检索结果-南通市图书馆

中国汽车（英文版） 1997年第2期 1-2,32页

作者： zhang xiaoyu, Director General of AIB, MMI

Ⅰ. The Environment For The Development Of China’s Auto Industry In 1997 1. Macro-economic environment As the second year of 9th Five-Year Plan, 1997 will be a very important year in China’s history. For promoting the two basic changements, the moderately restricted fiscal & monetary policies will continue for reducing the inflation with some flexible tactics to be used,

关键词： Environment And Tasks In 1997 in Beijing Abstract from the report given by zhang xiaoyu at the 4th session ofthe 3rd councilmeeting of CAAM held during 21 to 22 zhang

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： xiaoyu zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

考虑构件震害影响的城市桥梁震后通行功能损失评估方法

在线全文

学校读者我要写书评

暂无评论

哈尔滨工业大学学报 2025年第1期57卷 35-45页

作者：李天翊张东昱张晓宇哈尔滨工业大学土木工程学院哈尔滨150090 土木工程智能防灾减灾工业和信息化部重点实验室(哈尔滨工业大学) 哈尔滨150090 中交公路长大桥建设国家工程研究中心有限公司北京100120

桥梁作为城市交通网络重要节点,其车辆通行能力在震后救灾和重建过程中起着至关重要的作用。但现有城市桥梁震后损失研究多集中于结构损伤维修成本方面,对桥梁震后车辆通行功能损失研究关注不足,难以为震后紧急救援和桥梁修复决策提供... 详细信息

桥梁作为城市交通网络重要节点,其车辆通行能力在震后救灾和重建过程中起着至关重要的作用。但现有城市桥梁震后损失研究多集中于结构损伤维修成本方面,对桥梁震后车辆通行功能损失研究关注不足,难以为震后紧急救援和桥梁修复决策提供有效指导。因此,本文提出了综合考虑桥梁构件震害破坏及其对车辆通行影响的桥梁震后通行功能损失评估方法。首先,为了更准确地分析地震对桥梁结构整体系统的影响,采用copula函数,开展了考虑桥梁构件破坏相关性的桥梁系统地震易损性分析;其次,提出了地震导致桥梁车辆通行能力损失的评估方法。该方法综合考虑了桥梁结构损伤、承载力下降导致的开放车道减少以及桥梁伸缩缝损坏导致的车辆行驶速度降低等因素影响,因而可以更准确地反映震后桥梁车辆通行能力;最后,通过一个4跨连续梁桥算例发现相较于现有评估方法,本文提出的城市桥梁震后通行功能损失评估方法具有准确度更高、离散程度和不确定性更小的特点。与传统的定性和主观震后桥梁功能损失评估方法相比,本项研究提出的分析方法从物理层面考虑了桥梁构件震害对桥梁车辆通行能力的具体影响,为震后决策过程提供了一个数学模型。

关键词：桥梁易损性构件破坏相关性车辆通行能力桥梁通行功能损失

An Intelligent Ellipsoid Calibration Method Based on the Grey Wolf Algorithm for Magnetic Compass

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2021年第2期18卷 453-461页

作者： Xusheng Lei xiaoyu zhang Yankun Hao School of the Instrumentation Science and Opto-Electronic Engineering Beihang UniversityBeijing 100191China

With the measurement of the Earth’s magnetic field,magnetic compass can provide high frequency heading ***,it suffers from local magnetic *** intelligent ellipsoid calibration method based on the grey wolf is proposed to generate optimal parameters for magnetic compass to generate high performance heading *** the analysis of the projection relationship among the navigation coordinate frame,the body frame and the local horizontal frame,the heading ellipsoid equation is ***,an improved grey wolf algorithm is proposed to find optimization solution in a large solution *** the improvement of the convergence factor and the evolutionary mechanism,the improved grey wolf algorithm can generate optimized solution for heading ellipsoid *** effectiveness of the proposed method has been verified by a series of vehicle and flight *** experimental results show that the proposed method can eliminate errors caused by sensor defects,hard-iron interference,and soft-iron interference *** heading error generated by the magnetic compass is less than 0.2162 degree in real flight tests.

