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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan zhou Gaoxiong Duan Ying Liu Bei Peng xiaoyan zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Purification,initial characterization and immune activities of polysaccharides from the fungus,Polyporus umbellatus

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Food Science and Human Wellness 2014年第2期3卷 73-78页

作者： Ye Sun xiaoyan zhou Department of Biology Shanghai Institute of TechnologyShanghai 201418PR China Shanghai Institute of Industrial Microbiology Shanghai 200233PR China

Polyporus umbellatus(formerly Grifola umbellatus),an edible fungus,has been used as traditional Chinese *** present investigation aimed to uncover the active ingredients in this fungal species,with the emphasis on its *** polysaccharides,one from fermented mycelium and the other from the fruiting body,were chromatographically *** weights,anti-microbial and immune activities of the polysaccharides were *** mycelium polysaccharide was found to have a molecular weight of 857 kDa and consist of glucose and galactose at a molar ratio of 1.57:1,while the one from the fruiting body,679 kDa in molecular weight,was also made up of glucose and galactose but at a molar ratio of 5.42:*** immune assays,these fungal polysaccharides increased the killing potency of natural killer(NK)and lymphokineactivated killer(LAK)cells from mouse spleen and promoted proliferation of mouse B and T ***,both *** mycelium and its extract were found to inhibit Escherichia coli and Staphylococcus aureus,but had no effects on Aspergillus niger or Aspergillus *** results indicated that fermented *** mycelium is indeed immune active,most probably due to its ingredients of *** consumption of this fungus may be beneficial for human health.

关键词： polysaccharides fungus weights

Influence of glucose feeding on the ligninolytic enzyme production of the white-rot fungus Phanerochaete chrysosporium

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Frontiers of Environmental Science & Engineering 2007年第1期1卷 89-94页

作者： zhou xiaoyan WEN Xianghua FENG Yan The State Key Joint Laboratory of Environmental Simulation and Pollution Control Department of Environmental Science and EngineeringTsinghua UniversityBeijing 100084China

The present work studied the influence of glucose feeding on the ligninolytic enzyme production of Phanerochaete chrysosporium in a nitrogen-limited(C/N ratio is 56/8.8 mmol/L)*** sets of shaking flask experiments were *** results showed that 2 g/L glucose feeding on the first day of the culture(24 h after the inoculation)stimulated both fungal biomass growth and enzyme *** manganese peroxidase(MnP)activ-ity was 2.5 times greater than that produced in cultures with-out glucose ***,the glucose feeding mode in fed-batch culture was also *** to cul-tures with glucose feeding every 48 h,cultures with glucose feeding of 1.5 g/L(final concentration)every 24 h produced more *** peak and total yield of MnP activity were 2.7 and 3 times greater compared to the contrast culture,respectively,and the enzyme was kept stable for 4 days with an activity of over 200 U/L.

关键词： white-rot fungus ligninolytic enzymes glucose feeding fed-batch culture

Effect of an electric field on dewetting transition of nitrogen-water system

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Chinese Physics B 2022年第3期31卷 455-460页

作者： Qi Feng Jiaxian Li xiaoyan zhou Hangjun Lu Department of Physics Zhejiang Normal UniversityJinhua 321004China

We investigate the influence of an external electric field on the dewetting behavior of nitrogen-water systems between two hydrophobic plates using molecular dynamics simulations. It is found that the critical distance of dewetting increases obviously with the electric field strength, indicating that the effective range of hydrophobic attraction is extended. The mechanism behind this interesting phenomenon is related to the rearrangement of hydrogen bond networks between water molecules induced by the external electric field. Changes in the hydrogen bond networks and in the dipole orientation of the water molecules result in the redistribution of the neutral nitrogen molecules, especially in the region close to the hydrophobic plates. Our findings may be helpful for understanding the effects of the electric field on the long-range hydrophobic interactions.

关键词： dewetting transition hydrophobic interactions electric field

Fabrication of Bionic Superhydrophobic Manganese Oxide/Polystyrene Nanocomposite Coating

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Journal of Bionic Engineering 2012年第1期9卷 11-17页

作者： Xianghui Xu Zhaozhu Zhang Fang Guo Jin Yang Xiaotao Zhu xiaoyan zhou Qunji Xue State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 P. R. China Graduate School Chinese Academy of Sciences Beijing 100039 P. R. China

A superhydrophobic manganese oxide/polystyrene （MnO2/PS） nanocomposite coating was fabricated by a facile spraying process. The mixture solution of MnO2/PS was poured into a spray gun, and then sprayed onto the copper substrate using 0.2 MPa nitrogen gas to construct superhydrophobic coating. The wettability of the composite coating was measured by sessile drop method. When the weight ratio of MnO2 to PS is 0.5：1, the maximum of contact angle （CA）（140°） is obtained at drying temperature of 180 ℃. As the content of MnO2 increases, the maximum of CA （155°） is achieved at 100 ℃. Surface morphologies and chemical composition were analyzed to understand the effect of the content of MnO2 nanorods and the drying temperature on CA. The results show that the wettability of the coating can be controlled by the content of MnO2 nanorods and the drying temperature. Using the proposed method, the thickness of the coating can be controlled by the spraying times. If damaged, the coating can be repaired just by spraying the mixture solution again.

