检索结果-南通市图书馆

Chinese Chemical Letters 2025年第2期36卷 373-377页

作者： Shaojie Deng Peihua Ma Qinghong Bai xin xiao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Department of Chemistry Guizhou University

Nor-seco-cucurbit[10]uril(ns-CB[10]) is a kinetic product with unique structure. The single bridged methylene in its structure makes the molecular cavity of ns-CB[10] more deformable when compared to ordinary cucurbit[n]uril, reducing its structural stability. Repeated experiments showed that ns-CB[10] gradually cracks in an acidic solution and changes the specificity of cucurbit[5]uril(CB[5]) and cucurbit[8]uril(CB[8]) under more robust acidic solutions and when heated. A series of experiments were designed to study the transformation behavior of ns-CB[10]. It was found that the concentration of ns-CB[10] was correlated with the content distribution of CB[5] and CB[8]. This study explores the influencing factors and mechanisms of the transformation of ns-CB[10] to CB[5] and CB[8]. The results are of great significance for the application of ns-CB[10], understanding the formation mechanism of cucurbit[n]urils. Furthermore,it provides a new pathway for synthesizing new cucurbit[n]urils.

关键词： Concentration control Cracking Mechanism Nor-seco-cucurbituril Transformation

A novel supramolecular assembly based on nor-seco-cucurbit[10]uril for spermine sensing and artificial light-harvesting

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第1期36卷 262-266页

作者： Ran Cen Yan-Yan Tang Li-Xia Chen Zhu Tao xin xiao National Key Laboratory of Green Pesticide State Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationKey Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou ProvinceGuizhou UniversityGuiyang 550025China

A supramolecular assembly composed of perylene diimide derivative(PDI-nm)and nor-secocucurbit[10]uril(ns-Q[10])was *** excellent host-guest interaction between PDI-nm and nsQ[10]prevented the aggregation-caused quenching(ACQ)effect of PDI-nm,resulting in a luminescent *** addition of spermine to the PDI-nm/ns-Q[10]assembly restored the ACQ of PDI-nm due to the competitive binding of spermine to ns-Q[10],which released *** assembly based on this principle showed ultra-high sensitivity for the detection of spermine with a detection limit as low as7.84×10^(-7)mol/L in aqueous solution and 3.69×10^(-7)mol/L in plasma ***,an artificial light-harvesting system based on this assembly was proposed,benefiting from its good luminescent *** red(Ni R)functioned as an acceptor loaded into assembly,and a highly efficient energy transfer process occurred from PDI-nm/ns-Q[10]to Ni R,with an efficiency up to 87%.

关键词： Nor-seco-cucurbituril Perylene diimide derivative Spermine Light-harvesting

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian MAO Jin-Song WANG Xiu-Qing HU xiao-xin ZHANG Liping FU Nan JIA Tianfang WANG National Space Science Center Chinese Academy of SciencesBeijing100090China Beijing Key Laboratory of Space Environment Exploration Beijing100090China Key Laboratory of Environmental Space Situation Awareness Technology Beijing100090China National Satellite Meteorological Center China Meteorological AdministrationBeijing100081China

The Triple Ionosphere Photo Meter(TRIPM)is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E(FY-3E),which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:(1)135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight(nighttime channel);(2)135.6 nm airglow from the OI when sunlight is present(daytime/dusk-dawn 135.6 nm channel);and(3)Airglow in the N_(2)LBH of the TRIPM(daytime/dusk-dawn N_(2)LBH channel).FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N_(2)derived from the 135.6 nm channel and N_(2)LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content(TEC)*** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N_(2)is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

同方期刊数据库

Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第2期17卷 159-169页

作者： Zhen-Yu Xu Jia-Shi Gao Ying He xin-Qiang xiao Guo-Zhong Gong Min Zhang Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Hepatitis B virus(HBV)evades the innate immunity and leads to persistent chronic infection,but the molecular mechanism is still not well *** To investigate whether HBV-miR-3 is involved in HBV immune *** HBV-miR-3 agomir and antagomir were employed to verify the effectiveness of HBV-miR-3 on cGAS-Sting-IFN pathway through the experiments on relative luciferase activity,cGAS protein expression,Sting phosphorylation and interferon(IFN)*** HBV-miR-3 down-regulates cGAS protein expression post-transcriptionally by inhibition of cGAS 3’-untranslated region(3’-UTR)activity,which results in lower Sting phosphorylation and IFN ***-miR-3 antagomir rescued cGAS protein expression,Sting phosphorylation and IFN-β*** HBV-miR-3 plays an important role in HBV immunity evasion by targeting cGAS 3’-UTR and interfering with cGAS-Sting-IFN pathway.

