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Chinese Chemical Letters 2020年第5期31卷 1141-1146页

作者： ximing pu Xingxing Zhou Zhongbing Huang Guangfu Yin Xianchun Chen College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Non-nerve cell-derived extracellular matrix(ECM)wa s coated on the aligned porous polypyrrole-poly(Llactide)(PPy-PLLA)fiber-films with the conductivity of^12 mS/m via L929 cells culture and lysing,resulting in^10%increase of PC12 cells attachment and^26μm increase of neurites *** neurite length of^149μm in EGF/NGF group(optimal concentration radio of 12.5/50(ng/mL))on aligned and ECM-conjugated fiber-films was significantly larger than^94μm in only NGF group(50 ng/mL),confirming the synergy of EGF,NGF and aligned ECM-conjuaged PPy-PLLA *** differentiated PC12 cells were exerted electrical stimulation(ES)of 100 mV/cm for 4 h/day in 2 day through ECM-PPyPLLA fiber-films,their neurite length reached to^251μm,significantly larger than^149μm of group without ES,due to the higer expression of related neural proteins in ES group.A simple mechanism was proposed to analyze synergistical effect of ECM,EGF,NGF on axons adhesion and elongation along the aligned ECM-coated fibers under ES condition.

关键词： Extracellular matrix Axonal growth Conducting PPy-PLLA fiber-film Nerve growth factor Epidermal growth factor Electrical stimulation

Preparation,properties and biomedical applications progress of 1D magnetic nanomaterials with iron

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Biosurface and Biotribology 2023年第4期9卷 101-113页

作者： Zhongbing Huang Juan Wang ximing pu Guangfu Yin College of Biomedical Engineering Sichuan UniversityChengduChina

1D magnetic nanomaterials with iron,with the special physical properties and biological behaviour,have been found to possess the great promising applications in many *** this review,the components,structure,physicochemical properties,biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires(MNWs),nanorods(MNRs)with iron are summarised,especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment *** potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal-compositions or bio-compositions and with existing biotechnology as well as by point-ing out their specific *** limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field.

关键词： biocompatibility biointerface biomaterials biosurface

Fabrication of carboxylic graphene oxide-composited polypyrrole film for neurite growth under electrical stimulation

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Frontiers of Materials Science 2019年第3期13卷 258-269页

作者： Chaoyuan LIU Zhongbing HUANG ximing pu Lei SHANG Guangfu YIN Xianchun CHEN Shuang CHENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

An aligned composite film was fabricated via the deposition of carboxylic graphe ne oxide(C-GO)and polypyrrole(PPy)nano particles on alig ned poly(L-lactic acid)(PLLA)fiber-films(named as C-GO/PPy/PLLA),which has the core(PLLA)-sheath(C-GO/PPy)structure,and the composition of C-GO(~4.8 wt.%of PPy sheath)significantly enhanced the tensile strength and the conductivity of the PPy/PLLA film?Especially,after 4 weeks of immersion in the PBS solution,the conductivity and the tensile strength of CGO/PPy/PLLA films still remained-6.10 S/cm and 28.9 MPa,respectively,which could meet the need of the sustained electrical stimulation(ES)therapy for nerve ***,the neurite length and the neurite alignment were significantly in creased through exerting ES on C-GO/PPy/PLLA films due to their sustained conductivity in the fluid of cell *** results indicated that C-GO/PPy/PLLA with sustained conductivity and mechanical property possessed great potential of nerve repair by exerting lasting-ES.

