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Multi-source data integration and multi-scale modeling framework for progressive prediction of complex geological interfaces in tunneling

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Underground Space 2024年第2期15卷 1-25页

作者： Jingxiao Wang Peinan Li Xiaoying zhuang xiaojun Li Xi Jiang Jun Wu Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China College of Environmental Science and Engineering Donghua UniversityShanghai 201620China Institute of Photonics Department of Mathematics and PhysicsLeibniz University HannoverHannover 30167Germany Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 100872China College of Civil Engineering Shanghai Normal UniversityShanghai 200233China

A reliable geological model plays a fundamental role in the efficiency and safety of mountain tunnel ***,regional models based on limited survey data represent macroscopic geological environments but not detailed internal geological characteristics,especially at tunnel portals with complex geological *** paper presents a comprehensive methodological framework for refined modeling of the tunnel surrounding rock and subsequent mechanics analysis,with a particular focus on natural space distortion of hard-soft rock interfaces at tunnel *** progressive prediction of geological structures is developed considering multi-source data derived from the tunnel survey and excavation *** improve the accuracy of the models,a novel modeling method is proposed to integrate multi-source and multi-scale data based on data extraction and potential field ***,a regional-scale model and an engineering-scale model are built,providing a clear insight into geological phenomena and supporting numerical *** addition,the proposed framework is applied to a case study,the Long-tou mountain tunnel project in Guangzhou,China,where the dominant rock type is *** results show that the data integration and modeling methods effectively improve model structure *** improved model’s calculation deviation is reduced by about 10%to 20%in the mechanical *** study contributes to revealing the complex geological environment with singular interfaces and promoting the safety and performance of mountain tunneling.

关键词： Mountain tunnel Geological modeling Multi-source data Progressive prediction Tunnel portals

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Development and validation of a nomogram to predict indolent course in patients with ulcerative colitis:a single-center retrospective study

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Gastroenterology Report 2022年第1期10卷 405-412页

作者： Na Li Shukai Zhan Caiguang Liu Tong Li Tong Tu Baili Chen Yao He Minhu Chen Zhirong Zeng xiaojun zhuang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:The natural disease course for patients with ulcerative colitis(UC)is heterogeneous and few data are available on the indolent course of UC and its related *** aimed to develop and validate a nomogramto predict indolent course in patients with ***:Data of patients diagnosed with UC in the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between April 2007 and February 2021 were retrospectively *** course was defined as a disease course without need for strict interventions(steroids,immunomodulators,biological agents,hospitalization,or surgery therapy)during the follow-up *** whole cohort was randomly divided into training set and validation *** nomogram was constructed in the training set based on the results of univariate and multivariate Cox regression *** performance of the nomogram was assessed by the concordance index(C-index),area under the receiver-operating characteristic curve(AUC),and calibration *** addition,we internally validated the nomogramvia the bootstrap method and the validation ***:Of 969 treatment-naive patients with UC,771(79.6%)had an indolent course after *** these,313 patients were included in the development and validation of the *** nomogram incorporating age,disease activity,C-reactive protein,and platelet count showed good calibration and *** C-index was 0.759(0.741 in bootstrap validation)and the AUC at 2,4,and 6 years was 0.767,0.782,and 0.775,*** nomogramperformed well when applied to the validation ***:A majority of patients with UC had an indolent course after *** nomogram developed in this study might be useful in therapeutic decision-making and follow-up management for patients with UC.

