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Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone

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Neural Regeneration Research 2023年第6期18卷 1364-1370页

作者： Madeha Ishag Adam Ling Lin Amir Mahmoud Makin Xiao-Fen Zhang Lu-Xi Zhou xin-Yue liao Li Zhao Feng Wang Dao-Shu Luo Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Laboratory of Clinical Applied AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Public Technology Service Center of Fujian Medical University FuzhouFujian ProvinceChina Center for Membrane and Water Science&Technology Institute of Oceanic and Environmental Chemical EngineeringZhejiang University of TechnologyHangzhouZhejiang ProvinceChina

The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central *** special anatomical and physiological structure renders it susceptible to nerve *** etiology of most primary trigeminal neuralgia is closely related to microvascular compression of the trigeminal root entry *** study aimed to develop an efficient in vitro model mimicking the glial environment of trigeminal root entry zone as a tool to investigate the effects of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor on the structural and functional integrity of trigeminal root entry zone and modulation of cellular *** astrocytes and Schwann cells isolated from trigeminal root entry zone of postnatal rats were inoculated into a two-well silicon culture insert to mimic the trigeminal root entry zone microenvironment and treated with glial cell line-derived neurotrophic factor and brain-derived neurotrophic *** monoculture,glial cell line-derived neurotrophic factor promoted the migration of Schwann cells,but it did not have effects on the migration of *** the co-culture system,glial cell line-derived neurotrophic factor promoted the bidirectional migration of astrocytes and Schwann ***-derived neurotrophic factor markedly promoted the activation and migration of ***,in the co-culture system,brain-derived neurotrophic factor inhibited the migration of astrocytes and Schwann cells to a certain *** findings suggest that glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor are involved in the regulation of the astrocyte-Schwann cell interaction in the co-culture system derived from the trigeminal root entry *** system can be used as a cell model to study the mechanism of glial dysregulation associated with trigeminal nerve injury and possible therapeutic interventions.

关键词： astrocytes brain-derived neurotrophic factor cell migration glial cell line-derived neurotrophic factor glial interaction Schwann cells trigeminal nerve

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Adenocarcinoma transformed into squamous cell carcinoma in non-small cell lung cancer

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Journal of Genetics and Genomics 2021年第7期48卷 656-659页

作者： Yueqiang Jiang Jun Zhang Jin Feng Yaping Lu Yuan Fan Ling Cheng xin liao Liya Hu Shiying Yu Tiejun Yin Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Sinopharm Genomics Technology Co. LTDBlock B3No.9Changyang RoadWest Taihu Lake Science and Technology Industrial ZoneChangzhouJiangsu 213000China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Non-small cell lung cancer(NSCLC)is the most common form of lung cancer which remains the deadliest malignancy worldwide(Siegel et al.,2019).In general,NSCLC can be divided into several subtypes,including adenocarcino... 详细信息

关键词： ADC Adenocarcinoma transformed into squamous cell carcinoma in non-small cell lung cancer

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基于拉普拉斯算子统计量的LSB替换隐写分析方法

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电子与信息学报 2009年第5期31卷 1054-1058页

作者：廖鑫温巧燕北京邮电大学网络与交换技术国家重点实验室北京100876

该文基于对图像像素点的拉普拉斯算子统计量的分析,提出了两种新的LSB替换隐写分析方法。首先定义了描述像素点与4-邻域像素均值关系的统计量,进而通过对隐秘信息的嵌入、LSB平面二次嵌入和LSB平面置反带来的变化分析,提出了隐秘信息的... 详细信息

该文基于对图像像素点的拉普拉斯算子统计量的分析,提出了两种新的LSB替换隐写分析方法。首先定义了描述像素点与4-邻域像素均值关系的统计量,进而通过对隐秘信息的嵌入、LSB平面二次嵌入和LSB平面置反带来的变化分析,提出了隐秘信息的检测方法1和隐写嵌入率的准确估计方法2。该文提出的二个方法实际物理意义明显,实现简单。实验结果表明在嵌入率不小于20%时方法2估计准确率优于RS方法。

关键词：隐写分析最低有效比特位拉普拉斯算子二次曲线拟合

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Highly efficient H^1-Galerkin mixed finite element method (MFEM) for parabolic integro-differential equation

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Applied Mathematics and Mechanics(English Edition) 2014年第7期35卷 897-912页

作者：石东洋廖歆唐启立 School of Mathematics and Statistics Zhengzhou University

A highly efficient H1-Galerkin mixed finite element method （MFEM） is presented with linear triangular element for the parabolic integro-differential equation. Firstly, some new results about the integral estimation and asymptotic expansions are studied. Then, the superconvergence of order O（h^2） for both the original variable u in H1 （Ω） norm and the flux p = u in H（div, Ω） norm is derived through the interpolation post processing technique. Furthermore, with the help of the asymptotic expansions and a suitable auxiliary problem, the extrapolation solutions with accuracy O（h^3） are obtained for the above two variables. Finally, some numerical results are provided to confirm validity of the theoretical analysis and excellent performance of the proposed method.

