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Overview of the CMIP6 Historical Experiment Datasets with the Climate System Model CAS FGOALS-f3-L

Advances in Atmospheric Sciences 2020年第10期37卷 1057-1066页

作者： Yuyang GUO Yongqiang YU Pengfei LIN Hailong LIU Bian HE Qing BAO Shuwen ZHAO and xiaowei wang State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Yunnan University Kunming 650091China

The three-member historical simulations by the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System model,version f3-L(CAS FGOALS-f3-L),which is contributing to phase 6 of the Coupled Model Intercomparison Project(CMIP6),are described in this *** details of the CAS FGOALS-f3-L model,experiment settings and output datasets are briefly *** datasets include monthly and daily outputs from the atmospheric,oceanic,land and sea-ice component models of CAS FGOALS-f3-L,and all these data have been published online in the Earth System Grid Federation(ESGF,https://***/projects/cmip6/).The three ensembles are initialized from the 600th,650th and 700th model year of the preindustrial experiment(piControl)and forced by the same historical forcing provided by CMIP6 from 1850 to *** performance of the coupled model is validated in comparison with some recent observed atmospheric and oceanic *** is shown that CAS FGOALS-f3-L is able to reproduce the main features of the modern climate,including the climatology of air surface temperature and precipitation,the long-term changes in global mean surface air temperature,ocean heat content and sea surface steric height,and the horizontal and vertical distribution of temperature in the ocean and ***,like other state-of-the-art coupled GCMs,there are still some obvious biases in the historical simulations,which are also *** paper can help users to better understand the advantages and biases of the model and the datasets。

关键词： CMIP6 historical simulation FGOALS-f3-L coupled model data description

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Application of the Mole-8.5 supercomputer:Probing the whole influenza virion at the atomic level

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Chinese Science Bulletin 2011年第20期56卷 2114-2118页

作者： XU Ji wang xiaowei HE XianFeng REN Ying GE Wei LI JingHai State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Graduate University of the Chinese Academy of Sciences Beijing 100049China

Discrete computer simulations are quite helpful in understanding dynamic structures in complex ***,using the Mole-8.5 supercomputer and molecular dynamics simulations as a"computational microscope",we simulated the dynamic structure of a whole H1N1 influenza virion in solution for the first time at the atomic *** total,300 million atoms in a periodic cube with an edge length of 148.5 nm were *** 288 low level hybrids with 1728 C2050 GPUs and a software package developed specifically for the hardware,the simulation executed 770 ps/d with an integration time step of 1 fs,and analyzed the dynamic *** the tremendous computational power of GPUs,efficient software packages for various hardware designs,and consistent physical models,more challenging applications will be carried out in the near future.

关键词：超级计算机病毒粒子应用程序原子流感鼹鼠计算机模拟分子动力学模拟

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Generation of 88 as Isolated Attosecond Pulses with Double Optical Gating

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Chinese Physics Letters 2020年第2期37卷 11-14页

作者： xiaowei wang Li wang Fan Xiao Dongwen Zhang Zhihui Lü Jianmin Yuan Zengxiu Zhao Department of Physics National University of Defense TechnologyChangsha 410073 Department of Physics Graduate School of China Academy of Engineering PhysicsBeijing 100193 IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240

Isolated attosecond pulses with a duration of 88 as are generated in the spectral range of 29–72 eV using double optical gating *** gate width is set to be shorter than half the optical cycle to avoid carrier envelop phase stabilization of the 4.2 fs driving laser pulses centered at 800 *** attosecond pulse duration is measured with the technique of frequency resolved optical gating for complete reconstruction of attosecond bursts.

关键词： technique. second stabilization

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Generation of Intense Sub-10 fs Pulses at 385 nm

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Chinese Physics Letters 2020年第11期37卷 39-43页

作者： Fan Xiao Xiaohui Fan Li wang Dongwen Zhang Jianhua Wu xiaowei wang Zengxiu Zhao Department of Physics National University of Defense TechnologyChangsha 410073China

We demonstrated the generation and characterization of 9.7 fs,180 J pulses centered at 385 nm via the frequency doubling of few-cycle near-infrared *** moderate conversion efficiency(9.5%)and broad phase matching bandwidth(20 nm)were achieved by shaping the spectra of the fundamental *** strong intensity dependence of second-order harmonic generation and well controlled material dispersion ensured the inexistence of satellite pulses,which was confirmed by the self-diffraction frequency resolved optical gating measurement.

