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Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

Military Medical Research 2022年第5期9卷 543-552页

作者： Kun Xiao Du-Chao Zhang Ye Hu Li-Cheng Song Jian-Qiao Xu Wan-Xue He Pan Pan Yu-Wei Wang Li-xin xie Center of Pulmonary and Critical Care Medicine Chinese People's Liberation Army(PLA)General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China Department of Pulmonary and Critical Care Medicine Beijing Shijitan HospitalBeijing 100071China Medical School of Chinese People's Liberation Army(PLA) Chinese PLA General HospitalBeijing 100853China Department of Geriatric Comprehensive Surgery the Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China

Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be *** current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy *** patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data *** male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 ***:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients *** healthy control(P<0.001),as well as in the sepsis non-survivor group *** sepsis survivor group(P<0.001,P=0.0338,or P=0.0013,respectively).Lower serum VDBP level was associated with higher Acute Physiology and Chronic Health Evaluation(APACHE)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,P<0.001)and total protein(TP,r=0.263,P=0.02).In CLP mice,there was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day *** was also decreased in LPS-treated THLE2 cells(P<0.001).VDBP overexpression reduced LPS-induced THLE2 *** damage was associated with decreased oxidative stress and inactivation of the c-Jun N-terminal kinase signaling ***:VDBP may be protective against sepsis-induced liver injury.

关键词： Vitamin D binding protein Sepsis Human Mouse Liver Injury c-Jun N-terminal kinase

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Numerical simulation of groundwater and early warnings from the simulated dynamic evolution trend in the plain area of Shenyang,Liaoning Province(P.R. China)

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Journal of Groundwater Science and Engineering 2016年第4期4卷 367-376页

作者： LIU Jun-qiu xie xin-min Department of Water Resources China Institute of Water Resources and Hydropower Research College of Hydrology and Water Resources Hohai University

Groundwater level is the most direct factor reflecting whether groundwater is in a virtuous cycle. It is the most important benchmark for deciding whether a balance can be struck between groundwater discharge and recharge and whether groundwater exploitation will trigger problems pertinent to environment, ecology and environmental geology. According to the borehole and long-term monitoring wells data in the plain area of Shenyang, a numerical groundwater model is established and used to identify and verify the hydrogeological parameters and balanced items of groundwater. Then the concept of red line levels, the control levels of groundwater is proposed, the dynamic evolution trend of groundwater under different scenarios is analyzed and predicted and groundwater alerts are given when groundwater tables are not between the lower limit and the upper limit. Results indicated:(1) The results of identification and verification period fitted well, and the calculation accuracy of balanced items was high;(2) with the implementation of shutting wells, groundwater levels in urban areas of Shenyang would exceed the upper limit water level after 2020 and incur some secondary disasters;(3) under the recommended scenario of water resources allocation, early-warnings for groundwater tables outside the range would occur in the year of 2020, 2023, 2025 respectively for successive wet, normal and dry years. It was imperative to reopen some groundwater sources and enhance real-time supervision and early-warning to prevent the occurrence of potential problems.

关键词： Groundwater table Groundwater exploitation Numerical modeling of groundwater Plain area of Shenyang

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Moxifloxacin-induced multiple organ dysfunction possibly related to mutations in several genes involved in drug metabolism pathways

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Chinese Medical Journal 2013年第7期126卷 1396-1398页

作者： XIAO Yong-jiu SU Long-xiang ZHANG xin xie Li-xin Department of Respiratory Medicine Hainan Branch of Chinese People's Liberation Army General Hospital Sanya Hainan 572013 China Department of Respiratory Medicine L anzhou General Hospital of Lanzhou Military Area Command of Chinese People's Liberation Army Lanzhou Gansu 730050 China Medical College of Nankai University Tianjin 300071 China Department of Respiratory Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China

Quinolones have been used to treat various infectious diseases. The addition of fluorine atoms has allowedfor extensive modifications of structures, which has enhanced the spectrum of activities and oral bioavailability of quinolones and resulted in the creation of fluoroquinolones） Although the adverse effects associated with fluoroquinolone antibiotics have decreased considerably and these drugs are generally well tolerated, adverse effects do sometimes occur.

关键词： moxifloxacin multiple organ dysfunction mutations

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Interpretation of the 7th edition of the"diagnosis and treatment guidelines of coronavirus disease 2019 in China":Progress and challenges

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Chronic Diseases and Translational Medicine 2020年第2期6卷 75-78页

作者： Li-xin xie Center of Pulmonary and Critical Care Medicine Chinese PLA General HospitalBeijing100853China

Since the first patient infected with the novel coronavirus(SARS-CoV-2)was identified in December 2019,the cumulative number of confirmed cases of coronavirus disease 2019(COVID-19)has exceeded 2,100,000 and has resulted in more than 140,000 deaths globally,as of April 17,*** progression of the epidemic can be divided into two *** first phase,which started in December 2019 and ended in February 2020,primarily involved Chinese mainland,which battled the epidemic.