关键词： parabolic integro-differential equation H1-Galerkin mixed finite elementmethod (MFEM) linear triangular element asymptotic expansion superconvergence andextrapolation

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Synthesis and antitumor activity of α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidines

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Chinese Chemical Letters 2015年第6期26卷 755-758页

作者： Yan-Chun Guo Jing Li Jiao-Li Ma Zhi-Ran Yu Hai-Wei Wang Wen-Juan Zhu xin-Cheng liao Yu-Fen Zhao The College of Chemistry and Molecular Engineering The Key Laboratory of Chemical Biology and Organic Chemistry of Henan ProvinceZhengzhou University Department of Chemistry College of Chemistry and Chemical EngineeringThe Key Laboratory for Chemical Biology of Fujian ProvinceXiamen University

Two series of thieno[2,3-d]pyrimidine derivatives were designed and synthesized, in which bioactive α-aminophosphonate subunits were introduced at the N3 position through an N-N bond connection. The in vitro cytotoxic activity of the novel compounds was tested against human esophageal carcinoma cells （EC109）, human hepatocarcinoma cells （HepG2）, human gastric carcinoma cells （MGC-803）, respectively, by the MTT method. The evaluation results revealed that compounds fimb, 6mf, 6mg, 6rid and 6nh exerted the most potent inhibition against HepG2, MGC-803 and EC109 cells, respectively. In particular, compound 6rag presented excellent inhibitory effect against HepG2 （91.2%） and MGC-803 （94.4%） cells.

关键词： α-Aminophosphonate derivatives Thieno[2 3-d]pyrimidine Synthesis Antitumor

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Palliative primary tumor resection provides survival beneits for the patients with metastatic colorectal cancer and low circulating levels of dehydrogenase and carcinoembryonic antigen

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Chinese Journal of Cancer 2016年第9期35卷 468-475页

作者： Wen-Zhuo He Yu-Ming Rong Chang Jiang Fang-xin liao Chen-Xi Yin Gui-Fang Guo Hui-Juan Qiu Bei Zhang Liang-Ping Xia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat?sen University Cancer Center VIP Region Sun Yat?sen University Cancer Center

Background: It remains controversial whether palliative primary tumor resection(PPTR) can provide survival benefits to the patients with metastatic colorectal cancer(m CRC) who have unresectable metastases. The aim of this study was to evaluate whether PPTR could improve the survival of patients with m ***: We conducted a retrospective study on consecutive m CRC patients with unresectable metastases who were diagnosed at Sun Yat?sen University Cancer Center in Guangzhou, Guangdong, China, between January 2005 and December 2012. Overall survival(OS) and progression?free survival(PFS) after first?line chemotherapy failure were compared between the PPTR and non?PPTR patient ***: A total of 387 patients were identified, including 254 who underwent PPTR and 133 who did not. The median OS of the PPTR and non?PPTR groups was 20.8 and 14.8 months(P < 0.001), respectively. The median PFS after first?line chemotherapy was 7.3 and 4.8 months(P < 0.001) in the PPTR and non?PPTR groups, respectively. A larger proportion of patients in the PPTR group(219 of 254, 86.2%) showed local progression compared with that of patients in the non?PPTR group(95 of 133, 71.4%; P < 0.001). Only patients with normal lactate dehydrogenase(LDH) levels and with carcinoembryonic antigen(CEA) levels <70 ng/m L benefited from PPTR(median OS, 22.2 months for the PPTR group and 16.2 months for the non?PPTR group; P < 0.001).Conclusions: For m CRC patients with unresectable metastases, PPTR can improve OS and PFS after first?line chemo?therapy and decrease the incidence of new organ involvement. However, PPTR should be recommended only for patients with normal LDH levels and with CEA levels <70 ng/m L.

关键词：乳酸脱氢酶结直肠癌转移性患者肿瘤水福利手术切除

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Transcriptomics reveals the effect of ammonia nitrogen concentration on Pseudomonas stutzeri F2 assimilation and the analysis of amtB function

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Synthetic and Systems Biotechnology 2023年第2期8卷 262-272页

作者： Wei-lai Fu Pei-feng Duan Qiang Wang Ya-xin liao Yun-shuang Wang Mei-juan Xu Hui-hui Jiang Xian Zhang Zhi-ming Rao The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi214122PR China The Key Laboratory of Functional Aquafeed and Culture Environment Control Fujian DBN Huayou Aquatic Science and Technology Co.LtdZhangzhou363500PR China School of Biological and Environmental Engineering Chaohu UniversityHefei238024PR China