关键词： Hepatitis B virus HBV-miR-3 cGAS Sting IFN-β

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于原始肺音的端到端深度学习肺炎辅助诊断

中国医学物理学杂志 2025年第2期42卷 274-280页

作者：肖欣高玉清张建敏江汉大学人工智能学院湖北武汉430056

提出一种基于双路径不同卷积核的DCL-Net的端到端肺炎辅助诊断方法。该方法无需进行特征工程,将原始肺音信号直接输入模型,利用卷积核分别为1∗3和1∗5的双路径卷积网络,每个路径包含3个残差块,以便模型自动学习肺音信号不同尺度的特征,... 详细信息

提出一种基于双路径不同卷积核的DCL-Net的端到端肺炎辅助诊断方法。该方法无需进行特征工程,将原始肺音信号直接输入模型,利用卷积核分别为1∗3和1∗5的双路径卷积网络,每个路径包含3个残差块,以便模型自动学习肺音信号不同尺度的特征,同时避免模型退化问题。为验证端到端方法的性能,将其与信号分析领域常用的梅尔倒谱图、短时傅里叶变换和小波变换这3种特征提取方法进行比较。结果显示,四分类任务(正常、普通、病重、病危)诊断准确率为61.4%,相比3种特征工程方法分别提高1.6%、5.0%和3.7%;二分类任务(正常、异常)诊断准确率为89.7%,相比3种特征工程方法分别提高11.0%、5.1%和11.2%。实验结果表明该方法可为肺炎病情评估提供更有效的诊断工具。

关键词：原始肺音肺炎智能辅助诊断端到端学习 DCL-Net

在线全文

学校读者我要写书评

暂无评论

基于多尺度偏移感知网络的结肠息肉目标检测

陕西科技大学学报 2025年第1期43卷 177-184页

作者：池晓鑫杜晓刚王营博雷涛陕西科技大学电子信息与人工智能学院陕西省人工智能联合实验室陕西西安710021

一些息肉目标检测方法难以充分提取全局及长距离语义信息,导致在具有环境噪声的情况下对尺寸差异较大的息肉目标检测精度低.为了解决该问题,提出了一种基于多尺度偏移感知的息肉检测网络.首先,设计了多尺度偏移感知注意力模块,通过在不... 详细信息

一些息肉目标检测方法难以充分提取全局及长距离语义信息,导致在具有环境噪声的情况下对尺寸差异较大的息肉目标检测精度低.为了解决该问题,提出了一种基于多尺度偏移感知的息肉检测网络.首先,设计了多尺度偏移感知注意力模块,通过在不同尺度上对图像特征进行注意力加权和偏移感知,提高了图像特征的提取和融合能力.其次,设计了渐近特征融合模块,对不同尺度的特征图进行自适应空间加权融合,从而捕捉了更丰富的上下文信息.通过大量实验证明,该方法在三个不同类型的息肉数据集上分别达到了94.8%、94.6%和95.8%的检测精度,相比于当前主流的目标检测方法取得了更好的检测结果.

关键词：医学图像息肉检测注意力机制多尺度特征特征融合

维普期刊数据库博看期刊

基于混合模型的长江流域洞庭湖区陆域磷输入通量及其削减预测

在线全文

学校读者我要写书评

暂无评论

环境科学 2025年第1期46卷 172-183页

作者：刘杰陈前许妍张美一辛小康唐文忠张洪东南大学土木工程学院南京210018 中国科学院生态环境研究中心环境水质学国家重点实验室北京100085 上海市政工程设计研究总院(集团)有限公司上海200092 中国科学院大学北京100049 长江水资源保护科学研究所武汉430051

陆域磷输入(磷输入)通量研究对于面源污染控制至关重要.利用SWAT模型模拟洞庭湖区磷输入通量,并针对农业控制、畜禽减排与水土保持措施的3种典型削减情景,利用混合模型(LSTM模型和SWAT模型)进行水系区间磷输入通量削减预测.结果表明,洞... 详细信息

