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Parameter identification and global sensitivity analysis of xin'anjiang model using meta-modeling approach

Water Science and Engineering 2013年第1期6卷 1-17页

作者： Xiao-meng SONG Fan-zhe KONG Che-sheng ZHAN Ji-wei HAN xin-hua ZHANG Hydrology and Water Resources Department Nanjing Hydraulic Research Institute School of Resource and Earth Science China University of Mining and Technology Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

Parameter identification, model calibration, and uncertainty quantification are important steps in the model-building process, and are necessary for obtaining credible results and valuable information. Sensitivity analysis of hydrological model is a key step in model uncertainty quantification, which can identify the dominant parameters, reduce the model calibration uncertainty, and enhance the model optimization efficiency. There are, however, some shortcomings in classical approaches, including the long duration of time and high computation cost required to quantitatively assess the sensitivity of a multiple-parameter hydrological model. For this reason, a two-step statistical evaluation framework using global techniques is presented. It is based on （1） a screening method （Morris） for qualitative ranking of parameters, and （2） a variance-based method integrated with a meta-model for quantitative sensitivity analysis, i.e., the Sobol method integrated with the response surface model （RSMSobol）. First, the Morris screening method was used to qualitatively identify the parameters＇ sensitivity, and then ten parameters were selected to quantify the sensitivity indices. Subsequently, the RSMSobol method was used to quantify the sensitivity, i.e., the first-order and total sensitivity indices based on the response surface model （RSM） were calculated. The RSMSobol method can not only quantify the sensitivity, but also reduce the computational cost, with good accuracy compared to the classical approaches. This approach will be effective and reliable in the global sensitivity analysis of a complex large-scale distributed hydrological model.

关键词： xin'anjiang model," global sensitivity analysis parameter identification meta-modeling approach," response surface model

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Ga_xin_(1-x)N输运性质的温度特性的数值模拟

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工程热物理学报 2008年第10期29卷 1719-1721页

作者：于新刚梁新刚清华大学工程力学系北京100084

利用多粒子Monte Carlo方法对含位错Ga_xin_(1-x)N材料的输运性质进行了研究,计算表明材料的漂移速度随温度升高而降低,InN的漂移速度的温度特性优于***和InN的迁移率在相同温度范围内随温度的变化趋势不同,同时位错密度对材料迁移率的... 详细信息

利用多粒子Monte Carlo方法对含位错Ga_xin_(1-x)N材料的输运性质进行了研究,计算表明材料的漂移速度随温度升高而降低,InN的漂移速度的温度特性优于***和InN的迁移率在相同温度范围内随温度的变化趋势不同,同时位错密度对材料迁移率的温度特性影响较大。

关键词：温度漂移速度迁移率

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Effect of Shen Song Yang xin Capsule on Myocardial -lectrophysiology of Acute Atrial Fibrillation in Canine Model

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Chinese Medical Journal 2017年第20期130卷 2513-2514页

作者： Kai Zhang Liang Shi Hai-Jiao Tang Long Yang xin-Chun Yang Department of Oncology The Affiliated Hospital of Guizhou Medical University Guizhou Guiyang 550000 China Department of Cardiology Beijing Chaoyang Hospital Affiliated to Capital University of Medical Science Beijing 100020 China Department of Cardiology Guizhou Province People's Hospital Guizhou Guiyang 550000 China

Atrial fibrillation （AF） is the most common type of arrhythmia, which is reported to increase the incidence of stroke by five to seven tblds, leading to the irregular ventricular rhythm and adversely impacted life quality, and the mortality could be increased as well by AF per se. Shen Song Yang xin （SSYX） capsule is a novel traditional Chinese medicine composed of more than a dozen Chinese medicine herbs with significant antiarrhythmic effect. In the current study, the effect of SSYX capsule has been tested in an animal study and it was also indicated by randomized double-blinded, positive drug-controlled clinical trials, However, the working mechanism of SSYX capsule as antiarrhythmic drug is not completely clear yet. This study tried to investigate the effect of SSYX capsule on the myocardial electrophysiology of acute AF dog model.

关键词： Acetylcholine Animal Model Atrial Fibrillation Rapid Atrial Pacing Shen Song Yang xin Capsule

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Computational systems pharmacology reveals anantiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-xin injection in treatment of ischemic stroke

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中国药理学与毒理学杂志 2019年第10期 857-858页

作者： ZHAO Jing LYU Chao WU Qiu-ling ZENG Hua-wu GUO xin YANG Jian TIAN Sai-sai ZHANG Wei-dong Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine School of Pharmacy Fujian University of Traditional Chinese Medicine School of Pharmacy Second Military Medical University

Herbs are typically prescribed in traditional Chinese medicine(TCM) to treat complex diseases. The multicomponent nature of herbal drug ingredients makes it difficult to readily understand their mode of action. To decipher their molecular mechanisms, here we proposed a novel computational systems pharmacology based approach, which consisted of transcriptome profiling,data collection, statistical analysis, network algorithm,bioinformatics analysis and pharmacological *** network algorithm called signed random walk with restart(SRWR) was used to simulate the propagation of drugs effects on networks. This algorithm could identify proteins either positively or negatively regulated(activated or inhibited) by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-Xixin injection(DZXXI), which exhibits pharmacological effects in ischemic stroke but its mechanism was unclear,was analyzed. Eighty-three targets were predicted with high confidence for DZXXI′s active compounds in plasma,and 87 differentially expressed genes(DEGs) were identified in MCF7 cells treated with DZXXI. These target genes were further found to be associatedwith pathways involved in neuronal apoptosis in ischemic stroke, such as NF-κB signaling, TNF signaling, and PI3K-Akt *** analysis between DZXXI’s putative targets with ischemic stroke-associated genes identified two important targets(PTGS1, PTGS2) corresponding to four DZXXI compounds, which were further validated using in silico and in vitro/in vivo models. The most inhibited genes identified by the SRWR algorithm were significantly enriched with ischemic stroke-associated disease genes,antiplatelet associated pathways, and their encoded proteins were enriched in brain, vascular endothelium and platelets. The CMAP analysis based on DEGs suggested that DZXXI could function as both an anti-inflammatory and anti-platelet agent. Taken together, the computational analysis suggested

