic ability toward li;S;(n=1,2,4,8).In this review,we summarized the recent advances in the application of micro/nanoscale catalysts in li-S system and highlighted the catalytic effect of single-atom ***,the challenges and the future research prospects of single-atom catalysts were discussed.

关键词： li–S batteries High energy density Micro/nanoscale catalysts Single-atom catalysts

Activity of Azoxystrobin and SHAM to Four Phytopathogens

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Agricultural Sciences in China 2009年第7期8卷 835-842页

作者： JIN li-hua chen Yu chen Chang-jun WANG jian-xin ZHOU Ming-guo College of Plant Pathology Nanjing Agricultural University Nanjing 210095 P.R.China

The study was conducted to make clear the activity of azoxystrobin to 4 plant pathogens and the synergistic effects of salicylhydroxamic acid （SHAM）, which acted on the alternative oxidase. It was also conducted to be aware of the mechanism of azoxystrobin in inhibition on mycelial respiration and the influence of SHAM. The activity test of azoxystrobin and SHAM was carried out with a mycelial linear growth test and spore germination test. Other related biological properties were also observed. Inhibition of azoxystrobin and SHAM on 4 pathogens was determined by using SP-II oxygraph system. Azoxystrobin inhibited mycelial growth in Colletotrichum capsici, Botrytis cinerea, Rhizoctonia solani, and Magnaporthe grisea, respectively; it also inhibited conidia germination, and conidia production in C. capsici, B. cinerea M. grisea, and sclerotia formation in R. solani. Moreover, it created stayed pigment biosynthesis in C. capsici and M. grisea somehow. Salicylhydroxamic acid enhanced inhibition by azoxystrobin. An oxygen consuming test of the mycelia showed that azoxystrobin inhibited all the 4 fungi＇s respiration in the early stages. With the concentration rising up, the effectiveness increased. However, as time went on, the respiration of the mycelia treated with fungicides recovered and SHAM could not inhibit the oxygen consuming. This reaction between the mycelia and the fungicides appeared not to initiate alternative respiration but rather the other mechanism created a lack of efficacy.

关键词： azoxstrobin salicylhydroxamic acid (SHAM) plant pathogens spore germination mycelial growth oxygenconsumption rate

Open-circuit voltage analysis of p-i-n type amorphous silicon solar cells deposited at low temperature

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Chinese Physics B 2011年第8期20卷 403-407页

作者： Ni jian Zhang jian-jun Cao Yu Wang Xian-Bao li Chao chen xin-liang Geng xin-hua Zhao Ying Institute of Photo-electronics Thin Film Devices and Technique of Nankai University Key Laboratory of Photo-electronics Thin Film Devices and Technique of Tianjin Key Laboratory of Photo-electronicInformation Science and Technology of Ministry of Education (Nankai University) Tianjin 300071 China

This paper identifies the contributions of p-a-SiC：H layers and i-a-Si：H layers to the open circuit voltage of p-i-n type a-Si：H solar cells deposited at a low temperature of 125℃. We find that poor quality p-a-SiC：H films under regular conditions lead to a restriction of open circuit voltage although the band gap of the i-layer varies widely. A significant improvement in open circuit voltage has been obtained by using high quality p-~SiC：H films optimized at the ＂low-power regime＂ under low silane flow rates and high hydrogen dilution conditions.

关键词： amorphous silicon solar cell low temperature open-circuit voltage

Transcriptomic analyses reveal new genes and networks response to H5N1 influenza viruses in duck(Anas platyrhynchos)

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Journal of Integrative Agriculture 2019年第7期18卷 1460-1472页

作者： huang Yin-hua FENG hua-peng huang li-ren YI Kang RONG En-guang chen Xiao-yun li jian-wen WANG Zeng ZHU Peng-yang liU Xiao-juan WANG Xiao-xue HU Jia-xiang liU xin chen hua-lan WANG jun li Ning State Key Laboratory for Agrobiotechnology China Agricultural UniversityBeijing 100193P.R. China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China BGI-shenzhen Shenzhen 518083P.R.China China Veterinary Culture Collection Center China Institute of Veterinary Drug ControlBeijing 100081P.R.China

H5N1 influenza represents one of the great challenges to public *** H5N1 viruses(i.e.,A/goose/Hubei/65/05,GS/65) are weakly pathogenic,while the others(i.e.,A/duck/Hubei/49/05,DK/49) are highly pathogenic to their natural ***,we performed brain and spleen transcriptomic analyses of control ducks and ones infected by the DK/49 or the GS/65 H5N1 *** demonstrated that,compared to the GS/65 virus,the DK/49 virus infection changed more numerous immune genes’ expression and caused continuous increasing of immune pathways(i.e.,RIG-I and MDA5) in *** found that both H5N1 virus strains might escape or subvert host immune response through affecting alternative translation of immune genes,while the DK/49 virus seemed to induce alternative translation of more immune genes than the GS/65 *** also identified five co-expressional modules associated with H5N1 virus replication through the weight correlation network analysis(WGCNA).Moreover,we first demonstrated that the duck BCL2 L15 and DCSTAMP in one of these five modules inhibited both the highly pathogenic and weakly pathogenic H5N1 virus replication *** analyses,in combination with our comprehensive transcriptomic data,provided global view of the molecular architecture for the interaction between host and H5N1 viruses.

