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Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin xiao Liang Shu-Peng Liu Rui-Lan Wang Qing-Wei Zhang yu-Feng Shen xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,P<0.001].Additionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

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英国私立教会中小学发展状况与特色研究

长江大学学报（社会科学版） 2009年第5期32卷 99-101页

作者：鄢晓宇肖甦北京师范大学国际与比较教育研究所北京100875

在英国的私立中小学中,基于种族或宗教原因而产生的私立教会学校在基础教育中扮演着特殊的角色。以英国私立教会中小学中较有代表性的私立穆斯林学校和基督教福音派学校为例,多元文化主义与右翼势力的合力决定了前者的历史轨迹,财政难... 详细信息

在英国的私立中小学中,基于种族或宗教原因而产生的私立教会学校在基础教育中扮演着特殊的角色。以英国私立教会中小学中较有代表性的私立穆斯林学校和基督教福音派学校为例,多元文化主义与右翼势力的合力决定了前者的历史轨迹,财政难题则成为后者由盛转衰的关键。穆斯林学校最显著的特点在于坚持男女分校等穆斯林传统,以此保持自己的民族宗教特征并进而培养穆斯林儿童的自信;基督教福音派学校的最重要特点则在于其将宗教贯穿于学校生活的各个层面,将基督教教义、基督教文化融入到知识道理中传递给学生。然而由于资金、政策等问题的制约,导致私立教会学校在发展中存在着软硬件各方面的困境,政府扶持是改善这种状况的关键所在。

关键词：英国私立教会中小学发展特色

HPLC测定11种中药口服液中6种防腐剂的含量

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中国实验方剂学杂志 2012年第3期18卷 76-79页

作者：孙蒙闫小玉毕开顺陈晓辉沈阳药科大学药学院沈阳110016

目的:建立HPLC同时测定中药口服液体制剂中防腐剂含量的方法。方法:Kromasil C18色谱柱(4.6 mm×250mm,5μm),流动相乙腈-0.02 mol.L-1乙酸铵溶液梯度洗脱,流速1.0 ***-1,检测波长240 nm,柱温30℃。结果:苯甲酸、山梨酸、对羟基苯甲酸... 详细信息

目的:建立HPLC同时测定中药口服液体制剂中防腐剂含量的方法。方法:Kromasil C18色谱柱(4.6 mm×250mm,5μm),流动相乙腈-0.02 mol.L-1乙酸铵溶液梯度洗脱,流速1.0 ***-1,检测波长240 nm,柱温30℃。结果:苯甲酸、山梨酸、对羟基苯甲酸酯类在1.0～181.1 mg.L-1线性关系良好(r>0.999);平均回收率95.5%～100.8%(RSD 0.7%～1.5%)。结论:方法简单、可靠,精确,可用于中药口服液体制剂中防腐剂含量的测定。

关键词：口服液体制剂苯甲酸山梨酸对羟基苯甲酸酯测定

Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-Tong Cui Hua-Ru Xue Dian-Fang Wei xiao-yu Feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

Pluronic F127胶束的载药、固化及其片剂的溶出度

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中国药科大学学报 2011年第2期42卷 119-123页

作者：张传宝操锋肖衍宇平其能中国药科大学药剂学教研室南京210009

考察Pluronic F127(F127)增溶难溶性药物及载药胶束溶液固化的方法,制备载药胶束的固体制剂,提高口服药物的溶出度。本研究以辛伐他汀(simvastatin,SIM)为模型药物,采用薄膜分散-水化法制备F127-SIM胶束溶液。以载药率为指标,通过正交... 详细信息

考察Pluronic F127(F127)增溶难溶性药物及载药胶束溶液固化的方法,制备载药胶束的固体制剂,提高口服药物的溶出度。本研究以辛伐他汀(simvastatin,SIM)为模型药物,采用薄膜分散-水化法制备F127-SIM胶束溶液。以载药率为指标,通过正交试验优化载药胶束处方工艺;用喷雾干燥法对胶束进行固化,并对粉末进行物理性质表征;进行复溶实验,考察温度和稀释对载药胶束固体粉末复溶的影响;最后制备成片剂,考察片剂的体外溶出性能。最终得到的胶束载药量为13%,提高了F127对SIM的载药能力,同时SIM在水中的溶解度提高了近950倍。喷雾干燥后,载药胶束粉末为多孔状的无定形固体分散体。复溶后,对温度和稀释的稳定性显著提高。SIM载药胶束片的溶出度显著高于市售片的溶出度。

关键词： Pluronic F127 聚合物胶束喷雾干燥复溶辛伐他汀

p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-κB pathway in human ovarian cancer cells

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p62/SQSTM1 as an oncotarget mediates cisplatin resistance th...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： xiao-yu yan yu Zhang Juan-Juan Zhang Li-Chao Zhang Ya-Nan Liu Yao Wu Ya-Nan Xue Sheng-Yao Lu Jing Su Lian-Kun Sun Department of Pathophysiology College of Basic Medical SciencesJilin University

