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Improved multi-scale inverse bottleneck residual network based on triplet parallel attention for apple leaf disease identification

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Journal of Integrative Agriculture 2024年第3期23卷 901-922页

作者： Lei Tang Jizheng Yi xiaoyao li College of Computer&Information Engineering Central South University of Forestry and TechnologyChangsha 410004China Yuelushan Laboratory Carbon Sinks Forests Variety Innovation Center Changsha 410000China

Accurate diagnosis of apple leaf diseases is crucial for improving the quality of apple production and promoting the development of the apple industry. However, apple leaf diseases do not differ significantly from image texture and structural information. The difficulties in disease feature extraction in complex backgrounds slow the related research progress. To address the problems, this paper proposes an improved multi-scale inverse bottleneck residual network model based on a triplet parallel attention mechanism, which is built upon ResNet-50, while improving and combining the inception module and ResNext inverse bottleneck blocks, to recognize seven types of apple leaf(including six diseases of alternaria leaf spot, brown spot, grey spot, mosaic, rust, scab, and one healthy). First, the 3×3 convolutions in some of the residual modules are replaced by multi-scale residual convolutions, the convolution kernels of different sizes contained in each branch of the multi-scale convolution are applied to extract feature maps of different sizes, and the outputs of these branches are multi-scale fused by summing to enrich the output features of the images. Second, the global layer-wise dynamic coordinated inverse bottleneck structure is used to reduce the network feature loss. The inverse bottleneck structure makes the image information less lossy when transforming from different dimensional feature spaces. The fusion of multi-scale and layer-wise dynamic coordinated inverse bottlenecks makes the model effectively balances computational efficiency and feature representation capability, and more robust with a combination of horizontal and vertical features in the fine identification of apple leaf diseases. Finally, after each improved module, a triplet parallel attention module is integrated with cross-dimensional interactions among channels through rotations and residual transformations, which improves the parallel search efficiency of important features and the recogniti

关键词： multi-scale module inverse bottleneck structure triplet parallel attention apple leaf disease

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融入课程知识图谱的KMAKT预测

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计算机工程 2024年第7期50卷 23-31页

作者：王炼红林飞鹏李潇瑶谌桂枝周莉湖南大学电气与信息工程学院湖南长沙410082 中南林业科技大学计算机与信息工程学院湖南长沙410004 湖南汽车工程职业学院信息工程学院湖南株洲412001

现有多数深度知识追踪模型的知识追踪结果的可解释性弱,且忽视了习题与知识点的内在关联性对知识追踪效果与预测结果的影响。针对上述问题,提出一种用于学生表现预测的结合课程知识图谱与多头注意力机制的知识追踪(KMAKT)模型。首先,采... 详细信息

现有多数深度知识追踪模型的知识追踪结果的可解释性弱,且忽视了习题与知识点的内在关联性对知识追踪效果与预测结果的影响。针对上述问题,提出一种用于学生表现预测的结合课程知识图谱与多头注意力机制的知识追踪(KMAKT)模型。首先,采用Word2Vec和双向长短期记忆(Bi LSTM)网络将习题作答序列数据转换为低维稠密向量,利用图嵌入模型Trans R进行课程知识图谱嵌入表示,并使用多头注意力机制计算过往习题作答序列对当前知识状态的贡献程度;然后,通过注意力网络挖掘前驱知识对预测结果的影响程度;最后,通过多层神经网络获取预测结果,提高模型的可解释性与预测精度。实验结果表明,KMAKT模型在ASSISTments2017数据集上的受试者工作特征曲线下的面积(AUC)、准确率和F1值相比于深度知识追踪(DKT)模型分别提升了约5.20、4.20和2.40个百分点,具有较好的预测性能。在湖南大学信号与系统(HNU_SYS)子数据集上的知识追踪可视化结果验证了KMAKT模型的知识追踪结果符合教育学认知规律且具备一定程度的可解释性。

关键词：表现预测课程知识图谱注意力机制知识追踪长短期记忆网络语义特征

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基于山东省药品不良反应监测中心数据库的奥美拉唑不良反应风险信号挖掘

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药物不良反应杂志 2024年第1期26卷 33-37页

作者：张雪莲王冠杰王振华孙清海李效尧潍坊市中医院临床药学科潍坊261000

目的对奥美拉唑不良反应风险信号进行挖掘和评价,为临床安全使用该药提供参考。方法对山东省药品不良反应监测中心2018年1月至2021年12月收到的所有奥美拉唑不良反应报告进行数据清洗,收集患者性别、年龄,给药途径,不良反应累及系统/器... 详细信息

