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macrocyclic compound as ionophores in lead(Ⅱ) ion-selective electrodes with excellent response characteristics

Chinese Science Bulletin 2008年第21期53卷 3255-3266页

作者： HUANG MeiRong ma xiaoli LI XinGui Key Laboratory of Advanced Civil Engineering materials of Ministry of Education Institute of Materials Chemistry College of Materials Science and Engineering Tongji University Shanghai 200092 China

macrocyclic compounds,such as crown ethers,azacrown ethers,thiacrown ethers,calixarenes and porphyrins,which act as ionophores in lead(Ⅱ) ion-selective electrodes,are systematically summarized based on the latest *** molecular structure characteristics of the ionophores are *** modification regulations for the substituted ionophores are elaborated with the purpose of improving the response features of the lead(Ⅱ) ion-selective electrodes assembled by *** is pointed out that the introduction of pendant moieties which contain soft base coordination centers like N,S and P atoms is in favor of adjusting the cavity size and conformation of the macrocyclic ***,there is synergic effect between the cavity and the donor sites of the ligand and thus the selective complexation of lead ions is easily realized,resulting in significant avoidance of the interference from other metal *** macrocyclic ionophore having the best response characteris-tics thus far was found to be N,N'-dimethylcyanodiaza-18-crown-6 with the detection limit of 7.0×10-8(14.5 μg/L),which is one of the uncommon ionophores that can really eliminate the interference from silver and mercury *** selectivity coefficients of the ionophore for lead ions over other metal ions,such as alkali,alkaline earth and transition metal ions are in the order of 10-4 or smaller,where the se-lectivity coefficient of lead(Ⅱ) over mercury(Ⅱ) ions is much lower,down to 8.9×*** structure de-sign idea for high-performance ionophore is proposed according to present *** incorporation of nitrogen atom,especially cyano group or thiocyano group or amino/imino groups,rather than thio atom alone could result in new excellent lead *** aborative design for metacyclophanes containing aromatic nitrogen atoms with the aim of creating excellent ionophores would also become a potential research *** lead(Ⅱ) ion-selective electrodes have shown widely potential ap

关键词：大环复合物离子载体电极电路

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Join the club:YIPF3 and YIPF4 act as Golgiphagy receptors

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Life Metabolism 2024年第1期3卷 7-9页

作者： xiaoli ma Hong Zhang National Laboratory of Biomacromolecules New Cornerstone Science LaboratoryInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Autophagic degradation of membrane-bound organelles such as the endoplasmic reticulum(ER),mitochondria,and peroxisomes is mediated by a family of *** a recent study,Hickey et *** that autophagy triggered by nutrient stress,previously thought to degrade bulk cytoplasmic contents,prioritizes the ER and Golgi as cargoes for *** further demonstrated that Yip1 domain family member 3(YIPF3)and YIPF4 act as receptors to mediate the delivery of Golgi to the lysosomes for Golgi remodelling during nutrient stress and also neuronal differentiation.

关键词： PF4 reticulum

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Effect of building interface form on thermal Check foi comfort in gymnasiums in hot and humid climates

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Frontiers of Architectural Research 2019年第1期8卷 32-43页

作者： Xiaodan Huang xiaoli ma Qingyuan Zhang Institute of Urban Innovation Yokohama National University 240-8501 Japan School of Engineering and Computer Science University of Hull HU6 7RX UK

The thermal environment and thermal comfort of a building are greatly affected by the desig n of the build ing interface form. Most con temporary architectural designs con sider only the relations between architectural form and architectural beauty. Few studies on the correlati on of architectural form and thermal comfort address the in flue nee of architectural form on thermal comfort and thermal environment. These studies are particularly important for gymnasium architectures located in hot and humid areas, which have high requirements for thermal comfort. This paper presents an experimental investigati on and an an alysis of the effect of the building in terface form of gymnasiums on thermal comfort in hot and humid subtropical regions during summer. Results showed that the influence of the top interface forms on thermal comfort is mainly dominated by the mea n radiant temperature, which could be con trolled to improve thermal comfort. The in fluence of side interface forms on thermal comfort is mainly domi nated by air velocity, and thermal comfort could be improved by promoting natural ventilation on the side interface form design to reduce indoor heat. This research enhanced our understanding of the relation between the in terface form and the thermal comfort of gymnasiums. In addition, this paper provides a theoretical reference for the sustainable design of gymnasiums in hot and humid climates.

关键词： Thermal comfort Thermal environment Interface form Standard effective temperature Gymnasium Hot and humid climate

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Four new phenolic glycosides from Baoyuan decoction

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Acta Pharmaceutica Sinica B 2017年第2期7卷 173-178页

作者： xiaoli ma Xiaoyu Guo Mingbo Zhao Pengfei Tu Yong Jiang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Four new phenolic glycosides,including two flavonoid glycosides(1 and 2) and two lignan glycosides(3 and 4),were isolated from the traditional Chinese medicine formula,Baoyuan *** structures were established by detailed analysis of the NMR and HR-ESI-MS spectroscopic data and their absolute configurations were determined by the experimental electronic circular dichroism data as well as chemical ***,the sources of the four new compounds were determined by the UPLC-Qtrap-MS method,which proved that 1 and 2 are originated from Glycyrrhiza uralensis,and 3 and4 are from Cinnamomum cassia.