关键词： bionics superhydrophobic surface MnO2 nanorods nanocomposite coating drying temperature

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解决纳米孔道堵塞的一种新方法

浙江师范大学学报（自然科学版） 2025年第1期48卷 45-50页

作者：韦敏徐驰周晓艳陆杭军浙江师范大学凝聚态物理研究所浙江金华321004

为了解决微纳米流控器件中纳米气泡引起的堵塞问题,利用分子动力学模拟研究了气体分子在单壁碳纳米管中积聚形成纳米气泡并对通道中的水流造成堵塞的现象,提出了一种基于棘轮理论和机械共振的疏通方法.结果显示:与传统的静水压驱动法相... 详细信息

为了解决微纳米流控器件中纳米气泡引起的堵塞问题,利用分子动力学模拟研究了气体分子在单壁碳纳米管中积聚形成纳米气泡并对通道中的水流造成堵塞的现象,提出了一种基于棘轮理论和机械共振的疏通方法.结果显示:与传统的静水压驱动法相比,振动驱动法不需要极高的静水压,不仅可以在极短的时间里疏通纳米管道,而且还可以产生高水通量.该结果可为解决纳米孔道中的气体阻塞问题提供一种新方法.

关键词：纳米气泡孔道堵塞分子动力学水流量

All-fluorinated electrolyte for non-flammable batteries with ultra-high specific capacity at 4.7 V

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Green Energy & Environment 2024年第10期9卷 1601-1609页

作者： Zhe Wang Zhuo Li Jialong Fu Sheng Zheng Rui Yu xiaoyan zhou Guanjie He Xin Guo State Key Laboratory of Material Processing and Die&Mould Technology Laboratory of Solid State IonicsSchool of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College London20 Gordon StreetLondon WC1E 7JEUK

Li metal batteries(LMBs)with LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)cathodes could release a specific energy of>500 Wh kg^(-1) by increasing the charge ***,high-nickel cathodes working at high voltages accelerate degradations in bulk and at interfaces,thus significantly degrading the cycling lifespan and decreasing the specific ***,we rationally design an all-fluorinated electrolyte with addictive tri(2,2,2-trifluoroethyl)borate(TFEB),based on 3,3,3-fluoroethylmethylcarbonate(FEMC)and fluoroethylene carbonate(FEC),which enables stable cycling of high nickel cathode(LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),NMC811)under a cut-off voltage of 4.7 V in Li metal *** electrolyte not only shows the fire-extinguishing properties,but also inhibits the transition metal dissolution,the gas production,side reactions on the cathode ***,the NMC811||Li cell demonstrates excellent performance by using limited Li and high-loading cathode,delivering a specific capacity>220 mA h g^(-1),an average Coulombic efficiency>99.6%and capacity retention>99.7%over 100 cycles.

关键词： Fluorinated electrolyte Li metal batteries Solid electrolyte interphase Cathode electrolyte interphase Coulombic efficiency

Dramatic changes in the horizontal structure of mangrove forests in the largest delta of the northern Beibu Gulf, China

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Acta Oceanologica Sinica 2023年第7期42卷 116-123页

作者： Riming Wang Zhijun Dai Hu Huang Xixing Liang xiaoyan zhou Zhenming Ge Baoqing Hu Guangxi Key Laboratory of Marine Environmental Change and Disaster in Beibu Gulf/Beibu Gulf Ocean Development Research Center Beibu Gulf UniversityQinzhou 535011China State Key Laboratory of Estuarine and Costal Research East China Normal UniversityShanghai 200062China Key Laboratory of Environment Change and Resources Use in Beibu Gulf(Nanning Normal University) Ministry of EducationNanning 510310China

The horizontal structure of mangrove forests is an important characteristic that reflects a significant signal for coupling between mangroves and external *** the loss and gain of mangroves has received much attention,little information about how the horizontal structure of mangrove forests develops from the seedling stage to maturity has been ***,remote sensing images taken over approximately 15 years,UVA images,nutrient elements,sediments,and Aegiceras corniculatum vegetation parameters of the ecological quadrats along the Nanliu Delta,the largest delta of the northern Beibu Gulf in China,are analyzed to reveal changes in the horizontal structure of mangroves and their associated driving *** results show that both discrete structures and agglomerated structures can often be found in *** seedlings and ***,the combination of seedlings growing into maturity and new seedlings filling in available gaps causes the discrete structure of *** to gradually vanish and the agglomerate structure to become *** aggregated structure of seedlings,compared to the discrete structure,can enhance the elevation beneath mangroves by trapping significantly more sediments,providing available spaces and conditions for seedlings to continue ***,by catching fine sediments with enriched nutrients,the survival rate of *** seedlings in the agglomerated structure can be much higher than that in the discrete *** results highlight the significance of the agglomeration of ***,which can be beneficial to coastal mangrove restoration and management.

关键词： deltaic mangrove Aegiceras corniculatum horizontal structure biomorphodynamic processes Nanliu Delta

Phase regimes of parity-time-symmetric coupled-ring systems at exceptional points

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Photonics Research 2022年第10期10卷 2374-2379页

作者： ZHUANG MA xiaoyan zhou LIN ZHANG Tianjin Key Laboratory of Integrated Opto-electronics Technologies and Devices School of Precision Instruments and Opto-electronics EngineeringTianjin UniversityTianjin 300072China Peng Cheng Laboratory Shenzhen 518038China

The optical coupled resonant system consisting of an integrated resonator with gain and a resonator with loss provides an excellent platform to create exceptional points(EPs)in non-Hermitian *** previous studies have focused on the striking intensity feature of EPs,but its phase response is seldom *** this work,we present a thorough study on the phase response of an EP ***,the phase response exhibits distinct behavior depending on the ordering of the ring resonators:when the input light in a bus waveguide is coupled directly or indirectly to the ring with a gain,the phase response is featured by nonmonotonic transition and 2π monotonic transition,*** also prove that the newly identified phase features are theoretically *** phase responses produce unique group delays that have never been found in other coupled resonant *** results deepen our understanding on EPs in non-Hermitian systems and are potentially useful for practical applications exploiting phase features.

关键词： resonator waveguide coupled