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Chirality Transfer in Supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

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Advanced Fiber Materials 2020年第4期2卷 204-211页

作者： Nabila Mehwish xiaoqiu dou Changli Zhao Chuanliang Feng Qiang Fu State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Rd 800Shanghai 200240China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Molecular recognition of simple sugars is crucial due to their essential roles in most living ***,it remains extremely challenging to achieve a visual recognition of simple sugars like sucrose in water media under physiological *** this article,the visual recognition of sucrose is accomplished by a chiral supramolecular hydrogel formation through the co-assembly of a two-component fibrous solution(l-phenylalanine based gelator co-diaminopyridine,LDAP)and sucrose.H-bonding between the amino group of LDAP and the hydroxyl group of sucrose facilitates the gelation by loading sucrose into the LDAP *** formed hydrogel showed an amplified inversion of circular dichroism(CD)signals as compared to the corresponding LDAP *** addition,the effective chirality transfer was accompanied by a bathochromic shift in UV-Vis and FL spectra of the *** a simple and straightforward chiral co-assembled strategy to visually recognize sucrose will have the potential use of smart gelators in saccharides separation and proteomics to be further applied in medical diagnostics and cell imaging.

关键词： Supramolecular hydrogels Chirality inversion Molecular recognition Sugars Sucrose Glucose

Hydrogen-bonding regulated supramolecular chirality with controllable biostability

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Nano Research 2022年第3期15卷 2226-2234页

作者： Jinying Liu Yu Zhao Changli Zhao xiaoqiu dou Xiaoyu Ma Shaokang Guan Yu Jia Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China International Laboratory for Quantum Functional Materials of Henan and School of PhysicsZhengzhou UniversityZhengzhou 450001China

The regulation of natural helical nanostructures is principally supported and actuated by hydrogen bonds(H-bonds)formed from hydrogen-bonding groups(peptide bonds and base pairs)to realize biological activities and specific biofunctional ***,studying the role of H-bonding patterns on the handedness of supramolecular assemblies is still challenging,since supramolecular assemblies will be disassembled or destabilized with slightly varying H-bonding groups for most *** circumvent this issue,herein,two types of self-assembled C2-symmetric phenylalanine derivatives differed by a single H-bonding group(ester or amide)are systematically designed for deciphering the role of H-bonding pattern on the chirality of supramolecular assemblies and their related *** handedness nanofibrous structures with tailorable diameter and helical pitch are achieved with the transition from ester to amide groups in the *** and theoretical evidence suggests that helical orientation of ester-containing gelators ascribes to intermolecular *** contrast,the helical direction for the amide-counterparts is mainly due to intra-and intermolecular ***,these H-bonding groups greatly influence their stability,as revealed by in vitro and in vivo degradation experiments and the left-handed assemblies are more stable than the right-handed ***,the study offers a feasible model to have valuable insight into understanding the role of H-bonding patterns in biological folding.

关键词： supramolecular chirality helical structures hydrogen-bonding group hydrogen-bonding pattern biostability

Biphenyl-Induced Superhelix in L-Phenylalanine-Based Supramolecular Self-Assembly with Dynamic Morphology Transitions

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CCS Chemistry 2022年第8期4卷 2816-2828页

作者： Laiben Gao Yueyue Feng Chao Xing Yu Zhao Meng Sun Yunqing Zou Changli Zhao xiaoqiu dou Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240 College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234 School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001

Dynamic transitions of supramolecular assemblies between lower-order structures and higher-order superhelical structures(e.g.,double-helical DNA,helical biopolymers)are of vital importance in many physiological processes,but still remain a great challenge to be realized in artificially assembled ***,a novel biphenyl central core symmetrically coupled with phenylalanine groups drives the construction of the dynamic superhelix.

关键词： superhelix biphenyl chirality morphological transition cell release

Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway

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Bioactive Materials 2021年第4期6卷 990-997页

作者： Na Sun xiaoqiu dou Zhimin Tang Dandan Zhang Ni Ni Jiajing Wang Huiqin Gao Yahan Ju Xiaochan Dai Changli Zhao Ping Gu Jing Ji Chuanliang Feng Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Department of OphthalmologyNinth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Road 800200240ShanghaiChina

Retinal degeneration is a main class of ocular *** far,retinal progenitor cell(RPC)transplantation has been the most potential therapy for it,in which promoting RPCs neuronal differentiation remains an unmet *** address this issue,innovatively designed L/D-phenylalanine based chiral nanofibers(LPG and DPG)are employed and it finds that chirality of fibers can efficiently regulate RPCs ***,western blot,and immunofluorescence analysis show that right-handed helical DPG nanofibers significantly promote RPCs neuronal differentiation,whereas left-handed LPG nanofibers decrease this *** effects are mainly ascribed to the stereoselective interaction between chiral helical nanofibers and retinol-binding protein 4(RBP4,a key protein in the retinoic acid(RA)metabolic pathway).The findings of chirality-dependent neuronal differentiation provide new strategies for treatment of neurodegenerative diseases via optimizing differentiation of transplanted stem cells on chiral nanofibers.