The biological treatment of wastewater with high concentrations of ammonia nitrogen has become a hot research issue,but there are limited reports on the mechanism of ammonia nitrogen utilization by *** this paper,a transcriptomic approach was used to investigate the differences in gene expression at 500.0 mg/L(Amo 500)and 100.0 mg/L(Amo 100)ammonium concentrations to reveal the mechanism of ammonia nitrogen removal from water by Pseudomonas stutzeri *** transcriptome data showed 1015(459 up-regulated and 556 down-regulated)differentially expressed genes with functional gene annotation related to nitrogen source metabolism,glycolysis,tricarboxylic acid cycle,extracellular polysaccharide synthesis,energy conversion and transmembrane transport,revealing the metabolic process of ammonium nitrogen conversion to biological ni-trogen in *** F2 through *** verify the effect of ammonium transporter protein(AmtB)of cell membrane on assimilation,a *** F2-ΔamtB mutant strain was obtained by constructing a knockout plasmid(pK18mobsacB-ΔamtB),and it was found that the growth characteristics and ammonium removal rate of the mutant strain were significantly reduced at high ammonium *** carbon source components and dissolved oxygen conditions were optimized after analyzing the transcriptome data,and the ammonium removal rate was increased from 41.23%to 94.92%with 500.0 mg/L ammonium *** study of *** F2 transcript level reveals the mechanism of ammonia nitrogen influence on microbial assimilation process and improvement strategy,which provides a new strategy for the treatment of ammonia nitrogen wastewater.

关键词： Ammonia nitrogen Pseudomonas stutzeri F2 Transcriptomic Assimilation amtB

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大口径天线伺服系统的建模及控制算法设计

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华南理工大学学报（自然科学版） 2013年第5期41卷 22-27,33页

作者：张磊廖鑫江华南理工大学自动化科学与工程学院广东广州510640

在大口径天线伺服系统存在高频未建模动态不确定性和低频风扰动的情况下,传统的PID控制算法无法满足天线伺服系统的高指向和跟踪精度要求.针对该问题,文中设计了一种基于灵敏度函数和补灵敏度函数的、兼顾系统性能和稳定性的混合灵敏度H... 详细信息

在大口径天线伺服系统存在高频未建模动态不确定性和低频风扰动的情况下,传统的PID控制算法无法满足天线伺服系统的高指向和跟踪精度要求.针对该问题,文中设计了一种基于灵敏度函数和补灵敏度函数的、兼顾系统性能和稳定性的混合灵敏度H_infinity控制算法,并将其应用于天线伺服系统.仿真结果表明,该算法不仅能显著提高天线伺服系统的动态性能,而且具有较强的扰动抑制能力和鲁棒性.

关键词：大口径天线伺服系统指向精度 H_infinity控制扰动抑制鲁棒性

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Application of deep learning in upper gastrointestinal diseases

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实用休克杂志（中英文） 2022年第5期6卷 315-320页

作者： Luo Ju Ding Ning liao xin Chen Wei Department of Gastroenterology Central South UniversityThe Third Xiangya Hospital Department of Emergency University of South ChinaChangsha Central Hospital Hunan University College of Computer Science and Electronic Engineering Department of Geriatrics University of South ChinaChangsha Central Hospital

In recent years,deep learning has made tremendous progress in diagnosis assistance and prognosis prediction along with the accumulation of abundant medical data and the improvement of computer *** studies have focused on applying deep learning to digestive system *** concerning deep learning and upper gastrointestinal diseases mainly concentrate on cancer and precancerous lesions,while few studies focus on other digestive *** order to better understand this emerging inter-discipline,this paper reviews the ways in which deep learning may help doctors make a diagnosis or establish a prognosis and discusses its limitations,knowing that further randomized controlled studies and deeper cooperation between computer experts and doctors will be required.

关键词： Deep Learning Artificial Intelligence Upper Gastrointestinal Diseases Esophageal Carcinoma Gastric Carcinoma

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Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease

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Journal of Integrative Medicine 2023年第6期21卷 518-527页

作者： Lin-hong Jiang Pei-jun Li Ying-qi Wang Mei-ling Jiang Xiao-yu Han Yi-die Bao xin-liao Deng Wei-bing Wu Xiao-dan Liu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Exercise and Health Shanghai University of SportShanghai 200438China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghai 201203China Institute of Rehabilitation Medicine Shanghai Academy of Traditional Chinese MedicineShanghai 201203China

Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease(COPD).However,the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized *** is central to the development of *** this review,we elucidate the effects and underlying mechanisms of acupuncture from an antiinflammatory perspective based on animal *** smoke combined with lipopolysaccharide is often used to establish animal models of *** can be an effective intervention to improve inflammation in COPD,and Feishu(BL13)and Zusanli(ST36)can be used as basic acupoints in COPD animal *** acupuncture types can regulate different types of inflammatory cytokines;meanwhile,different acupuncture types and acupoint options have similar effects on modulating the level of inflammatory *** particular,acupuncture exerts anti-inflammatory effects by inhibiting the release of inflammatory cells,inflammasomes and inflammatory *** main underlying mechanism through which acupuncture improves inflammation in COPD is the modulation of relevant signalling pathways:nuclear factor-κB(NF-κB)(e.g.,myeloid differentiation primary response 88/NF-κB,toll-like receptor-4/NF-κB,silent information regulator transcript-1/NF-κB),mitogen-activated protein kinase signalling pathways(extracellular signal-regulated kinase 1/2,p38 and c-Jun NH2-terminal kinase),cholinergic anti-inflammatory pathway,and dopamine D2 receptor *** current synthesis will be beneficial for further research on the effect of acupuncture on COPD inflammation.

关键词： Acupuncture Chronic obstructive pulmonary disease Anti-inflammatory effects Mechanisms Animal study

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