MBG/PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features

作     者：Jiangfeng Li Chunyi Wang Guoxing Gao Xing Yin Ximing Pu Bing Shi Yang Liu Zhongbing Huang Juan Wang Jingtao Li Guangfu Yin 

作者机构：College of Biomedical EngineeringSichuan UniversityChengdu610065PR China State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu610041PR China State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041PR China Shandong Provincial Key Laboratory of Biomedical PolymersShandong Academy of Pharmaceutical SciencesJinan250101PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第9期

页      面：53-67页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by National Key R&D Program of China(2018YFC1105703) Key R&D Program of Sichuan Province(2017SZ0047) 

主　　题：Mesoporous bioactive glasses Poly(caprolactone-co-glycolide) Osteogenic differentiation Bone repair 

摘      要：It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone *** this study,we aimed to address this challenge by incorporating mesoporous bioactive glass(MBG)into poly(caprolactone-co-glycolide)(PGA-PCL)at gradient ***/PGA-PCL(PGC/M)scaffolds with MBG incorporation ratio at 0,10%,25%and 40%(PGC/M0-40)were synthesized using a modified solvent casting-particulate leaching method,and their physiochemical and biological properties were comprehensively ***/M scaffolds exhibited highly perforated porous structure with a large-pore size of 300-450μm,with ordered MBGs of around 6.0 nm mesopores size uniformly *** increase in MBG incorporation ratio significantly improved the scaffold surface hydrophilicity,apatite-formation ability and pH stability,increased the weight loss rate while insignificantly influenced the molecular chains degradation of PGA-PCL component,and facilitated the attachment,spreading,viability and proliferation of rat bone marrow stromal cells(rBMSCs)on ***,rBMSCs cultured on PGC/M10-40 scaffolds demonstrated enhanced ALP activity and osteogenesis-related gene expression in a MBG dose-dependent manner as compared with those cultured on PGC/M0 *** implanted to the rat cranial bone defect,PGC/M25 and PGC/M40 scaffolds induced significantly better bone repair as compared to PGC/M0 and PGC/M10 ***,the biodegradability of PGC/M scaffolds correlated with the MBG incorporation *** data suggested this novel PGC/M scaffolds as promising bone repair biomaterial with highly tunable hydrophilicity,bioactivity,cytocompatibility,osteogenic activity as well as biodegradability.