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Chinese Chemical Letters 2022年第9期33卷 4175-4178页

作者： Junping Bai Junliang Zhou xin ji Nannan Wang Xiaochun Dong Wei Wu Weili Zhao School of Pharmacy Institutes of Integrative MedicineFudan UniversityShanghai 201203China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China

Fluorescent dyes play a crucial role in fluorescence imaging and sensing ***,there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane *** dyes with strong fluorescence emission in both nonpolar and polar solvents are highly *** this manuscript,we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N'-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties.

关键词： Fluorescent dyes BODIPY Environment-insensitive Bioimaging

Symmetry Reduction and Rotational Re-quantization of Symmetric Top Molecules at Local Mode Limit

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Chinese Physics Letters 1997年第9期14卷 656-659页

作者： CHENG ji-xin WANG Xiao-gang LIN Hai ZHU Qing-shi Department of Chemical Physics University of Science and Technology of ChinaHefei 230026

The(400)stretching overtone band of AsH3 has been observed near 8029.0 cm^(-1) and analyzed in both symmetric and asymmetric top *** results indicate that the dynamical symmetry of the(400)local mode state has reduced to that of an asymmetric top and the rotational energy levels can be assigned by a set of quantum numbers J,K_(a),and K_(c).

关键词： asymmetric stretching symmetry

Modified Approach for Establishing Filament-induced Permanent Middle Cerebral Artery Occlusion Rats and Mice Models

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Chinese Medical Sciences Journal 2011年第4期26卷 257-258页

作者： You-xin ji Ke-tao Lan Chuan-xin Geng Xiao Zou Song-ping Wang Department of Medical Oncology Qingdao Central Hospital Second Affiliated Hospital of Qingdao University Qingdao 266042 China

BRAIN ischemia stroke is a devastating disease,with more than 10％ stroke patients either severely disabled or *** rodent filament middle cerebral artery occlusion (MCAO)model can mimic human brain ischemic stroke well,its wide use was restricted by difficulty in surgery,especially in ligating pterygopalatineartery (PPA).Twenty-seven male Sprague-Dawley rats were randomly divided into A,B,C groups (n=9).All the rats were performed MCAO surgery with sutures of difference *** A used 4-0 blocking suture plus ipsilateral PPA block,group B used 3-0 blocking suture plus ipsilateral common carotid artery (CCA) block,and group C used 3-0 suture plus ipsilateral PPA ***-seven male C57BL/6 wild type mice were also randomly divided into a,b,c *** a used 5-0blocking suture plus ipsilateral PPA block,group b used 6-0blocking suture plus ipsilateral CCA block,group c use 6-0suture plus ipsilateral PPA block.

关键词： SD大鼠小鼠模型动脉闭塞大脑永久性立方纤维

Bond-selective transient phase imaging via sensing of the infrared photothermal effect

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Light(Science & Applications) 2019年第1期8卷 70-81页

作者： Delong Zhang Lu Lan Yeran Bai Hassaan Majeed Mikhail E.Kandel Gabriel Popescu ji-xin Cheng Department of Biomedical Engineering Boston UniversityBostonMA 02215USA Department of Physics Zhejiang UniversityHangzhou 310028China National Laboratory on High Power Laser and Physics Shanghai 201800China Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Bioengineering University of Illinois at Urbana-ChampaignChampaignIL 61801USA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignChampaignIL 61801USA Department of Electrical&Computer Engineering Boston UniversityBostonMA 02215USA Photonics Center Boston UniversityBostonMA 02215USA

Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen,e.g.,a biological cell,into brightness variations in an *** ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life *** these advantages,phase-contrast microscopy lacks the ability to reveal molecular *** address this gap,we developed a bond-selective transient phase(BSTP)imaging technique that excites molecular vibrations by infrared light,resulting in a transient change in phase shift that can be detected by a diffraction phase *** developing a time-gated pump-probe camera system,we demonstrate BSTP imaging of live cells at a 50 Hz frame rate with high spectral fidelity,sub-microsecond temporal resolution,and sub-micron spatial *** approach paves a new way for spectroscopic imaging investigation in biology and materials science.