关键词： Baoyuan decoction Traditional Chinese med icine formula Flavonoid glycosides Lignan glycosides Electronic circular dichroism UPLC–Qtrap-MS

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DICER1 mutations in twelve Chinese patients with pleuropulmonary blastoma

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Science China(Life Sciences) 2017年第7期60卷 714-720页

作者： Siyu Cai Xisi Wang Wen Zhao Libing Fu xiaoli ma Xiaoxia Peng Center for Clinical Epidemiology & Evidence-based Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 Chin Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing 100045 China Department of Pathology Beijing Children's Hospital Capital Medical University Beijing 100045 China Beijing Key Laboratory of Pediatric Hematology Oncology Beijing 100045 China Key Laboratory of major Diseases in Children Ministry of Education Beijng 100045 China

Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma(PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The family histories of 12 children with PPB recruited consecutively were surveyed. Blood samples from patients and their first-degree relatives were tested for DICER1 mutations. Whole-genome sequencing of blood samples and formalin-fixed and paraffin-embedded(FFPE) tumor tissue was performed in one family with twins. Twelve patients with PPB included six type II and six type III cases. Seven of the12 patients harbored DICER1 mutations, six of which were frameshift or nonsense mutations. Another case carried a germline DICER1 mutation affecting the splice site. FFPE sample had a nonsense mutation in TDG and missense mutations in *** addition, two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of PPB. Furthermore, one patient had a family history remarkable for thyroid diseases. Our results indicate that the germline mutation frequency in Chinese patients with PPB is similar to the ones reported for patients from USA, UK, and Japan. Moreover, our study strongly suggests that investigating the family history and detecting germline DICER1 mutations might be of benefit to increasing awareness and improving the accuracy of the differential diagnosis of PPB from non-malignant lung cysts.

关键词： China DICER1 mutation pleuropulmonary blastoma

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Evaluation model for arc fluctuations of triple-electrode high speed fillet welding

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China Welding 2014年第2期23卷 17-21页

作者： ma xiaoli Hua Xueming Wang Fei Wu Yixiong School of materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240

To improve the welding efficiency of conventional arc welding, triple-electrode fillet welding was proposed and developed. Stability of triple-electrode fillet welding process is the assurance for ideal joint. The evaluation model for arc fluctuations of triple-electrode fillet welding was established based on the characteristic parameters and their variation coefficients. This model indicated that variation coefficients could reflect arc voltage flnctuations of welding process, and its analysis result was consistent with the actual welding process.

关键词： process stability variation coefficient triple-electrode fillet welding

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The great triangular seismic region in eastern Asia:Thoughts on its dynamic context

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Geoscience Frontiers 2011年第1期2卷 57-65页

作者： Xianglin Gao Xiaojing ma xiaoli Li Institute of Geology China Earthquake Administration Beijing 100029 China

A huge triangle-shaped tectonic region in eastern Asia plays host to numerous major earth- quakes. The three boundaries of this region, which contains plateaus, mountains, and intermountain basins, are roughly the Himalayan arc, the Tianshan-Baikal, and longitude line -105°E. Within this trian- gular region, tectonism is intense and major deformation occurs both between crustal blocks and within most of them. Outside of this region, rigid blocks move as a whole with relatively few major earthquakes and relatively weak Cenozoic deformation. On a large tectonic scale, the presence of this broad region of intraplate deformation results from dynamic interactions between the Indian, Philippine Sea-West Pacific, and Eurasian plates, as well as the influence of deep-level mantle flow. The Indian subcontinent, which continues to move northwards at -40 mm/a since its collision with Eurasia, has plunged beneath Tibet, resulting in various movements and deformations along the Himalayan arc that diffuse over a long distance into the hinterland of Asia. The northward crustal escape of Asia from the Himalayan collisional zone turns eastwards and southeastwards along 95°-100°E longitude and defines the eastern Himalayan syntaxis. At the western Himalayan syntaxis, the Pamirs continue to move into central Asia, leading to crustal deformation and earthquakes that are largely accommodated by old EW or NW trending faults in the bordering areas between China, Mongolia, and Russia, and are restricted by the stable landmass northwest of the Tianshan-Altai-Baikal region. The subduction of the Philippine and Pacific plates under the Eurasian continent has generated a very long and narrow seismic zone along trenches and island arcs in the marginal seas while imposing only slight horizontal compression on the Asian continent that does not impede the eastward motion of eastern Asia. In the third dimension, there may be southeastward deep mantle flow beneath most of Eurasia that reaches the ma