关键词： magnetic compass ellipsoid parameters grey wolf algorithm error model

Observer-Based Path Tracking Controller Design for Autonomous Ground Vehicles With Input Saturation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2023年第3期10卷 749-761页

作者： Heng Wang Tengfei zhang xiaoyu zhang Qing Li School of Automation and Electrical Engineering and also with the Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083China School of Automation and Electrical Engineering and also with the Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083

This paper investigates the problem of path tracking control for autonomous ground vehicles(AGVs),where the input saturation,system nonlinearities and uncertainties are ***,the nonlinear path tracking system is formulated as a linear parameter varying(LPV)model where the variation of vehicle velocity is taken into ***,considering the noise effects on the measurement of lateral offset and heading angle,an observer-based control strategy is proposed,and by analyzing the frequency domain characteristics of the derivative of desired heading angle,a finite frequency H_∞index is proposed to attenuate the effects of the derivative of desired heading angle on path tracking ***,sufficient conditions are derived to guarantee robust H_∞performance of the path tracking system,and the calculation of observer and controller gains is converted into solving a convex optimization ***,simulation examples verify the advantages of the control method proposed in this paper.

关键词： Autonomous ground vehicles(AGVs) H_∞index input saturation observer-based controller path tracking control

Numerical analyses of pile performance in laterally spreading frozen ground crust overlying liquefiable soils

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2018年第3期17卷 491-499页

作者： xiaoyu Ryan zhang Zhaohui Joey Yang Mueser Rutledge Consulting Engineers New YorkNY 10122USA College of Engineering University of AlaskaAnchorageAK 99508USA

Lateral spread of frozen ground crust over liquefied soil has caused extensive bridge foundation damage in the past winter earthquakes.A shake table experiment was conducted to investigate the performance of a model pile in this scenario and revealed unique pile failure *** modelling results provided valuable data for validating numerical *** paper presents analyses and results of this experiment using two numerical modeling approaches： solid-fluid coupled finite element（FE） modeling and the beam-on-nonlinear-Winkler-foundation（BNWF） method.A FE model was constructed based on the experiment configuration and subjected to earthquake *** and pile response results were presented and compared with experimental results to validate this *** BNWF method was used to predict the pile response and failure mechanism.A p-y curve was presented for modelling the frozen ground crust with the free-field displacement from the experiment as *** responses were presented and compared with those of the experiment and FE *** was concluded that the coupled FE model was effective in predicting formation of three plastic hinges at ground surface,ground crust-liquefiable soil interface and within the medium dense sand layer,while the BNWF method was only able to predict the latter two.

关键词： frozen ground crust lateral spread Finite Element (FE) modeling BNWF method

Non-isothermal kinetics and characteristics of calcium carbide nitridation reaction with calcium-based additives

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第4期18卷 49-61页

作者： Zhihan zhang Mengxiao Yu xiaoyu zhang Jinli zhang You Han School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The nitridation reaction of calcium carbide and N_(2) at high temperatures is the key step in the production of ***,the challenges faced by this process,such as high energy consumption and poor product quality,are mainly attributed to the lack of profound understanding of the *** study aimed to improve this process by investigating the non-isothermal kinetics and reaction characteristics of calcium carbide nitridation reaction at different heating rates(10,15,20,and 30℃·min^(-1))using thermogravimetric *** kinetic equation for the nitridation reaction of additive-free calcium carbide sample was obtained by combining model-free methods and model-fitting *** effect of different calcium-based additives(CaCl_(2) and CaF_(2))on the reaction was also *** results showed that the calcium-based additives significantly reduced reaction temperature and activation energy E_(a) by about 40% with CaF_(2) and by 55%-60% with CaCl_(2).The reaction model f(α)was also changed from contracting volume(R3)to 3-D diffusion models with D3 for CaCl_(2) and D4 for CaF_(2).This study provides valuable information on the mechanism and kinetics of calcium carbide nitridation reaction and new insights into the improvement of the lime-nitrogen process using calcium-based additives.