关键词： ulcerative colitis indolent course predict nomogram

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Serum exosomal microRNA-144-3p:a promising biomarker for monitoring Crohn’s disease

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Gastroenterology Report 2022年第1期10卷 313-321页

作者： Peng Chen Shanshan Huang Qiao Yu Kang Chao Ying Wang Gaoshi Zhou xiaojun zhuang Zhirong Zeng Minhu Chen Shenghong Zhang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouP.R.China Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China

Background:Crohn’s disease(CD)has a tendency for recurrence and requires adequate monitoring and personalized *** endoscopy is considerably invasive,serum biomarkers are required as alternatives for CD *** this,exosomal microRNAs(miRNAs)may serve as promising *** this study,we aimed to assess the role of serum exosomal microRNA-144-3p(miR-144-3p)as a biomarker for CD ***:We prospectively recruited 154 patients without a history of surgery(Cohort 1)and 75 patients who were to undergo intestinal resection(Cohort 2).Serum samples were collected from Cohort 1 before colonoscopy and from Cohort 2 before surgery and during post-operative colonoscopic *** serum levels of exosomal miR-144-3p were measured using quantitative reverse-transcription polymerase chain reaction(PCR).Correlations between relative exosomal miR-144-3p levels,disease activity,and disease behavior were *** area under the receiver-operating characteristic curve(AUC)was used to assess the predictive value of exosomal miR-144-3p regarding mucosal activity and postoperative ***:A 3.33-fold increase in serum exosomal miR-144-3p levels was recorded in patients with CD compared with those in healthy controls(P<0.001).The exosomalmiR-144-3p levels were positively correlated with the simple endoscopic score of CD(q=0.547,P<0.001)as well as the Rutgeerts score(q=0.478,P<0.001).Elevated exosomalmiR-144-3p levels were correlated with the penetrating disease with high specificity(100%[95%confidence interval,95.1%–100%]).The accuracy of exosomalmiR-144-3p for identifying post-operative recurrence was higher than that of C-reactive protein(CRP)(AUC,0.775 vs 0.639;P<0.001).Conclusions:Serum exosomal miR-144-3p is a reliable biomarker of mucosal inflammation and penetrating *** may identify endoscopic CD recurrence after intestinal resection with higher accuracy than CRP testing.

关键词： Crohn’s disease microRNA-144-3p serum biomarker exosome

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ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 134-150页

作者： Shanshou Liu Jiangang Xie Chujun Duan xiaojun Zhao Zhusheng Feng Zheng Dai Xu Luo Yu Li Minghe Yang Ran zhuang Junjie Li Wen Yin Emergency Department Xijing HospitalFourth Military Medical UniversityXi’anShaanxiChina Emergency Department Tangdu HospitalFourth Military Medical UniversityXi’anShaanxiChina Third Student Brigade School of Basic Medical ScienceFourth Military Medical UniversityXi’anShaanxiChina Department of Immunology Fourth Military Medical UniversityXi’anShaanxiChina

apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ *** previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage during ***,the roles and mechanism of ADAR1 in sepsis-induced liver injury remain ***:We performed transcriptome and single-cell RNA sequencing of peripheral blood mononuclear cells(PBMCs)from patients with sepsis to investigate the effects of ADAR1 on immune cell *** also employed a cecal ligation and puncture(CLP)sepsis mouse model to evaluate the roles of ADAR1 in sepsisinduced liver ***,we treated murine RAW 264.7 macrophages with lipopolysaccharide to explore the underlying ADAR1-mediated mechanisms in ***:PBMCs from patients with sepsis had obvious apoptotic morphological ***-cell RNA sequencing indicated that apoptosis-related pathways were enriched in monocytes,with significantly elevated ADAR1 and BCL2A1 expression in severe ***-induced septic mice had aggravated liver injury and Kupffer cell apoptosis that were largely alleviated by ADAR1 ***1 directly bound to premiR-122 to modulate miR-122 ***-122 was an upstream regulator of ***,ADAR1 also reduced macrophage apoptosis in mice with CLP-induced sepsis through the miR-122/BCL2A1 signaling pathway and protected against sepsis-induced liver ***:The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling *** study provides novel insights into the development of therapeutic interventions in sepsis.