关键词： SARS-CoV-2 COVID-19 Coronavirus disease Diagnosis and treatment

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Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of Fusarium graminearum on Wheat

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Engineering 2020年第5期6卷 546-552页

作者： Xuli Wang xin xie Jin Liu Guo-Liang Wang Dewen Qiu State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China College of Agriculture Guizhou UniversityGuiyang 550025China Department of Plant Pathology The Ohio State UniversityColumbusOH 43210USA

Reliable knowledge on pathogenic agents contributes to effective plant *** most plant pathogens,maintaining protein homeostasis(proteostasis)is essential for unfolding the cellular functions to survive and ***,the fungal proteins involved in proteostasis remain poorly characterized in the process of *** this study,we characterized the function of the nascent polypeptideassociated complex(NAC)in Fusarium graminearum(***)(FgNAC),one of the top 10 fungal pathogens with predominant scientific/economic *** found that FgNACa,a subunit of FgNAC,manifests high structural and functional similarity to its homologous counterparts in yeast and other *** mutants of *** lacking NACa are viable but suffer significant defects in vegetative growth,conidial production,and *** addition,we show here that FgNACa can interact with another subunit of NAC(FgNACb)in a yeast-two-hybrid *** subcellular localization results show that FgNACa and FgNACb are predominantly localized in the *** studies should focus on deciphering the mechanism by which NAC orchestrates protein biogenesis and consequentially modulates development and pathogenesis.

关键词： Fusarium head blight Nascent polypeptide-associated complex Gene knockout Pathogenicity Subcellular localization

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Grain yield and water use of winter wheat as affected by water and sulfur supply in the North China Plain

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Journal of Integrative Agriculture 2017年第3期16卷 614-625页

作者： xie Ying-xin ZHANG Hui ZHU Yun-ji ZHAO Li YANG Jia-heng CHA Fei-na LIU Cao WANG Chen-yang GUO Tian-cai State Key Laboratory of Wheat and Maize Crop Science Henan Agricultural University Zhengzhou 450002 P.R.China College of Resources and Environment Henan Agricultural University Zhengzhou 450002 P.R. China Zhoukou Academy of Agricultural Sciences Zhoukou 466001 P.R. China Zhengzhou Meteorological Bureau Zhengzhou 450000 P.R. China

Water shortage has threatened sustainable development of agriculture globally as well as in the North China Plain（NCP）.Irrigation,as the most effective way to increase food production in dry land,may not be readily available in the situation of *** of the alternatives is to supply plants with enough nutrients so that they can be more sustainable to the water *** objective of this study was to explore effects of irrigation and sulphur（S）application on water consumption,dry matter accumulation（DMA）,and grain yield of winter wheat in *** irrigation regimes including no irrigation（rainfed,I0）during the whole growth period,once irrigation only at jointing stage（90 mm,I1）,and twice respective irrigation at jointing and anthesis stages（90 mm plus 90 mm,I2）,and two levels of S application including 0S0and 60 kg ha^–1（S60）were designed in the field experiment in *** showed that increasing irrigation times significantly increased mean grain yield of wheat by 12.5–23.7%and nitrogen partial factor productivity（NPFP）by 21.2–45.0%in two wheat seasons,but markedly decreased crop water use efficiency（YWUE）.Furthermore,S supply 60 kg ha^–1 significantly increased mean grain yield,YWUE,IWUE and NPFP by 5.6,6.1,23.2,and 5.6%（across two wheat seasons）,***,we also found that role of soil moisture prior to S application was one of important greater factors on improving the absorption and utilization of storage water and nutrients of ***,water supply is still the most important factor to restrict the growth of wheat in the present case of NCP,supplying 60 kg ha^–1 S with once irrigation 90 mm at the jointing stage is a relatively appropriate recommended combination to improve grain yield and WUE of wheat when saving water resources is be considered in irrigated wheat farmlands of NCP.

