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Characteristics and sources of peroxyacetyl nitrate(PAN)in the rural North China Plain:Results from1-year continuous observations

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Journal of Environmental Sciences 2024年第4期138卷 719-731页

作者： Xin Liu xiaowei He Chenglong Zhang Yifei Song Shuyang xie Chengtang Liu Pengfei Liu Yuanyuan Zhang Yujing Mu Junfeng Liu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Peroxyacetyl nitrate(PAN)is an important photochemical pollutant in the troposphere,whereas long-term measurements are scarce in rural areas in North China Plain(NCP),resulting in unclear seasonal variations and sources of PAN in rural NCP.In this study,we conducted a 1-year observation of PAN during 2021-2022 at the rural NCP site.The average concentrations of PAN were 1.10,0.75,0.65,and 0.88 ppbv in spring,summer,autumn,and winter,respectively,with a 1-year average of 0.81±0.60 ppbv.Calculations indicate that the loss of PAN through thermal decomposition in summer accounts for 43.2% of the total formed PAN,which is an important reason for the low concentration of PAN in summer.We speculate that since the correlation between PAN and O_(3) in winter is significantly lower than that in other seasons,the observed regional transport of PAN cannot be ignored in winter.Through budget analysis,regional transport accounted for 12.8% and 55.9% of the observed PAN on the spring and winter pollution days,respectively,which showed that regional transport played key roles during the photochemical pollution of the rural NCP in winter.The potential source contribution function revealed that the transported PAN mainly comes from southern Hebei in spring.In winter,the transported PAN was mainly from Langfang,Hengshui,and southern Beijing.Our findings may aid in understanding PAN variations in different seasons in rural areas and highlight the impact of regional transport on the PAN budget.

关键词： Photochemical pollution Peroxyacetyl nitrate(PAN) Seasonal variations Regional transport Rural area

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Boosting selectivity and stability on Pt/BN catalysts for propane dehydrogenation via calcination & reduction-mediated strong metal-support interaction

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Journal of Energy Chemistry 2022年第4期31卷 451-457页

作者： Yaoxin Wang Jiandian Wang Ping Zheng Changyong Sun Junyin Luo xiaowei xie Key Laboratory of Clean Chemical Technology of Guangdong Regular Higher Education Institutions School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006GuangdongChina

Propane dehydrogenation(PDH) provides an alternative route for producing propylene. Herein, we demonstrates that h-BN is a promising support of Pt-based catalysts for PDH. The Pt catalysts supported on h-BN were prepared by an impregnation method using Pt(NH_(3))_(4)(NO_(3))_(2) as metal precursors. It has been found that the Pt/BN catalyst undergoing calcination and reduction is highly stable in both PDH reaction and coke-burning regeneration, together with low coke deposition and outstanding propylene selectivity(99%). Detailed characterizations reveal that the high coke resistance and high propylene selectivity of the Pt/BN catalyst are derived not only from the absence of acidity on BN support, but also from the calcination-induced and reduction-adjusted strong metal-support interaction(SMSI) between Pt and BN, which causes the partial encapsulation of Pt particles by BO_(x) overlayers. The BO_(x) overlayers can block the low-coordinated Pt sites and constrain Pt particles into smaller ensembles, suppressing side reactions such as cracking and deep dehydrogenation. Moreover, the BO_(x) overlayers can effectively inhibit Pt sintering by the spatial isolation of Pt during periodic reaction-regeneration cycles. In this work, the catalyst support for PDH is expanded to nonoxide BN, and the understanding of SMSI between Pt and BN will provide rational design strategy for BN-based catalysts.