关键词： sustained conductivity electrical stimulation carboxylic graphene oxide polypyrrole

A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process

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Regenerative Biomaterials 2017年第4期4卷 233-242页

作者： Yao Deng Mengjiao Zhang Xianchun Chen ximing pu Xiaoming Liao Zhongbing Huang Guangfu Yin College of Materials Science and Engineering Sichuan UniversityChengdu 610064PR China

Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitablemicroenvironments mimicked the extracellular matrices for desired cellular interactions and to providesupports for the formation of new tissues. In this work, a kind of slightly soluble bioactiveceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix,a novel L-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold wasfabricated via a solvent casting-particulate leaching method improved by solvent self-proliferatingprocess. The effects of m-AKT contents on properties of composite scaffolds and on MC3T3-E1 cellularbehaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited threedimensionalporous networks, in which homogenously distributed cavities in size of 300–400 lmwere interconnected by some smaller holes in a size of 100–200 lm. Meanwhile, the mechanicalstructure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic productsreleased by m-AKT could neutralize the acidic degradation products of PLGA, and the apatitemineralizationability of scaffolds could be largely improved. More valuably, significant promotionson adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied thecalcium, magnesium and especially silidous ions released sustainably from composite scaffoldscould regulate the behaviors of osteogenesis-related cells.

关键词： akermanite PLGA composite scaffolds solvent self-proliferating process

Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor

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Chinese Chemical Letters 2020年第1期31卷 285-291页

作者： Weina Zhang Zhongbing Huang ximing pua Xianchun Chen Guangfu Yin Lei Wang Fei Zhang Fabao Gao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Molecular Imaging Center Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610093China

It is urgent to find a technology accurately to better diagnose and treat to brain ***-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH *** results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging *** orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was *** research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.

关键词： Brain tumor Dual-model imaging Doxorubicin Chlorotoxin Eu-Gd2O3 nanorods Targeted therapy

MBG/PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features

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Bioactive Materials 2022年第9期7卷 53-67页

作者： Jiangfeng Li Chunyi Wang Guoxing Gao Xing Yin ximing pu Bing Shi Yang Liu Zhongbing Huang Juan Wang Jingtao Li Guangfu Yin College of Biomedical Engineering Sichuan UniversityChengdu610065PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu610041PR China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041PR China Shandong Provincial Key Laboratory of Biomedical Polymers Shandong Academy of Pharmaceutical SciencesJinan250101PR China

It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone *** this study,we aimed to address this challenge by incorporating mesoporous bioactive glass(MBG)into poly(caprolactone-co-glycolide)(PGA-PCL)at gradient ***/PGA-PCL(PGC/M)scaffolds with MBG incorporation ratio at 0,10%,25%and 40%(PGC/M0-40)were synthesized using a modified solvent casting-particulate leaching method,and their physiochemical and biological properties were comprehensively ***/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450μm,with ordered MBGs of around 6.0 nm mesopores size uniformly *** increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity,apatite-formation ability and pH stability,increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component,and facilitated the attachment,spreading,viability and proliferation of rat bone marrow stromal cells(rBMSCs)on ***,rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 *** implanted to the rat cranial bone defect,PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 ***,the biodegradability of PGC/M scaffolds correlated with the MBG incorporation *** data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity,bioactivity,cytocompatibility,osteogenic activity as well as biodegradability.

关键词： Mesoporous bioactive glasses Poly(caprolactone-co-glycolide) Osteogenic differentiation Bone repair

Investigation on the streamer propagation in atmospheric pressure helium plasma jet by the capacitive probe

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Plasma Science and Technology 2020年第5期22卷 1-4页

作者： Wenchao ZHU Bangdou HUANG ximing ZHU Wencong CHEN Yikang pu State Key Laboratory of NBC Protection for Civilian Institute of Chemical Defense AMSBeijing 102205People's Republic of China Department of Engineering Physics Tsinghua UniversityBeijing 100084People's Republic of China Key Laboratory of Power Electronics and Electric Drive Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190People's Republic of China Harbin Institute of Technology Harbin 150001People’s Republic of China

In this letter,the streamer propagation in the atmospheric pressure helium plasma jet with afloating electrode nozzle driven by the kHz AC power supply is *** current signal induced by the space charges and the mean propagation velocity of the guided ionization waves are measured by the capacitive probe method in the discharge *** space charges in the guided ionization waves are found to increase with the applied voltage,which enhances both the electric field near the streamer head and the propagation *** applicability of the streamer mechanism to the propagation of the guided ionization waves is validated by this electrical diagnostic method.