关键词： Eastern Asian tectonics Huge triangular seismicregion India plate Philippine Sea-WestPacific region Eurasian mantle flow

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Dual-Tone Radio Interferometric Positioning Systems for Multi-Target Localization Using a Single Mobile Anchor

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China Communications 2015年第1期12卷 25-35页

作者： LI Li'an WANG Yiyin ma xiaoli CHEN Cailian GUAN Xinping Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China School of Electrical & Computer Engineering Georgia Institute of Technology

In this paper, a low-cost dualtone radio interferometric positioning system using a single mobile anchor is proposed to locate multiple targets at the same time. We name it mDRIPS. In mDRIPS, each target continuously transmits a dual-tone signal with its dedicated frequencies, and the mobile anchor receives the signals at different positions along its trajectory, Neither time synchronization between the mobile anchor and the targets nor time synchronization among the targets is required. We take the instability of targets clocks into consideration and develop an ESPRIT-type algorithm to estimate frequencies of each dual-tone signal. Furthermore, the time of arrival （TOA） of each target signal is extracted from the phase estimates of the received dual-tone signals. After measuring several TOAs at different locations along the anchor＇s trajectory, each target can be located. Since the frequency difference of the two tones of each dualtone signal is designed to be smaller than the channel coherence bandwidth, the same fading effect on these two tones can be eliminated. Moreover, the integer ambiguity problem due to phase wrapping is investigated, and a localization algorithm to deal with a simplified ambiguity problem is proposed. Numerical results demonstrate the efficiency of the proposed mDRIPS.

关键词： ranging localization mobile anchor radio interferometry oscillator instability

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Reciprocal activation ofα5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation

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Journal of Genetics and Genomics 2017年第7期44卷 355-362页

作者： Yao Zhang Yanfei Jia Ping Li Huanjie li Dongjie Xiao YunshanWang xiaoli ma Central Laboratory Jinan Central Hospital Affiliated to Shandong UniversityJinan 250100China State Key Laboratory of Microbial Technology Shandong UniversityJinan 250100China

Cigarette smoking is the top environmental risk factor for lung cancer. Nicotine, the addictive component of cigarettes, induces lung cancer cell proliferation, invasion and migration via the activation of nicotinic acetylcholine receptors （nAChRs）. Genome-wide association studies （GWAS） show that CI4RNA5 gene encoding α5-nAChR is especially relevant to lung cancer. However, the mechanism of this subunit in lung cancer is not clear. In the present study, we demonstrate that the expression of α5-nAChR is correlated with phosphorylated STAT3 （pSTAT3） expression, smoking history and lower survival of non-small cell lung cancer （NSCLC） samples. Nicotine increased the levels of α5-nAChR mRNA and protein in NSCLC cell lines and activated the ]AK2/STAT3 signaling cascade. Nicotine-induced activation of JAK2/STAT3 signaling was inhibited by the silencing of α5-nAChR. Characterization of the CHRNA5 promoter revealed four STAT3-response elements. ChiP assays confirmed that the CHRNA5 promoter contains STAT3 binding sites. By silencing STAT3 expression, nicotine-induced upregulation of α5-nAChR was suppressed. Downregulation of α5-nAChR and/or STAT3 expression inhibited nicotine-induced lung cancer cell proliferation. These results suggest that there is a feedback loop between α5-nAChR and STAT3 that contributes to the nicotine-induced tumor cell proliferation, which indicates that α5-nAChR is an important therapeutic target involved in tobacco-associated lung carcinogenesis.

关键词： α5-nAChR STAT3 Cell proliferation Nicotine Non-small cell lung cancer

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Analysis of Channeling-Path Phenomena in a Complex Fault-Block Reservoir with Low Recovery Factor and High Water-Cut Ratio

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Fluid Dynamics & materials Processing 2023年第2期19卷 361-377页

作者： Qunyi Wang xiaoli ma Yongbin Bi Haiyan He Xiao Gu Tongjing Liu Lekun Zhao Jidong Oilfield Company Ltd.Exploration and Development Research Institute Tangshan063000China Unconventional Oil and Gas Institute China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China

Current methods for the analysis of channeling-path phenomena in reservoirs cannot account for the influence of time and space on the actual seepage *** the present study,this problem is addressed considering actual production data and dynamic characteristic parameters quantitatively determined in the near wellbore area by fitting the water-cut curve of the *** from the dynamic relationship between injection and production data,the average permeability is determined and used to obtain a real-time quantitative characterization of the seepage behavior of the channeling-path in the far wellbore *** the considered case study(Jidong oilfield),it is found that the seepage capacity of the channeling-path in the far wellbore area is far less(10 times smaller)than that of the channeling-path in the near wellbore *** present study and the proposed model(combining near wellbore area and far wellbore area real-time data)have been implemented to support the definition of relevant adjustment measures to ultimately improve oil recovery.

关键词： Complex fault-block reservoirs channeling path quantitative identification characteristic parameters dynamic inversion

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