关键词： transient phase utilized

Effects of Nutrient Limitation on Pigments in Thalassiosira weissflogii and Prorocentrum donghaiense

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Journal of Integrative Plant Biology 2007年第5期49卷 686-697页

作者： jian-Jun Hou Bang-Qin Huang Zhen-Rui Cao ji-xin Chen Hua-Sheng Hong State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China College of Fisheries Huazhong Agricultural University Wuhan 430070 China Hubei Institute for Nationalities Enshi 445000 China

The response of Prorocentrum donghaiense and Thalassiosira weissfiogii pigments under nitrate （N） and phosphate （P） limitation were studied using HPLC and in vivo fluorescence protocols in batch cultures. For P. donghaiense, the pigment ratio was kept stable under different nutrient conditions from the results of HPLC. For T. weissflogii, there was a lower ratio of chlorophyllide to Chl a during the exponential phase, but the reverse during the stationary phase. Different members of the phytoplankton had different pigments response mechanisms under nutrient limitation. From the results of in vivo fluorescence, the ratio of peridinin to Chl a for P. donghaiense increased in nutrient-free culture, while it was kept stable for nutrient-limited cultures during the exponential phase. For T. weissflogii, the ratio of fucoxanthin to Chl a for each culture increased during the exponential phase, but the ratio under N limitation was apparently lower than that for P limitation during the stationary phase. The results indicate that both pigment ratios from HPLC and in vivo fluorescence of To weissflogii were changed greatly under different nutrient conditions, which suggests that both ratios could be used as indicators of algal physiological status in different nutrient conditions.

关键词： HPLC in vivo fluorescence nutrient limitation pigments Prorocentrum donghaiense Thalassiosira weissflogii.

Sesquiterpenoids from the leaves of Sarcandra glabra

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Chinese Journal of Natural Medicines 2022年第3期20卷 215-220页

作者： WANG Yong-Yue LI Qiu-Rong CHI Jun LI ji-xin KONG Ling-Yi LUO Jun jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Sarglanoids A-F,six new sesquiterpenoids belonging to eudesmane(1-5)and eremophilane(6)types,were isolated from the leaves of Sarcandra glabra,a famous traditional Chinese medicine(TCM).Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism(ECD)*** 1-2 were rare N-containing eudesmane-type *** 3 exhibited inhibitory activity against nitric oxide(NO)production in lipopolysaccharides(LPS)-induced RAW 264.7 cells with IC_(50) values at 20.00±1.30μmol·L^(-1).These findings provide scientific evidence for sesquiterpenoids as the material foundation of ***.

关键词： Sarcandra glabra Sesquiterpenoids N-containing sesquiterpenoids Anti-inflammatory

Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy

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Light(Science & Applications) 2023年第7期12卷 1354-1369页

作者： jian Zhao Lulu jiang Alex Matlock Yihong Xu jiabei Zhu Hongbo Zhu Lei Tian Benjamin Wolozin ji-xin Cheng Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA The Picower Institute for Learning and Memory Massachusetts Institute of TechnologyCambridgeMA 02142USA Department of Pharmacology and Experimental Therapeutics Boston University School of MedicineBostonMA 02118USA Department of Physics Boston UniversityBostonMA 02215USA State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of Sciences130033 ChangchunChina Department of Biomedical Engineering Boston UniversityBostonMA 02215USA photonics Center Boston UniversityBostonMA 02215USA present address:Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02142USA

Amyloid proteins are associated with a broad spectrum of neurodegenerative ***,it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular *** address this challenge,we developed a computational chemical microscope integrating 3D midinfrared photothermal imaging with fluorescence imaging,termed Fluorescence-guided Bond-Selective Intensity Diffraction Tomography(FBS-IDT).Based on a low-cost and simple optical design,FBS-IDT enables chemical-specific volumetric imaging and 3D site-specific mid-IR fingerprint spectroscopic analysis of tau fbrils,an important type of amyloid protein aggregates,in their intracellular ***-free volumetric chemical imaging of human cells with/without seeded tau fibrils is demonstrated to show the potential correlation between lipid accumulation and tau aggregate ***-resolved mid-infrared fingerprint spectroscopy is performed to reveal the protein secondary structure of the intracellular tau fibrils.3D visualization of theβ-sheet for tau fibril structure is achieved.