关键词： Pt catalyst BN SMSI Propane dehydrogenation Selectivity Stability Coke Sintering

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Single-cell analysis of transcription factor regulatory networks reveals molecular basis for subtype-specific dysregulation in acute myeloid leukemia

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Blood Science 2022年第2期4卷 65-75页

作者： Ruixia Sun Lina Sun xiaowei xie Xuan Li Peng Wu Lu Wang Ping Zhu State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Center for Stem Cell Medicine and Department of Stem Cell&Regenerative Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina

Highly heterogeneous acute myeloid leukemia(AML)exhibits dysregulated transcriptional programs.Transcription factor(TF)regulatory networks underlying AML subtypes have not been elucidated at single-cell resolution.Here,we comprehensively mapped malignancy-related TFs activated in different AML subtypes by analyzing single-cell RNA sequencing data from AMLs and healthy donors.We first identified six modules of regulatory networks which were prevalently dysregulated in all AML patients.AML subtypes featured with different malignant cellular composition possessed subtype-specific regulatory TFs associated with differentiation suppression or immune modulation.At last,we validated that ERF was crucial for the development of hematopoietic stem/progenitor cells by performing loss-and gain-of-function experiments in zebrafish embryos.Collectively,our work thoroughly documents an abnormal spectrum of transcriptional regulatory networks in AML and reveals subtype-specific dysregulation basis,which provides a prospective view to AML pathogenesis and potential targets for both diagnosis and therapy.

关键词： Acute myeloid leukaemia Co-expression analysis Single-cell RNA-sequencing Transcription factor Transcriptional regulatory network

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Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 713-727页

作者： Xudong Fan Tianxiang Yue Aidi Liu xiaowei xie Weixiang Fang Yinghui Wei Hangsheng Zheng Hongyue Zheng Meiqi Zhou Jigang Piao Fanzhu Li School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Libraries of Zhejiang Chinese Medical University Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Breast Surgery Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationSecond Hospital of ZhejiangUniversity College of MedicineHangzhou 310009China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Photothermal therapy(PTT)has brought hope for cancer treatments,with hyperthermia-induced immunogenic cell death(ICD),which is a critical part of therapeutically induced antitumor immune responses.Limited immune stimulation response in PTT is the primary reason for incomplete tumor ablation,therefore demonstrating urgent requirements for ICD amplifier.Herein,a sub-10 nm supramolecular nanoassembly was formed by coassembly of clinically approved aluminum adjuvant and commonly used indocyanine green(ICG)under the assistance of lignosulfonate(LS,a green and sustainable multifunctional lignin derivative)for localized photothermal-immunotherapy of breast cancer.The overall results revealed that LS-Al-ICG is capable of inducing amplified ICD,efficiently eliciting solid immune responses through dendritic cells(DCs)activation and cytotoxic T-cell responses initiation for tumor killing.Moreover,anti-PD-1 therapy blocked the PD-1 pathway and led to remarkable anti-tumor efficacy against laser-irradiated primary tumors and distant tumors by potentiating systemic tumor specific T cell immunity.The results of this study demonstrate a handy and extensible approach for engineering green natural lignin nanoparticles for cancer immunotherapy,which shows promise for delivering other therapeutics in biomedical applications.

关键词： Lignin Supramolecular self-assembly Photothermal-immunotherapy Anti-PD-1

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二次扰动巷道注浆支护研究

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山西化工 2024年第2期44卷 171-173页

作者：谢小伟国家能源神东石圪台煤矿陕西榆林719000

为了解决二次扰动下巷道围岩变形大的问题,通过数值模拟对注浆支护方案下巷道围岩变形量进行分析,在得出最佳注浆加固方案后进行工业化试验,试验发现巷道的顶底板变形量最大值为294 mm,两帮的移近量最大值为417 mm,能够满足矿井开采的要... 详细信息

为了解决二次扰动下巷道围岩变形大的问题,通过数值模拟对注浆支护方案下巷道围岩变形量进行分析,在得出最佳注浆加固方案后进行工业化试验,试验发现巷道的顶底板变形量最大值为294 mm,两帮的移近量最大值为417 mm,能够满足矿井开采的要求,为矿井二次扰动巷道安全开采提供一定的依据。

关键词：数值模拟注浆加固工业化试验二次扰动

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个性化健康教育联合导乐对初产妇心理及分娩结局的影响

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中国基层医药 2024年第4期31卷 595-599页

作者：谢小伟曹晓丹陶洁静温州市人民医院产科温州325000

目的探讨个性化健康教育联合导乐对初产妇心理状态及分娩结局的影响。方法采用便利抽样法,选取2022年1—11月于温州市人民医院产科门诊就诊并建立档案的初产妇102例为研究对象,采用随机对照研究方法,以随机数字表法分为对照组与观察组,... 详细信息

