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应用蛋白质组学探索2型糖尿病增殖期视网膜病变潜在生物标志物

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首都医科大学学报 2024年第3期45卷 385-391页

作者：杨芳远彭诗洁刘婧杨金奎朱晓蓉首都医科大学附属北京同仁医院内分泌科北京100730 北京市糖尿病研究所北京100730 北京老年医院内分泌科北京100089 北京市海淀医院感染性疾病科北京100080

目的利用同位素标记相对和绝对定量(isobaric tag for relative and absolute quantification,iTRAQ)蛋白质组学技术,分析糖尿病增殖期视网膜病变(proliferative diabetic retinopathy,PDR)患者与糖尿病无视网膜病变患者(diabetes patients without retina diseases,NDR)之间蛋白表达的差异,寻找PDR的候选血清标志物。方法收集2016年至2017年首都医科大学附属北京同仁医院内分泌科住院的PDR患者21例,以及性别年龄匹配的NDR患者21例。患者血清样本混匀后提取蛋白,采用iTRAQ标记,并进行液相质谱-串联质谱检测(liquid chromatograph-mass spectrometer and mass spectrometer,LC-MS/MS)分析,筛选出差异蛋白行基因本体论(Gene Ontology,GO)数据库功能富集及京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genome,KEGG)通路显著性富集分析。对相对定量结果进行独立样本t检验,通过差异倍数(fold change,FC)和P值判定蛋白表达量变化。结果以差异倍数>1.2倍(上/下调),P值≤0.05为标准,筛选出差异蛋白29个,其中PDR组上调蛋白8个,下调蛋白21个。通过对差异蛋白的GO功能显著性富集分析,结果显示,差异基因的功能可分为生物过程、细胞组分和分子功能三个板块。差异表达基因功能涉及生物调节、细胞组成、细胞代谢过程、细胞结合和催化活性等方面。KEGG通路显著性分析显示,上调最为明显的血管紧张素转换酶(angiotensin converting enzyme,ACE)参与肾素-血管紧张素系统(renin angiotensin system,RAS)、肾素分泌等通路,上调蛋白——胰岛素样生长因子I(insulin like growth factor I,IGF-1)参与HIF-1、FoxO、mTOR、PI3K-Akt和AMPK等多条与代谢相关的信号通路。下调显著的蛋白——肌球蛋白6(myosin-6)参与心肌细胞收缩和信号传导通路。结论采用iTRAQ蛋白质组学分析显示,PDR患者与NDR患者存在多种蛋白表达差异,ACE、IGF-1和Myosin-6有望作为糖尿病视网膜病变候选血清诊断标志物,未来可能为PDR的诊断和治疗提供新的靶点。

关键词：糖尿病视网膜病变血清蛋白质组学生物标志物液相质谱

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基于区块链和IPFS的存储机制设计

无线互联科技 2024年第1期21卷 82-87页

作者：朱亚丽许鸣睿丰茂智朱晓荣江苏商贸职业学院江苏南通226000 南京邮电大学江苏南京210003 兰山经济开发区管理委员会山东临沂276015

随着物联网设备的普及和人工智能应用的落地,物联网数据的规模呈爆炸式增长。要想实现物与物、物与人之间更便捷沟通的美好愿景,必须考虑物联网海量数据的存储问题。文章设计了一种基于区块链和星际文件系统(IPFS)的存储机制,通过与传... 详细信息

随着物联网设备的普及和人工智能应用的落地,物联网数据的规模呈爆炸式增长。要想实现物与物、物与人之间更便捷沟通的美好愿景,必须考虑物联网海量数据的存储问题。文章设计了一种基于区块链和星际文件系统(IPFS)的存储机制,通过与传统的区块链对比,基于区块链和IPFS的存储机制为存储和管理数据提供了一种安全、分散且可扩展的解决方案。

关键词：区块链 IPFS 存储机制

Data-flow in mobile edge computing networks: end-to-end performance analysis using stochastic network calculus

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The Journal of China Universities of Posts and Telecommunications 2022年第1期29卷 81-92页

作者： zhu xiaorong Jing Chuanfang Shi Jindou Wang Yong Ho Chifong College of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationNanjing 210003China School of Electrical Engineering Nanjing Vocational University of Industry TechnologyNanjing 210003China Ultra Intelligent Technology Company Limited MacaoChina