关键词： sulphur irrigation winter wheat grain yield water use efficiency 1

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基于信息年龄的工业无线传感器网络混合数据调度方法

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电子与信息学报 2023年第3期45卷 1065-1073页

作者：王恒余蕾谢鑫重庆邮电大学工业物联网与网络化控制教育部重点实验室重庆400065 重庆邮电大学通信与信息工程学院重庆400065

在工业无线传感器网络(IWSN)中,实时交付工业现场的周期性控制/传感数据流与非周期性事件数据流,是保障生产安全高效运行的关键。信息年龄(AoI)作为一种新兴的数据新鲜度衡量指标,能够从目标节点角度全面地度量网络数据交付的实时性。... 详细信息

在工业无线传感器网络(IWSN)中,实时交付工业现场的周期性控制/传感数据流与非周期性事件数据流,是保障生产安全高效运行的关键。信息年龄(AoI)作为一种新兴的数据新鲜度衡量指标,能够从目标节点角度全面地度量网络数据交付的实时性。针对周期性和非周期性数据混合的工业无线传感器网络,该文在引入网络数据整体新鲜度指标的同时,考虑到周期性数据新鲜度在超过阈值后可能会对工业生产造成负面影响,建立了最小化系统平均AoI和周期性数据AoI逾期概率的联合优化模型,并将优化问题表述为马尔可夫决策过程(MDP)进行求解。由于传统基于相对值迭代的最优求解方法在大规模网络中因为维度灾难难以实施,因此采用深度强化学习(DRL)降低优化问题的状态空间维度,并改进决策探索机制以加快学习速度,提出了基于优化决策探索的深度强化学习(DRL-ODE)调度方法。仿真结果表明,所提方法能够提高网络数据交付的实时性,并有效减少周期性数据的AoI逾期概率。

关键词：网络调度工业无线传感器网络信息年龄

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真实、不确定与相干性:始于现代主义艺术的量子思考

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北京电影学院学报 2021年第5期 56-63页

作者：谢辛北京电影学院视听传媒学院

塞尚(Paul Cézanne)之后,现代主义(Modernism)飓风席卷艺术领域,即便后现代主义(Postmodernism)、元现代主义(Metamodernism)顺理成章的出现,也改变不了现代主义的母体本质。与之并行出现的量子力学(Quantum Mechanics)是20世纪初物理... 详细信息

塞尚(Paul Cézanne)之后,现代主义(Modernism)飓风席卷艺术领域,即便后现代主义(Postmodernism)、元现代主义(Metamodernism)顺理成章的出现,也改变不了现代主义的母体本质。与之并行出现的量子力学(Quantum Mechanics)是20世纪初物理学领域的重大突破,成为现代物理学支柱。二者对人类发展产生前所未有的巨大影响,艺术呈现出哲学、科学与人文紧密结合的叠态。本文基于艺术与量子的哲思,探讨艺术与科学的边界、关联与衍生性,为当下媒介艺术研究提供更广视阈的思路拓展。

关键词：艺术不确定性波粒二象性量子纠缠相干性

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民国前期书籍封面设计的断裂性变革研究

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编辑之友 2018年第7期 91-98页

作者：谢欣哈尔滨工业大学深圳研究生院人文与社会科学学院广东深圳518055

民国前期,伴随着书籍出版业的繁荣,书籍封面设计也开始摆脱以往的各种限制和束缚,不仅在形式上,且在观念上有别于传统,并因此呈现出断裂性的特征。从文化层面来看,书籍封面设计的断裂性变革同时也体现出这一时期的国人逐渐形成关于书籍... 详细信息

民国前期,伴随着书籍出版业的繁荣,书籍封面设计也开始摆脱以往的各种限制和束缚,不仅在形式上,且在观念上有别于传统,并因此呈现出断裂性的特征。从文化层面来看,书籍封面设计的断裂性变革同时也体现出这一时期的国人逐渐形成关于书籍出版新的问题意识,标志着书籍出版与当时其他充满变革的领域一样,开始步入历史的新纪元。

关键词：民国前期书籍封面设计

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加氢基础油抗氧化性能的模拟预测研究

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石油炼制与化工 2020年第2期51卷 57-61页

作者：谢欣中国石化石油化工科学研究院

针对不同加氢精制Ⅱ/Ⅲ类润滑油基础油(简称基础油)的结构特征,分别应用多层感知神经网络和径向基神经网络方法将加氢基础油链烷烃、环烷烃、烷基苯含量和黏度指数作为输入变量,建立了以氧化安定性为输出变量的9参数神经网络模型。首次... 详细信息

针对不同加氢精制Ⅱ/Ⅲ类润滑油基础油(简称基础油)的结构特征,分别应用多层感知神经网络和径向基神经网络方法将加氢基础油链烷烃、环烷烃、烷基苯含量和黏度指数作为输入变量,建立了以氧化安定性为输出变量的9参数神经网络模型。首次将黏度指数作为预测模型输入参数,使模型预测准确度得到大幅提高。通过对影响加氢基础油氧化安定性的因素分析,找出了与氧化安定性有正/负相关关系的Ⅱ/Ⅲ类基础油的烷烃组成成分。在Ⅱ/Ⅲ类基础油中,在芳烃含量很低的情况下,随着链烷烃含量的增加,二环、三环环烷烃含量减少,润滑油的氧化安定性增加。

关键词：润滑油基础油氧化安定性神经网络人工智能模拟

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