关键词： Sepsis Macrophage ADAR1 microRNA122 BCL2A1 Apoptosis

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Recent advances of digitization in rock mechanics and rock engineering

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Journal of Rock Mechanics and Geotechnical Engineering 2011年第3期3卷 220-233页

作者： Hehua Zhu*,xiaojun Li,Xiaoying zhuang Key Laboratory of Geotechnical Engineering,Department of Geotechnical Engineering,Tongji University,Shanghai,200092,China Key Laboratory of Geotechnical Engineering Department of Geotechnical Engineering Tongji University Shanghai 200092 China

In recent years,there are growing demands of representing rock mechanics and rock engineering in a digital format that can be easily managed,manipulated,analyzed and *** objective of this paper is to give a comprehensive review of the status quo and future trends of digitization in rock mechanics and rock *** topics essential to the process of digitization are firstly discussed,including data acquisition,data standardization,geological modeling,visualization and digital-numerical *** techniques that will play an important role in digitization process but require further improvement are then briefly ***,achievements of present methods and techniques for digitization in substantial rock mechanics and rock engineering are presented.

关键词： information digitization rock mechanics and rock engineering digital tunnel digital-numerical integration

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Adipocyte-secreted sPLA2 represses gut epithelial repair by inhibition of peroxisome elevation in intestinal stem cells

Adipocyte-secreted sPLA2 represses gut epithelial repair by ...

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第四届中国生物物理学会代谢生物学分会学术研讨会

作者： Zhiming Liu Lishou Xiong Juanyu Zhou Xiaoxin Guo xiaojun zhuang Xiao Sheng Haiyang Chen National Clinical Research Center for Geriatrics West China Hospital Sichuan University

＜正＞Obesity increases the risk of inflammatory bowel diseases （IBD）. However, the underlying molecular mechanisms by which obesity affects the regeneration of the intestinal mucosa in IBD patients remain largely unknown. Herein, we used high-fat diet （HFD）-induced obese mice and Drosophila to validate how obesity is linked to the intestinal epithelial repair. We found that HFD-induced obesity represses intestinal stem cell （ISC） differentiation and epithelial repair in DSS-induced ulcerative colitis mice and Drosophila.

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CT衰减值在术前评估低位直肠癌直肠周围间隙侵犯和小淋巴结转移的应用价值

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四川医学 2015年第11期36卷 1591-1594页

作者：庄小军广汉市人民医院普外科四川广汉618300

目的初步探讨低位直肠癌直肠周围脂肪间隙的平均CT值对于判断低位直肠癌周围脂肪间隙侵犯和直肠周围小淋巴结转移的应用价值。方法前瞻性纳入2011年7月至2013年2月于本院拟行外科手术治疗并被术前病理结果证实为低位直肠癌患者。所有患... 详细信息

目的初步探讨低位直肠癌直肠周围脂肪间隙的平均CT值对于判断低位直肠癌周围脂肪间隙侵犯和直肠周围小淋巴结转移的应用价值。方法前瞻性纳入2011年7月至2013年2月于本院拟行外科手术治疗并被术前病理结果证实为低位直肠癌患者。所有患者均于术前接受Philips Brilliance 64排螺旋CT全腹检查,并于后处理工作站对图像进行观察测量。采用ROI CT值测量法分别测出每个病例在平扫及增强时直肠周围脂肪间隙的平均CT值。结合病理结果,根据有无直肠周围脂肪间隙侵犯将病例分为T(+)、T(-)两组,根据有无直肠周围小淋巴结转移将病例分为N(+)、N(-)两组,分别比较T(+)、T(-)两组患者及N(+)、N(-)两组患者的ROI平均CT值的差异性。结果 T(-)组与T(+)组患者直肠周围脂肪间隙ROI CT值差异有统计学意义(P<0.05),N(-)组与N(+)组患者直肠周围脂肪间隙ROI CT值差异有统计学意义(P<0.05)。其ROC诊断效能曲线下面积有统计学意义(平扫:AZ=0.686,P=0.016;增强:AZ=0.682,P=0.019)。平扫及增强时,当ROI平均CT值取-80^-70 Hu为诊断直肠周围间隙侵犯参考值;平扫及增强时,当ROI平均CT值取-70^-60Hu,为诊断直肠周围小淋巴结转移的参考值。结论直肠周围脂肪间隙CT表现分型及ROI平均CT值的测量能够为直肠癌周围脂肪间隙侵犯和直肠周围小淋巴结转移提供辅助诊断依据。