Mobile edge computing(MEC) networks can provide a variety of services for different applications. End-to-end performance analysis of these services serves as a benchmark for the efficient planning of network resource allocation and routing strategies. In this paper, a performance analysis framework is proposed for the end-to-end data-flows in MEC networks based on stochastic network calculus(SNC). Due to the random nature of routing in MEC networks, probability parameters are introduced in the proposed analysis model to characterize this randomness into the derived expressions. Taking actual communication scenarios into consideration, the end-to-end performance of three network data-flows is analyzed, namely, voice over Internet protocol(VoIP), video, and file transfer protocol(FTP). These network data-flows adopt the preemptive priority scheduling scheme. Based on the arrival processes of these three data-flows, the effect of interference on their performances and the service capacity of each node in the MEC networks, closed-form expressions are derived for showing the relationship between delay, backlog upper bounds, and violation probability of the data-flows. Analytical and simulation results show that delay and backlog performances of the data-flows are influenced by the number of hops in the network and the random probability parameters of interference-flow(IF).

关键词： delay mobile edge computing random routing stochastic network calculus

6G网络任务卸载与细粒度切片资源调度联合优化算法

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电信科学 2024年第5期40卷 86-99页

作者：王晔王逸飞陈康朱晓荣童恩徐语菲江苏移动信息系统集成有限公司江苏南京210013 南京邮电大学通信与信息工程学院江苏南京210003 中国移动通信集团江苏有限公司江苏南京210013

针对未来全域、全场景多样化的业务需求,6G网络需要提供场景化、个性化的服务能力。针对未来细粒度业务服务质量保障问题,提出了6G网络任务卸载与细粒度切片资源调度联合优化算法,联合考虑多MEC的计算卸载和网络切片的资源调度,在有限... 详细信息

针对未来全域、全场景多样化的业务需求,6G网络需要提供场景化、个性化的服务能力。针对未来细粒度业务服务质量保障问题,提出了6G网络任务卸载与细粒度切片资源调度联合优化算法,联合考虑多MEC的计算卸载和网络切片的资源调度,在有限的资源内,最小化任务的执行时延和能耗成本,并采用异步训练的A3C强化学习算法进行求解。仿真结果表明,对比传统算法,该算法可以在满足用户业务需求的情况下降低计算成本,并且算法收敛速度快,可以实现快速决策。

关键词： 6G网络任务卸载细粒度切片多维资源联合优化

Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium: Differences of administration occasion and time

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Neural Regeneration Research 2006年第9期1卷 844-846页

作者： Changling Peng Yuhua zhu Ankang Hu xiaorong zhu Experimental Animal Center Xuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China Experimental Animal CenterXuzhou Medical CollegeXuzhou 221002 Jiangsu Province China

BACKGROUND: Generally speaking, anesthesia is often used in gravid body and it has been already proved that many kind of medicine can result in malformation. OBJECTIVE: To explore embryonic skeleton development and neonatal learning and memory of rats anesthetized with pentobarbital sodium in gravid rats. DESIGN: A randomized control trial. SETTING: Laboratory Animal Center of Xuzhou Medical College. MATERIALS: A total of 80 adult female SD rats, of clean grade and weighing 220-240 g, were selected in this study. The main reagents were detailed as follows: pentobarbital sodium (Shanghai Xingzhi Chemical Plant, batch number: 921019); MG-2 maze test apparatus (Zhangjiagang Biomedical Instrument Factory); somatotype microscope (Beijing Taike Instrument Co., Ltd.). METHODS: ① A total of 160 SD rats of half males and females were selected in this study. All rats were copulated. The day that the plug was checked out in the vagina next day was looked as the first day of pregnancy. Gravid rats were divided randomly into four groups, including early anesthesia group, second anesthesia group, late anesthesia group and control group with 20 in each group. Rats in the early anesthesia group were injected with 25 mg/kg soluble pentobarbitone on the 7th day of pregnancy for once; rats in the second anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 7th and the 14th days of pregnancy for once; rats in the late anesthesia group were anesthetized with 25 mg/kg soluble pentobarbitone on the 14th day of pregnancy for once; rats in the control group did not treat with anything. The time of anesthetizing was controlled in 3 to 4 hours and ether was absorbed while the time was not enough. ② Half of each group was sacrificed on day 20th of pregnancy and the fetus was taken out to be stained with alizarin red S. After stained, the fetal skeleton was examined. The learning and memorizing of one-month rats that were given birth by the rest gravid rats were tested

关键词： Embryonic skeleton development and neonatal learning and memory ability of rats anesthetized with pentobarbital sodium Differences of administration occasion and time