关键词： duck innate immune genes H5N1 influenza viruses transcriptomes

Clinical features of coronary artery ectasia in the elderly

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Journal of Geriatric Cardiology 2014年第3期11卷 185-191页

作者： Qiao-Juan huang Yan ZHANG Xiao-lin li Sha li Yuan-lin GUO cheng-Gang ZHU Rui-Xia XU li-xin jianG Meng-hua chen jian-jun li Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College BeiLiShi Road 167 Beijing 100037 China Department of Cardiology Institute of Cardiovascular Diseases the First Affiliated Hospital Guangxi Medical University Nanning Guangxi 530021 China

Objective To investigate the incidence, imaging and clinical characteristics in elderly patients with coronary artery ectasia （CAE）. Methods A retrospective analysis was conducted on patients with CAE who underwent coronary angiography between January 2006 and December 2012. According to age, the enrolled patients were divided into two groups （elderly group, age≥ 65 years; non-elderly group, age 〈 65 years）. The clinical feature, imaging characteristics and the 5-year survival rate of the two groups were *** The preva-lence of CAE in elderly patients was 0.33%. Patients in elderly group were found to have significantly higher proportion of female （30.1%vs. 10.1%,P〈 0.001）, three-vessel disease （60.5%vs. 45.2%,P = 0.003） and localized ectasia （55.0%vs. 40.2%,P = 0.003）. In addition, body mass index （20.90 ± 2.71 kg/m2vs. 22.31 ± 2.98 kg/m2,P 〈 0.001） and percentage of current smokers （45.0%vs. 64.6%,P 〈 0.001） were significantly lower in elderly group. Cumulative survival curves demonstrated reduced 5-year cumulative survival at the follow-up in the elderly group compared with the non-elderly group （88.0%vs. 96.0%,P = 0.002）. But the 5-year event free survival rate failed to show a significant difference between the two groups （31.0%vs. 35.0%,P= 0.311）.ConclusionThe prevalence of CAE in elderly patients was 0.33%, which was about 1/3 of the entire numbers of CAE patients. There were significant differences between the elderly and the non-elderly patients with CAE in terms of coronary artery disease risk factors and coronary artery ectatic characteristics. CAE might be asso-ciated with increased mortality risk in the elderly.

关键词： Coronary artery ectasia Elderly patients Clinical feature

UNSTEADY INTERMITTENT FLOW IN A ROTATING CURVED PIPE

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Journal of Hydrodynamics 2004年第2期16卷 158-165页

作者： YINjian-an shenxin-rong chenhua-jun ZHANGBen-zhao DepartmentofMechanics ZhejiangUniversityHangzhou310027Chinae-mail：mec-zbzq@emb***

The effects of rotation and intermittent frequency on the flow transition ofsecondary flow and, main flow were examined in detail. Certain hitherto unknown flow patterns werefound. A numerical study was performed to study the characteristics of unsteady intermittent flow ina rotating curved pipe. Due to the rotation, both the Coriolis force and the centrifugal forcecould contribute to the unsteady intermittent flow and some complicated phenomena can be found. Theresults indicate that the unsteady intermittent flow are mainly characterized by five parameters:the Dean number Dn, the curvature κ, the maximal force ratio F (of the Coriolis force to thecentrifugal force in a cycle), the intermittent frequency parameter η (the ratio of a pulslatingtime to the cycle period), and the Womersley number α. Present works shows the natures of theunsteady intermittent flow in a rotating curved pipe.