关键词： lime-nitrogen calcium carbide calciumbased additive thermogravimetric analysis nonisothermal kinetics

An Enhanced Searching Strategy for Multi-Agent Mobile Applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2022年第11期19卷 282-296页

作者： xiaoyu zhang Wei Liu Fangchun Yang School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Networking and Switching Technology(Beijing University of Posts and Telecommunications) Beijing 100876China

Multi-agent mobile applications play an essential role in mobile applications and have attracted more and more researchers’*** work has always focused on multi-agent applications with perfect *** are usually based on human-designed rules to provide decision-making searching ***,existing methods for solving perfect-information mobile applications cannot be directly applied to imperfect-information mobile ***,we take the Contact Bridge,a multi-agent application with imperfect information,for the case *** propose an enhanced searching strategy to deal with multi-agent applications with imperfect *** design a self-training bidding system model and apply a Recurrent Neural Network(RNN)to model the bidding *** bridge system model consists of two parts,a bidding prediction system based on imitation learning to get a contract quickly and a visualization system for hands understanding to realize regular communication between ***,to dynamically analyze the impact of other players’unknown hands on our final reward,we design a Monte Carlo sampling algorithm based on the bidding system model(BSM)to deal with imperfect *** the same time,a double-dummy analysis model is designed to efficiently evaluate the results of *** results indicate that our searching strategy outperforms the top rule-based mobile applications.

关键词： multi-agent mobile applications imperfect information deep neural network Monte Carlo Contact Bridge

Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第5期10卷 789-798页

作者： Ke Tang xiaoyu zhang Ying Guo State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacology Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The limited treatment options for the increasing occurrence of Lassa hemorrhagic fever in West Africa poses an urgent need for the discovery and development of novel *** supplements,especially natural products that are edible and safe for human use,are a good source of drug discovery with potential for uncovering novel applications,In this study,we tested 40 natural products of dietary supplements and identified capsaicin,a common dietary supplement abundant in chili peppers,as an inhibitor of Lassa virus(LASV)entry with EC5,of 6.9-10.0μmol/L using an HIV based pseudo virus *** inhibits the entry of five LASV strains but not against the Old World arenavirus lymphocytic choriomeningitis virus(LCMV),showing a preferential activity against *** inhibits LASV entry by blocking the pH dependent viral fusion through affecting the stable signal peptide(SSP)-GP2 transmembrane(GP2TM)region of the LASV surface *** study revealed the key residues Ala25,Val431,Phe434 and Val435 in SsP-CP2TM region in capsaicin’s antiviral *** study for the first time reveals a direct acting antiviral effect of capsaicin against the hemorrhagic fever causing LASV,providing detailed interaction hot spots in the unique SSP-GP2TMinterface of LASV glycoprotein that is crucial in fusion inhibition,and offering a new strategy in discovering and developing antivirals from natural products that are safe for human use.

关键词： Lassa virus Fusion inhibitor Capsaicin Dietary supplement Natural product antivirals Viral entry Hemorrhagic fever SSP-GP2TM region

Revisited dynamic modeling and eigenvalue analysis of the cable-stayed beam

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2020年第4期36卷 950-963页

作者： Lianhua Wang xiaoyu zhang Kai He Jian Peng College of Civil Engineering Hunan UniversityChangsha 410082China Key Laboratory for Wind and Bridge Engineering of Hunan Province Hunan UniversityChangsha 410082China Guangxi Communications Design Group Co. LtdNanning 530022China Hunan Provincial Key Laboratory of Structures for Wind Resistance and Vibration Control Hunan University of Science and TechnologyXiangtan 411201China

In this study,the Hamilton’s principle is applied to revisit the dynamic modeling of the cable-stayed beam,and the motion equations governing the nonlinear response of the cable-stayed beam are *** corresponding boundary terms are transformed to the dynamic equilibrium conditions through the continuity of the displacement at the anchoring *** the standard condensation procedure,the condensed model of the cable-stayed beam is *** eigenvalue analysis is performed to determine the closed-form eigenvalue solution of the linear problems,and two types of eigenvalue solution are *** is shown that the frequency spectrum of the cable-stayed beam exhibits the curve veering and crossover *** to these phenomena,the mode shapes of the cable-stayed beam may exhibit the coupling ***,the discrete model of the cable-stayed beam is determined,and the possible nonlinear interactions are discussed.

关键词： Cable-stayed beam Dynamic modeling Natural frequencies Mode shapes Curve veering