关键词： tau amyloid chemical

An investigation of changes in water quality throughout the drinking water production/distribution chain using toxicological and fluorescence analyses

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Journal of Environmental Sciences 2020年第1期32卷 310-318页

作者： Xue Han xin ji Xuan Ma Jun-Ling Liu Zhen-Yu He Wei Chang Fei Tang Ai-Lin Liu Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Wuhan Center for Disease Control and Prevention Wuhan 430015China School of Public Health Wuhan University of Science and TechnologyWuhan 430030China

Changes in water quality from source water to finished water and tap water at two conventional drinking water treatment plants(DWTPs)were *** the routine water quality testing,Caenorhabditis elegans-based toxicity assays and the fluorescence excitation–emission matrices technique were also *** DWTPs supplied drinking water that met government *** current test conditions,both the investigated finished water and tap water samples exhibited stronger lethal,genotoxic and reprotoxic potential than the relative source water sample,and the tap water sample was more lethal but tended to be less genotoxic than the corresponding finished water ***,the nearly complete removal of tryptophan-like substances and newly generated tyrosine-like substances were observed after the treatment of drinking water,and humic-like substances were identified in the tap *** on these findings,toxic pollutants,including genotoxic/reproductive toxicants,are produced in the drinking water treatment and/or distribution ***,further studies are needed to clarify the potentially important roles of tyrosine-like and humic-like substances in mediating drinking water toxicity and to identify the potential sources of these ***,tryptophan-like fluorescence may be adopted as a useful parameter to monitor the treatment performance of *** observations provided insights into the importance of utilizing biotoxicity assays and fluorescence spectroscopy as tools to complement the routine evaluation of drinking water.

关键词： Bioassay C.elegans EEM Water treatment Distribution system

Identification of the activity source of CO2 electroreduction by strategic catalytic site distribution in stable supramolecular structure system

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National Science Review 2021年第3期8卷 78-87页

作者： Sheng-Nan Sun Ning Li jiang Liu Wen-xin ji Long-Zhang Dong Yi-Rong Wang Ya-Qian Lan jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials Science Nanjing Normal University School of Chemistry and Chemical Engineering Yangzhou University State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering Ningxia University

Identification of the real catalytic site in CO;2;reduction reaction（CO;2;RR） is critical for the rational design of catalysts and the understanding of reactive *** this study,the catalytic activity of pyridine-containing materials was for the first time structurally demonstrated in CO;2;RR by crystalline supramolecular coordination compounds model *** system consists of three stable supramolecular coordination compounds（Ni-TPYP,Ni-TPYP-1 and Ni-TPP） with different numbers（4,2 and 0） of active pyridine groups（*** pyridine nitrogen atoms）.The electrocatalytic test results show that with the decrease of the number of active pyridine groups,the CO;2;RR performance is gradually reduced,mainly showing the reduction of highest FE;CO;（99.8%,83.7% and 25.6%,respectively）.The crystallographic,experimental and theoretical evidences prove that the CO;2;RR activity is more likely derived from uncoordinated pyridine nitrogen than the electrocatalytic inert metal nickel in porphyrin *** work serves as an important case study for the identification of electrocatalytic activity of pyridine-containing materials in CO;2;RR by simple supramolecular model system.

关键词： strategic catalytic site distribution supramolecular structure system active source CO2 electroreduction

Electric Field and Ion Diffusion Triggered Precisely Regulated Construction of Micron-scale Water-based Polymer Films:a Detailed Mechanistic Exploration

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Chemical Research in Chinese Universities 2022年第6期38卷 1435-1445页

作者： WANG Dan LIU jinfang YANG Shuqi ji xin WANG Yuliang OMONIYI Ahmed Olalekan ZHANG jianfu SU Zhongmin School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022P.R.China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun130022P.R.China jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry Changchun University of Science and TechnologyChangchun130022P.R.China

Water-based polymer films can be readily deposited onto a wide range of metallic materials as an environmentally friendly coating through the demulsification-induced fast solidification(DIFS)***,there is still a lack of in-depth understanding of the demulsification process of the water-based emulsions and their deposition ***,we demonstrate that the build-up process of the commercial water-based micron-scale waterborne polyurethane,polyvinyl acetate,polyurethane acrylate,and natural rubber polymer films is affected by the collective effect of electric field and ion diffusion exerted by anode-cathode electrode pairs,applied voltage,conduction time,electrode distance,and emulsion species.A structural investigation of as-prepared polymer films allows us to propose two new structure build-up *** a flat film deposition,isolated islands are formed first and grow on the substrate surface,and eventually,their mutual coalescence forms the final ***,for a convex layer formation,the layer is first formed in the middle of the substrate and then grows toward the sides of the convex structure of the *** results presented in this work expand the understanding of the mechanism of the DIFS process and may provide some new insights into structure-oriented multifunctional material design.

关键词： Polymer film Emulsion Demulsification-induced fast solidification Mechanism