关键词： streamer propagation capacitive probe guided ionization waves

Haemostatic therapy in spontaneous intracerebral haemorrhage patients with high-risk of haematoma expansion by CT marker: a systematic review and meta- analysis of randomised trials

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Stroke & Vascular Neurology 2021年第2期6卷 170-179页

作者： ximing Nie Jingyi Liu Dacheng Liu Qi Zhou Wanying Duan Yuehua pu Zhonghua Yang Miao Wen Haixin Sun Wenzhi Wang Shengjun Sun Hongqiu Gu Liping Liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Current randomised controlled trials(RCTs)showed an uncertain benefit of haemostatic therapy on preventing haematoma expansion and improving the outcome in patients with intracerebral haemorrhage(ICH).This meta-analysis aims to systematically evaluate the effect of haemostatic agents on the prevention of haemorrhage growth in patients with high-risk spontaneous ICH predicted by CT signs in *** A comprehensive search of pubMed,EMBASE and Cochrane library from 1 January 2005 to 30 June 2021 was *** that compared haemostatic agents with placebo for the treatment of spontaneous patients with ICH with high-risk haemorrhage growth were *** primary endpoint was haematoma expansion at 24 *** major endpoints of interest included 90-day functional outcome and *** The meta-analysis included four RCTs that randomised 2666 patients with ICH with high-risk haemorrhage *** therapy reduced the rate of haematoma expansion at a marginally statistically significant level when compared with placebo(OR 0.84;95% CI 0.70 to 1.00;p=0.051).Subgroup analysis for patients with black hole sign on CT revealed a significant reduction of haematoma expansion with haemostatic therapy(OR 0.61;95% CI 0.39 to 0.94;p=0.03).However,both the primary analysis and subgroup analyses showed that haemostatic therapy could not reduce the rate of poor functional outcome(modified Rankin Scale>3)or *** Haemostatic therapy showed a marginally significant benefit in reducing early haematoma expansion in patients with high-risk spontaneous ICH predicted by markers on CT ***,no significant improvement in functional outcome or reduction of mortality was observed.

关键词： patients prevention expansion

Collective rotations of fission isomers in actinide nuclei

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Science China(Physics,Mechanics & Astronomy) 2014年第2期57卷 189-193页

作者： XIE KePing KE WeiYao LIANG WuYang FU ximing JIAO ChangFeng PEI JunChen XU FuRong School of Physics Peking University State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University National Institute for Radiological Protection Chinese Center for Disease Control and Prevention

Using the total-Routhian-surface （TRS） method, the rotational behaviors of fission isomers in the second well of actinide nuclei 234-242U, 236-244pu and 238-246Cm were investigated. The pairing-deformation-frequency self-consistent TRS calculations repro- duced reasonably the experimental moments of inertia extracted from spectroscopic data. It is calculated that, in these largely elongated （β2 ≈0.65 and β4≈ 0.03） fission isomers, the ν1/2-[981] neutron and π1/2＋[651] proton align simultaneously at rotational frequency hω≈0.4 - 0.6 MeV （corresponding to spin I≈80h）, which leads to clear upbending in moments of inertia （MoI＇s）. Our calculations have indicated that the hexadecapole deformation f14 influenced significantly the frequency of the rotational alignment of the proton 1/2＋[651] orbit.

关键词： fission isomers total Routhian surface moments of inertia upbending alignment

Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial

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Stroke & Vascular Neurology 2021年第2期6卷 160-169页

作者： Jingyi Liu ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Xi'an Jiaotong UniversityBeijingChina Department of Medicine and Therapeutics Prince of Wales HospitalShatinHong Kong Department of Neurology Tangshan People’s HospitalTangshanChina Department of Neurology Tangshan Gongren HospitalTangshanChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Pinggu HospitalBeijingChina Department of Neurology Liangxiang Hospital of Beijing Fangshan DistrictBeijingChina Department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial *** aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage *** We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in *** supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom *** were randomly assigned(1:1)to receive either tranexamic acid or a matching *** primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 *** outcomes were assessed at 90 *** Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received *** primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and *** Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage *** studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients.

关键词： placebo centre absolute