陆域磷输入(磷输入)通量研究对于面源污染控制至关重要.利用SWAT模型模拟洞庭湖区磷输入通量,并针对农业控制、畜禽减排与水土保持措施的3种典型削减情景,利用混合模型(LSTM模型和SWAT模型)进行水系区间磷输入通量削减预测.结果表明,洞庭湖区的TP入河总量为3.9×10^(4)t·a^(-1),TP负荷为14.4 kg·(hm^(2)·a)^(-1).磷通量季节变化显著,汛期高,非汛期低,与径流挟带、土壤侵蚀和耕作密度有显著相关性.三口区间是磷输入通量最大的区域,每年平均值为1.87×10^(4)t,需重点关注其磷污染风险.水系面积和农业用地面积是该区域磷输入通量主要的决定因素.多特征输入的LSTM模型在子流域尺度上对磷输入通量模拟效果良好,NSE>0.6.混合模型在水系区间尺度上表现出更好的结果,NSE>0.8,RPE<10%,且对数据特征要求降低.在削减预测中,以三口区间为例,入河泥沙量削减是相对有效的磷减排方式,泥沙作为磷的主要载体是面源污染控制的主要目标,同时还应关注畜禽养殖的污染.研究可为了解洞庭湖区磷输入通量的时空格局并制定磷减排策略提供科学依据和数据支撑.

关键词：磷通量磷削减 SWAT模型 LSTM模型洞庭湖区

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang xiao Guo Hua Guo Shou-Feng Jia xiao-xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Blunt aortic injury-traumatic aortic isthmus pseudoaneurysm with right iliac artery dissection aneurysm:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第15期10卷 4998-5004页

作者： xiao-xin Fang xin-Hui Wu xiao-Feng Chen Department of Cardiology Taizhou Hospital of Zhejiang Province(Taizhou HospitalZhejiang University School of Medicine)Linhai 317000Zhejiang ProvinceChina Department of Orthopedics Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Radiation Oncology Indiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Blunt aortic injury is a special type of aortic *** to its low incidence,high prehospital mortality and high probability of leakage diagnosis,the timely identification of patients with blunt aortic injury who survive the initial injury has always been a clinical *** SUMMARY We report a case of traumatic aortic pseudoaneurysm with right iliac artery dissection aneurysm that was diagnosed 3 mo after a traffic *** patient is a 76-year-old male who was knocked down by a fast-moving four-wheel motor vehicle while crossing the road(the damage mechanism was side impact).He received chest,cranial computed tomography(CT)and whole abdomen enhanced CT in the local *** images suggested subarachnoid hemorrhage,right frontoparietal scalp hematoma,fracture of the right clavicle and second rib,lumpshaped mediastinal shadow outside the anterior descending thoracic aorta(mediastinal hematoma),mesenteric vascular injury with hematoma formation,pelvic fracture,and subluxation of the left sacroiliac *** the pelvic fracture was fixed with an external stent,he was sent to our hospital for further *** our hospital,he successfully underwent partial resection of the small intestine and CT-guided screw internal fixation of the left sacroiliac joint and returned to the local hospital for rehabilitation ***,since the accident,the patient has been suffering from mild chest pain,which has not aroused the attention of *** rehabilitation,his chest pain gradually worsened,and the thoracic aorta computed tomography angiography performed in the local hospital showed a pseudoaneurysm in the initial descending segment of the aortic *** transfer to our hospital,a dissecting aneurysm of the right external iliac artery was incidentally found in the preoperative ***,endovascular stent graft repair was performed,and he was discharged on the 10th day after the *** obvious endo-leak was f

关键词： Motor vehicle collision Blunt aortic injury Chest pain Traumatic pseudoaneurysm Traumatic dissecting aneurysm Case report

Remark on Mild Solution to the 3D Incompressible Micropolar System in Fourier–Herz Framework

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2019年第10期35卷 1595-1616页

作者： Yao NIE xiao xin ZHENG School of Mathematics and Systems Science Beihang University

This paper is devoted to investigating the existence and uniqueness of mild solution to the 3D incompressible micropolar fluid system in the Fourier–Herz framework. By taking advantage of microlocal analysis and the mutual effect in the same frequency range of convection term, we give a special initial data(u0,ω0) whose norm of FB1,q^-1(q>2) is arbitrarily small, however, the couple(u0,ω0) produces a solution which is arbitrarily large in FB1,q^-1 after an arbitrarily short time. This implies the system is ill-posed in the sense of "norm inflation" as q>2.

关键词： Ill-posedness micropolar system Fourier-Herz space norm inflation