目的对奥美拉唑不良反应风险信号进行挖掘和评价,为临床安全使用该药提供参考。方法对山东省药品不良反应监测中心2018年1月至2021年12月收到的所有奥美拉唑不良反应报告进行数据清洗,收集患者性别、年龄,给药途径,不良反应累及系统/器官、临床表现及转归情况等信息;采用报告比值比(ROR)法、比例报告比值比(PRR)法和英国药品和保健品管理局(MHRA)综合标准法对与奥美拉唑相关的不良反应风险信号进行挖掘和评价。ROR法和PRR法的风险信号判断标准为报告数≥3,ROR或PRR的95%置信区间(CI)下限>1;MHRA综合标准法的风险信号判断标准为报告数≥3,PRR≥2且χ^(2)≥4。结果以奥美拉唑为怀疑药物的报告共2706份,其中严重不良反应234例(8.7%);男性1270例(46.9%),女性1432例(52.9%);中位年龄58岁,其中60岁1203例;奥美拉唑不良反应共累及17个系统/器官,按报告数排名前5位的依次为胃肠系统[1412例次(37.6%)]、皮肤及其附件[883例次(23.5%)]、神经系统[716例次(19.1%)]、呼吸系统[269例次(7.2%)]及全身系统[207例次(5.5%)];不良反应中位发生时间为用药后30 min,发生在用药后1 d内的有1710例(63.2%);1595例(58.9%)患者痊愈,1098例(40.6%)好转,无死亡病例。ROR法和PRR法分别挖掘出风险信号27个,MHRA综合标准法21个;采用ROR法挖掘出的信号强度排名前5位的不良反应分别为胃肠胀气、头痛、便秘、舌麻木和关节疼痛;采用PRR法挖掘出的信号强度排名前5位的不良反应分别胃肠胀气、头痛、便秘、舌麻木和眩晕;采用MHRA综合标准法挖掘出的信号强度排名前5位的不良反应分别为胃肠胀气、头痛、便秘、腹胀和口干。27个风险信号中,说明书未提及的有胸闷、寒战、紫绀、口麻木、全身颤抖、舌麻木。结论奥美拉唑不良反应涉及多个系统/器官,常见不良反应有胃肠胀气、头痛、便秘等,胸闷、寒战、紫绀、口麻木、全身颤抖、舌麻木等风险信号在说明书中未记载,临床应予以警惕并及时干预。

关键词：奥美拉唑药物不良反应报告系统信号处理,计算机辅助山东省药品不良反应监测中心

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GPD1基因新发突变p.K327N致高甘油三酯血症性急性胰腺炎反复发作1例报告

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临床肝胆病杂志 2024年第2期40卷 361-364页

作者：李孝尧段剑锋王大成陈显成张北源虞文魁南京大学医学院附属鼓楼医院重症医学科南京210008

高甘油三酯血症为我国急性胰腺炎的第二大病因,可以由原发性因素即基因突变引起,所导致的高甘油三酯血症性急性胰腺炎(HTG-AP)易反复发作,且甘油三酯水平难以有效控制。本文报道了1例罹患8次HTG-AP的中国成年男性患者,发现其携带GPD1新... 详细信息

高甘油三酯血症为我国急性胰腺炎的第二大病因,可以由原发性因素即基因突变引起,所导致的高甘油三酯血症性急性胰腺炎(HTG-AP)易反复发作,且甘油三酯水平难以有效控制。本文报道了1例罹患8次HTG-AP的中国成年男性患者,发现其携带GPD1新发杂合突变p.K327N,可能导致甘油三酯水平持续较高及HTG-AP反复发作。

关键词：高甘油三酯血症胰腺炎甘油磷酸脱氢酶突变

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Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy

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Signal Transduction and Targeted Therapy 2024年第2期9卷 709-723页

作者： Leyang Wu Zengzheng Du lin li liyuan Qiao Shuhui Zhang Xingpeng Yin xiaoyao Chang Chenyang li Zichun Hua The State Key Laboratory of Pharmaceutical Biotechnology and Department of Neurology of Nanjing Drum Tower Hospital School of Life Sciences and The Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 21008 JiangsuChina Nanjing Generecom Biotechnology Co. LtdNanjing 210023China Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc Changzhou 213164 JiangsuChina School of Biopharmacy China Pharmaceutical UniversityNanjing 210023 JiangsuChina

live bacteria-mediated antitumor therapies mark a pivotal point in cancer ***,the difficulty in reconciling the safety and efficacy of bacterial therapies has limited their *** bacterial tumor-targeted delivery while maintaining biosafety is a critical hurdle for the clinical translation of live microbial therapy for ***,we developed“dead”yet“functional”Salmonella-loaded macrophages using liquid nitrogen cold shock of an attenuated Salmonella typhimurium VNP20009-contained macrophage cell *** obtained“dead”macrophages achieve an average loading of approximately 257 live bacteria per 100 *** engineered cells maintain an intact cellular structure but lose their original pathogenicity,while intracellular bacteria retain their original biological activity and are delay freed,followed by ***“Trojan horse”-like bacterial camouflage strategy avoids bacterial immunogenicity-induced neutrophil recruitment and activation in peripheral blood,reduces the clearance of bacteria by neutrophils and enhances bacterial tumor enrichment efficiently after systemic ***,this strategy also strongly activated the tumor microenvironment,including increasing antitumor effector cells(including M1-like macrophages and CD8+Teffs)and decreasing protumor effector cells(including M2-like macrophages and CD4+Tregs),and ultimately improved antitumor efficacy in a subcutaneous H22 tumor-bearing mouse *** cryo-shocked macrophage-mediated bacterial delivery strategy holds promise for expanding the therapeutic applications of living bacteria for cancer.