Platinum-based therapeutic strategies have been widely used in ovarian cancer treatment. However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to cisplatin has been attributed to other factors unrelated to DNA. p62(also known as SQSTM1) functions as a multifunctional hub participating in tumorigenesis and may be a therapeutic target. Our previous study showed that p62 was overexpressed in drug-resistant ovarian epithelial carcinoma and its inhibition increased the sensitivity to cisplatin. In this study, we demonstrate that the activity of the NF-κB signaling pathway and K63-linked ubiquitination of RIP1 was higher in cisplatin-resistant ovarian(SKOV3/DDP) cells compared with parental cells. In addition, cisplatin resistance could be reversed by inhibiting the expression of p62 using siRNA. Furthermore, deletion of the ZZ domain of p62 that interacts with RIP1 in SKOV3 cells markedly decreased K63-linked ubiquitination of RIP1 and inhibited the activation of the NF-κB signaling pathway. Moreover, loss of the ZZ domain from p62 led to poor proliferative capacity and high levels of apoptosis in SKOV3 cells and made them more sensitive to cisplatin treatment. Collectively, we provide evidence that p62 is implicated in the activation of NF-κB signaling that is partly dependent on RIP1. p62 promotes cell proliferation and inhibits apoptosis thus mediating drug resistance in ovarian cancer cells.

关键词： p62/SQSTM1 drug resistance NF-KB pathway RIP1 ovarian cancer

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基于情景模拟的电力应急演练设计

华东电力 2013年第12期41卷 2616-2619页

作者：颜晓宇马杰沈林吴若斌肖洋国网上海市电力公司上海200122 国网上海市电力公司培训中心上海200438 上海交通大学上海200240

面对电网大停电事故,依托电力应急管理机制实现快速、有效得应急响应是目前电力企业需要重点关注的问题。为了进一步完善电力应急机制,同时锻炼各职能部门面对突发状况的应急响应能力,开展切实的电力应急演练工作十分必要。提出了一套... 详细信息

面对电网大停电事故,依托电力应急管理机制实现快速、有效得应急响应是目前电力企业需要重点关注的问题。为了进一步完善电力应急机制,同时锻炼各职能部门面对突发状况的应急响应能力,开展切实的电力应急演练工作十分必要。提出了一套基于情景模拟的电力应急演练设计理念,从组织体系、硬件设施、脚本编写和评价机制等方面分别进行详细阐述。实践证明,这种方式能够有效锻炼各职能部门人员的应急处置能力,起到良好的演练目的。

关键词：电力应急情景模拟演练评价机制

姜黄素纳米脂质载体的制备及大鼠体内药代动力学

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中国药科大学学报 2012年第5期43卷 412-417页

作者：陈曦肖衍宇陈祎楠平其能张灿中国药科大学药剂学教研室南京210009 中国药科大学新药研究中心南京210009

采用熔融-乳化法制备姜黄素(Cur)纳米脂质载体(Cur-NLC),并考察其形态、粒径、Zeta电位、包封率和载药量等理化性质,同时以透析法研究制剂的体外释药特性。测定Cur-NLC和Cur原料的混悬液经大鼠灌胃后的体内药代动力学行为,并通过DAS2.0... 详细信息

采用熔融-乳化法制备姜黄素(Cur)纳米脂质载体(Cur-NLC),并考察其形态、粒径、Zeta电位、包封率和载药量等理化性质,同时以透析法研究制剂的体外释药特性。测定Cur-NLC和Cur原料的混悬液经大鼠灌胃后的体内药代动力学行为,并通过DAS2.0软件计算药代动力学参数。结果显示,透射电镜观察Cur-NLC呈较规则类球体,平均粒径为(187.5±4.67)nm,Zeta电位为(-23.65±2.86)mV,包封率、载药量分别为(98.33±0.40)%和(4.59±0.19)%;Cur-NLC和Cur混悬液体外释药行为分别符合一级方程和Peppas方程,Cur-NLC在HCl(pH 1)和PBS(pH 6.8)中的36 h累积释放量分别为24.3%和19.2%,Cur混悬液的36 h累积释放量分别为90.2%和84.2%,说明Cur担载于纳米脂质体后具有明显的缓释特性。经大鼠灌胃后,Cur-NLC和Cur混悬液的AUC0-∞分别为(621.14±179.92)ng.h/mL和(32.49±3.55)ng.h/mL,cmax分别为(92.81±38.52)ng/mL和(5.39±0.13)ng/mL,Cur-NLC的AUC0-∞和cmax分别提高了19.12倍和17.22倍。因此,Cur-NLC对Cur起到很好的保护作用,避免了药物的渗漏,载药量和包封率均较高,能显著增强Cur在胃肠道的吸收,提高Cur的口服生物利用度。

关键词：姜黄素纳米脂质载体理化性质口服生物利用度药代动力学

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19世纪艺术歌曲的创作与抒情诗的关系

星海音乐学院学报 2006年第1期 61-65页

作者：阎笑雨星海音乐学院音乐学系广东广州510006

本文从音乐与抒情诗结合的内在依据、浪漫主义抒情诗对艺术歌曲创作的影响等两个方面论述了19世纪前后艺术歌曲创作与抒情诗的关系,并从音乐与文学融合的角度证明这个时期艺术歌曲的创作是音乐与文学结合的一个成功范例。

关键词：艺术歌曲抒情诗浪漫主义