关键词： measurement. doubling matching

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GaN based ultraviolet laser diodes

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Journal of Semiconductors 2024年第1期45卷 6-15页

作者： Jing Yang Degang Zhao Zongshun Liu Yujie Huang Baibin wang xiaowei wang Yuheng Zhang Zhenzhuo Zhang Feng Liang Lihong Duan Hai wang Yongsheng Shi State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

In the past few years,many groups have focused on the research and development of GaN-based ultraviolet laser diodes(UV LDs).Great progresses have been achieved even though many challenges *** this article,we analyze the challenges of developing GaN-based ultraviolet laser diodes,and the approaches to improve the performance of ultraviolet laser diode are *** these techniques,room temperature(RT)pulsed oscillation of AlGaN UVA(ultraviolet A)LD has been realized,with a lasing wavelength of 357.9 *** with the suppression of thermal effect,the high output power of 3.8 W UV LD with a lasing wavelength of 386.5 nm was also fabricated.

关键词： diodes laser GaN

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Syntheses and Antiproliferative Evaluation of 6-Thienyl, 6-Polyphenyl Aryl and 6-Naphthyl Derivatives of 2,4-Diaminopyrido [3,2-d] pyramidine as Non-classical Antifolate Targeting DHFR

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Chemical Research in Chinese Universities 2017年第4期33卷 559-568页

作者： YANG Jiajia wang Meng LI Xia FAN Ningning XUE Liangmin LI Hao TIAN Chao wang xiaowei LIU Junyi ZHANG Zhili Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing 100191 P. R. China State Key Laboratory of Natural and Biomimenc Drugs Peking University Beijing 100191 P. R. China Marine College Shandong University Weihai 264209 P. R. China

A series of 6-thienylethenyl, 6-polyphenyl arylethenyl, 6-thienylethyl and 6-polyphenyl arylethyl deriva- tives of 2,4-diaminopyrido[3,2-d]pyrimidine for targeting dihydrofolate reductase（DHFR） was designed and synthe- sized as non-classical antifolates in order to overcome drug resistance. The compounds were evaluated for in vitro antitumor activities, rhDHFR and antimicrobial activities. All the compounds exhibited antitumor activities, with ICs0 values in the range of 0.13--17.8 gmol/L against HL-60, HeLa and A549. Both the types of aryl groups and the orientation of polyphenyl aryl made an impact on the biological activities. 6-Naphthylethyl derivatives 5c and 5d were proved to be the most active Dt-IFR inhibitors, which were more potent than 6-phenylethyl, 6-thienylethyl and 6-biphenylethyl derivatives. Docking studies reveal that flexible saturated carbon-carbon bond of C9--C10 is essential for biological activities in molecular backbone. Antimicrobial test shows that most of the compounds exhibit antibacterial activities.

关键词： Non-classical antifolate Dihydrofolate reductase(DHFR) Antitumor Antimicrobial

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Acute effects of human protein S administration after traumatic brain injury in mice

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Neural Regeneration Research 2020年第11期15卷 2073-2081页

作者： xiaowei wang Jing Tong Xiaodi Han Xiaoming Qi Jun Zhang Erxi Wu Jason H.Huang Center for Translational Neuromedicine University of RochesterRochesterNYUSA Department of Neurosurgery 4th Affiliated Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery Tiantan HospitalBeijingChina Department of Neurosurgery Baylor Scott&White HealthTempleTXUSA Department of Neurosurgery PLA General HospitalBeijingChina College of Medicine Texas A&M Health Science CenterTempleTXUSA

Despite years of effort,no effective acute phase treatment has been discovered for traumatic brain *** impediment to successful drug development is entangled secondary injury *** we show that protein S,a natural multifunctional protein that regulates coagulation,inflammation,and apoptosis,is able to reduce the extent of multiple secondary injuries in traumatic brain injury,and therefore improve *** subjected to controlled cortical impact were treated acutely(10–15 minutes post-injury)with a single dose of either protein S(1 mg/kg)or vehicle phosphate buffered saline via intravenous *** 24 hours post-injury,compared to the non-treated group,the protein S treated group showed substantial improvement of edema and fine motor coordination,as well as mitigation of progressive tissue *** and western blot targeting caspase-3,B-cell lymphoma 2(Bcl-2)along with terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay revealed that apoptosis was suppressed in treated *** targeting CD11 b showed limited leukocyte infiltration in the protein S-treated ***,protein S treatment increased the ipsilesional expression of aquaporin-4,which may be the underlying mechanism of its function in reducing *** results indicate that immediate intravenous protein S treatment after controlled cortical impact is beneficial to traumatic brain injury *** Use Protocols(AUPs)were approved by the University Committee on Animal Resources(UCAR)of University of Rochester Medical Center(approval ***-2008-102 R)on November 12,2013.