关键词： ischemic stroke Deng-Zhan-Xi-xin injection computational analysis

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Study on Yan-xin Wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

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TMR Integrative Medicine 2023年第17期7卷 1-9页

作者： Yan-Yan Chen Yan-xin Wang Man Wen Zheng Yu Jing-Jing Wu First Clinical Medical College Anhui University of Chinese MedicineHefei 230031China Department of Neurology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China

Background:Professor Yan-xin Wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years,and has achieved excellent clinical *** order to better inherit Yan-xin Wang’s academic *** purpose of this study is to use clinical data to explore the clinical experience of ***-xin Wang in the application of Chinese medicine to treat insomnia patients from the liver,explore the compatibility and medication rules of traditional Chinese medicine,and give more clinical treatment ideas for ***:The general data and prescription information of insomnia patients treated with Chinese herbal medicine by ***-xin Wang from January 1,2021,to December 31,2021,were summarized according to the inclusion and exclusion criteria,and the data were subjected to frequency statistics and drug association rules,complex network diagram analysis and cluster ***:A total of 159 patients and prescriptions were included in the study,of which 81.1%were women and 18.9%were men,containing 128 herbs;the highest frequency of use was 91.8%for Bupleuri *** Chinese herbs were used more than 70%of the time,namely Bupleuri Radix,Scutellariae Radix,oyster shell,Glycyrrhizae Radix,Os Draconis,and Ziziphi Spinosae *** top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi,five flavours,and their *** four Qi were mainly calm and warm,the five flavours were mainly bitter and acrid,followed by sweet,and the attributions were mainly to the liver,spleen,and heart *** Chinese medicine association rules set the confidence level>80%and the support level>10%,resulting in 10 two-herb and three-herb associations with the highest confidence level,such as Os Draconis is associated with oyster shell,Platycodonis Radix is associated with Achyranthis Bidentatae Radix,Scutellariae Radix is associated with Bupleuri Radix,Os Draconis,Bupleuri Radix is associated

关键词： data mining insomnia liver-based treatment medication patterns

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Kai xin San ameliorates scopolamine-induced cognitive dysfunction

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Neural Regeneration Research 2019年第5期14卷 794-804页

作者： Yu-Min Xu xin-Chen Wang Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen Li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong Liang Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine First Affiliated Hospital of Henan University of Chinese Medicine School of Food and Pharmaceutical Engineering Zhaoqing University First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Neurology The First Affiliated Hospital Guangzhou Medical University Guangdong Provincial Hospital of Chinese Medicine

Kai xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups(which received physiological saline), the doses of KXS(0.7, 1.4 and 2.8 g/kg per day) and donepezil(3 mg/kg per day) were gastrointestinally administered once daily for 2 weeks. On day 8 after intragastric treatment, the behavioral tests were carried out. Scopolamine group and intervention groups received scopolamine 3 mg/kg per day through intraperitoneal injection. The effects of KXS on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. The results confirmed the following.(1) KXS shortened the escape latency and increased residence time in the target quadrant and the number of platform crossings in the Morris water maze.(2) KXS increased the percentage of alternations between the labyrinth arms in the mice of KXS groups in the Y-maze.(3) Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining revealed that KXS promoted the production of Nissl bodies and inhibited the formation of apoptotic bodies.(4) Western blot assay showed that KXS up-regulated the expression of anti-apoptotic protein Bcl-2 and inhibited the expression of pro-apoptotic protein Bax. KXS up-regulated the expression of postsynaptic density 95, synaptophysin, and brain-derived neurotrophic factor in the cerebral cortex and hippocampus.(5) KXS increased the level and activity of choline acetyltransferase, acetylcholi

关键词： Kai xin San cognitive dysfunction scopolamine hydrobromide neuroprotection oxidative stress synaptic dysfunction apoptosis cholinergic system dysfunction donepezil neural regeneration

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清华大学xin中心召开2015年论坛 004

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新清华

作者： xin中心

本报讯 10月15日~16日，清华大学xin中心2015年论坛举行。以色列驻华大使马腾，以色列特拉维夫大学校长克拉夫特，我校校长邱勇、副校长杨斌出席论坛。邱勇在致辞中肯定了过去一年xin中心在推动尖端技术创新、开展国际学术交流与合作...

本报讯 10月15日~16日，清华大学xin中心2015年论坛举行。以色列驻华大使马腾，以色列特拉维夫大学校长克拉夫特，我校校长邱勇、副校长杨斌出席论坛。邱勇在致辞中肯定了过去一年xin中心在推动尖端技术创新、开展国际学术交流与合作、探索国际技术转移模式等方面取?

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： WANG xin SHEN Dejian TAO Sijie LIU Ruixin WU Shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution

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