关键词： shock holds maintain

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Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao li Fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of life Health Dalian UniversityDalian 116622China Dalian Fusheng Pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and *** studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of ***,the combined synergistic effect of relieving the inflammatory response has yet to be *** on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological *** the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and *** analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT,*** combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced *** lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and *** conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词： FRET Swertiamarin Phillygenin AKT Anti-inflammation Combinatorial drug

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Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 68-73页

作者： Guanzhun Cao Chuan Feng Tong li Hongjuan Zhang xiaoyao Guo Wen li Yanshuang Jia Leping Chen Yuan Xu Qingsong Wang Guifang Chen Xueliang Yuan China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Shandong Academy of Environmental Sciences Jinan 250109China Shandong Electrical Engineering&Equipment Group Co. Ltd.Jinan 250001China School of Energy and Power Engineering Shandong UniversityJinan 250061China

Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy *** study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system *** on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized *** results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic *** overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural ***,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power *** research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems.

关键词： Micro-energy network life cycle assessment Optimal operation Environmental impact

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F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao li Fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of life Health Dalian University Dalian Fusheng Pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. Previous studies illustrate that phillygenin(Phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(PH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the F?rster resonance energy transfer(FRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of Phi and Swe for FRET were designed and synthesized. FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LPS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(NF-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNF-α), interleukin(IL)-6 and IL-8. In conclusion, FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

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基于对称平面的三维人脸点云姿态估计

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激光与光电子学进展 2022年第8期59卷 73-81页

作者：马泽齐石志良李晓垚蔡旺月武汉理工大学机电工程学院湖北武汉430070 中兴通讯研发中心湖北武汉430000

人脸姿态估计在人脸识别、人机交互和面部表情分析等领域应用广泛,其中一个重要的指标是人脸姿态估计的精度。针对获取的三维(3D)人脸模型存在偏转角度的问题,提出一种基于对称平面的3D人脸姿态估计算法。依据人脸具有的左右对称性来提... 详细信息

人脸姿态估计在人脸识别、人机交互和面部表情分析等领域应用广泛,其中一个重要的指标是人脸姿态估计的精度。针对获取的三维(3D)人脸模型存在偏转角度的问题,提出一种基于对称平面的3D人脸姿态估计算法。依据人脸具有的左右对称性来提取对称平面,进而计算对称轮廓;将对称平面与yoz坐标平面对齐,获得首次姿态调整结果;将对称轮廓两端点构成的向量调整到与y坐标轴平行,获得第二次姿态调整结果。综合两次调整,得出姿态估计结果。以面部模型绕y坐标轴旋转的β角作为评价指标来评价算法的准确性,利用BJUT-3D人脸数据库,生成12个偏航角度下的人脸点云模型,将其作为测试的数据集进行实验。实验结果表明,在-30°~30°范围内,所提方法的β值的平均绝对误差不超过0.55°,其相较于其他基于特征点的人脸姿态估计算法具有更高的精度。

关键词：图像处理三维人脸点云姿态估计对称平面对称轮廓

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变频调速技术在对旋式轴流通风机节能中的应用

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煤炭与化工 2022年第9期45卷 81-83页

作者：李逍遥华阳集团泊里公司安监通风部山西晋中032700

我国煤炭开采大都在井下,而井下作业必须在通风良好的情况下进行。对旋式轴流通风机是煤矿常用通风设备之一,但泊里煤矿对旋式轴流通风机在实际使用中存在效率不高、能耗较大等现象。为解决这一问题,针对其工作特性,决定采用变频调速原... 详细信息

我国煤炭开采大都在井下,而井下作业必须在通风良好的情况下进行。对旋式轴流通风机是煤矿常用通风设备之一,但泊里煤矿对旋式轴流通风机在实际使用中存在效率不高、能耗较大等现象。为解决这一问题,针对其工作特性,决定采用变频调速原理,对风机的驱动电机进行频率调整,实现风机两级动叶干涉性调速的最佳流动匹配,达到对通风机工况进行实时调节的目的,满足矿井风量、负压需求的同时减少通风机满负荷运行,达到节能效果。

关键词：对旋式轴流通风机节能环保变频调速

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