关键词： Chiral structures Self-assembly Nanofibers Retinal progenitor cell Neuronal differentiation

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如何在本科教学中培养学生科研兴趣

科教文汇 2020年第1期 68-69,79页

作者：冯传良窦晓秋赵常利上海交通大学

本文以本科生课程“材料化学”为例,探讨了如何在本科教学过程中培养学生科研兴趣。从教学内容和教学方式出发,提出了几点本科教学的创新方法、思路和注意事项,这将为高校培养创新人才、建设一流学科打下坚实基础。

关键词：本科教学科研兴趣创新人才

How can manufacturers make decisions on product appearance design? A research on optimal design based on customers' emotional satisfaction

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Journal of Management Science and Engineering 2021年第2期6卷 177-196页

作者： Runliang dou Wei Li Guofang Nan xiaoqiu Wang Yanjie Zhou College of Management and Economics Tianjin UniversityTianjin300072China School of Management Engineering Zhengzhou University450001China

With changing customer attitudes toward consumption and function homogenization,product appearance designs have an increasing influence on the purchase *** characteristics and emotional factors play an important role *** study proposes a novel approach for modelling satisfaction and accomplishing a configuration that overcomes the limitations of conventional methods to precisely predict satisfaction,provide optimal product recommendations,and advise manufacturers on product appearance *** newly proposed approach considers satisfaction,clusters customers through the Kansei perspective,and constructs a satisfaction model for each ***,the study employs data mining to understand the basic design principles and conflicted combinations that must be followed and avoided,*** bidirectional association rules-constrained genetic algorithm is presented to limit configuration freedom,ensuring that results are in the range of *** prediction errors and recommended sample votes between the novel and conventional approaches revealed the presented approach’s efficiency and accuracy,thereby providing suggestions for manufacturers to make precise decisions on launching new product appearance designs through predicting customer emotional satisfaction.

关键词： Product appearance design Kansei engineering Customer emotional satisfaction Bidirectional association rules-constrained genetic algorithm Product customisation

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中国RAFM钢中驻留氘的热脱附行为研究

材料导报 2016年第14期30卷 10-14页

作者：刘凌博窦天军王博饶咏初叶小球陈长安表面物理与化学重点实验室绵阳621907

分别研究了中国自主研发的2种低活化铁素体/马氏体钢(CLAM钢和CLF-1钢)中氘的驻留情况,利用金相显微镜对材料的金相组织进行分析。结果表明,CLAM钢为等轴的回火马氏体相,而CLF-1钢金相组织为保持了板条马氏体形态的细小回火马氏体。通... 详细信息

分别研究了中国自主研发的2种低活化铁素体/马氏体钢(CLAM钢和CLF-1钢)中氘的驻留情况,利用金相显微镜对材料的金相组织进行分析。结果表明,CLAM钢为等轴的回火马氏体相,而CLF-1钢金相组织为保持了板条马氏体形态的细小回火马氏体。通过氘的扩散常数计算2种钢中氘浓度分布,结果显示,CLAM钢和CLF-1钢在500℃、500kPa条件下,氘充饱和情况下氘浓度分别为7.43μg/g和5.7μg/g。在室温下放置0.5h后,CLAM钢和CLF-1钢中的氘分别损失了23%和51%。TDS实验结果表明,CLAM钢中的氘只有1个解吸峰,激活能为21kJ/mol,对应的氢陷阱为晶界和位错。CLF-1钢中的氘有2个解吸峰,解吸峰激活能为31kJ/mol,高温段解吸峰激活能为94kJ/mol。2种钢中低温段解吸峰对应的氢陷阱为晶界和位错,CLF-1钢低温段解吸峰的激活能略高是因为其晶粒尺寸小,氘原子的扩散路径更多。CLF-1钢样品高温段解吸峰对应的氢陷阱是由晶界和位错等缺陷与MC碳化物复合形成的新的氢陷阱。

关键词：低活化铁素体/马氏体钢氘热解吸谱