关键词： apoptosis aquaporin-4 controlled cortical impact edema inflammation protein S TBI therapy traumatic brain injury

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Dominance rank of adult females and mating competition in Sichuan snub-nosed monkeys(Rhinopithecus roxellana)in the Qinling Mountains,China

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Chinese Science Bulletin 2013年第17期58卷 2205-2211页

作者： HE HaiXia ZHAO HaiTao QI XiaoGuang wang xiaowei GUO SongTao JI WeiHong wang ChengLiang WEI Wei LI BaoGuo College of Life Sciences Northwest University Institute of Zoology Shaanxi Academy of Sciences Institute of Natural Resources Massey University

Dominance hierarchy reflects resource competition in male primates as well as *** this study,we collected data on the social rank and mating competition of female Sichuan snub-nosed monkeys from September 2009 to June 2010 in the Qinling Mountains,Shaanxi,*** was used to determine social hierarchy of the studied wild females.A total of 1223 displacement bouts between adult females and 316 mating behaviors within one-male units(OMUs) were *** displacement among females was very low(0.22 displacements per observation hour).The dominant ranks of females in target OMUs were determined by displacement,from one OMU to another:JB unit:YL > DBC > YCM >XBC > BD;JZT unit:XHW > JG > DT;PK unit:QQ > TM > HF;LP unit:SK > TH > ***-ranking females performed significantly more sexual behavior than lower-ranking females in this rare ***-ranking females were more likely to win mating contests within those *** on these studies,we assessed the social relationships among adult females and clarified possible explanations for the strategies of female mating competition in the ***,the notion that reproductive success may also be related to female dominance hierarchies in this polygynous species should be considered in future research.

关键词：竞争优势交配行为川金丝猴女性成年秦岭中国社会等级

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Multi-scale HPC system for multi-scale discrete simulation—Development and application of a supercomputer with 1 Petaflops peak performance in single precision

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Particuology 2009年第4期7卷 332-335页

作者： Feiguo Chen Wei Ge Li Guo Xianfeng He Bo Li Jinghai Li Xipeng Li xiaowei wang Xiaolong Yuan State Key Laboratory o fMulti-Phase Complex System Institute of Process Engineering Chinese Academy of Sciences P.O. Box 353 Beijing 100190 China

A supercomputer with 1.0 Petaflops peak performance in single precision, designed and established by Institute of Process Engineering, Chinese Academy of Sciences, is introduced in this brief communication. A designing philosophy utilizing the similarity between hardware, software and the problems to be solved is embodied, based on the multi-scale method and discrete simulation approaches developed at Institute of Process Engineering （IPE） and implemented in a graphic processing unit （GPU）-based hybrid computing mode. The preliminary applications of this machine in areas of multi-phase flow, molecular dynamics and so on are reported, demonstrating the supercomputer as a paradigm of green computation in new architecture.

关键词： High-performance computing (HPC) Graphic processing unit (GPU) Lattice Boltzmann method Molecular dynamics Multi-phase flow Multi-scale method Particle method

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Shadow regions detection algorithm by adaptive narrowband two-phase Chan-Vese model

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Chinese Journal of Acoustics 2016年第3期35卷 292-308页

作者： wang Xingmei YIN Guisheng LIU Guangyu LIU Zhipeng wang xiaowei College of Computer Science and Technology Harbin Engineering University College of Shipbuilding Engineering Harbin Engineering University

An adaptive narrowband two-phase Chan-Vese （ANBCV） model is proposed for improving the shadow regions detection performance of sonar images. In the first noise smoothing step, the anisotropic second-order neighborhood MRF （Markov Random Field, MRF） is used to describe the image texture feature parameters. Then, initial two-class segmentation is processed with the block mode k-means clustering algorithm, to estimate the approximate position of the shadow regions. On this basis, the zero level set function is adaptively initialized by the approximate position of shadow regions. ANBCV model is provided to complete local optimization for eliminating the image global interference and obtaining more accurate results. Experimental results show that the new algorithm can efficiently remove partial noise, increase detection speed and accuracy, and with less human intervention.

关键词： MRF Shadow regions detection algorithm by adaptive narrowband two-phase Chan-Vese model

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