NEAR OPTIMAL CLUSTER-HEAD SELECTION FOR WIRELESS SENSOR NETWORKS

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Journal of Electronics(China) 2007年第6期24卷 721-725页

作者： zhu xiaorong Shen Lianfeng National Mobile Comm. Research Lab Southeast University Nanjing 210096 China

Clustering in wireless sensor networks is an effective way to save energy and reuse bandwidth. To our best knowledge, most of the clustering protocols proposed in literature are of a dynamic type, where cluster heads are selected in each period, followed by cluster formation. In this paper, a new static type clustering method called Hausdorff clustering, which is based on the location of sensor nodes as well as communication efficiency and network connectivity, is proposed. The cluster head, however, is rotated within the cluster by a fuzzy logic algorithtn that optimizes the network lifetime. Simulation results show that this approach can significantly increase the lifetime of the sensor network.

关键词： Sensor networks Hausdorff clustering Fuzzy logic

Advanced dual-atom catalysts for rechargeable zinc-air batteries

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Energy Reviews 2024年第3期3卷 58-75页

作者： xiaorong Lin Gao Chen Yanping zhu Haitao Huang Department of Applied Physics and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomHong KongChina

Rechargeable zinc-air batteries(ZABs)have gained extensive research attention as a promising sustainable energy technology due to their considerable theoretical specific energy density,low toxicity,abundant availability,and robust safety ***,the practical implementation of ZABs still faces challenges,primarily attributed to the sluggish kinetics of oxygen-involved reactions,including oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)during the discharge and charge ***,searching for efficient bifunctional oxygen electrocatalysts is crucial to address these ***-atom catalysts(DACs),an extension of singleatom catalysts(SACs),exhibit flexible architectures that allow for the combination of homogeneous and/or heterogeneous active sites,making them highly attractive for improving bifunctional *** this review,we first introduce the basic framework of ZABs and the structural characteristics of ***,we organize the research progress on applying DACs in liquid and solid-state ZABs and elaborate on their unique catalytic ***,we highlight the challenges and future research directions for further innovation of DACs in *** summary,this review highlights the advantages of DACs compared with SACs used as bifunctional oxygen electrocatalysts and provides a reference for the broad applications of DACs in energy conversion and storage.

关键词： Dual-atom catalysts Bifunctional oxygen electrocatalysis Zinc-air batteries Solid-state zinc-air batteries

Alignment technology of heavy ion medicalmachine

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Radiation Detection Technology and Methods 2019年第2期3卷 37-43页

作者： Wenjun Chen Yaqing Yang Guozhu Cai Zhiguo Cui xiaorong zhu Shaoming Wang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Huizhou Research Center of Ion Science Huizhou 516000China

Background Heavy ion medical machine(HIMM)is built by the Institute of Modern Physics,Chinese Academy of Sciences,with a high-energy beam transport line with a height of 18 m,and its complex space mounting structure increases the difficulty of installation and *** The aim of this paper is to provide methods to install all accelerator components efficiently and to ensure that the alignment accuracies of all installed components are within the designed *** We accomplished the fiducialization and pre-alignment of complex modules by combining the laser tracker and the alignment *** analyzing various elements that affect the accuracy of alignment,a method of alignment for high-energy beam transport line was proposed based on high-precision three-dimensional control *** All components have been installed and aligned in a short time,alignment position accuracy of magnets is less than 0.1 mm,and the treatment components alignment accuracy is no more than 0.4 *** On the basis of error analysis,all alignment results are better than the required precisions,and all of these guaranteed the successful operation of HIMM.

关键词： Heavy ion accelerator Three-dimensional control network Laser tracker Alignment Fiducialization

H-Implanted Pd Icosahedra for Oxygen Reduction Catalysis: From Calculation to Practice

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CCS Chemistry 2021年第8期3卷 1972-1982页

作者： Lingzheng Bu xiaorong zhu Yiming zhu Chen Cheng Yafei Li Qi Shao Liang Zhang Xiaoqing Huang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123 State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005 Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityJiangsu 210023 Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversityJiangsu 215123

Although palladium(Pd)has gradually emerged as the most likely candidate to replace platinum(Pt)in the oxygen reduction reaction(ORR),the specific electronic structure of conventional Pd results in too strong Pd–O binding strength and unsatisfactory ORR ***,guided by density functional theory,we have explored a strategy to expand lattice spacing by implanting hydrogen(H)atoms in Pd nanocrystals(NCs),which realizes decreased electron density to boost ORR.

关键词： H-implanting palladium icosahedron non-platinum oxygen reduction catalysis