关键词：低位直肠癌小淋巴结转移术前评估多层螺旋CT

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肠道微生态参与肠易激综合征发病的相关机制

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胃肠病学 2017年第3期22卷 181-183页

作者：庄晓君陈旻湖熊理守中山大学附属第一医院消化内科 510080

肠易激综合征(IBS)的病因和发病机制尚未明了,近年认为肠道微生态可能发挥重要作用。有研究表明IBS患者存在肠道菌群改变,干预肠道微生态对IBS有一定的治疗作用。本文就肠道微生态通过改变黏膜通透性、激活免疫反应、改变胃肠动力和影响... 详细信息

肠易激综合征(IBS)的病因和发病机制尚未明了,近年认为肠道微生态可能发挥重要作用。有研究表明IBS患者存在肠道菌群改变,干预肠道微生态对IBS有一定的治疗作用。本文就肠道微生态通过改变黏膜通透性、激活免疫反应、改变胃肠动力和影响脑-肠轴等参与IBS发病的相关机制作一综述。

关键词：肠易激综合征肠道菌群通透性免疫胃肠活动微生物-脑-肠轴

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精细加工——汽车模具企业提高竞争力的利器

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上海电机学院学报 2003年第1期6卷 1-4,17页

作者：庄孝君上海电机技术高等专科学校机械工程系上海200240

精细加工这里特指通过精细的工作流程,编制出高效的NC程序,用来制造高精度、高光洁度汽车模具的一种技术。本文详细论证了精细加工的意义;阐述了实施精细加工的基础,从而引伸出无人加工的概念;最后,用丰富的图表说明了精细加工的内涵及... 详细信息

精细加工这里特指通过精细的工作流程,编制出高效的NC程序,用来制造高精度、高光洁度汽车模具的一种技术。本文详细论证了精细加工的意义;阐述了实施精细加工的基础,从而引伸出无人加工的概念;最后,用丰富的图表说明了精细加工的内涵及实现的方法。

关键词： CAM NC程序 2NC 3NC 刀轨精细加工

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The Relationship between Father-Love Absence and Loneliness:Based on the Perspective of the Social Functionalist Theory and the Social Needs Theory

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International Journal of Mental Health Promotion 2024年第2期26卷 139-148页

作者： Yaping Zhou He Zhong xiaojun Li Yanhui Xiang Moral Culture Research Center of Hunan Normal University Hunan Normal UniversityChangsha410081China Research Center for Mental Health Education of Hunan Province Changsha410081China Beijing Huijia Private School Beijing102200China Tao Xingzhi Research Institute Nanjing Xiao Zhuang UniversityNanjing211171China Cognition and Human Behavior Key Laboratory of Hunan Province Hunan Normal UniversityChangsha410081China

Fathers play an important role in adolescents’development,which is significant for their development and influences their mental health,including feeling of ***,the effects and mechanisms of father-love absence on individual loneliness are not *** on the social functionalist theory and the social needs theory,this study examines the influence of individual fatherlove absence on loneliness and its underlying mechanisms.A questionnaire survey was administered to 319 junior high school students and 1,476 high school *** results showed that adolescents with father-love absence had higher levels of loneliness,and that father-love absence affected loneliness levels through mediating pathways of individual gratitude,peer relationships,and gratitude to peer *** study not only confirms the negative effects of father-love absence on adolescents’loneliness,but also explains the mediate roles of individual gratitude and peer *** enriches the theoretical system related to family education and has important theoretical and practical implications for further interventions on adolescents’mental health from the perspective of fatherless parenting.

关键词： Father-love absence loneliness gratitude peer relationships

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