关键词： unsteady flow secondary flow rotating pipes

Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

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Journal of Geriatric Cardiology 2024年第4期21卷 407-420页

作者： jian-Guo CUI Feng TIAN Yu-Hao MIAO Qin-hua JIN Ya-jun SHI li li Meng-jun shen Xiao-Ming XIE Shu-lin ZHANG Yun-Dai chen School of Medicine Nankai UniversityTianjinChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Joint Laboratory of Bioimaging Technology and Applications SAS-SIM-IT&MEDIShanghaiChina Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghaiChina

OBJECTIVE To evalu ate the role of resting magnetocardiography in identifying seve re coronary artery stenosis in patients with suspected coronary artery *** A total of 513 patients with angina symptoms were included and divided into two groups based on the extent of coronary artery disease determined by angiography:the non-severe coronary stenusis group(linical *** performance of the models was evaluated using receiver operating characteristic curves,accuracy,sensitivity,specificity,positive predictive value(PPV) and ne gative predictive value(NPV).Calibration plots and decision curve analysis were performed to investigate the clinical utility and performance of the models,*** In the severe coronary stenosis group,QR_MCTDd,S_MDp,and TT_(MA)C_(50) were significantly higher than those in the non-severe coronary stenosis group(10,46±10.66 vs,5.11±6.07,P <0.001;7.2±8.64 vs.4.68±6.95,P=0.003;0.32±57.29 vs.0.26±57.29,P <0.001).While,QR_MV_(amp),R_(MA),and T_(MA) in the severe coronary stenosis group were lower(0.23±0.16 vs.0.28±0.16,P<0.001;55.06±48.68 vs.59.24±53.01,P<0.001;51.67±39.32 vs. 60.45±51.33,P <0.001).Seven MFM parameters were integrated into the model,resulting in an area under the curve of 0.810(95% CI:0.765-0.855).The sensitivity,specificity,PPV,NPV,and accurecy were 71.7%,80.4%,93.3%,42.8 %,and 73.5%;*** combined model exhibited an area under the curve of 0.845(95% CI:0.798-0.892).The sensitivity,specificity,PPV,NPV,and accuracy were 84.3%,73.8%,92.6%,54.6%,and 82.1%;*** curves demonstrate d excellent agreement between the nomogram prediction and actual *** decision curve analysis showed that the c ombine d model provided greater net benefit compared to the magnetocardingraphy model.C

关键词： coronary stenosis specificity

Randomized study of sinusoidal chronomodulated versus flat intermittent induction chemotherapy with cisplatin and 5-fluorouracil followed by traditional radiotherapy for locoregionally advanced nasopharyngeal carcinoma

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Chinese Journal of Cancer 2013年第9期32卷 502-511页

作者： huan-xin lin Yi-jun hua Qiu-Yan chen Dong-hua Luo Rui Sun Fang Qiu Hao-Yuan Mo Hai-Qiang Mai Xiang Guo li-jian Xian Ming-huang Hong ling Guo State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Nasopharyngeal Cancer Sun Yat-sen University Cancer Center Clinical Research Center Sun Yat-sen University Cancer Center

Neoadjuvant chemotherapy plus radiotherapy is the most common treatment regimen for advanced nasopharyngeal carcinoma(NPC).Whether chronomodulated infusion of chemotherapy can reduce its toxicity is *** study aimed to evaluate the toxic and therapeutic effects of sinusoidal chronomodulated infusion versus flat intermittent infusion of cisplatin(DDP)and 5-fluorouracil(5-FU)followed by radiotherapy in patients with locoregionally advanced *** with biopsy-diagnosed untreated stages III and IV NPC(according to the 2002 UICC staging system)were randomized to undergo2 cycles of sinusoidal chronomodulated infusion(Arm A)or flat intermittent constant rate infusion(Arm B)of DDP and 5-FU followed by radical *** a"MELODIE"multi-channel programmed pump,the patients were given 12-hour continuous infusions of DDP(20 mg/m2)and 5-FU(750 mg/m2)for 5days,repeated every 3 weeks for 2 *** was administered from 10:00 am to 10:00 pm,and 5-FU was administered from 10:00 pm to 10:00 am each *** infusion was performed in Arm A,with the peak deliveries of 5-FU at 4:00 am and DDP at 4:00 *** patients in Arm B underwent a constant rate of *** was initiated in the fifth week,and both arms were treated with the same radiotherapy techniques and dose *** june 2004 and june 2006,125 patients were registered,and 124 were eligible for analysis of response and *** major toxicity observed during neoadjuvant chemotherapy was *** incidence of acute toxicity was similar in both *** radiotherapy,the incidence of stomatitis was significantly lower in Arm A than in Arm B(38.1%vs.59.0%,P=0.020).No significant differences were observed for other *** 1-,3-,and 5-year overall survival rates were 88.9%,82.4%,and 74.8%for Arm A and 91.8%,90.2%,and 82.1%for Arm *** 1-,3-,and 5-year progression-free survival rates were 91.7%,88.1%,and 85.2%for Arm A and 100%,94.5%,and 86.9%for Arm ***

关键词：氟尿嘧啶鼻咽癌放疗化疗顺铂间歇正弦晚期