目的探讨个性化健康教育联合导乐对初产妇心理状态及分娩结局的影响。方法采用便利抽样法,选取2022年1—11月于温州市人民医院产科门诊就诊并建立档案的初产妇102例为研究对象,采用随机对照研究方法,以随机数字表法分为对照组与观察组,每组51例。对照组采用常规护理方法,观察组在常规护理基础上实施个性化健康教育伴导乐陪伴分娩干预,比较两组初产妇在一般自我效能、压力水平、剖宫产率以及新生儿1min Apgar评分的差异。结果对照组失访1例,纳入50例,观察组失访3例,纳入48例。干预前,对照组初产妇一般自我效能感评分为(27.44±6.38)分,与观察组的(26.52±7.19)分比较,差异无统计学意义(t=0.17,P=0.548);观察组知觉压力量表评分为(62.88±11.39)分,与对照组的(62.76±10.44)分比较,差异无统计学意义(t=0.10,P=0.672)。干预后,观察组一般自我效能感评分为(35.89±8.64)分,与对照组的(29.67±8.73)分比较,差异有统计学意义(t=3.38,P=0.012);新生儿1min Apgar评分:对照组为(6.52±2.69)分,观察组为(8.13±1.56)分,两组差异有统计学意义(t=3.97,P<0.001);知觉压力量表得分:对照组为(58.77±11.34)分,观察组为(52.13±10.78)分,两组差异有统计学意义(t=1.49,P=0.003);剖宫产率:对照组为28.00%(14/50),观察组为18.75%(9/48),两组差异有统计学意义(χ^(2)=1.01,P<0.001)。结论个性化健康教育伴导乐陪伴分娩干预有助于提高初产妇自我效能,降低分娩压力并改善分娩结局。

关键词：健康教育导乐孕产妇健康剖宫产术阿普加评分

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全天时便携式户外型红外探测气溶胶激光雷达系统设计及应用

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红外与激光工程 2024年第3期53卷 118-128页

作者：庄鹏谢晨波康宝荣刘建明夏小维铜陵学院电气工程学院安徽铜陵244061 安徽蓝科信息科技有限公司安徽合肥230031 中国科学院安徽光学精密机械研究所中国科学院大气光学重点实验室安徽合肥230031 巢湖学院机械工程学院安徽合肥238000

介绍了全天时便携式户外型红外探测气溶胶激光雷达的工作原理、系统设计与多种场景应用分析。红外探测气溶胶激光雷达具有大气穿透性强,受天空背景光影响小、对大粒子敏感等特点,在大气气溶胶污染时空分布特征获取、水平能见度监测和垂... 详细信息

介绍了全天时便携式户外型红外探测气溶胶激光雷达的工作原理、系统设计与多种场景应用分析。红外探测气溶胶激光雷达具有大气穿透性强,受天空背景光影响小、对大粒子敏感等特点,在大气气溶胶污染时空分布特征获取、水平能见度监测和垂直边界层监测的应用上取得较好的效果。系统水平扫描可获取大区域颗粒物分布图,及时发现污染源并联合近地面风速风向、颗粒物和一氧化碳浓度等数据评估污染源影响程度,同时能够准确地反演水平能见度,与标准能见度仪比对相对误差均小于20%。激光雷达反演边界层高度采用消光系数梯度法,实验结果与探空气球反演绝对偏差为200 m,能够准确反演边界层高度。该系统能够实时精确地捕获大气气溶胶分布与传输情况,准确反演水平能见度、边界层高度等信息,在大气监测领域具有广泛的应用场景。

关键词：红外气溶胶激光雷达颗粒物分布能见度边界层

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以旗舰物种为视角的生物多样性价值评估初探

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环境工程技术学报 2024年第3期14卷 1077-1086页

作者：李晓蔚邓陈宁黄小娱谢明辉中国环境科学研究院

利益相关者对生物多样性的价值感知影响其态度与行为,从而影响环境保护政策执行的效率与效果。为准确刻画出利益相关者对特定区域内生物多样性的价值感知,提出一套以旗舰物种为视角的选择实验设计方法,具体步骤包括:结合研究区域选择旗... 详细信息

利益相关者对生物多样性的价值感知影响其态度与行为,从而影响环境保护政策执行的效率与效果。为准确刻画出利益相关者对特定区域内生物多样性的价值感知,提出一套以旗舰物种为视角的选择实验设计方法,具体步骤包括:结合研究区域选择旗舰物种进行属性设计;根据预调研结果优化生成正式调研的选择实验问卷;通过问卷调研获取支付意愿;评估局地生物多样性价值。将该方法应用于秦岭(陕西段),选取秦岭大熊猫、秦岭金丝猴、朱鹮为旗舰物种,调查了1288位受访者,结果显示:陕西省内、省外受访者对秦岭生物多样性保护的边际货币支付意愿分别为146.29、212.60元/a,边际时间支付意愿价值分别为240.12、350.01元/a。根据边际支付意愿估算得到秦岭(陕西段)生物多样性价值为4897.72亿~9795.45亿元/a。该方法能较为全面地反映局地生物多样性的价值并兼具可理解性,为生物多样性保护政策的制定与执行提供数据基础。

关键词：旗舰物种选择实验支付意愿生物多样性价值秦岭

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新质生产力本身就是绿色生产力的理论内涵与实践向度

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环境污染与防治 2024年第6期46卷 771-776页

作者：俞海宁晓巍张强谢茂敏生态环境部环境与经济政策研究中心北京100029

绿色发展是高质量发展的底色,新质生产力本身就是绿色生产力,体现了新质生产力在低碳、环保、可持续等方面丰富的绿色内涵。通过梳理生产力理论的发展历程,分析新质生产力的基本特征、核心标志等理论问题,重点阐释新质生产力本身就是绿... 详细信息

绿色发展是高质量发展的底色,新质生产力本身就是绿色生产力,体现了新质生产力在低碳、环保、可持续等方面丰富的绿色内涵。通过梳理生产力理论的发展历程,分析新质生产力的基本特征、核心标志等理论问题,重点阐释新质生产力本身就是绿色生产力的内在逻辑、内涵外延和价值意蕴,并围绕从理论上进一步总结、概括绿色新质生产力提出意见建议和思路举措。

关键词：新质生产力绿色生产力高质量发展

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Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19

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Science China(Life Sciences) 2021年第10期64卷 1634-1644页

作者： xiaowei xie Xuelian Cheng Gaoxiang Wang Biao Zhang Mengyao Liu Liting Chen Hui Cheng Sha Hao Jianfeng Zhou Ping Zhu Tao Cheng State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Center for Stem Cell Medicine and Department of Stem Cell&Regenerative Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

The blood and immune system of coronavirus disease 2019(COVID-19)infected patients are dysfunctional,and numerous studies have been conducted to resolve their characteristics and pathogenic mechanisms.Nevertheless,the variations of immune responses along with disease severity have not been comprehensively documented.Here,we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells(PBMCs)derived from 12 COVID-19 patients(including four moderate,four severe and four critical cases)and three healthy donors.We showed that proliferative CD8 effector T cells with declined immune functions and cytotoxicity accumulated in the critical stage.By contrast,the quantity of natural killer(NK)cells was significantly reduced,while they exhibited enhanced immune activities.Notably,a gradually attenuated responseto COVID-19 along with disease severity was observed in monocytes,in terms of cellular composition,transcriptional discrepancy and transcription factor regulatory network.Furthermore,we identified immune cell-type dependent cytokine signatures distinguishing the severity of COVID-19 patients.In addition,cell interactions between CD8 effector T/NK cells and monocytes mediated by inflammatory cytokines were enhanced in moderate and severe stages,but weakened in critical cases.Collectively,our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity,which could provide valuable insights for the treatment of critical COVID-19 patients.

关键词： COVID-19 severity PBMCs immune response single-cell RNA-seq

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